Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply

In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For...

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Autores:
da Silva, Wanderson A
Feiteira, Fernanda N
Francisco, Janaína E
Toloza, Carlos A. T
Aucélio, Ricardo Q
Pacheco, Wagner F
Tipo de recurso:
http://purl.org/coar/resource_type/c_816b
Fecha de publicación:
2020
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/6059
Acceso en línea:
https://hdl.handle.net/11323/6059
https://repositorio.cuc.edu.co/
Palabra clave:
Rosuvastatin
Statins
Emerging pollutants
Molecularly imprinted polymer
Solid-phase extraction
Water supply
Rights
openAccess
License
CC0 1.0 Universal
id RCUC2_bcf7374fe3de8301cb0db42a2159e948
oai_identifier_str oai:repositorio.cuc.edu.co:11323/6059
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
title Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
spellingShingle Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
Rosuvastatin
Statins
Emerging pollutants
Molecularly imprinted polymer
Solid-phase extraction
Water supply
title_short Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
title_full Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
title_fullStr Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
title_full_unstemmed Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
title_sort Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply
dc.creator.fl_str_mv da Silva, Wanderson A
Feiteira, Fernanda N
Francisco, Janaína E
Toloza, Carlos A. T
Aucélio, Ricardo Q
Pacheco, Wagner F
dc.contributor.author.spa.fl_str_mv da Silva, Wanderson A
Feiteira, Fernanda N
Francisco, Janaína E
Toloza, Carlos A. T
Aucélio, Ricardo Q
Pacheco, Wagner F
dc.subject.spa.fl_str_mv Rosuvastatin
Statins
Emerging pollutants
Molecularly imprinted polymer
Solid-phase extraction
Water supply
topic Rosuvastatin
Statins
Emerging pollutants
Molecularly imprinted polymer
Solid-phase extraction
Water supply
description In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP–RSVagainst other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSVand atorvastatin. The conjugation of SPE and UV–Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-02-27T20:56:40Z
dc.date.available.none.fl_str_mv 2020-02-27T20:56:40Z
dc.date.issued.none.fl_str_mv 2020-01-20
dc.type.spa.fl_str_mv Pre-Publicación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_816b
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/preprint
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dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
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status_str acceptedVersion
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/6059
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
url https://hdl.handle.net/11323/6059
https://repositorio.cuc.edu.co/
identifier_str_mv Corporación Universidad de la Costa
REDICUC - Repositorio CUC
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.spa.fl_str_mv CC0 1.0 Universal
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/publicdomain/zero/1.0/
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eu_rights_str_mv openAccess
dc.publisher.spa.fl_str_mv Universidad de la Costa
institution Corporación Universidad de la Costa
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spelling da Silva, Wanderson AFeiteira, Fernanda NFrancisco, Janaína EToloza, Carlos A. TAucélio, Ricardo QPacheco, Wagner F2020-02-27T20:56:40Z2020-02-27T20:56:40Z2020-01-20https://hdl.handle.net/11323/6059Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP–RSVagainst other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSVand atorvastatin. The conjugation of SPE and UV–Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).da Silva, Wanderson AFeiteira, Fernanda NFrancisco, Janaína EToloza, Carlos A. TAucélio, Ricardo QPacheco, Wagner FengUniversidad de la CostaCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2RosuvastatinStatinsEmerging pollutantsMolecularly imprinted polymerSolid-phase extractionWater supplyPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supplyPre-Publicaciónhttp://purl.org/coar/resource_type/c_816bTextinfo:eu-repo/semantics/preprinthttp://purl.org/redcol/resource_type/ARTOTRinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply.pdfPre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply.pdfapplication/pdf67415https://repositorio.cuc.edu.co/bitstreams/015b07d0-f75a-4b4b-b20d-56cb73e6b471/downloadd34bdf5a0df427bc3125d4f01a26811bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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