Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring

The reduced standard model of three populations (healthy and diseased hepatocytes, and viral load) for the study of hepatitis C virus (HCV) dynamics is compared with the model of viral dynamics with alanine aminotransferase (ALT). In terms of the threshold parameter that is the same for both models,...

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Autores:
Alavez-Ramírez, Justino
Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad EAFIT
Repositorio:
Repositorio EAFIT
Idioma:
spa
OAI Identifier:
oai:repository.eafit.edu.co:10784/14556
Acceso en línea:
http://hdl.handle.net/10784/14556
Palabra clave:
Hepatitis C
Viral Load
Liver Damage
Biopsies
Parameters
Threshold Parameter
Hepatitis C
Carga Viral
Daño Hepático
Biopsias
Parámetros
Parámetro Umbral
Rights
License
Copyright (c) 2006 Justino Alavez-Ramírez
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spelling Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees2006-12-012019-11-22T19:18:48Z2006-12-012019-11-22T19:18:48Z2256-43141794-9165http://hdl.handle.net/10784/14556The reduced standard model of three populations (healthy and diseased hepatocytes, and viral load) for the study of hepatitis C virus (HCV) dynamics is compared with the model of viral dynamics with alanine aminotransferase (ALT). In terms of the threshold parameter that is the same for both models, the existence and stability of the endemic equilibrium state is determined, as well as the overall stability of the healthy individual's equilibrium state. On the other hand, an experimental study is presented that shows that it is possible to monitor liver damage without biopsies, by numerical estimation of the model parameters, considering only measurements of viral load, ALT levels and a reasonable assessment of liver damage pretreatment.Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral) para el estudio de la dinámica del virus de la hepatitis C (VHC), con el modelo de la dinámica viral con alanina aminotransferasa (ALT). En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aapplication/pdfspaUniversidad EAFIThttp://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472Copyright (c) 2006 Justino Alavez-RamírezAcceso abiertohttp://purl.org/coar/access_right/c_abf2instname:Universidad EAFITreponame:Repositorio Institucional Universidad EAFITIngeniería y Ciencia; Vol 2, No 4 (2006)Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoringDinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsiasarticleinfo:eu-repo/semantics/articlepublishedVersioninfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Hepatitis CViral LoadLiver DamageBiopsiesParametersThreshold ParameterHepatitis CCarga ViralDaño HepáticoBiopsiasParámetrosParámetro UmbralAlavez-Ramírez, JustinoUniversidad Juárez Autónoma de TabascoIngeniería y Ciencia24125144ing.cienc.THUMBNAILminaitura-ig_Mesa de trabajo 1.jpgminaitura-ig_Mesa de trabajo 1.jpgimage/jpeg265796https://repository.eafit.edu.co/bitstreams/b6c4e65d-b60a-4eae-8c87-e32bddb0bf52/downloadda9b21a5c7e00c7f1127cef8e97035e0MD51ORIGINALdocument (3).pdfdocument (3).pdfTexto completo PDFapplication/pdf242197https://repository.eafit.edu.co/bitstreams/895e45cc-e509-4822-a87b-e177832d0f35/download4e9d673c10c4bf15565c618e11b53d69MD52articulo.htmlarticulo.htmlTexto completo HTMLtext/html373https://repository.eafit.edu.co/bitstreams/baaa77f0-103e-42c6-a2a4-4b30f0bf1cf5/download7815b2d3f30d253f02166806134ea161MD5310784/14556oai:repository.eafit.edu.co:10784/145562020-03-02 23:30:09.009open.accesshttps://repository.eafit.edu.coRepositorio Institucional Universidad EAFITrepositorio@eafit.edu.co
dc.title.eng.fl_str_mv Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
dc.title.spa.fl_str_mv Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias
title Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
spellingShingle Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
Hepatitis C
Viral Load
Liver Damage
Biopsies
Parameters
Threshold Parameter
Hepatitis C
Carga Viral
Daño Hepático
Biopsias
Parámetros
Parámetro Umbral
title_short Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
title_full Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
title_fullStr Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
title_full_unstemmed Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
title_sort Hepatitis C virus dynamics with viral load and ALT and biopsy-free liver damage monitoring
dc.creator.fl_str_mv Alavez-Ramírez, Justino
dc.contributor.author.spa.fl_str_mv Alavez-Ramírez, Justino
dc.contributor.affiliation.spa.fl_str_mv Universidad Juárez Autónoma de Tabasco
dc.subject.keyword.eng.fl_str_mv Hepatitis C
Viral Load
Liver Damage
Biopsies
Parameters
Threshold Parameter
topic Hepatitis C
Viral Load
Liver Damage
Biopsies
Parameters
Threshold Parameter
Hepatitis C
Carga Viral
Daño Hepático
Biopsias
Parámetros
Parámetro Umbral
dc.subject.keyword.spa.fl_str_mv Hepatitis C
Carga Viral
Daño Hepático
Biopsias
Parámetros
Parámetro Umbral
description The reduced standard model of three populations (healthy and diseased hepatocytes, and viral load) for the study of hepatitis C virus (HCV) dynamics is compared with the model of viral dynamics with alanine aminotransferase (ALT). In terms of the threshold parameter that is the same for both models, the existence and stability of the endemic equilibrium state is determined, as well as the overall stability of the healthy individual's equilibrium state. On the other hand, an experimental study is presented that shows that it is possible to monitor liver damage without biopsies, by numerical estimation of the model parameters, considering only measurements of viral load, ALT levels and a reasonable assessment of liver damage pretreatment.
publishDate 2006
dc.date.issued.none.fl_str_mv 2006-12-01
dc.date.available.none.fl_str_mv 2019-11-22T19:18:48Z
dc.date.accessioned.none.fl_str_mv 2019-11-22T19:18:48Z
dc.date.none.fl_str_mv 2006-12-01
dc.type.eng.fl_str_mv article
info:eu-repo/semantics/article
publishedVersion
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http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.spa.fl_str_mv Artículo
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 2256-4314
1794-9165
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10784/14556
identifier_str_mv 2256-4314
1794-9165
url http://hdl.handle.net/10784/14556
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.isversionof.none.fl_str_mv http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472
dc.relation.uri.none.fl_str_mv http://publicaciones.eafit.edu.co/index.php/ingciencia/article/view/472
dc.rights.eng.fl_str_mv Copyright (c) 2006 Justino Alavez-Ramírez
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso abierto
rights_invalid_str_mv Copyright (c) 2006 Justino Alavez-Ramírez
Acceso abierto
http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv application/pdf
dc.coverage.spatial.eng.fl_str_mv Medellín de: Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees
dc.publisher.spa.fl_str_mv Universidad EAFIT
dc.source.none.fl_str_mv instname:Universidad EAFIT
reponame:Repositorio Institucional Universidad EAFIT
dc.source.spa.fl_str_mv Ingeniería y Ciencia; Vol 2, No 4 (2006)
instname_str Universidad EAFIT
institution Universidad EAFIT
reponame_str Repositorio Institucional Universidad EAFIT
collection Repositorio Institucional Universidad EAFIT
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