EEG-based functional connectivity analysis for cognitive impairment classification
Understanding how mild cognitive impairment affects global neural networks may explain changes in brain electrophysiology. Using graph theory and the visual oddball paradigm, we evaluated the functional connectivity of neuronal networks in brain lobes. The study involved 30 participants: 14 with mil...
- Autores:
-
Isabel Echeverri-Ocampo
Echeverri Ocampo, Isabel Cristina
Ardila, Karen
José Molina-Mateo
Molina-Mateo, Jose
Padilla-Buritica, J. I.
Carceller, Héctor
Barceló-Martinez, Ernesto A.
Llamur, S. I.
Maria de la Iglesia-Vaya
de la Iglesia Vaya, Maria
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/13551
- Acceso en línea:
- https://hdl.handle.net/11323/13551
https://repositorio.cuc.edu.co/
- Palabra clave:
- Brain networks
Computational modeling
EEG
Neurodegenerative disease
Machine learning
Change point detection
- Rights
- openAccess
- License
- Atribución 4.0 Internacional (CC BY 4.0)
id |
RCUC2_9000f9d241eb6fa8778e21f9bfe2e158 |
---|---|
oai_identifier_str |
oai:repositorio.cuc.edu.co:11323/13551 |
network_acronym_str |
RCUC2 |
network_name_str |
REDICUC - Repositorio CUC |
repository_id_str |
|
dc.title.eng.fl_str_mv |
EEG-based functional connectivity analysis for cognitive impairment classification |
title |
EEG-based functional connectivity analysis for cognitive impairment classification |
spellingShingle |
EEG-based functional connectivity analysis for cognitive impairment classification Brain networks Computational modeling EEG Neurodegenerative disease Machine learning Change point detection |
title_short |
EEG-based functional connectivity analysis for cognitive impairment classification |
title_full |
EEG-based functional connectivity analysis for cognitive impairment classification |
title_fullStr |
EEG-based functional connectivity analysis for cognitive impairment classification |
title_full_unstemmed |
EEG-based functional connectivity analysis for cognitive impairment classification |
title_sort |
EEG-based functional connectivity analysis for cognitive impairment classification |
dc.creator.fl_str_mv |
Isabel Echeverri-Ocampo Echeverri Ocampo, Isabel Cristina Ardila, Karen José Molina-Mateo Molina-Mateo, Jose Padilla-Buritica, J. I. Carceller, Héctor Barceló-Martinez, Ernesto A. Llamur, S. I. Maria de la Iglesia-Vaya de la Iglesia Vaya, Maria |
dc.contributor.author.none.fl_str_mv |
Isabel Echeverri-Ocampo Echeverri Ocampo, Isabel Cristina Ardila, Karen José Molina-Mateo Molina-Mateo, Jose Padilla-Buritica, J. I. Carceller, Héctor Barceló-Martinez, Ernesto A. Llamur, S. I. Maria de la Iglesia-Vaya de la Iglesia Vaya, Maria |
dc.subject.proposal.none.fl_str_mv |
Brain networks Computational modeling EEG Neurodegenerative disease Machine learning Change point detection |
topic |
Brain networks Computational modeling EEG Neurodegenerative disease Machine learning Change point detection |
description |
Understanding how mild cognitive impairment affects global neural networks may explain changes in brain electrophysiology. Using graph theory and the visual oddball paradigm, we evaluated the functional connectivity of neuronal networks in brain lobes. The study involved 30 participants: 14 with mild cognitive impairment (MCI) and 16 healthy control (HC) participants. We conducted an examination using the visual oddball paradigm, focusing on electroencephalography signals with targeted stimuli. Our analysis employed functional connectivity utilizing the change point detection method. Additionally, we implemented training for linear discriminant analysis, K-nearest neighbor, and decision tree techniques to classify brain activity, distinguishing between subjects with mild cognitive impairment and those in the healthy control group. Our results demonstrate the efficacy of combining functional connectivity measurements derived from electroencephalography with machine learning for cognitive impairment classification. This research opens avenues for further exploration, including the potential for real-time detection of cognitive decline in complex real-world scenarios. |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
2023-10-27 |
dc.date.accessioned.none.fl_str_mv |
2024-10-26T18:00:27Z |
dc.date.available.none.fl_str_mv |
2024-10-26T18:00:27Z |
dc.type.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.content.none.fl_str_mv |
Text |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.citation.none.fl_str_mv |
Echeverri-Ocampo, I.; Ardila, K.; Molina-Mateo, J.; Padilla-Buritica, J.I.; Carceller, H.; Barceló-Martinez, E.A.; Llamur, S.I.; Iglesia-Vaya, M.d.l. EEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification. Electronics 2023, 12, 4432. https://doi.org/10.3390/electronics12214432 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11323/13551 |
dc.identifier.doi.none.fl_str_mv |
10.3390/electronics12214432 |
dc.identifier.eissn.none.fl_str_mv |
Electronics |
dc.identifier.instname.none.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.none.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
Echeverri-Ocampo, I.; Ardila, K.; Molina-Mateo, J.; Padilla-Buritica, J.I.; Carceller, H.; Barceló-Martinez, E.A.; Llamur, S.I.; Iglesia-Vaya, M.d.l. EEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification. Electronics 2023, 12, 4432. https://doi.org/10.3390/electronics12214432 10.3390/electronics12214432 Electronics Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
https://hdl.handle.net/11323/13551 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournal.none.fl_str_mv |
Electronics |
dc.relation.references.none.fl_str_mv |
Rossini, P.M.; Miraglia, F.; Vecchio, F. Early dementia diagnosis, MCI-to-dementia risk prediction, and the role of machine learning methods for feature extraction from integrated biomarkers, in particular for EEG signal analysis. Alzheimer’s Dement. 2022, 18, 2699–2706. Sabbagh, M.N.; Boada, M.; Borson, S.; Doraiswamy, P.M.; Dubois, B.; Ingram, J.; Iwata, A.; Porsteinsson, A.P.; Possin, K.L.; Rabinovici, G.D.; et al. Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting. J. Prev. Alzheimer’s Dis. 2020, 7, 171–178. Rossini, P.M.; Miraglia, F.; Alù, F.; Cotelli, M.; Ferreri, F.; Di Iorio, R.; Iodice, F.; Vecchio, F. Neurophysiological hallmarks of neurodegenerative cognitive decline: The study of brain connectivity as a biomarker of early dementia. J. Pers. Med. 2020, 10, 34. Echeverri-ocampo, I.; Ardila, K.; Molina-mateo, J.; Padilla, J.I.; Segura-giraldo, B.; Carceller, H.; Barceló-marti, E.A. Influence of Segmentation Schemes on the Interpretability of Functional Connectivity in Mild Cognitive Impairment. In Proceedings of the Sustainable Smart Cities and Territories International Conference, Manizales, Colombia, 21–23 June 2023; Springer: Manizales, Colombia, 2023; pp. 1–10. World Health Organization. Dementia. Available online: https://www.who.int/es/news-room/fact-sheets/detail/dementia (accessed on 22 September 2023). Johansson, M.M.; Marcusson, J.; Wressle, E. Cognitive impairment and its consequences in everyday life: Experiences of people with mild cognitive impairment or mild dementia and their relatives. Int. Psychogeriatr. 2015, 27, 949–958. Ahmed, T.; Ko, J. Editorial: Synaptic Failure and Circuits’ Impairment—Cognitive and Neurological Disorders—Moving a Step Forward. Front. Mol. Neurosci. 2022, 15, 979511. Boersma, M.; Smit, D.J.A.; De Bie, H.M.A.; Van Baal, G.C.M.; Boomsma, D.I.; De Geus, E.J.C.; Delemarre-Van De Waal, H.A.; Stam, C.J. Network analysis of resting state EEG in the developing young brain: Structure comes with maturation. Hum. Brain Mapp. 2011, 32, 413–425. Muthukrishnan, S.P.; Soni, S.; Sharma, R. Brain Networks Communicate Through Theta Oscillations to Encode High Load in a Visuospatial Working Memory Task: An EEG Connectivity Study. Brain Topogr. 2020, 33, 75–85. Michel, C.M.; Murray, M.M. Towards the utilization of EEG as a brain imaging tool. NeuroImage 2012, 61, 371–385. Lai, M.; Demuru, M.; Hillebrand, A.; Fraschini, M. A comparison between scalp- and source-reconstructed EEG networks. Sci. Rep. 2018, 8, 12269. Wu, X.; Zheng, W.-L.; Lu, B.-L. Identifying Functional Brain Connectivity Patterns for EEG-Based Emotion Recognition. In Proceedings of the 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), San Francisco, CA, USA, 20–23 March 2019; pp. 235–238. Winter, W.R.; Nunez, P.L.; Ding, J.; Srinivasan, R. Comparison of the effect of volume conduction on EEG coherence with the effect of field spread on MEG coherence. Stat. Med. 2007, 26, 3946–3957. Tsuchimoto, S.; Shibusawa, S.; Iwama, S.; Hayashi, M.; Okuyama, K.; Mizuguchi, N.; Kato, K.; Ushiba, J. Use of common average reference and large-Laplacian spatial-filters enhances EEG signal-to-noise ratios in intrinsic sensorimotor activity. J. Neurosci. Methods 2021, 353, 109089. McFarland, D.J.; McCane, L.M.; David, S.V.; Wolpaw, J.R. Spatial filter selection for EEG-based communication. Electroencephalogr. Clin. Neurophysiol. 1997, 103, 386–394. Kayser, J.; Tenke, C.E. On the benefits of using surface Laplacian (current source density) methodology in electrophysiology. Int. J. Psychophysiol. 2015, 97, 171–173. Padilla-Buritica, J.I.; Ferrandez-Vicente, J.M.; Castaño, G.A.; Acosta-Medina, C.D. Non-stationary Group-Level Connectivity Analysis for Enhanced Interpretability of Oddball Tasks. Front. Neurosci. 2020, 14, 446. Imperatori, L.S.; Betta, M.; Cecchetti, L.; Canales-Johnson, A.; Ricciardi, E.; Siclari, F.; Pietrini, P.; Chennu, S.; Bernardi, G. EEG functional connectivity metrics wPLI and wSMI account for distinct types of brain functional interactions. Sci. Rep. 2019, 9, 8894. Adebisi, A.T.; Veluvolu, K.C. Brain network analysis for the discrimination of dementia disorders using electrophysiology signals: A systematic review. Front. Aging Neurosci. 2023, 15, 1039496. Yan, Y.; Zhao, A.; Ying, W.; Qiu, Y.; Ding, Y.; Wang, Y.; Xu, W.; Deng, Y. Functional Connectivity Alterations Based on the Weighted Phase Lag Index: An Exploratory Electroencephalography Study on Alzheimer’s Disease. Curr. Alzheimer Res. 2021, 18, 513–522. Porto, M.; Benítez Agudelo, J.; Aguirre-Acevedo, D.; Barcelo, E.; Allegri, R. Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer’s disease in Colombia. Appl. Neuropsychol. Adult 2021, 29, 1543–1551. Gramfort, A.; Luessi, M.; Larson, E.; Engemann, D.A.; Strohmeier, D.; Brodbeck, C.; Goj, R.; Jas, M.; Brooks, T.; Parkkonen, L.; et al. MEG and EEG data analysis with MNE-Python. Front. Neurosci. 2013, 7, 267. Delorme, A.; Sejnowski, T.; Makeig, S. Enhanced detection of artifacts in EEG data using higher-order statistics and independent component analysis. NeuroImage 2007, 34, 1443–1449. Sharma, S.; Swayne, D.A.; Obimbo, C. Trend analysis and change point techniques: A survey. Energy Ecol. Environ. 2016, 1, 123–130. Truong, C.; De, D. Détection de Ruptures Multiples—Application Aux Signaux Physiologiques. Ph.D. Thesis, Université Paris Saclay (COmUE), Ile-De-France, France, 2019. Dickey, D.A.; Fuller, W.A. Distribution of the Estimators for Autoregressive Time Series with a Unit Root. J. Am. Stat. Assoc. 1979, 74, 427. Lilliefors, H.W. On the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown. J. Am. Stat. Assoc. 1967, 62, 399–402. Greenblatt, R.E.; Pflieger, M.E.; Ossadtchi, A.E. Connectivity measures applied to human brain electrophysiological data. J. Neurosci. Methods 2012, 207, 1–16. Maitin, A.M.; Nogales, A.; Chazarra, P.; García-Tejedor, Á.J. EEGraph: An open-source Python library for modeling electroencephalograms using graphs. Neurocomputing 2023, 519, 127–134. Raschka, S. Linear Discriminant Analysis. Available online: https://sebastianraschka.com/Articles/2014_python_lda.html (accessed on 9 December 2021). Varone, G.; Boulila, W.; Lo Giudice, M.; Benjdira, B.; Mammone, N.; Ieracitano, C.; Dashtipour, K.; Neri, S.; Gasparini, S.; Morabito, F.C.; et al. A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls. Sensors 2021, 22, 129. Gonen, S.; Maya, G. Applying data mining algorithms to encourage mental health disclosure in the workplace. Int. J. Bus. Inf. Syst. 2021, 36, 553–571. Reinders, C.; Ackermann, H.; Yang, M.Y.; Rosenhahn, B. Learning Convolutional Neural Networks for Object Detection with Very Little Training Data. In Multimodal Scene Understanding: Algorithms, Applications and Deep Learning; Academic Press: Cambridge, MA, USA, 2019; pp. 65–100. Tan, L. Code Comment Analysis for Improving Software Quality. In The Art and Science of Analyzing Software Data; Morgan Kaufmann: Burlington, MA, USA, 2015; pp. 493–517. Ortiz, E.; Stingl, K.; Müninger, J.; Braun, C.; Preissl, H.; Belardinelli, P. Weighted phase lag index and graph analysis: Preliminary investigation of functional connectivity during resting state in children. Comput. Math. Methods Med. 2012, 2012, 186353. Stam, C.J.; van Straaten, E.C.W. Go with the flow: Use of a directed phase lag index (dPLI) to characterize patterns of phase relations in a large-scale model of brain dynamics. NeuroImage 2012, 62, 1415–1428. Nieto-Castanon, A. Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA). PLoS Comput. Biol. 2022, 18, e1010634. Delorme, A.; Makeig, S. EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics. J. Neurosci. Methods 2004, 13, 9–21. Saetia, S.; Yoshimura, N.; Koike, Y. Constructing Brain Connectivity Model Using Causal Network Reconstruction Approach. Front. Neuroinform. 2021, 15, 619557. Engel, A.K.; Fries, P. Beta-band oscillations-signalling the status quo? Curr. Opin. Neurobiol. 2010, 20, 156–165. León-Jacobus, A.; Ariza, P.; Barcelo, E.; Piñeres-Melo, M.; Morales, R.; Ovallos, D. Machine Learning Approach Applied to the Prevalence Analysis of ADHD Symptoms in Young Adults of Barranquilla, Colombia. In Computer Information Systems and Industrial Management, Proceedings of the 19th International Conference, CISIM 2020, Bialystok, Poland, 16–18 October 2020; Springer: Cham, Switzerland, 2020; pp. 255–265. ISBN 978-3-030-47678-6. Vabalas, A.; Gowen, E.; Poliakoff, E.; Casson, A.J. Machine learning algorithm validation with a limited sample size. PLoS ONE 2019, 14, e0224365. Marlats, F.; Bao, G.; Chevallier, S.; Boubaya, M.; Djabelkhir-Jemmi, L.; Wu, Y.H.; Lenoir, H.; Rigaud, A.S.; Azabou, E. SMR/Theta Neurofeedback Training Improves Cognitive Performance and EEG Activity in Elderly with Mild Cognitive Impairment: A Pilot Study. Front. Aging Neurosci. 2020, 12, 147. Nobukawa, S.; Yamanishi, T.; Kasakawa, S.; Nishimura, H.; Kikuchi, M.; Takahashi, T. Classification Methods Based on Complexity and Synchronization of Electroencephalography Signals in Alzheimer’s Disease. Front. Psychiatry 2020, 11, 255. Youssef, N.; Xiao, S.; Liu, M.; Lian, H.; Li, R.; Chen, X.; Zhang, W.; Zheng, X.; Li, Y.; Li, Y. Functional Brain Networks in Mild Cognitive Impairment Based on Resting Electroencephalography Signals. Front. Comput. Neurosci. 2021, 15, 698386. |
dc.relation.citationendpage.none.fl_str_mv |
17 |
dc.relation.citationstartpage.none.fl_str_mv |
1 |
dc.relation.citationissue.none.fl_str_mv |
21 |
dc.relation.citationvolume.none.fl_str_mv |
12 |
dc.rights.none.fl_str_mv |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. |
dc.rights.license.none.fl_str_mv |
Atribución 4.0 Internacional (CC BY 4.0) |
dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución 4.0 Internacional (CC BY 4.0) © 2023 by the authors. Licensee MDPI, Basel, Switzerland. https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.none.fl_str_mv |
17 páginas |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.publisher.place.none.fl_str_mv |
Switzerland |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
https://www.mdpi.com/2079-9292/12/21/4432 |
institution |
Corporación Universidad de la Costa |
bitstream.url.fl_str_mv |
https://repositorio.cuc.edu.co/bitstreams/9499169d-8bcc-407a-8ab0-a9f00ae93a41/download https://repositorio.cuc.edu.co/bitstreams/3f3d9511-e67b-495c-83c6-c10ecfece367/download https://repositorio.cuc.edu.co/bitstreams/a2bcac23-e023-4362-a2c2-5b0b2e6f8902/download https://repositorio.cuc.edu.co/bitstreams/34bc7073-6ae6-480a-b0f4-778c95556acc/download |
bitstream.checksum.fl_str_mv |
e9c368a439d09889c072689bea534cb1 73a5432e0b76442b22b026844140d683 bb972813fb9f5e4a0b094d4ad90071e6 55481fdd0e94325eee3cfbc4540e2b13 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio de la Universidad de la Costa CUC |
repository.mail.fl_str_mv |
repdigital@cuc.edu.co |
_version_ |
1828166635970625536 |
spelling |
Atribución 4.0 Internacional (CC BY 4.0)© 2023 by the authors. Licensee MDPI, Basel, Switzerland.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Isabel Echeverri-OcampoEcheverri Ocampo, Isabel CristinaArdila, KarenJosé Molina-MateoMolina-Mateo, JosePadilla-Buritica, J. I.Carceller, HéctorBarceló-Martinez, Ernesto A.Llamur, S. I.Maria de la Iglesia-Vayade la Iglesia Vaya, Maria2024-10-26T18:00:27Z2024-10-26T18:00:27Z2023-10-27Echeverri-Ocampo, I.; Ardila, K.; Molina-Mateo, J.; Padilla-Buritica, J.I.; Carceller, H.; Barceló-Martinez, E.A.; Llamur, S.I.; Iglesia-Vaya, M.d.l. EEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification. Electronics 2023, 12, 4432. https://doi.org/10.3390/electronics12214432https://hdl.handle.net/11323/1355110.3390/electronics12214432ElectronicsCorporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Understanding how mild cognitive impairment affects global neural networks may explain changes in brain electrophysiology. Using graph theory and the visual oddball paradigm, we evaluated the functional connectivity of neuronal networks in brain lobes. The study involved 30 participants: 14 with mild cognitive impairment (MCI) and 16 healthy control (HC) participants. We conducted an examination using the visual oddball paradigm, focusing on electroencephalography signals with targeted stimuli. Our analysis employed functional connectivity utilizing the change point detection method. Additionally, we implemented training for linear discriminant analysis, K-nearest neighbor, and decision tree techniques to classify brain activity, distinguishing between subjects with mild cognitive impairment and those in the healthy control group. Our results demonstrate the efficacy of combining functional connectivity measurements derived from electroencephalography with machine learning for cognitive impairment classification. This research opens avenues for further exploration, including the potential for real-time detection of cognitive decline in complex real-world scenarios.17 páginasapplication/pdfengMultidisciplinary Digital Publishing Institute (MDPI)Switzerlandhttps://www.mdpi.com/2079-9292/12/21/4432EEG-based functional connectivity analysis for cognitive impairment classificationArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85ElectronicsRossini, P.M.; Miraglia, F.; Vecchio, F. Early dementia diagnosis, MCI-to-dementia risk prediction, and the role of machine learning methods for feature extraction from integrated biomarkers, in particular for EEG signal analysis. Alzheimer’s Dement. 2022, 18, 2699–2706.Sabbagh, M.N.; Boada, M.; Borson, S.; Doraiswamy, P.M.; Dubois, B.; Ingram, J.; Iwata, A.; Porsteinsson, A.P.; Possin, K.L.; Rabinovici, G.D.; et al. Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting. J. Prev. Alzheimer’s Dis. 2020, 7, 171–178.Rossini, P.M.; Miraglia, F.; Alù, F.; Cotelli, M.; Ferreri, F.; Di Iorio, R.; Iodice, F.; Vecchio, F. Neurophysiological hallmarks of neurodegenerative cognitive decline: The study of brain connectivity as a biomarker of early dementia. J. Pers. Med. 2020, 10, 34.Echeverri-ocampo, I.; Ardila, K.; Molina-mateo, J.; Padilla, J.I.; Segura-giraldo, B.; Carceller, H.; Barceló-marti, E.A. Influence of Segmentation Schemes on the Interpretability of Functional Connectivity in Mild Cognitive Impairment. In Proceedings of the Sustainable Smart Cities and Territories International Conference, Manizales, Colombia, 21–23 June 2023; Springer: Manizales, Colombia, 2023; pp. 1–10.World Health Organization. Dementia. Available online: https://www.who.int/es/news-room/fact-sheets/detail/dementia (accessed on 22 September 2023).Johansson, M.M.; Marcusson, J.; Wressle, E. Cognitive impairment and its consequences in everyday life: Experiences of people with mild cognitive impairment or mild dementia and their relatives. Int. Psychogeriatr. 2015, 27, 949–958.Ahmed, T.; Ko, J. Editorial: Synaptic Failure and Circuits’ Impairment—Cognitive and Neurological Disorders—Moving a Step Forward. Front. Mol. Neurosci. 2022, 15, 979511.Boersma, M.; Smit, D.J.A.; De Bie, H.M.A.; Van Baal, G.C.M.; Boomsma, D.I.; De Geus, E.J.C.; Delemarre-Van De Waal, H.A.; Stam, C.J. Network analysis of resting state EEG in the developing young brain: Structure comes with maturation. Hum. Brain Mapp. 2011, 32, 413–425.Muthukrishnan, S.P.; Soni, S.; Sharma, R. Brain Networks Communicate Through Theta Oscillations to Encode High Load in a Visuospatial Working Memory Task: An EEG Connectivity Study. Brain Topogr. 2020, 33, 75–85.Michel, C.M.; Murray, M.M. Towards the utilization of EEG as a brain imaging tool. NeuroImage 2012, 61, 371–385.Lai, M.; Demuru, M.; Hillebrand, A.; Fraschini, M. A comparison between scalp- and source-reconstructed EEG networks. Sci. Rep. 2018, 8, 12269.Wu, X.; Zheng, W.-L.; Lu, B.-L. Identifying Functional Brain Connectivity Patterns for EEG-Based Emotion Recognition. In Proceedings of the 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), San Francisco, CA, USA, 20–23 March 2019; pp. 235–238.Winter, W.R.; Nunez, P.L.; Ding, J.; Srinivasan, R. Comparison of the effect of volume conduction on EEG coherence with the effect of field spread on MEG coherence. Stat. Med. 2007, 26, 3946–3957.Tsuchimoto, S.; Shibusawa, S.; Iwama, S.; Hayashi, M.; Okuyama, K.; Mizuguchi, N.; Kato, K.; Ushiba, J. Use of common average reference and large-Laplacian spatial-filters enhances EEG signal-to-noise ratios in intrinsic sensorimotor activity. J. Neurosci. Methods 2021, 353, 109089.McFarland, D.J.; McCane, L.M.; David, S.V.; Wolpaw, J.R. Spatial filter selection for EEG-based communication. Electroencephalogr. Clin. Neurophysiol. 1997, 103, 386–394.Kayser, J.; Tenke, C.E. On the benefits of using surface Laplacian (current source density) methodology in electrophysiology. Int. J. Psychophysiol. 2015, 97, 171–173.Padilla-Buritica, J.I.; Ferrandez-Vicente, J.M.; Castaño, G.A.; Acosta-Medina, C.D. Non-stationary Group-Level Connectivity Analysis for Enhanced Interpretability of Oddball Tasks. Front. Neurosci. 2020, 14, 446.Imperatori, L.S.; Betta, M.; Cecchetti, L.; Canales-Johnson, A.; Ricciardi, E.; Siclari, F.; Pietrini, P.; Chennu, S.; Bernardi, G. EEG functional connectivity metrics wPLI and wSMI account for distinct types of brain functional interactions. Sci. Rep. 2019, 9, 8894.Adebisi, A.T.; Veluvolu, K.C. Brain network analysis for the discrimination of dementia disorders using electrophysiology signals: A systematic review. Front. Aging Neurosci. 2023, 15, 1039496.Yan, Y.; Zhao, A.; Ying, W.; Qiu, Y.; Ding, Y.; Wang, Y.; Xu, W.; Deng, Y. Functional Connectivity Alterations Based on the Weighted Phase Lag Index: An Exploratory Electroencephalography Study on Alzheimer’s Disease. Curr. Alzheimer Res. 2021, 18, 513–522.Porto, M.; Benítez Agudelo, J.; Aguirre-Acevedo, D.; Barcelo, E.; Allegri, R. Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer’s disease in Colombia. Appl. Neuropsychol. Adult 2021, 29, 1543–1551.Gramfort, A.; Luessi, M.; Larson, E.; Engemann, D.A.; Strohmeier, D.; Brodbeck, C.; Goj, R.; Jas, M.; Brooks, T.; Parkkonen, L.; et al. MEG and EEG data analysis with MNE-Python. Front. Neurosci. 2013, 7, 267.Delorme, A.; Sejnowski, T.; Makeig, S. Enhanced detection of artifacts in EEG data using higher-order statistics and independent component analysis. NeuroImage 2007, 34, 1443–1449.Sharma, S.; Swayne, D.A.; Obimbo, C. Trend analysis and change point techniques: A survey. Energy Ecol. Environ. 2016, 1, 123–130.Truong, C.; De, D. Détection de Ruptures Multiples—Application Aux Signaux Physiologiques. Ph.D. Thesis, Université Paris Saclay (COmUE), Ile-De-France, France, 2019.Dickey, D.A.; Fuller, W.A. Distribution of the Estimators for Autoregressive Time Series with a Unit Root. J. Am. Stat. Assoc. 1979, 74, 427.Lilliefors, H.W. On the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown. J. Am. Stat. Assoc. 1967, 62, 399–402.Greenblatt, R.E.; Pflieger, M.E.; Ossadtchi, A.E. Connectivity measures applied to human brain electrophysiological data. J. Neurosci. Methods 2012, 207, 1–16.Maitin, A.M.; Nogales, A.; Chazarra, P.; García-Tejedor, Á.J. EEGraph: An open-source Python library for modeling electroencephalograms using graphs. Neurocomputing 2023, 519, 127–134.Raschka, S. Linear Discriminant Analysis. Available online: https://sebastianraschka.com/Articles/2014_python_lda.html (accessed on 9 December 2021).Varone, G.; Boulila, W.; Lo Giudice, M.; Benjdira, B.; Mammone, N.; Ieracitano, C.; Dashtipour, K.; Neri, S.; Gasparini, S.; Morabito, F.C.; et al. A Machine Learning Approach Involving Functional Connectivity Features to Classify Rest-EEG Psychogenic Non-Epileptic Seizures from Healthy Controls. Sensors 2021, 22, 129.Gonen, S.; Maya, G. Applying data mining algorithms to encourage mental health disclosure in the workplace. Int. J. Bus. Inf. Syst. 2021, 36, 553–571.Reinders, C.; Ackermann, H.; Yang, M.Y.; Rosenhahn, B. Learning Convolutional Neural Networks for Object Detection with Very Little Training Data. In Multimodal Scene Understanding: Algorithms, Applications and Deep Learning; Academic Press: Cambridge, MA, USA, 2019; pp. 65–100.Tan, L. Code Comment Analysis for Improving Software Quality. In The Art and Science of Analyzing Software Data; Morgan Kaufmann: Burlington, MA, USA, 2015; pp. 493–517.Ortiz, E.; Stingl, K.; Müninger, J.; Braun, C.; Preissl, H.; Belardinelli, P. Weighted phase lag index and graph analysis: Preliminary investigation of functional connectivity during resting state in children. Comput. Math. Methods Med. 2012, 2012, 186353.Stam, C.J.; van Straaten, E.C.W. Go with the flow: Use of a directed phase lag index (dPLI) to characterize patterns of phase relations in a large-scale model of brain dynamics. NeuroImage 2012, 62, 1415–1428.Nieto-Castanon, A. Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA). PLoS Comput. Biol. 2022, 18, e1010634.Delorme, A.; Makeig, S. EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics. J. Neurosci. Methods 2004, 13, 9–21.Saetia, S.; Yoshimura, N.; Koike, Y. Constructing Brain Connectivity Model Using Causal Network Reconstruction Approach. Front. Neuroinform. 2021, 15, 619557.Engel, A.K.; Fries, P. Beta-band oscillations-signalling the status quo? Curr. Opin. Neurobiol. 2010, 20, 156–165.León-Jacobus, A.; Ariza, P.; Barcelo, E.; Piñeres-Melo, M.; Morales, R.; Ovallos, D. Machine Learning Approach Applied to the Prevalence Analysis of ADHD Symptoms in Young Adults of Barranquilla, Colombia. In Computer Information Systems and Industrial Management, Proceedings of the 19th International Conference, CISIM 2020, Bialystok, Poland, 16–18 October 2020; Springer: Cham, Switzerland, 2020; pp. 255–265. ISBN 978-3-030-47678-6.Vabalas, A.; Gowen, E.; Poliakoff, E.; Casson, A.J. Machine learning algorithm validation with a limited sample size. PLoS ONE 2019, 14, e0224365.Marlats, F.; Bao, G.; Chevallier, S.; Boubaya, M.; Djabelkhir-Jemmi, L.; Wu, Y.H.; Lenoir, H.; Rigaud, A.S.; Azabou, E. SMR/Theta Neurofeedback Training Improves Cognitive Performance and EEG Activity in Elderly with Mild Cognitive Impairment: A Pilot Study. Front. Aging Neurosci. 2020, 12, 147.Nobukawa, S.; Yamanishi, T.; Kasakawa, S.; Nishimura, H.; Kikuchi, M.; Takahashi, T. Classification Methods Based on Complexity and Synchronization of Electroencephalography Signals in Alzheimer’s Disease. Front. Psychiatry 2020, 11, 255.Youssef, N.; Xiao, S.; Liu, M.; Lian, H.; Li, R.; Chen, X.; Zhang, W.; Zheng, X.; Li, Y.; Li, Y. Functional Brain Networks in Mild Cognitive Impairment Based on Resting Electroencephalography Signals. Front. Comput. Neurosci. 2021, 15, 698386.1712112Brain networksComputational modelingEEGNeurodegenerative diseaseMachine learningChange point detectionPublication6943151a-be16-44c8-9bad-af3fb5d6396f5f703201-f3e1-4d6a-a79c-36fca3b995412792ff4d-4ed6-4a4d-8497-015a166009df0000-0003-4505-83990000-0002-1628-25700000-0002-0531-9876ORIGINALEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdfEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdfapplication/pdf2807100https://repositorio.cuc.edu.co/bitstreams/9499169d-8bcc-407a-8ab0-a9f00ae93a41/downloade9c368a439d09889c072689bea534cb1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.cuc.edu.co/bitstreams/3f3d9511-e67b-495c-83c6-c10ecfece367/download73a5432e0b76442b22b026844140d683MD52TEXTEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdf.txtEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdf.txtExtracted texttext/plain74732https://repositorio.cuc.edu.co/bitstreams/a2bcac23-e023-4362-a2c2-5b0b2e6f8902/downloadbb972813fb9f5e4a0b094d4ad90071e6MD53THUMBNAILEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdf.jpgEEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification.pdf.jpgGenerated Thumbnailimage/jpeg15354https://repositorio.cuc.edu.co/bitstreams/34bc7073-6ae6-480a-b0f4-778c95556acc/download55481fdd0e94325eee3cfbc4540e2b13MD5411323/13551oai:repositorio.cuc.edu.co:11323/135512025-02-25 19:47:57.648https://creativecommons.org/licenses/by/4.0/© 2023 by the authors. Licensee MDPI, Basel, Switzerland.open.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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 |