Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach

Furosemide (FUR) is a diuretic employed in hypertension treatment, this drug is excreted in unchanged form by human body which contributes to water contamination and toxic effects for humans and the environment. Due to the ineffective removal of this pollutant by conventional water treatment methods...

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Autores:
Oliveira, Guilherme
Schnorr, Carlos Eduardo
Bastista Nunes, Franciane
da Rosa Salles, Theodoro
Zancan Tonel, Mariana
Binotto Fagan, Solange
Zanella da Silva, Ivana
Silva Oliveira, Luis Felipe
Mortari, Sergio Roberto
Dotto, Guilherme Luiz
Bohn Rhoden, Cristiano Rodrigo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2023
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/10451
Acceso en línea:
https://hdl.handle.net/11323/10451
https://repositorio.cuc.edu.co/
Palabra clave:
Furosemide
Magnetic graphene oxide
DFT modeling
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embargoedAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
id RCUC2_be1e4c9eae3ccf1af93b7960e81e7392
oai_identifier_str oai:repositorio.cuc.edu.co:11323/10451
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.eng.fl_str_mv Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
title Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
spellingShingle Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
Furosemide
Magnetic graphene oxide
DFT modeling
title_short Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
title_full Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
title_fullStr Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
title_full_unstemmed Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
title_sort Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach
dc.creator.fl_str_mv Oliveira, Guilherme
Schnorr, Carlos Eduardo
Bastista Nunes, Franciane
da Rosa Salles, Theodoro
Zancan Tonel, Mariana
Binotto Fagan, Solange
Zanella da Silva, Ivana
Silva Oliveira, Luis Felipe
Mortari, Sergio Roberto
Dotto, Guilherme Luiz
Bohn Rhoden, Cristiano Rodrigo
dc.contributor.author.none.fl_str_mv Oliveira, Guilherme
Schnorr, Carlos Eduardo
Bastista Nunes, Franciane
da Rosa Salles, Theodoro
Zancan Tonel, Mariana
Binotto Fagan, Solange
Zanella da Silva, Ivana
Silva Oliveira, Luis Felipe
Mortari, Sergio Roberto
Dotto, Guilherme Luiz
Bohn Rhoden, Cristiano Rodrigo
dc.subject.proposal.eng.fl_str_mv Furosemide
Magnetic graphene oxide
DFT modeling
topic Furosemide
Magnetic graphene oxide
DFT modeling
description Furosemide (FUR) is a diuretic employed in hypertension treatment, this drug is excreted in unchanged form by human body which contributes to water contamination and toxic effects for humans and the environment. Due to the ineffective removal of this pollutant by conventional water treatment methods, this work reports a synthesis of magnetic graphene oxide (GO‧Fe3O4) with different amounts of iron nanoparticles for FUR adsorption. The nanomaterials were characterized by FTIR, XRD, SEM, Raman, and VSM techniques. DFT modeling and thermodynamic parameters show that the FUR adsorption is exothermic, favorable, and predominantly occurs in chemical interactions. The experimental study demonstrated that the best adsorbent was GO‧Fe3O4 1:1 showing a removal percentage and adsorption capacity of 96.15% and 96.91 mg g−1, respectively, at pH 3.0 and 293.15 K. The process was dependent on initial concentration, adsorbent dosage, and pH. ionic strength doesn’t significantly affect the adsorbent performance of GO‧Fe3O4 1:1. Sips and PSO model presented the best adjustment for experimental data, suggesting that the process occurs in a heterogeneous surface. Finally, GO‧Fe3O4 1:1 exhibited a high removal percentage after several cycles of adsorption/desorption.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-09-07T16:32:37Z
dc.date.available.none.fl_str_mv 2023-09-07T16:32:37Z
2025
dc.date.issued.none.fl_str_mv 2023
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.content.spa.fl_str_mv Text
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dc.type.version.spa.fl_str_mv info:eu-repo/semantics/draft
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dc.identifier.citation.spa.fl_str_mv Guilherme Oliveira Vargas, Carlos Schnorr, Franciane Bastista Nunes, Theodoro da Rosa Salles, Mariana Zancan Tonel, Solange Binotto Fagan, Ivana Zanella da Silva, Luis F.O. Silva, Sergio Roberto Mortari, Guilherme Luiz Dotto, Cristiano Rodrigo Bohn Rhoden, Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach, Journal of Molecular Liquids, Volume 379, 2023, 121652, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2023.121652.
dc.identifier.issn.spa.fl_str_mv 0167-7322
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/10451
dc.identifier.doi.none.fl_str_mv 10.1016/j.molliq.2023.121652
dc.identifier.eissn.spa.fl_str_mv 1873-3166
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv Guilherme Oliveira Vargas, Carlos Schnorr, Franciane Bastista Nunes, Theodoro da Rosa Salles, Mariana Zancan Tonel, Solange Binotto Fagan, Ivana Zanella da Silva, Luis F.O. Silva, Sergio Roberto Mortari, Guilherme Luiz Dotto, Cristiano Rodrigo Bohn Rhoden, Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach, Journal of Molecular Liquids, Volume 379, 2023, 121652, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2023.121652.
0167-7322
10.1016/j.molliq.2023.121652
1873-3166
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/10451
https://repositorio.cuc.edu.co/
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournal.spa.fl_str_mv Journal of Molecular Liquids
dc.relation.references.spa.fl_str_mv S.P. Maletić et al. State of the Art and Future Challenges for Polycyclic Aromatic Hydrocarbons Is Sediments: Sources, Fate, Bioavailability and Remediation Techniques J. Hazard. Mater. (2019)
M.P. da Rosa et al. A new approach to convert rice husk waste in a quick and efficient adsorbent to remove cationic dye from water J. Environ. Chem. Eng. (2019)
C. Laurencé et al. Anticipating the Fate and Impact of Organic Environmental Contaminants: A New Approach Applied to the Pharmaceutical Furosemide Chemosphere (2014)
Z. Heidari et al. Efficient Photocatalytic Degradation of Furosemide by a Novel Sonoprecipited ZnO over Ion Exchanged Clinoptilolite Nanorods Sep. Purif. Technol. (2020)
S. Mompelat et al. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water Environ. Int. (2009)
K. Zhang et al. Cardiovascular drugs and lipid regulating agents in surface waters at global scale: Occurrence, ecotoxicity and risk assessment Sci. Total Environ. (2020)
C.V. Montoya-Bautista et al. Sludge-based activated carbon from two municipal sewage sludge precursors for improved secondary wastewater-treatment discharge-effluent J. Environ. Chem. Eng. (2022)
G. Dahiya et al. From Oral to Subcutaneous Furosemide: The Road to Novel Opportunities to Manage Congestion Struct. Heart Dis. (2022)
C. Laurencé et al. A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration Biochem. Pharmacol. (2019)
Q. Qu et al. Nrf2 protects against furosemide-induced hepatotoxicity Toxicology (2014)
S. Erdem et al. Investigation of tetracycline removal from aqueous solutions using halloysite/chitosan nano-composites and halloysite nanotubes/alginate hydrogel beads Environ. Nanotechnol. Monit. Manag. (2021)
C.R.B. Rhoden et al. Study from the Influence of Magnetite onto Removal of Hydrochlorothiazide from Aqueous Solutions Applying Magnetic Graphene Oxide J. Water Proc. Eng. (2021)
F. da Silva Bruckmann et al. A DFT Theoretical and Experimental Study about Tetracycline Adsorption onto Magnetic Graphene Oxide J. Mol. Liq. (2022)
C. Wang et al. Study on the Adsorption of Cu(II) by Folic Acid Functionalized Magnetic Graphene Oxide J. Magn. Magn. Mater. (2017)
K. Takács-Novák et al. Biorelevant Solubility of Poorly Soluble Drugs: Rivaroxaban, Furosemide, Papaverine and Niflumic Acid J. Pharm. Biomed. Anal. (2013)
H.N. Tran et al. Innovative spherical biochar for pharmaceutical removal from water: Insight into adsorption mechanism J. Hazard. Mater. (2020)
I. Fatimah et al. Green reduction of graphene oxide using Annona muricata leaves extract for adsorption of methylene blue Inorg. Chem. Commun. (2022)
M. Lv et al. Effects of heavy metals on the adsorption of ciprofloxacin on polyethylene microplastics: Mechanism and toxicity evaluation Chemosphere (2023)
T. Zhou et al. Preparation of Ti-MOFs for efficient adsorptive desulfurization: Synthesis, characterization, and adsorption mechanisms Fuel (2023)
S. Subramaniam et al. Hydrothermal synthesis of phosphorylated chitosan and its adsorption performance towards Acid Red 88 dye Int. J. Biol. Macromol. (2021)
N. Rezazadeh et al. Application of graphene oxide and its derivatives on the adsorption of a cationic surfactant (interaction mechanism, kinetic, isotherm curves and thermodynamic studies) J. Mol. Liq. (2022)
H.N. Catherine et al. Surface interaction of tetrabromobisphenol A, bisphenol A and phenol with graphene-based materials in water: Adsorption mechanism and thermodynamic effects J. Hazard. Mater. (2023)
J. Zhi et al. Adsorption of diuretic furosemide onto chitosan nanoparticles prepared with a water-in-oil nanoemulsion system React. Funct. Polym. (2005)
M.L. Vieira et al. Chitosan and cyanoguanidine-crosslinked chitosan coated glass beads and its application in fixed bed adsorption Chem. Eng. Commun. (2019)
I. Vasilachi et al. Occurrence and Fate of Emerging Pollutants in Water Environment and Options for Their Removal Water (Basel) (2021)
H. Olvera-Vargas et al. Microbial Biotransformation of Furosemide for Environmental Risk Assessment: Identification of Metabolites and Toxicological Evaluation Environ. Sci. Pollut. Res. (2016)
F.S. Bruckmann et al. Biological Applications of Silica-Based Nanoparticles Magnetochemistry (2022)
P.V. Oliveira et al. Adsorption of 17 β- Estradiol in Graphene Oxide through the Competing Methanol Co-Solvent: Experimental and Computational Analysis J. Mol. Liq. (2021)
A. Alayli et al. Nanobiocatalyst beds with Fenton process for removal of methylene blue Appl. Water Sci. (2021)
L.R. Oviedo et al. Synthesis and Characterization of Nanozeolite from (Agro)Industrial Waste for Application in Heterogeneous Photocatalysis Environ. Sci. Pollut. Res. (2022)
O.N. Sani et al. Catalytic ozonation of ciprofloxacin using γ-Al2O3 nanoparticles in synthetic and real wastewaters J. Water Process Eng. (2019)
W. Kohn et al. Self-Consistent Equations Including Exchange and Correlation Effects Phys. Rev. (1965)
P. Hohenberg et al. Inhomogeneous Electron Gas Phys. Rev. (1964)
dc.relation.citationvolume.spa.fl_str_mv 379
dc.rights.eng.fl_str_mv © 2023 Elsevier B.V. All rights reserved.
dc.rights.license.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
© 2023 Elsevier B.V. All rights reserved.
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_f1cf
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2023 Elsevier B.V. All rights reserved.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfOliveira, GuilhermeSchnorr, Carlos EduardoBastista Nunes, Francianeda Rosa Salles, TheodoroZancan Tonel, MarianaBinotto Fagan, SolangeZanella da Silva, IvanaSilva Oliveira, Luis FelipeMortari, Sergio RobertoDotto, Guilherme LuizBohn Rhoden, Cristiano Rodrigo2023-09-07T16:32:37Z20252023-09-07T16:32:37Z2023Guilherme Oliveira Vargas, Carlos Schnorr, Franciane Bastista Nunes, Theodoro da Rosa Salles, Mariana Zancan Tonel, Solange Binotto Fagan, Ivana Zanella da Silva, Luis F.O. Silva, Sergio Roberto Mortari, Guilherme Luiz Dotto, Cristiano Rodrigo Bohn Rhoden, Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approach, Journal of Molecular Liquids, Volume 379, 2023, 121652, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2023.121652.0167-7322https://hdl.handle.net/11323/1045110.1016/j.molliq.2023.1216521873-3166Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Furosemide (FUR) is a diuretic employed in hypertension treatment, this drug is excreted in unchanged form by human body which contributes to water contamination and toxic effects for humans and the environment. Due to the ineffective removal of this pollutant by conventional water treatment methods, this work reports a synthesis of magnetic graphene oxide (GO‧Fe3O4) with different amounts of iron nanoparticles for FUR adsorption. The nanomaterials were characterized by FTIR, XRD, SEM, Raman, and VSM techniques. DFT modeling and thermodynamic parameters show that the FUR adsorption is exothermic, favorable, and predominantly occurs in chemical interactions. The experimental study demonstrated that the best adsorbent was GO‧Fe3O4 1:1 showing a removal percentage and adsorption capacity of 96.15% and 96.91 mg g−1, respectively, at pH 3.0 and 293.15 K. The process was dependent on initial concentration, adsorbent dosage, and pH. ionic strength doesn’t significantly affect the adsorbent performance of GO‧Fe3O4 1:1. Sips and PSO model presented the best adjustment for experimental data, suggesting that the process occurs in a heterogeneous surface. Finally, GO‧Fe3O4 1:1 exhibited a high removal percentage after several cycles of adsorption/desorption.1 páginaapplication/pdfengElsevierNetherlandshttps://www.sciencedirect.com/science/article/abs/pii/S0167732223004555Highly furosemide uptake employing magnetic graphene oxide: DFT modeling combined to experimental approachArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/drafthttp://purl.org/coar/version/c_b1a7d7d4d402bcceJournal of Molecular LiquidsS.P. Maletić et al. State of the Art and Future Challenges for Polycyclic Aromatic Hydrocarbons Is Sediments: Sources, Fate, Bioavailability and Remediation Techniques J. Hazard. Mater. (2019)M.P. da Rosa et al. A new approach to convert rice husk waste in a quick and efficient adsorbent to remove cationic dye from water J. Environ. Chem. Eng. (2019)C. Laurencé et al. Anticipating the Fate and Impact of Organic Environmental Contaminants: A New Approach Applied to the Pharmaceutical Furosemide Chemosphere (2014)Z. Heidari et al. Efficient Photocatalytic Degradation of Furosemide by a Novel Sonoprecipited ZnO over Ion Exchanged Clinoptilolite Nanorods Sep. Purif. Technol. (2020)S. Mompelat et al. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water Environ. Int. (2009)K. Zhang et al. Cardiovascular drugs and lipid regulating agents in surface waters at global scale: Occurrence, ecotoxicity and risk assessment Sci. Total Environ. (2020)C.V. Montoya-Bautista et al. Sludge-based activated carbon from two municipal sewage sludge precursors for improved secondary wastewater-treatment discharge-effluent J. Environ. Chem. Eng. (2022)G. Dahiya et al. From Oral to Subcutaneous Furosemide: The Road to Novel Opportunities to Manage Congestion Struct. Heart Dis. (2022)C. Laurencé et al. A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration Biochem. Pharmacol. (2019)Q. Qu et al. Nrf2 protects against furosemide-induced hepatotoxicity Toxicology (2014)S. Erdem et al. Investigation of tetracycline removal from aqueous solutions using halloysite/chitosan nano-composites and halloysite nanotubes/alginate hydrogel beads Environ. Nanotechnol. Monit. Manag. (2021)C.R.B. Rhoden et al. Study from the Influence of Magnetite onto Removal of Hydrochlorothiazide from Aqueous Solutions Applying Magnetic Graphene Oxide J. Water Proc. Eng. (2021)F. da Silva Bruckmann et al. A DFT Theoretical and Experimental Study about Tetracycline Adsorption onto Magnetic Graphene Oxide J. Mol. Liq. (2022)C. Wang et al. Study on the Adsorption of Cu(II) by Folic Acid Functionalized Magnetic Graphene Oxide J. Magn. Magn. Mater. (2017)K. Takács-Novák et al. Biorelevant Solubility of Poorly Soluble Drugs: Rivaroxaban, Furosemide, Papaverine and Niflumic Acid J. Pharm. Biomed. Anal. (2013)H.N. Tran et al. Innovative spherical biochar for pharmaceutical removal from water: Insight into adsorption mechanism J. Hazard. Mater. (2020)I. Fatimah et al. Green reduction of graphene oxide using Annona muricata leaves extract for adsorption of methylene blue Inorg. Chem. Commun. (2022)M. Lv et al. Effects of heavy metals on the adsorption of ciprofloxacin on polyethylene microplastics: Mechanism and toxicity evaluation Chemosphere (2023)T. Zhou et al. Preparation of Ti-MOFs for efficient adsorptive desulfurization: Synthesis, characterization, and adsorption mechanisms Fuel (2023)S. Subramaniam et al. Hydrothermal synthesis of phosphorylated chitosan and its adsorption performance towards Acid Red 88 dye Int. J. Biol. Macromol. (2021)N. Rezazadeh et al. Application of graphene oxide and its derivatives on the adsorption of a cationic surfactant (interaction mechanism, kinetic, isotherm curves and thermodynamic studies) J. Mol. Liq. (2022)H.N. Catherine et al. Surface interaction of tetrabromobisphenol A, bisphenol A and phenol with graphene-based materials in water: Adsorption mechanism and thermodynamic effects J. Hazard. Mater. (2023)J. Zhi et al. Adsorption of diuretic furosemide onto chitosan nanoparticles prepared with a water-in-oil nanoemulsion system React. Funct. Polym. (2005)M.L. Vieira et al. Chitosan and cyanoguanidine-crosslinked chitosan coated glass beads and its application in fixed bed adsorption Chem. Eng. Commun. (2019)I. Vasilachi et al. Occurrence and Fate of Emerging Pollutants in Water Environment and Options for Their Removal Water (Basel) (2021)H. Olvera-Vargas et al. Microbial Biotransformation of Furosemide for Environmental Risk Assessment: Identification of Metabolites and Toxicological Evaluation Environ. Sci. Pollut. Res. (2016)F.S. Bruckmann et al. Biological Applications of Silica-Based Nanoparticles Magnetochemistry (2022)P.V. Oliveira et al. Adsorption of 17 β- Estradiol in Graphene Oxide through the Competing Methanol Co-Solvent: Experimental and Computational Analysis J. Mol. Liq. (2021)A. Alayli et al. Nanobiocatalyst beds with Fenton process for removal of methylene blue Appl. Water Sci. (2021)L.R. Oviedo et al. Synthesis and Characterization of Nanozeolite from (Agro)Industrial Waste for Application in Heterogeneous Photocatalysis Environ. Sci. Pollut. Res. (2022)O.N. Sani et al. Catalytic ozonation of ciprofloxacin using γ-Al2O3 nanoparticles in synthetic and real wastewaters J. Water Process Eng. (2019)W. Kohn et al. Self-Consistent Equations Including Exchange and Correlation Effects Phys. Rev. (1965)P. Hohenberg et al. Inhomogeneous Electron Gas Phys. Rev. (1964)379FurosemideMagnetic graphene oxideDFT modelingPublicationORIGINALHighly furosemide uptake employing magnetic graphene oxide.pdfHighly furosemide uptake employing magnetic graphene oxide.pdfArtículoapplication/pdf81612https://repositorio.cuc.edu.co/bitstreams/2c1e0300-49fd-46b1-8e46-f8b8e3a27633/downloadd35d1183f407c43eb5195dd71abf565cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/e596dfbb-7fe8-473e-bb4a-47e8af518fdf/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTHighly furosemide uptake employing magnetic graphene oxide.pdf.txtHighly furosemide uptake employing magnetic graphene oxide.pdf.txtExtracted texttext/plain1722https://repositorio.cuc.edu.co/bitstreams/3c011d20-53e8-45b9-844e-6471bb752c3f/download9b546e9c99887529e8a00222d56dc541MD53THUMBNAILHighly furosemide uptake employing magnetic graphene oxide.pdf.jpgHighly furosemide uptake employing magnetic graphene oxide.pdf.jpgGenerated Thumbnailimage/jpeg14442https://repositorio.cuc.edu.co/bitstreams/9115b9c5-607f-4739-a764-dadfe143c4b3/download27a229dab3de779e46b651d1a2eefb8bMD5411323/10451oai:repositorio.cuc.edu.co:11323/104512024-09-16 16:36:35.2https://creativecommons.org/licenses/by-nc-nd/4.0/© 2023 Elsevier B.V. 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
