Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.
Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing remains limited. This study aimed to identify which neuropsychological te...
- Autores:
-
Clarens, Maria Florencia
Crivelli, Lucia
Calandri, Ismael Luis
Chrem Méndez, Patricio
Martin, María Eugenia
Russo, María Julieta
Campos, Jorge
Surace, Ezequiel
Vázquez, Silvia
Sevlever, Gustavo
Allegri, Ricardo Francisco
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/7778
- Acceso en línea:
- https://hdl.handle.net/11323/7778
https://repositorio.cuc.edu.co/
- Palabra clave:
- Ab42
Alzheimer’s disease
cognitive biomarkers
dementia
mild cognitive impairment
neuropsychology
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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| dc.title.spa.fl_str_mv |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| title |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| spellingShingle |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. Ab42 Alzheimer’s disease cognitive biomarkers dementia mild cognitive impairment neuropsychology |
| title_short |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| title_full |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| title_fullStr |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| title_full_unstemmed |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| title_sort |
Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort. |
| dc.creator.fl_str_mv |
Clarens, Maria Florencia Crivelli, Lucia Calandri, Ismael Luis Chrem Méndez, Patricio Martin, María Eugenia Russo, María Julieta Campos, Jorge Surace, Ezequiel Vázquez, Silvia Sevlever, Gustavo Allegri, Ricardo Francisco |
| dc.contributor.author.spa.fl_str_mv |
Clarens, Maria Florencia Crivelli, Lucia Calandri, Ismael Luis Chrem Méndez, Patricio Martin, María Eugenia Russo, María Julieta Campos, Jorge Surace, Ezequiel Vázquez, Silvia Sevlever, Gustavo Allegri, Ricardo Francisco |
| dc.subject.spa.fl_str_mv |
Ab42 Alzheimer’s disease cognitive biomarkers dementia mild cognitive impairment neuropsychology |
| topic |
Ab42 Alzheimer’s disease cognitive biomarkers dementia mild cognitive impairment neuropsychology |
| description |
Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing remains limited. This study aimed to identify which neuropsychological tests best indicated underlying AD pathophysiology.Methods: One hundred and forty-one patients with MCI (Mild Cognitive Impairment) were studied. A neuropsychological test battery based on the Uniform Data Set (UDS) from the Alzheimer's Disease Centers program of the National Institute on Aging (NIA) was performed and amyloid markers recorded; according to presence or absence of amyloid identified by positive PIB-PET findings, or low CSF Aβ42 levels, patients were separated into MCI amyloid-(n:58) and MCI amyloid + (n = 83) cases.Results: Statistical differences were found in all memory tests between groups. Delayed recall score at thirty minutes on the Rey Auditory Verbal Learning Test (AVLT) was the best predictor of amyloid pathology presence (AUC 0.68), followed by AVLT total learning (AUC 0.66) and AVLT Recognition (AUC 0.59) scores, providing useful cut off values in the clinical setting.Conclusions: Use of neuropsychological testing, specifically AVLT scores with cutoff values, contributed to the correct diagnosis of MCI due to AD in this SouthAmerican cohort |
| publishDate |
2020 |
| dc.date.issued.none.fl_str_mv |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2021-01-27T17:23:44Z |
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2021-01-27T17:23:44Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/acceptedVersion |
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https://hdl.handle.net/11323/7778 |
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10.1080/23279095.2020.1756816. |
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Corporación Universidad de la Costa |
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REDICUC - Repositorio CUC |
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https://repositorio.cuc.edu.co/ |
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https://hdl.handle.net/11323/7778 https://repositorio.cuc.edu.co/ |
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10.1080/23279095.2020.1756816. Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.references.spa.fl_str_mv |
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade Neuropsychological Testing Predicts Cerebrospinal Fluid Amyloid-β in Mild Cognitive Impairment Early neuropsychological detection of Alzheimer's disease “Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician Mini-mental state-practical method for grading cognitive state of patients for clinicians Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease The validity of the Trail Making Test as an indicator of organic brain damage Neuropsychological Markers of Cognitive Decline in Persons With Alzheimer Disease Neuropathology Creation of the Argentina-Alzheimer Disease Neuroimaging Initiative The learning profile of persistent mild cognitive impairment (MCI): A potential diagnostic marker of persistent amnestic MCI Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects Neuropsychological Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease Neuropsychological Assessment, 4th Edn Boston Naming Test Wechsler Memory Scale - Revised A Combination of Neuropsychological, Neuroimaging, and Cerebrospinal Fluid Markers Predicts Conversion from Mild Cognitive Impairment to Dementia The Clinical Examination in Psychology/L'examen Clinique En Psychologie Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CHThe diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade The Alzheimerʼs Disease Centersʼ Uniform Data Set (UDS): The Neuropsychologic Test Battery Differential Memory Test Sensitivity for Diagnosing Amnestic Mild Cognitive Impairment and Predicting Conversion to Alzheimer's Disease Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects Combining Early Markers Strongly Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease Cerebral Blood Flow in Dementia The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease Development of a multilingual aphasia battery. Progress and problems A New Clinical Scale for the Staging of Dementia Memory function in very early Alzheimer's disease The FAB: a Frontal Assessment Battery at bedside Neuropsychological Evaluation of Mild Cognitive Impairment: Three Case Reports ??-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease Neuropathological and Neuropsychological Changes in “Normal” Aging: Evidence for Preclinical Alzheimer Disease in Cognitively Normal Individuals Re: De Jager, CA, et al. Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease Neuropsychological Prediction of Conversion to Alzheimer Disease in Patients With Mild Cognitive Impairment Memory Evaluation in Mild Cognitive Impairment using Recall and Recognition Tests Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease WAIS-III: Wechsler adult intelligence scale: Psychological Corporation A, for the Alzheimer's Disease Neuroimaging Initiative The consortium to establish a registry for Alzheimer's disease (CERAD): I. Clinical and neuropsychological assessment of Alzheimer |
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Clarens, Maria FlorenciaCrivelli, LuciaCalandri, Ismael LuisChrem Méndez, PatricioMartin, María EugeniaRusso, María JulietaCampos, JorgeSurace, EzequielVázquez, SilviaSevlever, GustavoAllegri, Ricardo Francisco2021-01-27T17:23:44Z2021-01-27T17:23:44Z2020https://hdl.handle.net/11323/777810.1080/23279095.2020.1756816.Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing remains limited. This study aimed to identify which neuropsychological tests best indicated underlying AD pathophysiology.Methods: One hundred and forty-one patients with MCI (Mild Cognitive Impairment) were studied. A neuropsychological test battery based on the Uniform Data Set (UDS) from the Alzheimer's Disease Centers program of the National Institute on Aging (NIA) was performed and amyloid markers recorded; according to presence or absence of amyloid identified by positive PIB-PET findings, or low CSF Aβ42 levels, patients were separated into MCI amyloid-(n:58) and MCI amyloid + (n = 83) cases.Results: Statistical differences were found in all memory tests between groups. Delayed recall score at thirty minutes on the Rey Auditory Verbal Learning Test (AVLT) was the best predictor of amyloid pathology presence (AUC 0.68), followed by AVLT total learning (AUC 0.66) and AVLT Recognition (AUC 0.59) scores, providing useful cut off values in the clinical setting.Conclusions: Use of neuropsychological testing, specifically AVLT scores with cutoff values, contributed to the correct diagnosis of MCI due to AD in this SouthAmerican cohortClarens, Maria FlorenciaCrivelli, LuciaCalandri, Ismael Luis-will be generated-orcid-0000-0002-6983-1430-600Chrem Méndez, PatricioMartin, María EugeniaRusso, María JulietaCampos, JorgeSurace, EzequielVázquez, SilviaSevlever, GustavoAllegri, Ricardo Francisco-will be generated-orcid-0000-0001-7166-1234-600application/pdfengCorporación Universidad de la CostaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Appl Neuropsychol Adulthttps://pubmed.ncbi.nlm.nih.gov/32349554/#affiliation-1Ab42Alzheimer’s diseasecognitive biomarkersdementiamild cognitive impairmentneuropsychologyNeuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionHypothetical model of dynamic biomarkers of the Alzheimer's pathological cascadeNeuropsychological Testing Predicts Cerebrospinal Fluid Amyloid-β in Mild Cognitive ImpairmentEarly neuropsychological detection of Alzheimer's disease“Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinicianMini-mental state-practical method for grading cognitive state of patients for cliniciansUsefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer DiseaseThe validity of the Trail Making Test as an indicator of organic brain damageNeuropsychological Markers of Cognitive Decline in Persons With Alzheimer Disease NeuropathologyCreation of the Argentina-Alzheimer Disease Neuroimaging InitiativeThe learning profile of persistent mild cognitive impairment (MCI): A potential diagnostic marker of persistent amnestic MCIReduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjectsNeuropsychological Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's DiseaseNeuropsychological Assessment, 4th EdnBoston Naming TestWechsler Memory Scale - RevisedA Combination of Neuropsychological, Neuroimaging, and Cerebrospinal Fluid Markers Predicts Conversion from Mild Cognitive Impairment to DementiaThe Clinical Examination in Psychology/L'examen Clinique En PsychologieAlbert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CHThe diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelinesHypothetical model of dynamic biomarkers of the Alzheimer's pathological cascadeThe Alzheimerʼs Disease Centersʼ Uniform Data Set (UDS): The Neuropsychologic Test BatteryDifferential Memory Test Sensitivity for Diagnosing Amnestic Mild Cognitive Impairment and Predicting Conversion to Alzheimer's DiseaseSerial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's diseaseEpisodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsCerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative SubjectsCombining Early Markers Strongly Predicts Conversion from Mild Cognitive Impairment to Alzheimer's DiseaseCerebral Blood Flow in DementiaThe Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's diseaseDevelopment of a multilingual aphasia battery. Progress and problemsA New Clinical Scale for the Staging of DementiaMemory function in very early Alzheimer's diseaseThe FAB: a Frontal Assessment Battery at bedsideNeuropsychological Evaluation of Mild Cognitive Impairment: Three Case Reports??-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's diseaseNeuropathological and Neuropsychological Changes in “Normal” Aging: Evidence for Preclinical Alzheimer Disease in Cognitively Normal IndividualsRe: De Jager, CA, et al. Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's diseaseNeuropsychological Prediction of Conversion to Alzheimer Disease in Patients With Mild Cognitive ImpairmentMemory Evaluation in Mild Cognitive Impairment using Recall and Recognition TestsProfiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseWAIS-III: Wechsler adult intelligence scale: Psychological CorporationA, for the Alzheimer's Disease Neuroimaging InitiativeThe consortium to establish a registry for Alzheimer's disease (CERAD): I. Clinical and neuropsychological assessment of AlzheimerPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-83196https://repositorio.cuc.edu.co/bitstreams/12da437c-3098-452e-84bc-e5bba30f8a5e/downloade30e9215131d99561d40d6b0abbe9badMD53ORIGINALNeuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.pdfNeuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.pdfapplication/pdf301590https://repositorio.cuc.edu.co/bitstreams/e6487f6c-5449-45a8-b33b-404e2f82a957/download949658ff95d60d5c381709d9ee0a9996MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.cuc.edu.co/bitstreams/3ab9d705-bb49-4f5f-a18b-2e94c1d0702e/download4460e5956bc1d1639be9ae6146a50347MD52THUMBNAILNeuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.pdf.jpgNeuropsychological 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