Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.

Background and Objectives: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment,...

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Autores:: Rubio Zarapuz, Alejandro
Apolo Arenas, María Dolores
Tomas Carus, Pablo
Tornero Aguilera, José Francisco
Clemente Suárez, Vicente Javier
Parraca, Jose A.

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2024

Institución:: Corporación Universidad de la Costa

Repositorio:: REDICUC - Repositorio CUC

Idioma:: eng

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network_acronym_str	RCUC2
network_name_str	REDICUC - Repositorio CUC
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dc.title.eng.fl_str_mv	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
title	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
spellingShingle	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions. Electrostimulation Exercise therapy Fibromyalgia innovations Pain management Pain modulation Psychophysiological assessment Virtual rehabilitation
title_short	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
title_full	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
title_fullStr	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
title_full_unstemmed	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
title_sort	Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.
dc.creator.fl_str_mv	Rubio Zarapuz, Alejandro Apolo Arenas, María Dolores Tomas Carus, Pablo Tornero Aguilera, José Francisco Clemente Suárez, Vicente Javier Parraca, Jose A.
dc.contributor.author.none.fl_str_mv	Rubio Zarapuz, Alejandro Apolo Arenas, María Dolores Tomas Carus, Pablo Tornero Aguilera, José Francisco Clemente Suárez, Vicente Javier Parraca, Jose A.
dc.subject.proposal.eng.fl_str_mv	Electrostimulation Exercise therapy Fibromyalgia innovations Pain management Pain modulation Psychophysiological assessment Virtual rehabilitation
topic	Electrostimulation Exercise therapy Fibromyalgia innovations Pain management Pain modulation Psychophysiological assessment Virtual rehabilitation
description	Background and Objectives: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment, aimed to evaluate and compare the immediate effects of different treatments on fibromyalgia patients. Materials and Methods: The treatments included the EXOPULSE Mollii suit, a combination of the EXOPULSE Mollii suit with a virtual reality (VR) protocol, and a physical exercise regimen. A cohort of 89 female fibromyalgia patients was randomly assigned to one of four groups: Control (n = 20), Suit only (n = 22), Suit combined with VR (n = 21), and Exercise (n = 26). Results: This study found notable differences across the groups in several key parameters. In the Control group, significant changes were observed in Forced Expiratory Volume (FEV 1/FEV 6), the Numeric Rating Scale (NRS) for pain, Pressure Pain Threshold (PPT) at the epicondyle, cortical arousal levels, the 10 m up-and-go test, and in all measured variables related to temperature and muscle oxygenation. For the group using the suit alone, there were significant differences noted in the NRS, the chair stand test, palm temperature, and all muscle oxygenation parameters. The Suit + VR group showed significant changes in the NRS, PPT at the knee, handgrip strength test, the 10 m up-and-go test, one-leg balance test with the right leg, muscle oxygen saturation (SmO2), deoxygenated hemoglobin (HHb), and oxygenated hemoglobin (O2Hb). Finally, the Exercise group exhibited significant differences in FEV 1/FEV 6, chest perimeter difference, NRS, PPT at both the epicondyle and knee, cortical arousal, the chair stand test, the 10-m up-and-go test, and in SmO2, HHb, and O2Hb levels. Conclusions: combining neuromodulation with VR and targeted exercise regimens can effectively alleviate fibromyalgia symptoms, offering promising avenues for non-pharmacological management.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-10-24T12:31:05Z
dc.date.available.none.fl_str_mv	2024-10-24T12:31:05Z
dc.date.issued.none.fl_str_mv	2024-02-27
dc.type.none.fl_str_mv	Artículo de revista
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dc.type.content.none.fl_str_mv	Text
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.identifier.citation.none.fl_str_mv	Rubio-Zarapuz, A.; Apolo-Arenas, M.D.; Tomas-Carus, P.; Tornero-Aguilera, J.F.; ClementeSuárez, V.J.; Parraca, J.A. Comparative Analysis of Psychophysiological Responses in Fibromyalgia Patients: Evaluating Neuromodulation Alone, Neuromodulation Combined with Virtual Reality, and Exercise Interventions. Medicina 2024, 60, 404. https://doi.org/10.3390/medicina60030404
dc.identifier.issn.none.fl_str_mv	1010-660X
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/11323/13519
dc.identifier.doi.none.fl_str_mv	10.3390/medicina60030404
dc.identifier.eissn.none.fl_str_mv	1648-9144
dc.identifier.instname.none.fl_str_mv	Corporación Universidad de la Costa
dc.identifier.reponame.none.fl_str_mv	REDICUC - Repositorio CUC
dc.identifier.repourl.none.fl_str_mv	https://repositorio.cuc.edu.co/
identifier_str_mv	Rubio-Zarapuz, A.; Apolo-Arenas, M.D.; Tomas-Carus, P.; Tornero-Aguilera, J.F.; ClementeSuárez, V.J.; Parraca, J.A. Comparative Analysis of Psychophysiological Responses in Fibromyalgia Patients: Evaluating Neuromodulation Alone, Neuromodulation Combined with Virtual Reality, and Exercise Interventions. Medicina 2024, 60, 404. https://doi.org/10.3390/medicina60030404 1010-660X 10.3390/medicina60030404 1648-9144 Corporación Universidad de la Costa REDICUC - Repositorio CUC
url	https://hdl.handle.net/11323/13519 https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.relation.ispartofjournal.none.fl_str_mv	Medicina (Lithuania)
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[CrossRef] Wong, C.; Torabi, T.P.; Mortensen, K.R.L.; Michelsen, J.S. The Mollii-Suit®—A Novel Method Using Reciprocal Inhibition in Children with Cerebral Palsy, Gross Motor Function Classification System IV-V: A 6-Month Prospective Study. Toxicon 2018, 156, S116. [CrossRef] Sandell, J. A Case Study to Assess the Effects of the Exo-Pulse Neuromodulation Suit on Pain, Fatigue and Sleep Patterns of an Individual Diagnosed with CFS/ME. World J. Adv. Res. Rev. 2022, 14, 634–636. [CrossRef] Jonasson, L.-L.; Sörbo, A.; Ertzgaard, P.; Sandsjö, L. Patients’ Experiences of Self-Administered Electrotherapy for Spasticity in Stroke and Cerebral Palsy: A Qualitative Study. J. Rehabil. Med. 2022, 54, jrm00263. [CrossRef] [PubMed] Raffalt, P.C.; Bencke, J.; Mortensen, K.; Torabi, T.P.; Wong, C.; Speedtsberg, M.B. Electro-Suit Treatment of Children with Unilateral Cerebral Palsy Alters Nonlinear Dynamics of Walking. Clin. Biomech. 2022, 98, 105714. [CrossRef] [PubMed] Ottobock. Exopulse Molli Suit. 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Acute Effects of Caffeine Supplementation on Cortical Arousal, Anxiety, Physiological Response and Marksmanship in Close Quarter Combat. Ergonomics 2015, 58, 1842–1850. [CrossRef] [PubMed] Carbonell-Baeza, A.; Álvarez-Gallardo, I.C.; Segura-Jiménez, V.; Castro-Piñero, J.; Ruiz, J.R.; Delgado-Fernández, M.; Aparicio, V.A. Reliability and Feasibility of Physical Fitness Tests in Female Fibromyalgia Patients. Int. J. Sports Med. 2015, 36, 157–162. [CrossRef] Petzke, F.; Khine, A.; Williams, D.; Groner, K.; Clauw, D.J.; Gracely, R.H. Dolorimetry Performed at 3 Paired Tender Points Highly Predicts Overall Tenderness. J. Rheumatol. 2001, 28, 2568–2569. Kinser, A.M.; Sands, W.A.; Stone, M.H. Reliability and Validity of a Pressure Algometer. J. Strength Cond. Res. 2009, 23, 312–314. [CrossRef] [PubMed] Ernberg, M.; Christidis, N.; Ghafouri, B.; Bileviciute-Ljungar, I.; Löfgren, M.; Bjersing, J.; Palstam, A.; Larsson, A.; Mannerkorpi, K.; Gerdle, B.; et al. 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dc.rights.none.fl_str_mv	© 2024 by the authors.
dc.rights.license.none.fl_str_mv	Atribución 4.0 Internacional (CC BY 4.0)
dc.rights.uri.none.fl_str_mv	https://creativecommons.org/licenses/by/4.0/
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rights_invalid_str_mv	Atribución 4.0 Internacional (CC BY 4.0) © 2024 by the authors. https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.format.extent.none.fl_str_mv	20 páginas
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dc.publisher.none.fl_str_mv	Multidisciplinary Digital Publishing Institute (MDPI)
dc.publisher.place.none.fl_str_mv	Switzerland
publisher.none.fl_str_mv	Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv	https://www.mdpi.com/1648-9144/60/3/404
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spelling	Atribución 4.0 Internacional (CC BY 4.0)© 2024 by the authors.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rubio Zarapuz, AlejandroApolo Arenas, María DoloresTomas Carus, PabloTornero Aguilera, José FranciscoClemente Suárez, Vicente JavierParraca, Jose A.2024-10-24T12:31:05Z2024-10-24T12:31:05Z2024-02-27Rubio-Zarapuz, A.; Apolo-Arenas, M.D.; Tomas-Carus, P.; Tornero-Aguilera, J.F.; ClementeSuárez, V.J.; Parraca, J.A. Comparative Analysis of Psychophysiological Responses in Fibromyalgia Patients: Evaluating Neuromodulation Alone, Neuromodulation Combined with Virtual Reality, and Exercise Interventions. Medicina 2024, 60, 404. https://doi.org/10.3390/medicina600304041010-660Xhttps://hdl.handle.net/11323/1351910.3390/medicina600304041648-9144Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Background and Objectives: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment, aimed to evaluate and compare the immediate effects of different treatments on fibromyalgia patients. Materials and Methods: The treatments included the EXOPULSE Mollii suit, a combination of the EXOPULSE Mollii suit with a virtual reality (VR) protocol, and a physical exercise regimen. A cohort of 89 female fibromyalgia patients was randomly assigned to one of four groups: Control (n = 20), Suit only (n = 22), Suit combined with VR (n = 21), and Exercise (n = 26). Results: This study found notable differences across the groups in several key parameters. In the Control group, significant changes were observed in Forced Expiratory Volume (FEV 1/FEV 6), the Numeric Rating Scale (NRS) for pain, Pressure Pain Threshold (PPT) at the epicondyle, cortical arousal levels, the 10 m up-and-go test, and in all measured variables related to temperature and muscle oxygenation. For the group using the suit alone, there were significant differences noted in the NRS, the chair stand test, palm temperature, and all muscle oxygenation parameters. The Suit + VR group showed significant changes in the NRS, PPT at the knee, handgrip strength test, the 10 m up-and-go test, one-leg balance test with the right leg, muscle oxygen saturation (SmO2), deoxygenated hemoglobin (HHb), and oxygenated hemoglobin (O2Hb). Finally, the Exercise group exhibited significant differences in FEV 1/FEV 6, chest perimeter difference, NRS, PPT at both the epicondyle and knee, cortical arousal, the chair stand test, the 10-m up-and-go test, and in SmO2, HHb, and O2Hb levels. Conclusions: combining neuromodulation with VR and targeted exercise regimens can effectively alleviate fibromyalgia symptoms, offering promising avenues for non-pharmacological management.20 páginasapplication/pdfengMultidisciplinary Digital Publishing Institute (MDPI)Switzerlandhttps://www.mdpi.com/1648-9144/60/3/404Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Medicina (Lithuania)Rubio-Zarapuz, A.; Apolo-Arenas, M.D.; Clemente-Suárez, V.J.; Costa, A.R.; Pardo-Caballero, D.; Parraca, J.A. Acute Effects of a Session with The EXOPULSE Mollii Suit in a Fibromyalgia Patient: A Case Report. Int. J. Environ. Res. 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[CrossRef] [PubMed]20140460ElectrostimulationExercise therapyFibromyalgia innovationsPain managementPain modulationPsychophysiological assessmentVirtual rehabilitationPublicationORIGINALComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdfComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdfapplication/pdf1290221https://repositorio.cuc.edu.co/bitstreams/729e41f1-7e79-409e-bd4a-3fdeeb137297/download9336303d8b5109dabd270e48532a232dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.cuc.edu.co/bitstreams/15872864-c916-4e29-a799-1ece170e664a/download73a5432e0b76442b22b026844140d683MD52TEXTComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdf.txtComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdf.txtExtracted texttext/plain95382https://repositorio.cuc.edu.co/bitstreams/fe4d227c-97d8-434f-84f4-7e29d5d40f5d/download7d11a968ceef6e8bd690caa105021c9bMD53THUMBNAILComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdf.jpgComparative analysis of psychophysiological responses in fibromyalgia patients evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions..pdf.jpgGenerated 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ara ejercer estos derechos sobre la Obra tal y como se indica a continuación:</p>
    <ol type="a">
      <li>Reproducir la Obra, incorporar la Obra en una o más Obras Colectivas, y reproducir la Obra incorporada en las Obras Colectivas.</li>
      <li>Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.</li>
      <li>Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.</li>
    </ol>
    <p>Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).</p>
  </li>
  <br/>
  <li>
    Restricciones.
    <p>La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:</p>
    <ol type="a">
      <li>Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).</li>
      <li>Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.</li>
      <li>Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.</li>
      <li>
        Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
        <ol type="i">
          <li>Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.</li>
          <li>Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
        </ol>
      </li>
      <li>Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
    </ol>
  </li>
  <br/>
  <li>
    Representaciones, Garantías y Limitaciones de Responsabilidad.
    <p>A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Limitación de responsabilidad.
    <p>A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Término.
    <ol type="a">
      <li>Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.</li>
      <li>Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.</li>
    </ol>
  </li>
  <br/>
  <li>
    Varios.
    <ol type="a">
      <li>Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.</li>
      <li>Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.</li>
      <li>Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.</li>
      <li>Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.</li>
    </ol>
  </li>
  <br/>
</ol>


Comparative analysis of psychophysiological responses in fibromyalgia patients: evaluating neuromodulation alone, neuromodulation combined with virtual reality, and exercise interventions.

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