Hepatitis C virus dynamics with viral load and T killer cells and hepatic damage monitoring without liver biopsies

This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (heal...

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Autores:
Alavez-Ramírez, Justino
López López, Jorge
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad EAFIT
Repositorio:
Repositorio EAFIT
Idioma:
spa
OAI Identifier:
oai:repository.eafit.edu.co:10784/14487
Acceso en línea:
http://hdl.handle.net/10784/14487
Palabra clave:
Hepatitis C
Viral Load
Cytotoxic T Cells
Parameter
Hepatitis C
Carga Viral
Células T Citotóxicas
Parámetro
Rights
License
Copyright (c) 2010 Justino Alavez-Ramírez, Jorge López López
Description
Summary:This paper shows the possibility of predicting the status of an individual infected with the hepatitis C virus and monitoring the evolution of their viral load and liver damage, without the need for biopsies, by numerical estimation of the parameters of a Mathematical model of four populations (healthy and diseased hepatocytes, viral load and cytotoxic T cells), using measurements of viral load and cytotoxic T cells. It is also shown that the population of cytotoxic T cells does not significantly influence the estimation of the parameters, so it is sufficient to measure the viral load and the model reduced to three populations (healthy, diseased hepatocytes and viral load) to diagnose the disease evolution of an infected individual.