DIAN-TU ARGENTINA. A great human story of a small group of people
Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the disease and because of global aging, a very significant increase in the prevalence...
- Autores:
-
Chrem-Mendez, Patricio
Bagnati, Pablo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/10135
- Acceso en línea:
- https://hdl.handle.net/11323/10135
https://repositorio.cuc.edu.co/
- Palabra clave:
- DIAN-TU Argentina
ADAD
Anti-tau
Taco pozo
FLENI
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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DIAN-TU ARGENTINA. A great human story of a small group of people |
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DIAN-TU ARGENTINA. Una gran historia humana de un pequeño grupo de personas |
| title |
DIAN-TU ARGENTINA. A great human story of a small group of people |
| spellingShingle |
DIAN-TU ARGENTINA. A great human story of a small group of people DIAN-TU Argentina ADAD Anti-tau Taco pozo FLENI |
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DIAN-TU ARGENTINA. A great human story of a small group of people |
| title_full |
DIAN-TU ARGENTINA. A great human story of a small group of people |
| title_fullStr |
DIAN-TU ARGENTINA. A great human story of a small group of people |
| title_full_unstemmed |
DIAN-TU ARGENTINA. A great human story of a small group of people |
| title_sort |
DIAN-TU ARGENTINA. A great human story of a small group of people |
| dc.creator.fl_str_mv |
Chrem-Mendez, Patricio Bagnati, Pablo |
| dc.contributor.author.none.fl_str_mv |
Chrem-Mendez, Patricio Bagnati, Pablo |
| dc.subject.proposal.spa.fl_str_mv |
DIAN-TU Argentina ADAD |
| topic |
DIAN-TU Argentina ADAD Anti-tau Taco pozo FLENI |
| dc.subject.proposal.eng.fl_str_mv |
Anti-tau Taco pozo FLENI |
| description |
Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the disease and because of global aging, a very significant increase in the prevalence is expected in the upcoming decades, especially in countries in development. Several drugs with different targets have been tried so far and, still with no success. Frenzied efforts seeking a new disease-modifying drug are constantly being pursued and innovative models of the clinical trials have emerged. The DIAN initiative studies individuals with known mutations in the deterministic genes of the disease. Autosomal Dominantly Alzheimer Disease (ADAD) showed to be a more predictable model in terms of whom and when will get the disease. This allows testing novel therapeutics agents by choosing the drug according to the biological moment of the disease. But ADAD is also a uniquely human story full of courage and hope. The DIAN trial has started in Argentina and a new anti-tau age has begun as well. |
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2021 |
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2021-08-27 |
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2023-05-15T13:09:18Z |
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2023-05-15T13:09:18Z |
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Chrem-Mendez, P., & Bagnati, P. (2021). DIAN-TU ARGENTINA. A great human story of a small group of people: DIAN-TU ARGENTINA. Una gran historia humana de un pequeño grupo de personas. Journal of Applied Cognitive Neuroscience, 2(1), e00173805. https://doi.org/10.17981/JACN.2.1.2021.05 |
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10.17981/JACN.2.1.2021.05 |
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2745-0031 |
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Corporación Universidad de la Costa |
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REDICUC – Repositorio CUC |
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Chrem-Mendez, P., & Bagnati, P. (2021). DIAN-TU ARGENTINA. A great human story of a small group of people: DIAN-TU ARGENTINA. Una gran historia humana de un pequeño grupo de personas. Journal of Applied Cognitive Neuroscience, 2(1), e00173805. https://doi.org/10.17981/JACN.2.1.2021.05 10.17981/JACN.2.1.2021.05 2745-0031 Corporación Universidad de la Costa REDICUC – Repositorio CUC |
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Journal of Applied Cognitive Neuroscience |
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Aschenbrenner, A. J.; James, B. D.; McDade, E.; Wang, G.; Lim, Y. Y.; Benzinger, TLS.; Cruchaga, C.; Goate, A.; Xiong, C.; Perrin, R.; Buckles, V.; Allegri, R.; Berman, SB.; Chhatwal, JP.; Fagan, A.; Farlow, M.; O'Connor, A.; Ghetti, B.; Graff-Radford, N.; Goldman, J.; Gräber, S.; Karch, CM.; Lee, JH.; Levin, J.; Martins, R. N.; Masters, C.; Mori, H.; Noble, J.; Salloway, S.; Schofield, P.; Morris, J. C.; Bateman, R. J. & Hassenstab, J. (2020). Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & dementia: the journal of the Alzheimer's Association, 16(1), 219–228. https://doi.org/10.1002/alz.12010 Bateman, R. J.; Xiong, C.; Benzinger, T. L.; Fagan, A. M.; Goate, A.; Fox, N. C.; Marcus, D. S.; Cairns, N. J.; Xie, X.; Blazey, T. M.; Holtzman, D. M.; Santacruz, A.; Buckles, V.; Oliver, A.; Moulder, K.; Aisen, P. S.; Ghetti, B.; Klunk, W. E.; McDade, E.; Martins, R. N.; Masters, C. L.; Mayeux, R.; Ringman, J. M.; Rossor, M. N.; Schofield, P. R.; Sperling, R. A.; Salloway, S. & Morris, J. C. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. The New England journal of medicine, 367(9), 795–804. https://doi.org/10.1056/NEJMoa1202753 Bateman, R. J.; Aisen, P. S.; De Strooper, B.; Fox, N. C.; Lemere, C. A.; Ringman, J. M.; Salloway, S.; Sperling, R. A.; Windisch, M. & Xiong, C. (2011). Autosomal-dominant Alzheimer’s disease: A review and proposal for the prevention of Alzheimer’s disease. Alzheimer’s Research & Therapy, 2(6), 1–11. https://doi.org/10.1186/alzrt59 Bateman, R. J.; Benzinger, T. L.; Berry, S.; Clifford, D. B.; Fagan, A. M.; Fanning, K.; Farlow, M. R.; Hassenstab, J.; McDade, EM.; Mills, S.; Paumier, K.; Quintana, M.; Salloway, S. P.; Santacruz, A.; Schneider, L. S.; Wang, G. & Xiong, C. (2017). The DIAN-TU Next Generation Alzheimer’s prevention trial: Adaptive design and disease progression model. Alzheimer's & dementia: the journal of the Alzheimer's Association, 13(1), 8–19. https://doi.org/10.1016/j.jalz.2016.07.005 Libre-Guerra, J. J.; Li, Y.; Allegri, R. F.; Mendez, P. C.; Surace, E. I.; Llibre-Rodriguez, J. J.; Sosa, A. L.; Aláez-Verson, C.; Longoria, E. M.; Tellez, A.; Carrillo-Sánchez, K.; Flores-Lagunes, L. L.; Sánchez, V.; Takada, L. T.; Nitrini, R.; Ferreira-Frota, N. A.; Benevides-Lima, J.; Lopera, F.; Ramírez, L.; Jiménez-Velázquez, I.; Schenk, C.; Acosta, D.; Behrens, M. I.; Doering, M.; Ziegemeier, E.; Morris, J. C.; McDade, E. & Bateman, R. J. (2020). Dominantly inherited Alzheimer disease: Frequency, genetic heterogeneity, and clinical phenotype in Latin America: Genetic heterogeneity and clinical phenotypes. Alzheimer’s Dement, 16(S2), 653–664. https://doi.org/10.1002/alz.044794 Morris, J. C.; Aisen, P. S.; Bateman, R. J.; Benzinger, T. L. S.; Cairns, N. J.; Fagan, A. M.; Ghetti, B.; Goate, A. M.; Holtzman, D. M.; Klunk, W. E.; McDade, E.; Marcus, D. S.; Martins, R. N.; Masters, C.L.; Mayeux, R.; Oliver, A.; Quaid, K.; Ringman, J. M.; Rossor, M. N.; Salloway, S.; Schofield, P. R.; Selsor, N. J.; Sperling, R. A.; Weiner, M. W.; Xiong, C.; Moulder, K. L. & Buckles, Virginia D. (2012). Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network. Clinical investigation (Lond), 2(10), 975–984. Available: https://www.openaccessjournals.com/articles/developing-an-international-network-foralzheimers-research-the-dominantly-inherited-alzheimer-network.pdf Rahman, B.; Meiser, B.; Sachdev, P.; Barlow-Stewart, K.; Otlowski, M.; Zilliacus, E. & Schofield, P. (2012). To know or not to know: An update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk. Genetic testing and molecular biomarkers, 16(8), 935–942. https://doi.org/10.1089/gtmb.2011.0300 |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Copyright (c) 2021 Journal of Applied Cognitive Neurosciencehttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Chrem-Mendez, PatricioBagnati, Pablo2023-05-15T13:09:18Z2023-05-15T13:09:18Z2021-08-27Chrem-Mendez, P., & Bagnati, P. (2021). DIAN-TU ARGENTINA. A great human story of a small group of people: DIAN-TU ARGENTINA. Una gran historia humana de un pequeño grupo de personas. Journal of Applied Cognitive Neuroscience, 2(1), e00173805. https://doi.org/10.17981/JACN.2.1.2021.05https://hdl.handle.net/11323/1013510.17981/JACN.2.1.2021.052745-0031Corporación Universidad de la CostaREDICUC – Repositorio CUChttps://repositorio.cuc.edu.co/Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the disease and because of global aging, a very significant increase in the prevalence is expected in the upcoming decades, especially in countries in development. Several drugs with different targets have been tried so far and, still with no success. Frenzied efforts seeking a new disease-modifying drug are constantly being pursued and innovative models of the clinical trials have emerged. The DIAN initiative studies individuals with known mutations in the deterministic genes of the disease. Autosomal Dominantly Alzheimer Disease (ADAD) showed to be a more predictable model in terms of whom and when will get the disease. This allows testing novel therapeutics agents by choosing the drug according to the biological moment of the disease. But ADAD is also a uniquely human story full of courage and hope. The DIAN trial has started in Argentina and a new anti-tau age has begun as well.La enfermedad de Alzheimer es por mucho, la primera causa de demencia y la enfermedad neurodegenerativa más frecuente. Considerada como resultado de causas multifactoriales, el envejecimiento sigue siendo el principal factor de riesgo en su forma clásica y debido al envejecimiento global, se espera un aumento muy significativo de la prevalencia en las próximas décadas, especialmente en los países en desarrollo. Hasta ahora se han probado numerosos fármacos con diferentes dianas aunque aún sin éxito. Constantemente se realizan descomunales estudios en busca de un nuevo fármaco que logre modificar el destino de la enfermedad y así han surgido innovadores modelos de ensayos clínicos. La iniciativa DIAN estudia individuos con mutaciones conocidas en los genes determinantes de la enfermedad. La enfermedad de Alzheimer autosómica dominante (ADAD) demostró ser un modelo más predecible en términos de quién y cuándo contraerá la enfermedad. Esto permite probar nuevos agentes terapéuticos eligiendo el fármaco según el momento biológico de la enfermedad. Pero ADAD es también una historia muy humana llena de coraje y esperanza. El ensayo DIAN ha comenzado en Argentina y también ha comenzado una nueva era anti-tau.6 páginasapplication/pdfengCorporación Universidad de la CostaColombiahttps://revistascientificas.cuc.edu.co/JACN/article/view/3805DIAN-TU ARGENTINA. A great human story of a small group of peopleDIAN-TU ARGENTINA. Una gran historia humana de un pequeño grupo de personasArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85ArgentinaJournal of Applied Cognitive NeuroscienceAschenbrenner, A. J.; James, B. D.; McDade, E.; Wang, G.; Lim, Y. Y.; Benzinger, TLS.; Cruchaga, C.; Goate, A.; Xiong, C.; Perrin, R.; Buckles, V.; Allegri, R.; Berman, SB.; Chhatwal, JP.; Fagan, A.; Farlow, M.; O'Connor, A.; Ghetti, B.; Graff-Radford, N.; Goldman, J.; Gräber, S.; Karch, CM.; Lee, JH.; Levin, J.; Martins, R. N.; Masters, C.; Mori, H.; Noble, J.; Salloway, S.; Schofield, P.; Morris, J. C.; Bateman, R. J. & Hassenstab, J. (2020). Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & dementia: the journal of the Alzheimer's Association, 16(1), 219–228. https://doi.org/10.1002/alz.12010Bateman, R. J.; Xiong, C.; Benzinger, T. L.; Fagan, A. M.; Goate, A.; Fox, N. C.; Marcus, D. S.; Cairns, N. J.; Xie, X.; Blazey, T. M.; Holtzman, D. M.; Santacruz, A.; Buckles, V.; Oliver, A.; Moulder, K.; Aisen, P. S.; Ghetti, B.; Klunk, W. E.; McDade, E.; Martins, R. N.; Masters, C. L.; Mayeux, R.; Ringman, J. M.; Rossor, M. N.; Schofield, P. R.; Sperling, R. A.; Salloway, S. & Morris, J. C. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. The New England journal of medicine, 367(9), 795–804. https://doi.org/10.1056/NEJMoa1202753Bateman, R. J.; Aisen, P. S.; De Strooper, B.; Fox, N. C.; Lemere, C. A.; Ringman, J. M.; Salloway, S.; Sperling, R. A.; Windisch, M. & Xiong, C. (2011). Autosomal-dominant Alzheimer’s disease: A review and proposal for the prevention of Alzheimer’s disease. Alzheimer’s Research & Therapy, 2(6), 1–11. https://doi.org/10.1186/alzrt59Bateman, R. J.; Benzinger, T. L.; Berry, S.; Clifford, D. B.; Fagan, A. M.; Fanning, K.; Farlow, M. R.; Hassenstab, J.; McDade, EM.; Mills, S.; Paumier, K.; Quintana, M.; Salloway, S. P.; Santacruz, A.; Schneider, L. S.; Wang, G. & Xiong, C. (2017). The DIAN-TU Next Generation Alzheimer’s prevention trial: Adaptive design and disease progression model. Alzheimer's & dementia: the journal of the Alzheimer's Association, 13(1), 8–19. https://doi.org/10.1016/j.jalz.2016.07.005Libre-Guerra, J. J.; Li, Y.; Allegri, R. F.; Mendez, P. C.; Surace, E. I.; Llibre-Rodriguez, J. J.; Sosa, A. L.; Aláez-Verson, C.; Longoria, E. M.; Tellez, A.; Carrillo-Sánchez, K.; Flores-Lagunes, L. L.; Sánchez, V.; Takada, L. T.; Nitrini, R.; Ferreira-Frota, N. A.; Benevides-Lima, J.; Lopera, F.; Ramírez, L.; Jiménez-Velázquez, I.; Schenk, C.; Acosta, D.; Behrens, M. I.; Doering, M.; Ziegemeier, E.; Morris, J. C.; McDade, E. & Bateman, R. J. (2020). Dominantly inherited Alzheimer disease: Frequency, genetic heterogeneity, and clinical phenotype in Latin America: Genetic heterogeneity and clinical phenotypes. Alzheimer’s Dement, 16(S2), 653–664. https://doi.org/10.1002/alz.044794Morris, J. C.; Aisen, P. S.; Bateman, R. J.; Benzinger, T. L. S.; Cairns, N. J.; Fagan, A. M.; Ghetti, B.; Goate, A. M.; Holtzman, D. M.; Klunk, W. E.; McDade, E.; Marcus, D. S.; Martins, R. N.; Masters, C.L.; Mayeux, R.; Oliver, A.; Quaid, K.; Ringman, J. M.; Rossor, M. N.; Salloway, S.; Schofield, P. R.; Selsor, N. J.; Sperling, R. A.; Weiner, M. W.; Xiong, C.; Moulder, K. L. & Buckles, Virginia D. (2012). Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network. Clinical investigation (Lond), 2(10), 975–984. Available: https://www.openaccessjournals.com/articles/developing-an-international-network-foralzheimers-research-the-dominantly-inherited-alzheimer-network.pdfRahman, B.; Meiser, B.; Sachdev, P.; Barlow-Stewart, K.; Otlowski, M.; Zilliacus, E. & Schofield, P. (2012). To know or not to know: An update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk. Genetic testing and molecular biomarkers, 16(8), 935–942. https://doi.org/10.1089/gtmb.2011.03006112DIAN-TU ArgentinaADADAnti-tauTaco pozoFLENIPublicationORIGINALDIAN-TU ARGENTINA. A great human story of a small group of people.pdfDIAN-TU ARGENTINA. 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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