Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies
This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (heal...
- Autores:
-
Alavez-Ramírez, Justino
López López, Jorge
- Tipo de recurso:
- Fecha de publicación:
- 2010
- Institución:
- Universidad EAFIT
- Repositorio:
- Repositorio EAFIT
- Idioma:
- spa
- OAI Identifier:
- oai:repository.eafit.edu.co:10784/14487
- Acceso en línea:
- http://hdl.handle.net/10784/14487
- Palabra clave:
- Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
- Rights
- License
- Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López
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Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees2010-06-012019-11-22T19:01:25Z2010-06-012019-11-22T19:01:25Z2256-43141794-9165http://hdl.handle.net/10784/14487This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (healthy and diseased hepatocytes, viral load and cytotoxic T cells), using measurements of viral load and cytotoxic T cells. It is also shown that the population of cytotoxic T cells does not significantly influence the estimation of the parameters, so it is sufficient to measure the viral load and the model reduced to three populations (healthy, diseased hepatocytes and viral load) to diagnose the disease evolution of an infected individual.En este trabajo se muestra la posibilidad de predecir el estado de un individuo infectado por el virus de la hepatitis C y el monitoreo de la evolución de su carga viral y daño hepático, sin necesidad de biopsias, mediante la estimación numérica de los parámetros de un modelo matemático de cuatro poblaciones (hepatocitos sanos y enfermos, carga viral y células T citotóxicas), usando mediciones de la carga viral y células T citotóxicas. También se muestra que la población de células T citotóxicas no influye significativamente en la estimación de los parámetros, por lo que es suficiente la medición de la carga viral y el modelo reducido a tres poblaciones (hepatocitos sanos, enfermos y carga viral) para diagnosticar la evolución de la enfermedad de un individuo infectado.application/pdfspaUniversidad EAFIThttp://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López LópezAcceso abiertohttp://purl.org/coar/access_right/c_abf2instname:Universidad EAFITreponame:Repositorio Institucional Universidad EAFITIngeniería y Ciencia; Vol 6, No 11 (2010)Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsiesDinámica del virus de la hepatitis C concarga viral y células T citotóxicas y monitoreo del daño hepático sin biopsiasarticleinfo:eu-repo/semantics/articlepublishedVersioninfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Hepatitis CViral LoadCytotoxic T CellsParameterHepatitis CCarga ViralCélulas T CitotóxicasParámetroAlavez-Ramírez, JustinoLópez López, JorgeUniversidad Juárez Autónoma de TabascoIngeniería y Ciencia611933ing.cienc.THUMBNAILminaitura-ig_Mesa de trabajo 1.jpgminaitura-ig_Mesa de trabajo 1.jpgimage/jpeg265796https://repository.eafit.edu.co/bitstreams/208c54a8-220f-4def-b307-2c1b3c062bb9/downloadda9b21a5c7e00c7f1127cef8e97035e0MD51ORIGINAL1.pdf1.pdfTexto completo PDFapplication/pdf290995https://repository.eafit.edu.co/bitstreams/f0e23850-1e1a-40b4-9370-05c02b6c7dcf/download4467229cea50ef62511ac31d14f6257fMD52articulo.htmlarticulo.htmlTexto completo HTMLtext/html373https://repository.eafit.edu.co/bitstreams/c59e75a5-19b8-43ff-91ed-6509745bfc61/download30d5ea2c626a034fe30f9ee47e2213e9MD5310784/14487oai:repository.eafit.edu.co:10784/144872020-03-02 22:24:44.783open.accesshttps://repository.eafit.edu.coRepositorio Institucional Universidad EAFITrepositorio@eafit.edu.co |
dc.title.eng.fl_str_mv |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
dc.title.spa.fl_str_mv |
Dinámica del virus de la hepatitis C concarga viral y células T citotóxicas y monitoreo del daño hepático sin biopsias |
title |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
spellingShingle |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies Hepatitis C Viral Load Cytotoxic T Cells Parameter Hepatitis C Carga Viral Células T Citotóxicas Parámetro |
title_short |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
title_full |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
title_fullStr |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
title_full_unstemmed |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
title_sort |
Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies |
dc.creator.fl_str_mv |
Alavez-Ramírez, Justino López López, Jorge |
dc.contributor.author.spa.fl_str_mv |
Alavez-Ramírez, Justino López López, Jorge |
dc.contributor.affiliation.spa.fl_str_mv |
Universidad Juárez Autónoma de Tabasco |
dc.subject.keyword.eng.fl_str_mv |
Hepatitis C Viral Load Cytotoxic T Cells Parameter |
topic |
Hepatitis C Viral Load Cytotoxic T Cells Parameter Hepatitis C Carga Viral Células T Citotóxicas Parámetro |
dc.subject.keyword.spa.fl_str_mv |
Hepatitis C Carga Viral Células T Citotóxicas Parámetro |
description |
This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (healthy and diseased hepatocytes, viral load and cytotoxic T cells), using measurements of viral load and cytotoxic T cells. It is also shown that the population of cytotoxic T cells does not significantly influence the estimation of the parameters, so it is sufficient to measure the viral load and the model reduced to three populations (healthy, diseased hepatocytes and viral load) to diagnose the disease evolution of an infected individual. |
publishDate |
2010 |
dc.date.issued.none.fl_str_mv |
2010-06-01 |
dc.date.available.none.fl_str_mv |
2019-11-22T19:01:25Z |
dc.date.accessioned.none.fl_str_mv |
2019-11-22T19:01:25Z |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.eng.fl_str_mv |
article info:eu-repo/semantics/article publishedVersion info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.local.spa.fl_str_mv |
Artículo |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
2256-4314 1794-9165 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10784/14487 |
identifier_str_mv |
2256-4314 1794-9165 |
url |
http://hdl.handle.net/10784/14487 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.isversionof.none.fl_str_mv |
http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237 |
dc.relation.uri.none.fl_str_mv |
http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/237 |
dc.rights.eng.fl_str_mv |
Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
rights_invalid_str_mv |
Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López Acceso abierto http://purl.org/coar/access_right/c_abf2 |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.spatial.eng.fl_str_mv |
Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees |
dc.publisher.spa.fl_str_mv |
Universidad EAFIT |
dc.source.none.fl_str_mv |
instname:Universidad EAFIT reponame:Repositorio Institucional Universidad EAFIT |
dc.source.spa.fl_str_mv |
Ingeniería y Ciencia; Vol 6, No 11 (2010) |
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