Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica

El abordaje diagnóstico de pacientes con enfermedades que comprometen la cognición es un reto para los sistemas de salud. El electroencefalograma es considerado una técnica útil para evaluar el funcionamiento cerebral, de bajo costo y accesible a la población general. El presente estudio indica que...

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Autores:
Camargo Camargo, Loida
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2023
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
spa
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/10766
Acceso en línea:
https://hdl.handle.net/11323/10766
https://repositorio.cuc.edu.co/
Palabra clave:
Demencia tipo alzheimer (DA)
Deterioro cognitivo leve (DCL)
Electroencefalograma (EEG)
Espectro de potencia
Conectividad funcional
Fototest
MoCA
Alzheimer's dementia (AD)
Mild cognitive impairment (MCI)
Electroencephalogram (EEG)
Power spectra
Functional connectivity
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Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
id RCUC2_e2cbc0f3cdacffad8bb50eff5abe1981
oai_identifier_str oai:repositorio.cuc.edu.co:11323/10766
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
title Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
spellingShingle Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
Demencia tipo alzheimer (DA)
Deterioro cognitivo leve (DCL)
Electroencefalograma (EEG)
Espectro de potencia
Conectividad funcional
Fototest
MoCA
Alzheimer's dementia (AD)
Mild cognitive impairment (MCI)
Electroencephalogram (EEG)
Power spectra
Functional connectivity
title_short Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
title_full Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
title_fullStr Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
title_full_unstemmed Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
title_sort Perfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológica
dc.creator.fl_str_mv Camargo Camargo, Loida
dc.contributor.advisor.none.fl_str_mv Allegri, Ricardo Francisco
Barceló, Ernesto
Cuesta, Pablo
dc.contributor.author.none.fl_str_mv Camargo Camargo, Loida
dc.contributor.jury.none.fl_str_mv Cochen, Silvia
Thomson, Alfredo
Fabian Román, Nestor
dc.subject.proposal.spa.fl_str_mv Demencia tipo alzheimer (DA)
Deterioro cognitivo leve (DCL)
Electroencefalograma (EEG)
Espectro de potencia
Conectividad funcional
Fototest
MoCA
topic Demencia tipo alzheimer (DA)
Deterioro cognitivo leve (DCL)
Electroencefalograma (EEG)
Espectro de potencia
Conectividad funcional
Fototest
MoCA
Alzheimer's dementia (AD)
Mild cognitive impairment (MCI)
Electroencephalogram (EEG)
Power spectra
Functional connectivity
dc.subject.proposal.eng.fl_str_mv Alzheimer's dementia (AD)
Mild cognitive impairment (MCI)
Electroencephalogram (EEG)
Power spectra
Functional connectivity
description El abordaje diagnóstico de pacientes con enfermedades que comprometen la cognición es un reto para los sistemas de salud. El electroencefalograma es considerado una técnica útil para evaluar el funcionamiento cerebral, de bajo costo y accesible a la población general. El presente estudio indica que el análisis de la conectividad cerebral y su relación con las pruebas de tamización cognitiva pueden ser un adecuado biomarcador de la función cerebral tanto en las pacientes con enfermedad de Alzheimer como en la población general. Se realizaron análisis tanto en la distribución espectral como en la organización funcional. Se evidenció que el aumento de la potencia Theta se correlacionó negativamente con el desempeño obtenido en las pruebas de tamización cognitiva en toda la población. Por su parte, la conectividad funcional se vio afectada de manera heterogénea. Se demostró una disminución en la sincronización de las oscilaciones Gamma frontotemporales en pacientes con enfermedad de Alzheimer que se correlacionó negativamente con los resultados de las pruebas de tamización. Además, se encontró disminución en la sincronización Theta de similar localización que se correlacionó con la prueba de MOCA. Adicionalmente, se evidenció un aumento en la sincronización Alpha en toda la población que se correlacionó positivamente con los resultados de MOCA.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023
dc.date.accessioned.none.fl_str_mv 2024-02-21T23:56:38Z
dc.date.available.none.fl_str_mv 2024-02-21T23:56:38Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/draft
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_b1a7d7d4d402bcce
format http://purl.org/coar/resource_type/c_db06
status_str draft
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/10766
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC-Repositorio.cuc.
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
url https://hdl.handle.net/11323/10766
https://repositorio.cuc.edu.co/
identifier_str_mv Corporación Universidad de la Costa
REDICUC-Repositorio.cuc.
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbAllegri, Ricardo Franciscoe54a8d9c0479ed60d7234722e91b37c7600Barceló, Ernesto6d2dd71e9e8d5b84f2fdd24eebf0ee3f600Cuesta, Pablo7e884c627f42893aea529b58cf5b3d64600Camargo Camargo, Loidac31962c3607f3f9cf5418604b65ca111Cochen, SilviaThomson, AlfredoFabian Román, Nestor2024-02-21T23:56:38Z2024-02-21T23:56:38Z2023https://hdl.handle.net/11323/10766Corporación Universidad de la CostaREDICUC-Repositorio.cuc.https://repositorio.cuc.edu.co/El abordaje diagnóstico de pacientes con enfermedades que comprometen la cognición es un reto para los sistemas de salud. El electroencefalograma es considerado una técnica útil para evaluar el funcionamiento cerebral, de bajo costo y accesible a la población general. El presente estudio indica que el análisis de la conectividad cerebral y su relación con las pruebas de tamización cognitiva pueden ser un adecuado biomarcador de la función cerebral tanto en las pacientes con enfermedad de Alzheimer como en la población general. Se realizaron análisis tanto en la distribución espectral como en la organización funcional. Se evidenció que el aumento de la potencia Theta se correlacionó negativamente con el desempeño obtenido en las pruebas de tamización cognitiva en toda la población. Por su parte, la conectividad funcional se vio afectada de manera heterogénea. Se demostró una disminución en la sincronización de las oscilaciones Gamma frontotemporales en pacientes con enfermedad de Alzheimer que se correlacionó negativamente con los resultados de las pruebas de tamización. Además, se encontró disminución en la sincronización Theta de similar localización que se correlacionó con la prueba de MOCA. Adicionalmente, se evidenció un aumento en la sincronización Alpha en toda la población que se correlacionó positivamente con los resultados de MOCA.The diagnostic approach to patients with diseases that compromise cognition is a challenge for health systems. The electroencephalogram is considered a useful technique to assess brain function, inexpensive and accessible to the general population. The present study indicates that the analysis of brain connectivity and its relationship with cognitive screening tests may be a suitable biomarker of brain function in both Alzheimer's disease patients and the general population. Analyses were performed on both spectral distribution and functional organization. It was shown that the increase in Theta power was negatively correlated with the performance obtained in the cognitive screening tests in the whole population. Functional connectivity was heterogeneously affected. A decrease in the synchronization of frontotemporal Gamma oscillations was demonstrated in patients with Alzheimer's disease that correlated negatively with the results of the screening tests. In addition, a decrease in Theta synchronization of similar localization was found that correlated with MOCA testing. Additionally, an increase in Alpha synchronization was evidenced in the entire population that correlated positively with MOCA results.Lista de tablas y figuras7 -- Introducción 9 -- Planteamiento del problema 11 -- Pregunta problema 17 – Objetivos 18 -- Objetivo General 18 -- Objetivo Específicos 18 – Justificación 19 -- Marco Teórico 22 -- Una breve revisión histórica de los antecedentes en el estudio de la memoria 22 -- De la memoria a las espinas dendríticas 24 -- Procesos de memoria 26 -- Conectividad neural 26 -- Potenciación a largo plazo 28 -- Bases moleculares de la potenciación a largo plazo 30 -- Consolidación de la memoria 33 -- Cambios celulares en la consolidación 35 -- Consolidación en los sistemas corticales 37 -- Envejecimiento y alteraciones de memoria 39 -- Marco conceptual 41 -- Deterioro cognitivo leve y demencia 41 -- Deterioro cognitivo leve (DCL) 42 -- Enfermedad de Alzheimer 45 -- Criterios diagnósticos de la enfermedad de Alzheimer 46 -- Biomarcadores en enfermedad de Alzheimer 47 -- Biomarcador en imágenes cerebrales 47 -- Biomarcadores en LCR. 53 -- Electroencefalograma como biomarcador de alteración cognitiva 57 -- Estado del arte 61 -- Estudios del EEG en DCL y DA 61 -- Metodología 64 -- Tipo y Diseño de Investigación 64 -- Población y muestra 64 -- Población 64 -- Muestra 64 -- Valoración clínica 64 -- Valoración paraclínica 64 -- Valoración neuropsicológica 65 -- Clasificación de los grupos 69 -- Criterios de Inclusión 69 -- Criterios de Exclusión 69 -- Técnicas e instrumentos 70 – Filtrado 72 -- Análisis del espectro de potencia 75 -- Análisis de sincronización: conectividad funcional 75 – Procedimiento 77 -- Consideraciones Éticas 78 -- Cuadro de Variables 78 – Resultados 80 -- Poder espectral: consideraciones metodológicas particulares 84 -- Resultados análisis de potencia 86 -- FOTOTEST 86 -- MOCA 90 -- Resultados análisis de conectividad funcional 93 -- Consideraciones metodológicas especiales 93 – FOTOTEST 94 – MOCA 98 – Discusión 111 -- Conectividad funcional 118 – Conclusiones 124 – Limitaciones 125 – Recomendaciones 126 -- Direcciones futuras 126 – Referencias 127 --Doctor(a) en Neurociencia Cognitiva AplicadaDoctorado185 páginasapplication/pdfspaPerfil de conectividad cerebral y el rendimiento cognitivo en consulta neurológicaTrabajo de grado - Doctoradohttp://purl.org/coar/resource_type/c_db06Textinfo:eu-repo/semantics/doctoralThesishttp://purl.org/redcol/resource_type/TDinfo:eu-repo/semantics/drafthttp://purl.org/coar/version/c_b1a7d7d4d402bcceCiencias de la SaludBarranquilla, ColombiaDoctorado en Neurociencia Cognitiva Aplicada2021 Alzheimer’s disease facts and figures. 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corporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.


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