Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents

This paper reports a high efficiency uptake of captopril (CPT), employing magnetic graphene oxide (MGO) as the adsorbent. The graphene oxide (GO) was produced through an oxidation and exfoliation method, and the magnetization technique by the co-precipitation method. The nanomaterials were character...

Full description

Autores:
Pereira de Oliveira, Miguel
Schnorr, Carlos Eduardo
da Rosa Salles, Theodoro
da Silva Bruckmann, Franciele
Baumann, Luiza
Irineu Muller, Edson
da Silva Garcia, Wagner Jesus
Harres, Artur
Silva Oliveira, Luis Felipe
Bohn Rhoden, Cristiano Rodrigo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2023
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/10364
Acceso en línea:
https://hdl.handle.net/11323/10364
https://repositorio.cuc.edu.co/
Palabra clave:
Adsorption
Carbon nanomaterials
Magnetite
Captopril
Rights
openAccess
License
Atribución 4.0 Internacional (CC BY 4.0)
id RCUC2_a2e85fb307af79470a9954b6b845c69e
oai_identifier_str oai:repositorio.cuc.edu.co:11323/10364
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.eng.fl_str_mv Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
title Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
spellingShingle Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
Adsorption
Carbon nanomaterials
Magnetite
Captopril
title_short Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
title_full Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
title_fullStr Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
title_full_unstemmed Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
title_sort Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbents
dc.creator.fl_str_mv Pereira de Oliveira, Miguel
Schnorr, Carlos Eduardo
da Rosa Salles, Theodoro
da Silva Bruckmann, Franciele
Baumann, Luiza
Irineu Muller, Edson
da Silva Garcia, Wagner Jesus
Harres, Artur
Silva Oliveira, Luis Felipe
Bohn Rhoden, Cristiano Rodrigo
dc.contributor.author.none.fl_str_mv Pereira de Oliveira, Miguel
Schnorr, Carlos Eduardo
da Rosa Salles, Theodoro
da Silva Bruckmann, Franciele
Baumann, Luiza
Irineu Muller, Edson
da Silva Garcia, Wagner Jesus
Harres, Artur
Silva Oliveira, Luis Felipe
Bohn Rhoden, Cristiano Rodrigo
dc.subject.proposal.eng.fl_str_mv Adsorption
Carbon nanomaterials
Magnetite
Captopril
topic Adsorption
Carbon nanomaterials
Magnetite
Captopril
description This paper reports a high efficiency uptake of captopril (CPT), employing magnetic graphene oxide (MGO) as the adsorbent. The graphene oxide (GO) was produced through an oxidation and exfoliation method, and the magnetization technique by the co-precipitation method. The nanomaterials were characterized by FTIR, XRD, SEM, Raman, and VSM analysis. The optimal condition was reached by employing GO·Fe3O4 at pH 3.0 (50 mg of adsorbent and 50 mg L−1 of CPT), presenting values of removal percentage and maximum adsorption capacity of 99.43% and 100.41 mg g−1, respectively. The CPT adsorption was dependent on adsorbent dosage, initial concentration of adsorbate, pH, and ionic strength. Sips and Elovich models showed the best adjustment for experimental data, suggesting that adsorption occurs in a heterogeneous surface. Thermodynamic parameters reveal a favorable, exothermic, involving a chemisorption process. The magnetic carbon nanomaterial exhibited a high efficiency after five adsorption/desorption cycles. Finally, the GO·Fe3O4 showed an excellent performance in CPT removal, allowing future application in waste management.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-08-08T19:01:43Z
dc.date.available.none.fl_str_mv 2023-08-08T19:01:43Z
dc.date.issued.none.fl_str_mv 2023-01-10
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.identifier.citation.spa.fl_str_mv de Oliveira, M.P.; Schnorr, C.; da Rosa Salles, T.; da Silva Bruckmann, F.; Baumann, L.; Muller, E.I.; da Silva Garcia, W.J.; de Oliveira, A.H.; Silva, L.F.O.; Rhoden, C.R.B. Efficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents. Water 2023, 15, 293. https://doi.org/ 10.3390/w15020293
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/10364
dc.identifier.doi.none.fl_str_mv 10.3390/w15020293
dc.identifier.eissn.spa.fl_str_mv 2073-4441
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv de Oliveira, M.P.; Schnorr, C.; da Rosa Salles, T.; da Silva Bruckmann, F.; Baumann, L.; Muller, E.I.; da Silva Garcia, W.J.; de Oliveira, A.H.; Silva, L.F.O.; Rhoden, C.R.B. Efficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents. Water 2023, 15, 293. https://doi.org/ 10.3390/w15020293
10.3390/w15020293
2073-4441
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/10364
https://repositorio.cuc.edu.co/
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournal.spa.fl_str_mv Water
dc.relation.references.spa.fl_str_mv 1. Duarte, E.D.V.; Oliveira, M.G.; Spaolonzi, M.P.; Costa, H.P.S.; da Silva, T.L.; da Silva, M.G.C.; Vieira, M.G.A. Adsorption of Pharmaceutical Products from Aqueous Solutions on Functionalized Carbon Nanotubes by Conventional and Green Methods: A Critical Review. J. Clean. Prod. 2022, 372, 133743. [CrossRef]
2. Ramos, S.; Homem, V.; Alves, A.; Santos, L. A Review of Organic UV-Filters in Wastewater Treatment Plants. Environ. Int. 2016, 86, 24–44. [CrossRef] [PubMed]
3. Gavrilescu, M.; Demnerová, K.; Aamand, J.; Agathos, S.; Fava, F. Emerging Pollutants in the Environment: Present and Future Challenges in Biomonitoring, Ecological Risks and Bioremediation. N. Biotechnol. 2015, 32, 147–156. [CrossRef] [PubMed]
4. Wang, L.; Chen, G.; Shu, H.; Cui, X.; Luo, Z.; Chang, C.; Zeng, A.; Zhang, J.; Fu, Q. Facile Covalent Preparation of Carbon Nanotubes / Amine-Functionalized Fe3O4 Nanocomposites for Selective Extraction of Estradiol in Pharmaceutical Industry Wastewater. J. Chromatogr. A 2021, 1638, 461889. [CrossRef]
5. Xi, L.; Zhang, X.; Chen, Y.; Peng, J.; Liu, M.; Huo, D.; Li, G.; He, H. A Fluorescence Turn-on Strategy to Achieve Detection of Captopril Based on Ag Nanoclusters. Chem. Phys. Lett. 2022, 807, 140085. [CrossRef]
6. Qu, F.; Zhu, G.; Huang, S.; Li, S.; Qiu, S. Effective controlled release of captopril by silylation of mesoporous MCM-41. ChemPhysChem 2006, 7, 400–406. [CrossRef]
7. Mahmoud, W.M.M.; Kümmerer, K. Captopril and Its Dimer Captopril Disulfide: Photodegradation, Aerobic Biodegradation and Identification of Transformation Products by HPLC-UV and LC-Ion Trap-MS(n). Chemosphere 2012, 88, 1170–1177. [CrossRef]
8. Da Silva, D.M.; Carneiro da Cunha Areias, M. Voltammetric Detection of Captopril in a Commercial Drug Using a Gold-Copper Metal-organic Framework Nanocomposite Modified Electrode. Electroanalysis 2021, 33, 1255–1263. [CrossRef]
9. Cunha, M.R.; Lima, E.C.; Lima, D.R.; Da Silva, R.S.; Thue, P.S.; Seliem, M.K.; Sheir, F.; Dos Reis, G.S.; Larsson, S.H. Removal of captopril pharmaceutical from synthetic pharmaceutical-industry wastewaters: Use of activated carbon derived from Butia catarinensis. J. Environ. Chem. Eng. 2020, 8, 104506. [CrossRef]
10. Alayli, A.; Nadaroglu, H.; Turgut, E. Nanobiocatalyst beds with Fenton process for removal of methylene blue. Appl. Water Sci. 2021, 11, 32. [CrossRef]
11. Oviedo, L.R.; Muraro, P.C.L.; Pavoski, G.; Espinosa, D.C.R.; Ruiz, Y.P.M.; Galembeck, A.; Rhoden, C.R.B.; da Silva, W.L. Synthesis and Characterization of Nanozeolite from (Agro)Industrial Waste for Application in Heterogeneous Photocatalysis. Environ. Sci. Pollut. Res. Int. 2022, 29, 3794–3807. [CrossRef] [PubMed]
12. Sani, O.N.; Yazdani, M.; Taghavi, M. Catalytic ozonation of ciprofloxacin using γ-Al2O3 nanoparticles in synthetic and real wastewaters. J. Water Process Eng. 2019, 32, 100894. [CrossRef]
13. Erdem, S.; Öztekin, M.; Açıkel, Y.S. Investigation of tetracycline removal from aqueous solutions using halloysite/chitosan nano-composites and halloysite nanotubes/alginate hydrogel beads. Environ. Nanotechnol. Monit. Manag. 2021, 16, 100576.
14. Ci ˘gero ˘glu, Z.; Kazan-Kaya, E.S.; El Messaoudi, N.; Fernine, Y.; Américo-Pinheiro, J.H.P.; Jada, A. Remediation of tetracycline from aqueous solution through adsorption on g-C3N4 -ZnO-BaTiO3 nanocomposite: Optimization, modeling, and theoretical calculation. J. Mol. Liq. 2022, 369, 120866. [CrossRef]
15. Silveira, C.C.; Botega, C.S.; Rhoden, C.R.B.; Nunes, M.R.S.; Braga, A.L.; Lenardão, E.J. A Facile Synthesis of α-Phenylchalcogeno(S, Se) α,β-Unsaturated Esters from Ethyl α-Bromo-α-Phenylchalcogeno Acetates. Synth. Commun. 1998, 28, 3371–3380. [CrossRef]
16. Kasperiski, F.M.; Lima, E.C.; Umpierres, C.S.; Dos Reis, G.S.; Thue, P.S.; Lima, D.R.; Dias, S.L.P.; Saucier, C.; Da Costa, J.B. Production of porous activated carbons from Caesalpinia ferrea seed pod wastes: Highly efficient removal of captopril from aqueous solutions. J. Clean. Prod. 2018, 197, 919–929. [CrossRef]
17. Singh, S.; Kumar, V.; Anil, A.G.; Kapoor, D.; Khasnabis, S.; Shekar, S.; Pavithra, N.; Samuel, J.; Subramanian, S.; Singh, J.; et al. Adsorption and Detoxification of Pharmaceutical Compounds from Wastewater Using Nanomaterials: A Review on Mechanism, Kinetics, Valorization and Circular Economy. J. Environ. Manag. 2021, 300, 113569. [CrossRef]
18. El Messaoudi, N.; El Mouden, A.; Fernine, Y.; El Khomri, M.; Bouich, A.; Faska, N.; Ci ˘gero ˘glu, Z.; Américo-Pinheiro, J.H.P.; Jada, A.; Lacherai, A. Green synthesis of Ag2O nanoparticles using Punica granatum leaf extract for sulfamethoxazole antibiotic adsorption: Characterization, experimental study, modeling, and DFT calculation. Environ. Sci. Pollut. Res. 2022, 29, 1–18. [CrossRef]
19. Singh, S.; Anil, A.G.; Khasnabis, S.; Kumar, V.; Nath, B.; Adiga, V.; Kumar Naik, T.S.S.; Subramanian, S.; Kumar, V.; Singh, J.; et al. Sustainable Removal of Cr(VI) Using Graphene Oxide-Zinc Oxide Nanohybrid: Adsorption Kinetics, Isotherms and Thermodynamics. Environ. Res. 2022, 203, 111891. [CrossRef]
20. Li, R.; Liu, Y.; Lan, G.; Qiu, H.; Xu, B.; Xu, Q.; Sun, N.; Zhang, L. Pb(II) Adsorption Characteristics of Magnetic GO-Hydroxyapatite and the Contribution of GO to Enhance Its Acid Resistance. J. Environ. Chem. Eng. 2021, 9, 105310. [CrossRef]
21. Rhoden, C.R.B.; Bruckmann, F.d.S.; Salles, T.d.R.; Kaufmann Junior, C.G.; Mortari, S.R. Study from the Influence of Magnetite onto Removal of Hydrochlorothiazide from Aqueous Solutions Applying Magnetic Graphene Oxide. J. Water Proc. Eng. 2021, 43, 102262. [CrossRef]
22. Salles, T.d.R.; Rodrigues, H.d.B.; Bruckmann, F.d.S.; Alves, L.C.S.; Mortari, S.R.; Rhoden, C.R.B. Graphene Oxide Optimization Synthesis for Application on Laboratory of Universidade Franciscana. Discip. Sci. 2020, 21, 15–26. [CrossRef]
23. Bruckmann, F.d.S.; Zuchetto, T.; Ledur, C.M.; dos Santos, C.L.; da Silva, W.L.; Binotto Fagan, S.; Zanella da Silva, I.; Bohn Rhoden, C.R. Methylphenidate Adsorption onto Graphene Derivatives: Theory and Experiment. New J. Chem. 2022, 46, 4283–4291. [CrossRef]
24. Bruckmann, F.S.; Schnorr, C.; Oviedo, L.R.; Knani, S.; Silva, L.F.O.; Silva, W.L.; Dotto, G.L.; Bohn Rhoden, C.R. Adsorption and Photocatalytic Degradation of Pesticides into Nanocomposites: A Review. Molecules 2022, 27, 6261. [CrossRef]
25. Tran, H.N.; You, S.-J.; Chao, H.-P. Thermodynamic Parameters of Cadmium Adsorption onto Orange Peel Calculated from Various Methods: A Comparison Study. J. Environ. Chem. Eng. 2016, 4, 2671–2682. [CrossRef]
26. Da Rosa Salles, T.; Da Silva Bruckamann, F.; Viana, A.R.; Krause, L.M.F.; Mortari, S.R.; Rhoden, C.R.B. Magnetic nanocrystalline cellulose: Azithromycin adsorption and in vitro biological activity against melanoma cells. J. Polym. Environ. 2022, 30, 2695–2713. [CrossRef]
27. Cimirro, F.N.; Lima, C.E.; Cunha, M.R.; Dias, S.L.; Thue, P.S.; Mazzocato, A.C.; Dotto, G.L.; Gelesky, M.A.; Pavan, F.A. Removal of pharmaceutical compounds from aqueous solution by novel activated carbon synthesized from lovegrass (Poaceae). Environ. Sci. Pollut. Res. 2020, 27, 21442–21454. [CrossRef]
28. Kanta, U.-A.; Thongpool, V.; Sangkhun, W.; Wongyao, N.; Wootthikanokkhan, J. Preparations, Characterizations, and a Comparative Study on Photovoltaic Performance of Two Different Types of Graphene/TiO2 Nanocomposites Photoelectrodes. J. Nanomater. 2017, 2017, 2758294. [CrossRef]
29. Ossonon, B.D.; Bélanger, D. Synthesis and Characterization of Sulfophenyl-Functionalized Reduced Graphene Oxide Sheets. RSC Adv. 2017, 7, 27224–27234. [CrossRef]
30. Da Silva Bruckmann, F.; Viana, A.R.; Lopes, L.Q.S.; Santos, R.C.V.; Muller, E.I.; Mortari, S.R.; Rhoden, C.R.B. Synthesis, Characterization, and Biological Activity Evaluation of Magnetite-Functionalized Eugenol. J. Inorg. Organomet. Polym. Mater. 2022, 32, 1459–1472. [CrossRef]
31. Bruckmann, F.d.S.; Pimentel, A.C.; Viana, A.R.; Salles, T.d.R.; Krause, L.M.F.; Mortari, S.R.; da Silva, I.Z.; Rhoden, C.R.B. Synthesis, Characterization and Cytotoxicity Evaluation of Magnetic Nanosilica in L929 Cell Line. Discip. Sci. 2020, 21, 1–14. [CrossRef]
32. Ain, Q.T.; Haq, S.H.; Alshammari, A.; Al-Mutlaq, M.A.; Anjum, M.N. The Systemic Effect of PEG-NGO-Induced Oxidative Stress in Vivo in a Rodent Model. Beilstein J. Nanotechnol. 2019, 10, 901–911. [CrossRef] [PubMed]
33. Liu, J.; Xu, D.; Chen, P.; Yu, Q.; Qiu, H.; Xiong, X. Solvothermal Synthesis of Porous Superparamagnetic RGO@Fe3O4 Nanocomposites for Microwave Absorption. J. Mater. Sci. Mater. Electron. 2019, 30, 17106–17118. [CrossRef]
34. Kellici, S.; Acord, J.; Ball, J.; Reehal, H.S.; Morgan, D.; Saha, B. A Single Rapid Route for the Synthesis of Reduced Graphene Oxide with Antibacterial Activities. RSC Adv. 2014, 4, 14858–14861. [CrossRef]
35. Côa, F.; Strauss, M.; Clemente, Z.; Rodrigues Neto, L.L.; Lopes, J.R.; Alencar, R.S.; Souza Filho, A.G.; Alves, O.L.; Castro, V.L.S.S.; Barbieri, E.; et al. Coating Carbon Nanotubes with Humic Acid Using an Eco-Friendly Mechanochemical Method: Application for Cu(II) Ions Removal from Water and Aquatic Ecotoxicity. Sci. Total Environ. 2017, 607–608, 1479–1486. [CrossRef] [PubMed]
36. Zhang, K.; Zhang, Q.; Gao, X.; Chen, X.; Wang, Y.; Li, W.; Wu, J. Effect of absorbers’ composition on the microwave absorbing performance of hollow Fe3O4 nanoparticles decorated CNTs/graphene/C composites. J. Alloys Compd. 2018, 748, 70–716. [CrossRef]
37. Hatel, R.; Majdoub, S.E.; Bakour, A.; Khenfouch, M.; Baitoul, M. Graphene Oxide/Fe3O4 Nanorods Composite: Structural and Raman Investigation. J. Phys. Conf. Ser. 2018, 1081, 012006. [CrossRef]
38. Ghosh, B.; Sarma, S.; Pontsho, M.; Ray, S.C. Tuning of Magnetic Behaviour in Nitrogenated Graphene Oxide Functionalized with Iron Oxide. Diam. Relat. Mater. 2018, 89, 35–42. [CrossRef]
39. Da Silva Bruckmann, F.; Mafra Ledur, C.; Zanella da Silva, I.; Luiz Dotto, G.; Rodrigo Bohn Rhoden, C. A DFT Theoretical and Experimental Study about Tetracycline Adsorption onto Magnetic Graphene Oxide. J. Mol. Liq. 2022, 353, 118837. [CrossRef]
40. Cheng, Y.; Yang, S.; Tao, E. Magnetic graphene oxide prepared via ammonia coprecipitation method: The effects of preserved functional groups on adsorption property. Inorg. Chem. Commun. 2021, 128, 108603. [CrossRef]
41. Zeng, K.; Hachem, K.; Kuznetsova, M.; Chupradit, S.; Su, C.H.; Nguyen, H.C.; El-Shafay, A.S. Molecular dynamic simulation and artificial intelligence of lead ions removal from aqueous solution using magnetic-ash-graphene oxide nanocomposite. J. Mol. Liq. 2022, 347, 118290. [CrossRef]
42. Nuengmatcha, P.; Mahachai, R.; Chanthai, S. Thermodynamic and kinetic study of the intrinsic adsorption capacity of graphene oxide for malachite green removal from aqueous solution. Orient. J. Chem. 2014, 30, 1463. [CrossRef]
43. Nasiri, A.; Rajabi, S.; Amiri, A.; Fattahizade, M.; Hasani, O.; Lalehzari, A.; Hashemi, M. Adsorption of tetracycline using CuCoFe2O4@ Chitosan as a new and green magnetic nanohybrid adsorbent from aqueous solutions: Isotherm, kinetic and thermodynamic study. Arab. J. Chem. 2022, 15, 104014. [CrossRef]
44. Da Silva Bruckmann, F.; Schnorr, C.E.; Da Rosa Salles, T.; Nunes, F.B.; Baumann, L.; Müller, E.I.; Silva, L.F.O.; Dotto, G.L.; Bohn Rhoden, C.R. Highly Efficient Adsorption of Tetracycline Using Chitosan-Based Magnetic Adsorbent. Polymers 2022, 14, 4854. [CrossRef]
45. Pereira, A.V.; Garabeli, A.A.; Schunemann, G.D.; Borck, P.C. Determination of dissociation constant (Ka) of captopril and nimesulide: Analytical chemistry experiments for undergraduate pharmacy. Quim Nova 2011, 34, 1656–1660. [CrossRef]
46. Zhu, H.; Chen, T.; Liu, J.; Li, D. Adsorption of tetracycline antibiotics from an aqueous solution onto graphene oxide/calcium alginate composite fibers. RSC Adv. 2018, 8, 2616–2621. [CrossRef]
47. Bruckmann, F.S.; Rossato Viana, A.; Tonel, M.Z.; Fagan, S.B.; Garcia, W.J.D.S.; Oliveira, A.H.D.; Dorneles, L.S.; Mortari, S.R.; Da Silva, W.L.; Da Silva, I.Z.; et al. Influence of magnetite incorporation into chitosan on the adsorption of the methotrexate and in vitro cytotoxicity. Environ. Sci. Pollut. Res. 2022, 29, 70413–70434. [CrossRef]
48. Ji, L.; Chen, W.; Bi, J.; Zheng, S.; Xu, Z.; Zhu, D.; Alvarez, P.J. Adsorption of tetracycline on single-walled and multi-walled carbon nanotubes as affected by aqueous solution chemistry. Environ. Toxicol. Chem. 2010, 29, 2713–2719. [CrossRef]
49. Liang, J.; Fang, Y.; Luo, Y.; Zeng, G.; Deng, J.; Tan, X.; Tang, N.; Li, X.; He, X.; Feng, C.; et al. Magnetic nanoferromanganese oxides modified biochar derived from pine sawdust for adsorption of tetracycline hydrochloride. Environ. Sci. Pollut. Res. 2019, 26, 5892–5903. [CrossRef]
50. Agarry, S.E.; Aworanti, O.A. Kinetics, Isothermal and Thermodynamic Modelling Studies of Hexavalent Chromium Ions Adsorption from Simulated Wastewater onto Parkia biglobosa-Sawdust Derived Acid-Steam Activated Carbon. Appl. J. Envir. Eng. Sci. 2017, 3, 58–76.
51. De Souza, F.M.; Dos Santos, O.A.A.; Vieira, M.G.A. Adsorption of herbicide 2,4-D from aqueous solution using organo-modified bentonite clay. Environ. Sci. Pollut. Res. 2019, 26, 18329–18342. [CrossRef] [PubMed]
52. Nunes, F.B.; Da Silva Bruckmann, F.; Da Rosa Salles, T.; Rhoden, C.B.R. Study of phenobarbital removal from the aqueous solutions employing magnetite-functionalized chitosan. Environ. Sci. Pollut. Res. 2022, 29, 1–14. [CrossRef] [PubMed]
53. Carvajal-Bernal, A.M.; Gomez-Granados, F.; Giraldo, L.; Moreno-Pirajan, J.C. Application of the Sips model to the calculation of maximum adsorption capacity and immersion enthalpy of phenol aqueous solutions on activated carbons. Eur. J. Chem. 2017, 8, 112–118. [CrossRef]
54. Kalam, S.; Abu-Khamsin, S.A.; Kamal, M.S.; Patil, S. Surfactant Adsorption Isotherms: A Review. ACS Omega 2021, 6, 32342–32348. [CrossRef]
55. Gago, D.; Chagas, R.; Ferreira, L.M.; Velizarov, S.; Coelhoso, I. A Novel Cellulose-Based Polymer for Efficient Removal of Methylene Blue. Membranes 2020, 10, 13. [CrossRef]
56. Salvstrini, S.; Ambrosone, L.; Kopinke, F.D. Some mistakes and misinterpretations in the analysis of thermodynamic adsorption data. J. Mol. Liq. 2022, 352, 118762. [CrossRef]
57. Tran, H.N. Improper Estimation of Thermodynamic Parameters in Adsorption Studies with Distribution Coefficient KD (Qe/Ce) or Freundlich Constant (KF): Considerations from the Derivation of Dimensionless Thermodynamic Equilibrium Constant and Suggestions. Adsorp. Sci. Technol. 2022, 2022, 5553212. [CrossRef]
58. Lima, E.C.; Hosseini-Bandegharaei, A.; Moreno-Piraján, J.C.; Anastopoulos, I. A Critical Review of the Estimation of the Thermodynamic Parameters on Adsorption Equilibria. Wrong Use of Equilibrium Constant in the Van’t Hoof Equation for Calculation of Thermodynamic Parameters of Adsorption. J. Mol. Liq. 2019, 273, 425–434. [CrossRef]
59. Tran, H.N.; Lima, E.C.; Juang, R.-S.; Bollinger, J.-C.; Chao, H.-P. Thermodynamic Parameters of Liquid–Phase Adsorption Process Calculated from Different Equilibrium Constants Related to Adsorption Isotherms: A Comparison Study. J. Environ. Chem. Eng. 2021, 9, 106674. [CrossRef]
60. Dotto, G.L.; Moura, J.M.D.; Cadaval, T.R.S.; Pinto, L.A.D.A. Application of chitosan films for the removal of food dyes from aqueous solutions by adsorption. Chem. Eng. J. 2013, 214, 8–16. [CrossRef]
61. Li, Z.; Wu, D.; Liang, Y.; Xu, F.; Fu, R. Facile Fabrication of Novel Highly Microporous Carbons with Superior Size-Selective Adsorption and Supercapacitance Properties. Nanoscale 2013, 5, 10824–10828. [CrossRef] [PubMed]
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spelling Atribución 4.0 Internacional (CC BY 4.0)© 2023 by the authors. Licensee MDPI, Basel, Switzerlandhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Pereira de Oliveira, MiguelSchnorr, Carlos Eduardoda Rosa Salles, Theodoroda Silva Bruckmann, FrancieleBaumann, LuizaIrineu Muller, Edsonda Silva Garcia, Wagner JesusHarres, ArturSilva Oliveira, Luis FelipeBohn Rhoden, Cristiano Rodrigo2023-08-08T19:01:43Z2023-08-08T19:01:43Z2023-01-10de Oliveira, M.P.; Schnorr, C.; da Rosa Salles, T.; da Silva Bruckmann, F.; Baumann, L.; Muller, E.I.; da Silva Garcia, W.J.; de Oliveira, A.H.; Silva, L.F.O.; Rhoden, C.R.B. Efficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents. Water 2023, 15, 293. https://doi.org/ 10.3390/w15020293https://hdl.handle.net/11323/1036410.3390/w150202932073-4441Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/This paper reports a high efficiency uptake of captopril (CPT), employing magnetic graphene oxide (MGO) as the adsorbent. The graphene oxide (GO) was produced through an oxidation and exfoliation method, and the magnetization technique by the co-precipitation method. The nanomaterials were characterized by FTIR, XRD, SEM, Raman, and VSM analysis. The optimal condition was reached by employing GO·Fe3O4 at pH 3.0 (50 mg of adsorbent and 50 mg L−1 of CPT), presenting values of removal percentage and maximum adsorption capacity of 99.43% and 100.41 mg g−1, respectively. The CPT adsorption was dependent on adsorbent dosage, initial concentration of adsorbate, pH, and ionic strength. Sips and Elovich models showed the best adjustment for experimental data, suggesting that adsorption occurs in a heterogeneous surface. Thermodynamic parameters reveal a favorable, exothermic, involving a chemisorption process. The magnetic carbon nanomaterial exhibited a high efficiency after five adsorption/desorption cycles. Finally, the GO·Fe3O4 showed an excellent performance in CPT removal, allowing future application in waste management.19 páginasapplication/pdfengMultidisciplinary Digital Publishing Institute (MDPI)Switzerlandhttps://www.mdpi.com/2073-4441/15/2/293Efficient uptake of angiotensin-converting enzyme ii inhibitor employing graphene oxide-based magnetic nanoadsorbentsArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Water1. Duarte, E.D.V.; Oliveira, M.G.; Spaolonzi, M.P.; Costa, H.P.S.; da Silva, T.L.; da Silva, M.G.C.; Vieira, M.G.A. Adsorption of Pharmaceutical Products from Aqueous Solutions on Functionalized Carbon Nanotubes by Conventional and Green Methods: A Critical Review. J. Clean. Prod. 2022, 372, 133743. [CrossRef]2. Ramos, S.; Homem, V.; Alves, A.; Santos, L. A Review of Organic UV-Filters in Wastewater Treatment Plants. Environ. Int. 2016, 86, 24–44. [CrossRef] [PubMed]3. Gavrilescu, M.; Demnerová, K.; Aamand, J.; Agathos, S.; Fava, F. Emerging Pollutants in the Environment: Present and Future Challenges in Biomonitoring, Ecological Risks and Bioremediation. N. Biotechnol. 2015, 32, 147–156. [CrossRef] [PubMed]4. Wang, L.; Chen, G.; Shu, H.; Cui, X.; Luo, Z.; Chang, C.; Zeng, A.; Zhang, J.; Fu, Q. Facile Covalent Preparation of Carbon Nanotubes / Amine-Functionalized Fe3O4 Nanocomposites for Selective Extraction of Estradiol in Pharmaceutical Industry Wastewater. J. Chromatogr. A 2021, 1638, 461889. [CrossRef]5. Xi, L.; Zhang, X.; Chen, Y.; Peng, J.; Liu, M.; Huo, D.; Li, G.; He, H. A Fluorescence Turn-on Strategy to Achieve Detection of Captopril Based on Ag Nanoclusters. Chem. Phys. Lett. 2022, 807, 140085. [CrossRef]6. Qu, F.; Zhu, G.; Huang, S.; Li, S.; Qiu, S. Effective controlled release of captopril by silylation of mesoporous MCM-41. ChemPhysChem 2006, 7, 400–406. [CrossRef]7. Mahmoud, W.M.M.; Kümmerer, K. Captopril and Its Dimer Captopril Disulfide: Photodegradation, Aerobic Biodegradation and Identification of Transformation Products by HPLC-UV and LC-Ion Trap-MS(n). Chemosphere 2012, 88, 1170–1177. [CrossRef]8. Da Silva, D.M.; Carneiro da Cunha Areias, M. Voltammetric Detection of Captopril in a Commercial Drug Using a Gold-Copper Metal-organic Framework Nanocomposite Modified Electrode. Electroanalysis 2021, 33, 1255–1263. [CrossRef]9. Cunha, M.R.; Lima, E.C.; Lima, D.R.; Da Silva, R.S.; Thue, P.S.; Seliem, M.K.; Sheir, F.; Dos Reis, G.S.; Larsson, S.H. Removal of captopril pharmaceutical from synthetic pharmaceutical-industry wastewaters: Use of activated carbon derived from Butia catarinensis. J. Environ. Chem. Eng. 2020, 8, 104506. [CrossRef]10. Alayli, A.; Nadaroglu, H.; Turgut, E. Nanobiocatalyst beds with Fenton process for removal of methylene blue. Appl. Water Sci. 2021, 11, 32. [CrossRef]11. Oviedo, L.R.; Muraro, P.C.L.; Pavoski, G.; Espinosa, D.C.R.; Ruiz, Y.P.M.; Galembeck, A.; Rhoden, C.R.B.; da Silva, W.L. Synthesis and Characterization of Nanozeolite from (Agro)Industrial Waste for Application in Heterogeneous Photocatalysis. Environ. Sci. Pollut. Res. Int. 2022, 29, 3794–3807. [CrossRef] [PubMed]12. Sani, O.N.; Yazdani, M.; Taghavi, M. Catalytic ozonation of ciprofloxacin using γ-Al2O3 nanoparticles in synthetic and real wastewaters. J. Water Process Eng. 2019, 32, 100894. [CrossRef]13. Erdem, S.; Öztekin, M.; Açıkel, Y.S. Investigation of tetracycline removal from aqueous solutions using halloysite/chitosan nano-composites and halloysite nanotubes/alginate hydrogel beads. Environ. Nanotechnol. Monit. Manag. 2021, 16, 100576.14. Ci ˘gero ˘glu, Z.; Kazan-Kaya, E.S.; El Messaoudi, N.; Fernine, Y.; Américo-Pinheiro, J.H.P.; Jada, A. Remediation of tetracycline from aqueous solution through adsorption on g-C3N4 -ZnO-BaTiO3 nanocomposite: Optimization, modeling, and theoretical calculation. J. Mol. Liq. 2022, 369, 120866. [CrossRef]15. Silveira, C.C.; Botega, C.S.; Rhoden, C.R.B.; Nunes, M.R.S.; Braga, A.L.; Lenardão, E.J. A Facile Synthesis of α-Phenylchalcogeno(S, Se) α,β-Unsaturated Esters from Ethyl α-Bromo-α-Phenylchalcogeno Acetates. Synth. Commun. 1998, 28, 3371–3380. [CrossRef]16. Kasperiski, F.M.; Lima, E.C.; Umpierres, C.S.; Dos Reis, G.S.; Thue, P.S.; Lima, D.R.; Dias, S.L.P.; Saucier, C.; Da Costa, J.B. Production of porous activated carbons from Caesalpinia ferrea seed pod wastes: Highly efficient removal of captopril from aqueous solutions. J. Clean. Prod. 2018, 197, 919–929. [CrossRef]17. Singh, S.; Kumar, V.; Anil, A.G.; Kapoor, D.; Khasnabis, S.; Shekar, S.; Pavithra, N.; Samuel, J.; Subramanian, S.; Singh, J.; et al. Adsorption and Detoxification of Pharmaceutical Compounds from Wastewater Using Nanomaterials: A Review on Mechanism, Kinetics, Valorization and Circular Economy. J. Environ. Manag. 2021, 300, 113569. [CrossRef]18. El Messaoudi, N.; El Mouden, A.; Fernine, Y.; El Khomri, M.; Bouich, A.; Faska, N.; Ci ˘gero ˘glu, Z.; Américo-Pinheiro, J.H.P.; Jada, A.; Lacherai, A. Green synthesis of Ag2O nanoparticles using Punica granatum leaf extract for sulfamethoxazole antibiotic adsorption: Characterization, experimental study, modeling, and DFT calculation. Environ. Sci. Pollut. Res. 2022, 29, 1–18. [CrossRef]19. Singh, S.; Anil, A.G.; Khasnabis, S.; Kumar, V.; Nath, B.; Adiga, V.; Kumar Naik, T.S.S.; Subramanian, S.; Kumar, V.; Singh, J.; et al. Sustainable Removal of Cr(VI) Using Graphene Oxide-Zinc Oxide Nanohybrid: Adsorption Kinetics, Isotherms and Thermodynamics. Environ. Res. 2022, 203, 111891. [CrossRef]20. Li, R.; Liu, Y.; Lan, G.; Qiu, H.; Xu, B.; Xu, Q.; Sun, N.; Zhang, L. Pb(II) Adsorption Characteristics of Magnetic GO-Hydroxyapatite and the Contribution of GO to Enhance Its Acid Resistance. J. Environ. Chem. Eng. 2021, 9, 105310. [CrossRef]21. Rhoden, C.R.B.; Bruckmann, F.d.S.; Salles, T.d.R.; Kaufmann Junior, C.G.; Mortari, S.R. Study from the Influence of Magnetite onto Removal of Hydrochlorothiazide from Aqueous Solutions Applying Magnetic Graphene Oxide. J. Water Proc. Eng. 2021, 43, 102262. [CrossRef]22. Salles, T.d.R.; Rodrigues, H.d.B.; Bruckmann, F.d.S.; Alves, L.C.S.; Mortari, S.R.; Rhoden, C.R.B. Graphene Oxide Optimization Synthesis for Application on Laboratory of Universidade Franciscana. Discip. Sci. 2020, 21, 15–26. [CrossRef]23. Bruckmann, F.d.S.; Zuchetto, T.; Ledur, C.M.; dos Santos, C.L.; da Silva, W.L.; Binotto Fagan, S.; Zanella da Silva, I.; Bohn Rhoden, C.R. Methylphenidate Adsorption onto Graphene Derivatives: Theory and Experiment. New J. Chem. 2022, 46, 4283–4291. [CrossRef]24. Bruckmann, F.S.; Schnorr, C.; Oviedo, L.R.; Knani, S.; Silva, L.F.O.; Silva, W.L.; Dotto, G.L.; Bohn Rhoden, C.R. Adsorption and Photocatalytic Degradation of Pesticides into Nanocomposites: A Review. Molecules 2022, 27, 6261. [CrossRef]25. Tran, H.N.; You, S.-J.; Chao, H.-P. Thermodynamic Parameters of Cadmium Adsorption onto Orange Peel Calculated from Various Methods: A Comparison Study. J. Environ. Chem. Eng. 2016, 4, 2671–2682. [CrossRef]26. Da Rosa Salles, T.; Da Silva Bruckamann, F.; Viana, A.R.; Krause, L.M.F.; Mortari, S.R.; Rhoden, C.R.B. Magnetic nanocrystalline cellulose: Azithromycin adsorption and in vitro biological activity against melanoma cells. J. Polym. Environ. 2022, 30, 2695–2713. [CrossRef]27. Cimirro, F.N.; Lima, C.E.; Cunha, M.R.; Dias, S.L.; Thue, P.S.; Mazzocato, A.C.; Dotto, G.L.; Gelesky, M.A.; Pavan, F.A. Removal of pharmaceutical compounds from aqueous solution by novel activated carbon synthesized from lovegrass (Poaceae). Environ. Sci. Pollut. Res. 2020, 27, 21442–21454. [CrossRef]28. Kanta, U.-A.; Thongpool, V.; Sangkhun, W.; Wongyao, N.; Wootthikanokkhan, J. Preparations, Characterizations, and a Comparative Study on Photovoltaic Performance of Two Different Types of Graphene/TiO2 Nanocomposites Photoelectrodes. J. Nanomater. 2017, 2017, 2758294. [CrossRef]29. Ossonon, B.D.; Bélanger, D. Synthesis and Characterization of Sulfophenyl-Functionalized Reduced Graphene Oxide Sheets. RSC Adv. 2017, 7, 27224–27234. [CrossRef]30. Da Silva Bruckmann, F.; Viana, A.R.; Lopes, L.Q.S.; Santos, R.C.V.; Muller, E.I.; Mortari, S.R.; Rhoden, C.R.B. Synthesis, Characterization, and Biological Activity Evaluation of Magnetite-Functionalized Eugenol. J. Inorg. Organomet. Polym. Mater. 2022, 32, 1459–1472. [CrossRef]31. Bruckmann, F.d.S.; Pimentel, A.C.; Viana, A.R.; Salles, T.d.R.; Krause, L.M.F.; Mortari, S.R.; da Silva, I.Z.; Rhoden, C.R.B. Synthesis, Characterization and Cytotoxicity Evaluation of Magnetic Nanosilica in L929 Cell Line. Discip. Sci. 2020, 21, 1–14. [CrossRef]32. Ain, Q.T.; Haq, S.H.; Alshammari, A.; Al-Mutlaq, M.A.; Anjum, M.N. The Systemic Effect of PEG-NGO-Induced Oxidative Stress in Vivo in a Rodent Model. Beilstein J. Nanotechnol. 2019, 10, 901–911. [CrossRef] [PubMed]33. Liu, J.; Xu, D.; Chen, P.; Yu, Q.; Qiu, H.; Xiong, X. Solvothermal Synthesis of Porous Superparamagnetic RGO@Fe3O4 Nanocomposites for Microwave Absorption. J. Mater. Sci. Mater. Electron. 2019, 30, 17106–17118. [CrossRef]34. Kellici, S.; Acord, J.; Ball, J.; Reehal, H.S.; Morgan, D.; Saha, B. A Single Rapid Route for the Synthesis of Reduced Graphene Oxide with Antibacterial Activities. RSC Adv. 2014, 4, 14858–14861. [CrossRef]35. Côa, F.; Strauss, M.; Clemente, Z.; Rodrigues Neto, L.L.; Lopes, J.R.; Alencar, R.S.; Souza Filho, A.G.; Alves, O.L.; Castro, V.L.S.S.; Barbieri, E.; et al. Coating Carbon Nanotubes with Humic Acid Using an Eco-Friendly Mechanochemical Method: Application for Cu(II) Ions Removal from Water and Aquatic Ecotoxicity. Sci. Total Environ. 2017, 607–608, 1479–1486. [CrossRef] [PubMed]36. Zhang, K.; Zhang, Q.; Gao, X.; Chen, X.; Wang, Y.; Li, W.; Wu, J. Effect of absorbers’ composition on the microwave absorbing performance of hollow Fe3O4 nanoparticles decorated CNTs/graphene/C composites. J. Alloys Compd. 2018, 748, 70–716. [CrossRef]37. Hatel, R.; Majdoub, S.E.; Bakour, A.; Khenfouch, M.; Baitoul, M. Graphene Oxide/Fe3O4 Nanorods Composite: Structural and Raman Investigation. J. Phys. Conf. Ser. 2018, 1081, 012006. [CrossRef]38. Ghosh, B.; Sarma, S.; Pontsho, M.; Ray, S.C. Tuning of Magnetic Behaviour in Nitrogenated Graphene Oxide Functionalized with Iron Oxide. Diam. Relat. Mater. 2018, 89, 35–42. [CrossRef]39. Da Silva Bruckmann, F.; Mafra Ledur, C.; Zanella da Silva, I.; Luiz Dotto, G.; Rodrigo Bohn Rhoden, C. A DFT Theoretical and Experimental Study about Tetracycline Adsorption onto Magnetic Graphene Oxide. J. Mol. Liq. 2022, 353, 118837. [CrossRef]40. Cheng, Y.; Yang, S.; Tao, E. Magnetic graphene oxide prepared via ammonia coprecipitation method: The effects of preserved functional groups on adsorption property. Inorg. Chem. Commun. 2021, 128, 108603. [CrossRef]41. Zeng, K.; Hachem, K.; Kuznetsova, M.; Chupradit, S.; Su, C.H.; Nguyen, H.C.; El-Shafay, A.S. Molecular dynamic simulation and artificial intelligence of lead ions removal from aqueous solution using magnetic-ash-graphene oxide nanocomposite. J. Mol. Liq. 2022, 347, 118290. [CrossRef]42. Nuengmatcha, P.; Mahachai, R.; Chanthai, S. Thermodynamic and kinetic study of the intrinsic adsorption capacity of graphene oxide for malachite green removal from aqueous solution. Orient. J. Chem. 2014, 30, 1463. [CrossRef]43. Nasiri, A.; Rajabi, S.; Amiri, A.; Fattahizade, M.; Hasani, O.; Lalehzari, A.; Hashemi, M. Adsorption of tetracycline using CuCoFe2O4@ Chitosan as a new and green magnetic nanohybrid adsorbent from aqueous solutions: Isotherm, kinetic and thermodynamic study. Arab. J. Chem. 2022, 15, 104014. [CrossRef]44. Da Silva Bruckmann, F.; Schnorr, C.E.; Da Rosa Salles, T.; Nunes, F.B.; Baumann, L.; Müller, E.I.; Silva, L.F.O.; Dotto, G.L.; Bohn Rhoden, C.R. Highly Efficient Adsorption of Tetracycline Using Chitosan-Based Magnetic Adsorbent. Polymers 2022, 14, 4854. [CrossRef]45. Pereira, A.V.; Garabeli, A.A.; Schunemann, G.D.; Borck, P.C. Determination of dissociation constant (Ka) of captopril and nimesulide: Analytical chemistry experiments for undergraduate pharmacy. Quim Nova 2011, 34, 1656–1660. [CrossRef]46. Zhu, H.; Chen, T.; Liu, J.; Li, D. Adsorption of tetracycline antibiotics from an aqueous solution onto graphene oxide/calcium alginate composite fibers. RSC Adv. 2018, 8, 2616–2621. [CrossRef]47. Bruckmann, F.S.; Rossato Viana, A.; Tonel, M.Z.; Fagan, S.B.; Garcia, W.J.D.S.; Oliveira, A.H.D.; Dorneles, L.S.; Mortari, S.R.; Da Silva, W.L.; Da Silva, I.Z.; et al. Influence of magnetite incorporation into chitosan on the adsorption of the methotrexate and in vitro cytotoxicity. Environ. Sci. Pollut. Res. 2022, 29, 70413–70434. [CrossRef]48. Ji, L.; Chen, W.; Bi, J.; Zheng, S.; Xu, Z.; Zhu, D.; Alvarez, P.J. Adsorption of tetracycline on single-walled and multi-walled carbon nanotubes as affected by aqueous solution chemistry. Environ. Toxicol. Chem. 2010, 29, 2713–2719. [CrossRef]49. Liang, J.; Fang, Y.; Luo, Y.; Zeng, G.; Deng, J.; Tan, X.; Tang, N.; Li, X.; He, X.; Feng, C.; et al. Magnetic nanoferromanganese oxides modified biochar derived from pine sawdust for adsorption of tetracycline hydrochloride. Environ. Sci. Pollut. Res. 2019, 26, 5892–5903. [CrossRef]50. Agarry, S.E.; Aworanti, O.A. Kinetics, Isothermal and Thermodynamic Modelling Studies of Hexavalent Chromium Ions Adsorption from Simulated Wastewater onto Parkia biglobosa-Sawdust Derived Acid-Steam Activated Carbon. Appl. J. Envir. Eng. Sci. 2017, 3, 58–76.51. De Souza, F.M.; Dos Santos, O.A.A.; Vieira, M.G.A. Adsorption of herbicide 2,4-D from aqueous solution using organo-modified bentonite clay. Environ. Sci. Pollut. Res. 2019, 26, 18329–18342. [CrossRef] [PubMed]52. Nunes, F.B.; Da Silva Bruckmann, F.; Da Rosa Salles, T.; Rhoden, C.B.R. Study of phenobarbital removal from the aqueous solutions employing magnetite-functionalized chitosan. Environ. Sci. Pollut. Res. 2022, 29, 1–14. [CrossRef] [PubMed]53. Carvajal-Bernal, A.M.; Gomez-Granados, F.; Giraldo, L.; Moreno-Pirajan, J.C. Application of the Sips model to the calculation of maximum adsorption capacity and immersion enthalpy of phenol aqueous solutions on activated carbons. Eur. J. Chem. 2017, 8, 112–118. [CrossRef]54. Kalam, S.; Abu-Khamsin, S.A.; Kamal, M.S.; Patil, S. Surfactant Adsorption Isotherms: A Review. ACS Omega 2021, 6, 32342–32348. [CrossRef]55. Gago, D.; Chagas, R.; Ferreira, L.M.; Velizarov, S.; Coelhoso, I. A Novel Cellulose-Based Polymer for Efficient Removal of Methylene Blue. Membranes 2020, 10, 13. [CrossRef]56. Salvstrini, S.; Ambrosone, L.; Kopinke, F.D. Some mistakes and misinterpretations in the analysis of thermodynamic adsorption data. J. Mol. Liq. 2022, 352, 118762. [CrossRef]57. Tran, H.N. Improper Estimation of Thermodynamic Parameters in Adsorption Studies with Distribution Coefficient KD (Qe/Ce) or Freundlich Constant (KF): Considerations from the Derivation of Dimensionless Thermodynamic Equilibrium Constant and Suggestions. Adsorp. Sci. Technol. 2022, 2022, 5553212. [CrossRef]58. Lima, E.C.; Hosseini-Bandegharaei, A.; Moreno-Piraján, J.C.; Anastopoulos, I. A Critical Review of the Estimation of the Thermodynamic Parameters on Adsorption Equilibria. Wrong Use of Equilibrium Constant in the Van’t Hoof Equation for Calculation of Thermodynamic Parameters of Adsorption. J. Mol. Liq. 2019, 273, 425–434. [CrossRef]59. Tran, H.N.; Lima, E.C.; Juang, R.-S.; Bollinger, J.-C.; Chao, H.-P. Thermodynamic Parameters of Liquid–Phase Adsorption Process Calculated from Different Equilibrium Constants Related to Adsorption Isotherms: A Comparison Study. J. Environ. Chem. Eng. 2021, 9, 106674. [CrossRef]60. Dotto, G.L.; Moura, J.M.D.; Cadaval, T.R.S.; Pinto, L.A.D.A. Application of chitosan films for the removal of food dyes from aqueous solutions by adsorption. Chem. Eng. J. 2013, 214, 8–16. [CrossRef]61. Li, Z.; Wu, D.; Liang, Y.; Xu, F.; Fu, R. Facile Fabrication of Novel Highly Microporous Carbons with Superior Size-Selective Adsorption and Supercapacitance Properties. Nanoscale 2013, 5, 10824–10828. [CrossRef] [PubMed]191215AdsorptionCarbon nanomaterialsMagnetiteCaptoprilPublicationORIGINALEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdfEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdfArtículoapplication/pdf7509377https://repositorio.cuc.edu.co/bitstreams/f776e017-26ef-44d3-a2bf-6b9f5266c3c0/download664b4711747190f3c1fb2885a7c7a464MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/21e3a9af-2708-4afc-b62c-55e7afc04824/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdf.txtEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdf.txtExtracted texttext/plain83201https://repositorio.cuc.edu.co/bitstreams/75b1493c-9c21-453a-bfb3-64b811925b53/downloadd040a5055a9f2771def4d278ce629cdcMD53THUMBNAILEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdf.jpgEfficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents.pdf.jpgGenerated Thumbnailimage/jpeg15809https://repositorio.cuc.edu.co/bitstreams/fd9d4d98-05d4-4f7b-9762-516f8bb3e37a/download667aefb80e99fbd4d2312674aece4762MD5411323/10364oai:repositorio.cuc.edu.co:11323/103642024-09-17 14:23:05.901https://creativecommons.org/licenses/by/4.0/© 2023 by the authors. 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.


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