Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure
Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to indu...
- Autores:
-
Torres-Ávila, Jose F.
Espitia-Pérez, Lyda
Bonatto, Diego
Rabaioli da Silva, Fernanda
Moreira de Oliveira, Iuri Maicon
O. Silva, Luís F.
Silva Corrêa, Dione
Dias, Johnny
da Silva, Juliana
Henriques, João
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/6457
- Acceso en línea:
- https://hdl.handle.net/11323/6457
https://doi.org/10.1590/1678-4685-gmb-2019-0134
https://repositorio.cuc.edu.co/
- Palabra clave:
- Coal
Colombia
Cell cycle
Systems chemo-biology
Carbón
Ciclo celular
Quimiobiología de sistemas
- Rights
- openAccess
- License
- CC0 1.0 Universal
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| dc.title.spa.fl_str_mv |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| dc.title.translated.spa.fl_str_mv |
Sistemas de análisis de quimiobiología de la respuesta al daño del ADN y los efectos del ciclo celular inducidos por la exposición al carbón |
| title |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| spellingShingle |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure Coal Colombia Cell cycle Systems chemo-biology Carbón Ciclo celular Quimiobiología de sistemas |
| title_short |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_full |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_fullStr |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_full_unstemmed |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_sort |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| dc.creator.fl_str_mv |
Torres-Ávila, Jose F. Espitia-Pérez, Lyda Bonatto, Diego Rabaioli da Silva, Fernanda Moreira de Oliveira, Iuri Maicon O. Silva, Luís F. Silva Corrêa, Dione Dias, Johnny da Silva, Juliana Henriques, João |
| dc.contributor.author.spa.fl_str_mv |
Torres-Ávila, Jose F. Espitia-Pérez, Lyda Bonatto, Diego Rabaioli da Silva, Fernanda Moreira de Oliveira, Iuri Maicon O. Silva, Luís F. Silva Corrêa, Dione Dias, Johnny da Silva, Juliana Henriques, João |
| dc.subject.spa.fl_str_mv |
Coal Colombia Cell cycle Systems chemo-biology Carbón Ciclo celular Quimiobiología de sistemas |
| topic |
Coal Colombia Cell cycle Systems chemo-biology Carbón Ciclo celular Quimiobiología de sistemas |
| description |
Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-07-04T17:37:51Z |
| dc.date.available.none.fl_str_mv |
2020-07-04T17:37:51Z |
| dc.date.issued.none.fl_str_mv |
2020-04-06 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
acceptedVersion |
| dc.identifier.issn.spa.fl_str_mv |
1678-4685 |
| dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/11323/6457 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1590/1678-4685-gmb-2019-0134 |
| dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
| dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
| identifier_str_mv |
1678-4685 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| url |
https://hdl.handle.net/11323/6457 https://doi.org/10.1590/1678-4685-gmb-2019-0134 https://repositorio.cuc.edu.co/ |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.references.spa.fl_str_mv |
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Torres-Ávila, Jose F.Espitia-Pérez, LydaBonatto, DiegoRabaioli da Silva, FernandaMoreira de Oliveira, Iuri MaiconO. Silva, Luís F.Silva Corrêa, DioneDias, Johnnyda Silva, JulianaHenriques, João2020-07-04T17:37:51Z2020-07-04T17:37:51Z2020-04-061678-4685https://hdl.handle.net/11323/6457https://doi.org/10.1590/1678-4685-gmb-2019-0134Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role.Las alteraciones del ciclo celular se encuentran entre las principales características del cáncer. En consecuencia, el estudio de los reguladores del ciclo celular se ha convertido en un tema importante en la investigación del cáncer, particularmente en relación con la exposición ambiental. La materia particulada y el polvo de carbón alrededor de las minas de carbón tienen el potencial de inducir alteraciones en el ciclo celular. Por lo tanto, en el presente estudio, realizamos análisis químicos para identificar los principales compuestos presentes en dos muestras de carbón mineral de minas colombianas y realizamos análisis de quimiobiología de sistemas para dilucidar las interacciones entre estos compuestos químicos y proteínas asociadas con el ciclo celular. Nuestros resultados destacan el papel del estrés oxidativo generado por la exposición a los residuos de la extracción de carbón, como los principales óxidos inorgánicos (MIO), elementos inorgánicos (IEs) e hidrocarburos policíclicos aromáticos (PAH) en el daño del ADN y las alteraciones en la progresión de la ciclo celular (bloqueo y / o retraso), así como disfunción estructural en varias proteínas. En particular, los IEs como Cr, Ni y S y HAP como el benzo [a] pireno pueden tener papeles influyentes en la regulación del ciclo celular a través del daño del ADN y el estrés oxidativo. En este proceso, las ciclinas, las quinasas dependientes de ciclina, las proteínas de dedos de zinc como TP53 y las proteínas quinasas pueden desempeñar un papel central.Torres-Ávila, Jose F.Espitia-Pérez, Lyda-will be generated-orcid-0000-0002-3332-7814-600Bonatto, Diego-will be generated-orcid-0000-0001-8679-2448-600Rabaioli da Silva, FernandaMoreira de Oliveira, Iuri Maicon-will be generated-orcid-0000-0001-9585-2887-600O. Silva, Luís F.Silva Corrêa, DioneDias, Johnny-will be generated-orcid-0000-0002-1751-9541-600da Silva, JulianaHenriques, João-will be generated-orcid-0000-0002-8896-1716-600engGenetics and Molecular BiologyCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2CoalColombiaCell cycleSystems chemo-biologyCarbónCiclo celularQuimiobiología de sistemasSystems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposureSistemas de análisis de quimiobiología de la respuesta al daño del ADN y los efectos del ciclo celular inducidos por la exposición al carbónArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionAlfaro-Moreno E, Martínez L, García-Cuellar C, Bonner JC, Murray JC, Rosas I, Rosales SP and Osornio-Vargas AR (2002) Biologic effects induced in vitro by PM10 from three different zones of Mexico City. 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