Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For...
- Autores:
-
da Silva, Wanderson A
Feiteira, Fernanda N
Francisco, Janaína E
Toloza, Carlos A. T
Aucélio, Ricardo Q
Pacheco, Wagner F
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_816b
- Fecha de publicación:
- 2020
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/6059
- Acceso en línea:
- https://hdl.handle.net/11323/6059
https://repositorio.cuc.edu.co/
- Palabra clave:
- Rosuvastatin
Statins
Emerging pollutants
Molecularly imprinted polymer
Solid-phase extraction
Water supply
- Rights
- openAccess
- License
- CC0 1.0 Universal
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oai:repositorio.cuc.edu.co:11323/6059 |
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|
dc.title.spa.fl_str_mv |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
title |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
spellingShingle |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply Rosuvastatin Statins Emerging pollutants Molecularly imprinted polymer Solid-phase extraction Water supply |
title_short |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
title_full |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
title_fullStr |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
title_full_unstemmed |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
title_sort |
Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply |
dc.creator.fl_str_mv |
da Silva, Wanderson A Feiteira, Fernanda N Francisco, Janaína E Toloza, Carlos A. T Aucélio, Ricardo Q Pacheco, Wagner F |
dc.contributor.author.spa.fl_str_mv |
da Silva, Wanderson A Feiteira, Fernanda N Francisco, Janaína E Toloza, Carlos A. T Aucélio, Ricardo Q Pacheco, Wagner F |
dc.subject.spa.fl_str_mv |
Rosuvastatin Statins Emerging pollutants Molecularly imprinted polymer Solid-phase extraction Water supply |
topic |
Rosuvastatin Statins Emerging pollutants Molecularly imprinted polymer Solid-phase extraction Water supply |
description |
In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP–RSVagainst other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSVand atorvastatin. The conjugation of SPE and UV–Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4). |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-02-27T20:56:40Z |
dc.date.available.none.fl_str_mv |
2020-02-27T20:56:40Z |
dc.date.issued.none.fl_str_mv |
2020-01-20 |
dc.type.spa.fl_str_mv |
Pre-Publicación |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_816b |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/preprint |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ARTOTR |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_816b |
status_str |
acceptedVersion |
dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/11323/6059 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
url |
https://hdl.handle.net/11323/6059 https://repositorio.cuc.edu.co/ |
identifier_str_mv |
Corporación Universidad de la Costa REDICUC - Repositorio CUC |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
CC0 1.0 Universal |
dc.rights.uri.spa.fl_str_mv |
http://creativecommons.org/publicdomain/zero/1.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
CC0 1.0 Universal http://creativecommons.org/publicdomain/zero/1.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.publisher.spa.fl_str_mv |
Universidad de la Costa |
institution |
Corporación Universidad de la Costa |
bitstream.url.fl_str_mv |
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da Silva, Wanderson AFeiteira, Fernanda NFrancisco, Janaína EToloza, Carlos A. TAucélio, Ricardo QPacheco, Wagner F2020-02-27T20:56:40Z2020-02-27T20:56:40Z2020-01-20https://hdl.handle.net/11323/6059Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP–RSVagainst other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSVand atorvastatin. The conjugation of SPE and UV–Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).da Silva, Wanderson AFeiteira, Fernanda NFrancisco, Janaína EToloza, Carlos A. TAucélio, Ricardo QPacheco, Wagner FengUniversidad de la CostaCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2RosuvastatinStatinsEmerging pollutantsMolecularly imprinted polymerSolid-phase extractionWater supplyPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supplyPre-Publicaciónhttp://purl.org/coar/resource_type/c_816bTextinfo:eu-repo/semantics/preprinthttp://purl.org/redcol/resource_type/ARTOTRinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply.pdfPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply.pdfapplication/pdf67415https://repositorio.cuc.edu.co/bitstreams/015b07d0-f75a-4b4b-b20d-56cb73e6b471/downloadd34bdf5a0df427bc3125d4f01a26811bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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