Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies

This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (heal...

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Autores:
Alavez-Ramírez, Justino
López López, Jorge
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad EAFIT
Repositorio:
Repositorio EAFIT
Idioma:
spa
OAI Identifier:
oai:repository.eafit.edu.co:10784/14487
Acceso en línea:
http://hdl.handle.net/10784/14487
Palabra clave:
Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
Rights
License
Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López
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spelling Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees2010-06-012019-11-22T19:01:25Z2010-06-012019-11-22T19:01:25Z2256-43141794-9165http://hdl.handle.net/10784/14487This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (healthy and diseased hepatocytes, viral load and cytotoxic T cells), using measurements of viral load and cytotoxic T cells. It is also shown that the population of cytotoxic T cells does not significantly influence the estimation of the parameters, so it is sufficient to measure the viral load and the model reduced to three populations (healthy, diseased hepatocytes and viral load) to diagnose the disease evolution of an infected individual.En este trabajo se muestra la posibilidad de predecir el estado de un individuo infectado por el virus de la hepatitis C y el monitoreo de la evolución de su carga viral y daño hepático, sin necesidad de biopsias, mediante la estimación numérica de los parámetros de un modelo matemático de cuatro poblaciones (hepatocitos sanos y enfermos, carga viral y células T citotóxicas), usando mediciones de la carga viral y células T citotóxicas. También se muestra que la población de células T citotóxicas no influye significativamente en la estimación de los parámetros, por lo que es suficiente la medición de la carga viral y el modelo reducido a tres poblaciones (hepatocitos sanos, enfermos y carga viral) para diagnosticar la evolución de la enfermedad de un individuo infectado.application/pdfspaUniversidad EAFIThttp://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López LópezAcceso abiertohttp://purl.org/coar/access_right/c_abf2instname:Universidad EAFITreponame:Repositorio Institucional Universidad EAFITIngeniería y Ciencia; Vol 6, No 11 (2010)Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsiesDinámica del virus de la hepatitis C concarga viral y células T citotóxicas y monitoreo del daño hepático sin biopsiasarticleinfo:eu-repo/semantics/articlepublishedVersioninfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Hepatitis CViral LoadCytotoxic T CellsParameterHepatitis CCarga ViralCélulas T CitotóxicasParámetroAlavez-Ramírez, JustinoLópez López, JorgeUniversidad Juárez Autónoma de TabascoIngeniería y Ciencia611933ing.cienc.THUMBNAILminaitura-ig_Mesa de trabajo 1.jpgminaitura-ig_Mesa de trabajo 1.jpgimage/jpeg265796https://repository.eafit.edu.co/bitstreams/208c54a8-220f-4def-b307-2c1b3c062bb9/downloadda9b21a5c7e00c7f1127cef8e97035e0MD51ORIGINAL1.pdf1.pdfTexto completo PDFapplication/pdf290995https://repository.eafit.edu.co/bitstreams/f0e23850-1e1a-40b4-9370-05c02b6c7dcf/download4467229cea50ef62511ac31d14f6257fMD52articulo.htmlarticulo.htmlTexto completo HTMLtext/html373https://repository.eafit.edu.co/bitstreams/c59e75a5-19b8-43ff-91ed-6509745bfc61/download30d5ea2c626a034fe30f9ee47e2213e9MD5310784/14487oai:repository.eafit.edu.co:10784/144872020-03-02 22:24:44.783open.accesshttps://repository.eafit.edu.coRepositorio Institucional Universidad EAFITrepositorio@eafit.edu.co
dc.title.eng.fl_str_mv Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
dc.title.spa.fl_str_mv Dinámica del virus de la hepatitis C concarga viral y células T citotóxicas y monitoreo del daño hepático sin biopsias
title Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
spellingShingle Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
title_short Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
title_full Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
title_fullStr Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
title_full_unstemmed Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
title_sort Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
dc.creator.fl_str_mv Alavez-Ramírez, Justino
López López, Jorge
dc.contributor.author.spa.fl_str_mv Alavez-Ramírez, Justino
López López, Jorge
dc.contributor.affiliation.spa.fl_str_mv Universidad Juárez Autónoma de Tabasco
dc.subject.keyword.eng.fl_str_mv Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
topic Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
dc.subject.keyword.spa.fl_str_mv Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
description This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (healthy and diseased hepatocytes, viral load and cytotoxic T cells), using measurements of viral load and cytotoxic T cells. It is also shown that the population of cytotoxic T cells does not significantly influence the estimation of the parameters, so it is sufficient to measure the viral load and the model reduced to three populations (healthy, diseased hepatocytes and viral load) to diagnose the disease evolution of an infected individual.
publishDate 2010
dc.date.issued.none.fl_str_mv 2010-06-01
dc.date.available.none.fl_str_mv 2019-11-22T19:01:25Z
dc.date.accessioned.none.fl_str_mv 2019-11-22T19:01:25Z
dc.date.none.fl_str_mv 2010-06-01
dc.type.eng.fl_str_mv article
info:eu-repo/semantics/article
publishedVersion
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http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.spa.fl_str_mv Artículo
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 2256-4314
1794-9165
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10784/14487
identifier_str_mv 2256-4314
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url http://hdl.handle.net/10784/14487
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.relation.uri.none.fl_str_mv http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237
dc.rights.eng.fl_str_mv Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso abierto
rights_invalid_str_mv Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López
Acceso abierto
http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv application/pdf
dc.coverage.spatial.eng.fl_str_mv Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees
dc.publisher.spa.fl_str_mv Universidad EAFIT
dc.source.none.fl_str_mv instname:Universidad EAFIT
reponame:Repositorio Institucional Universidad EAFIT
dc.source.spa.fl_str_mv Ingeniería y Ciencia; Vol 6, No 11 (2010)
instname_str Universidad EAFIT
institution Universidad EAFIT
reponame_str Repositorio Institucional Universidad EAFIT
collection Repositorio Institucional Universidad EAFIT
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