Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall
The present study aims to evaluate and compare antimycotoxin additives (AMAs) composed of bentonite (AMA 1), clinoptilolite (AMA 2), and beta-glucans extracted from yeast cell wall (AMA 3), with respect to their ability to bind Aflatoxin B1 (AFB1) using the isothermal models of Freundlich, Langmuir,...
- Autores:
-
Medianeira de Lima Schlösser, Luara
Simões, Cristina Tonial
Alves Sarturi, Janine
Rosa da Silva, Cristiane
Fabris Laber, Isadora
Dison S.P., Franco
Mallmann, Carlos Augusto
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/13293
- Acceso en línea:
- https://hdl.handle.net/11323/13293
https://repositorio.cuc.edu.co/
- Palabra clave:
- Adsorption isotherm
Aflatoxin B1
Antimycotoxin additives
In vitro test
- Rights
- embargoedAccess
- License
- Atribución 4.0 Internacional (CC BY 4.0)
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dc.title.eng.fl_str_mv |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
title |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
spellingShingle |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall Adsorption isotherm Aflatoxin B1 Antimycotoxin additives In vitro test |
title_short |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
title_full |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
title_fullStr |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
title_full_unstemmed |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
title_sort |
Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall |
dc.creator.fl_str_mv |
Medianeira de Lima Schlösser, Luara Simões, Cristina Tonial Alves Sarturi, Janine Rosa da Silva, Cristiane Fabris Laber, Isadora Dison S.P., Franco Mallmann, Carlos Augusto |
dc.contributor.author.none.fl_str_mv |
Medianeira de Lima Schlösser, Luara Simões, Cristina Tonial Alves Sarturi, Janine Rosa da Silva, Cristiane Fabris Laber, Isadora Dison S.P., Franco Mallmann, Carlos Augusto |
dc.subject.proposal.eng.fl_str_mv |
Adsorption isotherm Aflatoxin B1 Antimycotoxin additives In vitro test |
topic |
Adsorption isotherm Aflatoxin B1 Antimycotoxin additives In vitro test |
description |
The present study aims to evaluate and compare antimycotoxin additives (AMAs) composed of bentonite (AMA 1), clinoptilolite (AMA 2), and beta-glucans extracted from yeast cell wall (AMA 3), with respect to their ability to bind Aflatoxin B1 (AFB1) using the isothermal models of Freundlich, Langmuir, and BET. The additives were submitted to an in vitro adsorption experiment with AFB1 (0.05–4 mg L−1), using solutions of pH 3 and pH 6, with an inclusion rate of 0.5%, and analyzed by HPLC–MS/MS. At pH 3, for the seven concentrations evaluated, AMA 1 obtained adsorption rates (99.69 to 99.98%) higher (p < 0. 05) than the other AMAs, which were from 82.97 to 88.72% (AMA 2) and from 79.43 to 89.32% (AMA 3). At pH 6, in concentrations of 1, 2, and 4 mg L−1 of AFB1, AMA 1 obtained higher (p < 0.05) adsorption results (97.86 to 99.86%) than AMA 2 (91.98 to 96.12%) and AMA 3 (87.56 to 93.50%). The Freundlich model best fitted the AMA 1 adsorption data. For the other additives, the Langmuir model obtained the best fit, demonstrating qm of 8.6 mg g−1 at pH 3 and 2.3 mg g−1 at pH 6 for AMA 2; and for AMA 3, with qm of 3.4 mg g−1 at pH 3 and 2.3 mg g−1 at pH 6. The isotherm models work as an effective tool to describe the adsorption process whereas the AMA adsorption capacity varies as a function of product composition, pH, and mycotoxin content. |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
2023-11-14 |
dc.date.accessioned.none.fl_str_mv |
2024-09-05T12:39:43Z |
dc.date.available.none.fl_str_mv |
2024-11-14 2024-09-05T12:39:43Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.content.spa.fl_str_mv |
Text |
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info:eu-repo/semantics/article |
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http://purl.org/redcol/resource_type/ART |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/draft |
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dc.identifier.citation.spa.fl_str_mv |
de Lima Schlösser, L.M., Simões, C.T., Sarturi, J.A. et al. Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall. Mycotoxin Res 40, 111–121 (2024). https://doi.org/10.1007/s12550-023-00508-z |
dc.identifier.issn.spa.fl_str_mv |
0178-7888 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11323/13293 |
dc.identifier.doi.none.fl_str_mv |
10.1007/s12550-023-00508-z |
dc.identifier.eissn.spa.fl_str_mv |
1867-1632 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
de Lima Schlösser, L.M., Simões, C.T., Sarturi, J.A. et al. Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall. Mycotoxin Res 40, 111–121 (2024). https://doi.org/10.1007/s12550-023-00508-z 0178-7888 10.1007/s12550-023-00508-z 1867-1632 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
https://hdl.handle.net/11323/13293 https://repositorio.cuc.edu.co/ |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournal.spa.fl_str_mv |
Mycotoxin Research |
dc.relation.references.spa.fl_str_mv |
Ali RK, Hulya K (2010) Adsorption of Pb (II) ions from aqueous solution by native and activated bentonite: kinectic, equilibrium and thermodynamic study. J Hazard Mater 179:332–339. https://doi.org/10.1016/j.jhazmat.2010.03.009 Arica MY, Arpa C, Ergene A, Bayramoğlu G, Genç O (2003) Ca-alginate as a support for Pb (II) and Zn (II) biosorption with immobilized Phanerochaete chrysosporium. Carbohyd Polym 52(2):167–174. https://doi.org/10.1016/S0144-8617(02)00307-7 Bettiol PS, Cechinel MAP, Oliveira CM, Goulart K, Dol-Bó AG, Bernardin AM, Peterson M (2022) Adsorption of aflatoxin B1 mycotoxins by raw and lyophilized bentonitic clay. Adv Powder Technol 33:8. https://doi.org/10.1016/j.apt.2022.103682 Bikmurzin R, Bandzevičiūtė R, Maršalka A, Maneikis A, Kalėdienė L (2022) FT-IR method limitations for β-glucan analysis. Molecules 27(14):4616. https://doi.org/10.3390/molecules27144616 Binder EM (2007) Managing the risk of mycotoxins in modern feed production. Anim Feed Sci Technol 133:149–166. https://doi.org/10.1016/j.anifeedsci.2006.08.008 Brunauer S, Emmett PH, Teller E (1938) Adsorption of gases in multimolecular layers. J Am Chem Soc 60:309–319. https://doi.org/10.1021/ja01269a023 Bryden WL (2012) Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security. Anim Feed Sci and Technol 173:134–158. https://doi.org/10.1016/j.anifeedsci.2011.12.014 Calvet RM, Pereira MMG, Costa APR, Torres AM, Muratori MCS (2015) Toxigenic mycobiota and mycotoxins in shrimp feed. Rural Science 45(6):1021–1026. https://doi.org/10.1590/0103-8478cr20140583 Carotenuto G, Camerlingo C (2020) Kinetic investigation of water physisorption on natural clinoptilolite at room temperature. Microporous Mesoporous Mater 302:110238. https://doi.org/10.1016/j.micromeso.2020.110238 Çelebi H, Gök G, Gök O (2020) Adsorption capability of brewed tea waste in waters containing toxic lead (II), cadmium (II), nickel (II), and zinc (II) heavy metal ions. Sci Rep 10:17570. https://doi.org/10.1038/s41598-020-74553-4 Desnelli D, Yohandini H, Nurnawaty E, Hariani PL (2022) Study of adsorption isotherm and thermodynamic aspects of congo red and procion red over natural and Zn/Fe pillared bentonite. Indones J Fundam Appl Chem 7(2):51–57. https://doi.org/10.24845/ijfac.v7.i2.51 Ebadi A, Soltan Mohammadzadeh JS, Khudiev A (2009) What is the correct form of BET isotherm for modeling liquid phase adsorption? Adsorption 15:65–73. https://doi.org/10.1007/s10450-009-9151-3 Fochesato AS, Cristofolini A, Poloni VL, Magnoli A, Merkis CI, Dogi CA, Cavaglieri LR (2020) Culture medium and gastrointestinal environment positively influence the Saccharomyces cerevisiae RC016 cell wall polysaccharide profile and aflatoxin B1 bioadsorption. LWT 126:109306. https://doi.org/10.1016/j.lwt.2020.109306 Freundlich HMF (1906) Über die adsorption in Lösungen. Z Phys Chem 57:385–470. https://doi.org/10.1515/zpch-1907-5723 Gimeno A, Martins ML (2011) Mycotoxins and mycotoxicosis in animals and humans. Special Nutrients, Miami, US, 3rd ed Grant PG, Phillips TD (1998) Isothermal adsorption of aflatoxin B1 on HSCAS clay. J Agric Food Chem 46:599–605. https://doi.org/10.1021/jf970604v Kadeche A, Ramdani A, Adjdir M, Guendouzi A, Taleb S, Kaid M, Derantani A (2020) Preparation, characterization and application of Fe-pillared bentonite to the removal of Coomassie blue dye from aqueous solutions. Res Chem Intermed 46(11):4985–5008. https://doi.org/10.1007/s11164-020-04236-2 Kang F, Ge Y, Hu X, Goikavi C, Waigi MG, Gao Y, Ling W (2016) Understanding the sorption mechanisms of aflatoxin B1 to kaolinite, illite, and smectite clays via a comparative computational study. J Hazard Mater 320:80–87. https://doi.org/10.1016/j.jhazmat.2016.08.006 Kogan G, Kocher A (2007) Role of yeast cell wall polysaccharides in pig nutrition and health protection. Livest Sci 109:161–165. https://doi.org/10.1016/j.livsci.2007.01.134 Lacerda EHC, Lacerda LHS, Andrade AVC, Fujiwara ST, Kloss JR (2023) Spectroscopic, mineralogical and photocatalytic characterization of bentonite clay: a jointed DFT and experimental approach. J Photochem Photobiol A 445:115077. https://doi.org/10.1016/j.jphotochem.2023.115077 Langmuir I (1918) The adsorption of gases on plane surface of glass, mica and platinum. J Am Chem Soc 40:1361–1403. https://doi.org/10.1021/ja02242a004 Limousin G, Gaudet JP, Charlet L, Szenknect S, Barthès V, Krimissa M (2007) Sorption isotherms: a review on physical bases, modeling and measurement. Appl Geochem 22:249–275. https://doi.org/10.1016/j.apgeochem.2006.09.010 Liu L, Xu J, Na R, Du R, Ping W, Ge J, Zhao D (2022) Purification, characterization and partial biological activities of exopolysaccharide produced by Saccharomyces cerevisiae Y3. Int J Biol Macromolecules 206:777–787. https://doi.org/10.1016/j.ijbiomac.2022.03.083 Mallmann CM, Dilkin P, Giacomini LZ, Rauber RH (2012) Criteria for selection of a sequestering agent for mycotoxins. In: APINCO Conference on Poultry Science and Technology 213–224. Available https://pt.engormix.com/micotoxinas/foruns/criterios-selecao-bom-sequestrante-t31580/ Oliveira MS, Rocha A, Sulyok M, Krska R, Mallmann CA (2017) Natural mycotoxin contamination of maize (Zea mays L.) in the south region of Brazil. Food Control 73:127–132. https://doi.org/10.1016/j.foodcont.2016.07.033 Pandey S, Fosso-Kankeu E, Spiro MJ, Waanders F, Kumar N, Ray SS, Kim J, Kang M (2020) Equilibrium, kinetic, and thermodynamic studies of lead ion adsorption from mine wastewater onto MoS2-clinoptilolite composite. Mater Today Chem 18:100376. https://doi.org/10.1016/j.mtchem.2020.100376 Papaioannou D, Katsoulos PD, Panousis N, Karatzias H (2005) The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: a review. Microporous Mesoporous Mater 84:161–170. https://doi.org/10.1016/j.micromeso.2005.05.030 Pereyra CM, Cavaglieri LR, Chiacchiera SM, Dalcero A (2012) The corn influence on the adsorption levels of aflatoxin B1 and zearalenone by yeast cell wall. J Appl Microbiol 114(3):2655–2662. https://doi.org/10.1111/jam.12082 Rasheed U, Ul Ain Q, Yaseen M, Fan X, Yao X, Tong Z, Liu B (2020) Modification of bentonite with orange peels extract and its application as mycotoxins’ binder in buffered solutions and simulated gastrointestinal fluids. J of Cleaner Production 267:122105. https://doi.org/10.1016/j.jclepro.2020.122105 Rosim RE, De Oliveira CAF, Corassin CH (2018) Aflatoxin M1 and aflatoxin B1-lysine as biomarkers to evaluate the efficiency of adsorbents for aflatoxins. Review Article, Essays and Science: C Biological Agrarians and Health 22(3):171–178. https://doi.org/10.17921/1415-6938.2018v22n3p171-178 Salomón YLO, Georgin J, Franco DSP, Netto MS, Piccilli DGA, Foletto EL, Manera C, Godinho M, Perondi D, Dotto GL (2022) Development of activated carbon from Schizolobium parahyba (guapuruvu) residues employed for the removal of ketoprofen. Environ Sci Pollut Res 29:21860–21875. https://doi.org/10.1007/s11356-021-17422-5 Slaný M, Kuzielová E, Žemlička M, Matejdes M, Struhárová A, Palou MT (2023) Metabentonite and metakaolin-based geopolymers/zeolites: relation between kind of clay, calcination temperature and concentration of alkaline activator. J Therm Anal Calorim. https://doi.org/10.1007/s10973-023-12267-1 Souza Neto VO, Oliveira AG, Teixeira RNP (2011) Use of Coconut Bagasse as alternative adsorbent for separation of copper (II) ions from aqueous solutions: isotherms, kinetics and thermodynamic studies. BioResources 6(1011):3376–3395 Synytsya A, Novak M (2014) Structural analysis of glucans. Ann Transl Med 2(2):17. https://doi.org/10.3978/j.issn.2305-5839.2014.02.07 Tomašević-Čanović M, Daković A, Medaković V, Stojšić D (2001) The effect of exchangeable cations in clinoptilolite and montmorillonite on the adsorption of aflatoxin B1. J Serb Chem Soc 66(8):555–561. https://doi.org/10.2298/JSC0108555T Tonk S, Rápó E (2022) Linear and nonlinear regression analysis for the adsorption of remazol dye by Romanian brewery waste by-product, Saccharomyces cerevisiae. Intern J Mol Sci 23(19):11827. https://doi.org/10.3390/ijms231911827 USP/NF (1990) 22/17 ed. Rockville, MD: United States Pharmacopeial Convention Inc, pp 1788–1789 Vila-Donat P, Marín S, Sanchis V, Ramos AJ (2019) New mycotoxin adsorbents based on tri-octahedral bentonites for animal feed. Anim Feed Sci Tech 255:114228. https://doi.org/10.1016/j.anifeedsci.2019.114228 Wan D, Wang G, Li W, Wei X (2017) Investigation into the morphology and structure of magnetic bentonite nanocomposites with their catalytic activity. Appl Surf Sci 413:398–407. https://doi.org/10.1016/j.apsusc.2017.03.265 Wang G, Miao Y, Sum Z, Zheng S (2018) Simultaneous adsorption of aflatoxin B1 and zearalenone by mono- and di-alkyl cationic surfactants modified montmorillonites. J Colloid Interface Sci 511:67–76. https://doi.org/10.1016/j.jcis.2017.09.074 Wielogórska E, Macdonald S, Elliot CT (2016) A review of the efficacy of mycotoxin detoxifying agents used in feed in light of changing global environment and legislation. World Mycotoxin J 9(3):419–433. https://doi.org/10.3920/WMJ2015.1919 Zhao Z, Liu N, Yang L, Wang J, Song S, Nie D, Yang X, Hou J, Wu A (2015) Cross-linked chitosan polymers as generic adsorbents for simultaneous adsorption of multiple mycotoxins. Food Control 57:362–369. https://doi.org/10.1016/j.foodcont.2015.05.014 |
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© 2024 Springer Nature |
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Atribución 4.0 Internacional (CC BY 4.0) |
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Atribución 4.0 Internacional (CC BY 4.0) © 2024 Springer Nature https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_f1cf |
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Atribución 4.0 Internacional (CC BY 4.0)© 2024 Springer Naturehttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfMedianeira de Lima Schlösser, LuaraSimões, Cristina TonialAlves Sarturi, JanineRosa da Silva, Cristiane Fabris Laber, IsadoraDison S.P., FrancoMallmann, Carlos Augusto2024-09-05T12:39:43Z2024-11-142024-09-05T12:39:43Z2023-11-14de Lima Schlösser, L.M., Simões, C.T., Sarturi, J.A. et al. Adsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wall. Mycotoxin Res 40, 111–121 (2024). https://doi.org/10.1007/s12550-023-00508-z0178-7888https://hdl.handle.net/11323/1329310.1007/s12550-023-00508-z1867-1632Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/The present study aims to evaluate and compare antimycotoxin additives (AMAs) composed of bentonite (AMA 1), clinoptilolite (AMA 2), and beta-glucans extracted from yeast cell wall (AMA 3), with respect to their ability to bind Aflatoxin B1 (AFB1) using the isothermal models of Freundlich, Langmuir, and BET. The additives were submitted to an in vitro adsorption experiment with AFB1 (0.05–4 mg L−1), using solutions of pH 3 and pH 6, with an inclusion rate of 0.5%, and analyzed by HPLC–MS/MS. At pH 3, for the seven concentrations evaluated, AMA 1 obtained adsorption rates (99.69 to 99.98%) higher (p < 0. 05) than the other AMAs, which were from 82.97 to 88.72% (AMA 2) and from 79.43 to 89.32% (AMA 3). At pH 6, in concentrations of 1, 2, and 4 mg L−1 of AFB1, AMA 1 obtained higher (p < 0.05) adsorption results (97.86 to 99.86%) than AMA 2 (91.98 to 96.12%) and AMA 3 (87.56 to 93.50%). The Freundlich model best fitted the AMA 1 adsorption data. For the other additives, the Langmuir model obtained the best fit, demonstrating qm of 8.6 mg g−1 at pH 3 and 2.3 mg g−1 at pH 6 for AMA 2; and for AMA 3, with qm of 3.4 mg g−1 at pH 3 and 2.3 mg g−1 at pH 6. The isotherm models work as an effective tool to describe the adsorption process whereas the AMA adsorption capacity varies as a function of product composition, pH, and mycotoxin content.5 páginasapplication/pdfengSpringer-Verlag GmbH and Co. KGGermanyhttps://link.springer.com/article/10.1007/s12550-023-00508-zAdsorption of aflatoxin B1 by different antimycotoxin additives: bentonite, clinoptilolite, and beta-glucans extracted from yeast cell wallArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/drafthttp://purl.org/coar/version/c_b1a7d7d4d402bcceMycotoxin ResearchAli RK, Hulya K (2010) Adsorption of Pb (II) ions from aqueous solution by native and activated bentonite: kinectic, equilibrium and thermodynamic study. J Hazard Mater 179:332–339. https://doi.org/10.1016/j.jhazmat.2010.03.009Arica MY, Arpa C, Ergene A, Bayramoğlu G, Genç O (2003) Ca-alginate as a support for Pb (II) and Zn (II) biosorption with immobilized Phanerochaete chrysosporium. Carbohyd Polym 52(2):167–174. https://doi.org/10.1016/S0144-8617(02)00307-7Bettiol PS, Cechinel MAP, Oliveira CM, Goulart K, Dol-Bó AG, Bernardin AM, Peterson M (2022) Adsorption of aflatoxin B1 mycotoxins by raw and lyophilized bentonitic clay. Adv Powder Technol 33:8. https://doi.org/10.1016/j.apt.2022.103682Bikmurzin R, Bandzevičiūtė R, Maršalka A, Maneikis A, Kalėdienė L (2022) FT-IR method limitations for β-glucan analysis. Molecules 27(14):4616. https://doi.org/10.3390/molecules27144616Binder EM (2007) Managing the risk of mycotoxins in modern feed production. Anim Feed Sci Technol 133:149–166. https://doi.org/10.1016/j.anifeedsci.2006.08.008Brunauer S, Emmett PH, Teller E (1938) Adsorption of gases in multimolecular layers. J Am Chem Soc 60:309–319. https://doi.org/10.1021/ja01269a023Bryden WL (2012) Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security. Anim Feed Sci and Technol 173:134–158. https://doi.org/10.1016/j.anifeedsci.2011.12.014Calvet RM, Pereira MMG, Costa APR, Torres AM, Muratori MCS (2015) Toxigenic mycobiota and mycotoxins in shrimp feed. Rural Science 45(6):1021–1026. https://doi.org/10.1590/0103-8478cr20140583Carotenuto G, Camerlingo C (2020) Kinetic investigation of water physisorption on natural clinoptilolite at room temperature. Microporous Mesoporous Mater 302:110238. https://doi.org/10.1016/j.micromeso.2020.110238Çelebi H, Gök G, Gök O (2020) Adsorption capability of brewed tea waste in waters containing toxic lead (II), cadmium (II), nickel (II), and zinc (II) heavy metal ions. Sci Rep 10:17570. https://doi.org/10.1038/s41598-020-74553-4Desnelli D, Yohandini H, Nurnawaty E, Hariani PL (2022) Study of adsorption isotherm and thermodynamic aspects of congo red and procion red over natural and Zn/Fe pillared bentonite. 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Food Control 57:362–369. https://doi.org/10.1016/j.foodcont.2015.05.014121111140Adsorption isothermAflatoxin B1Antimycotoxin additivesIn vitro testPublicationORIGINALAdsorption of aflatoxin B1 by different antimycotoxin additives.pdfAdsorption of aflatoxin B1 by different antimycotoxin additives.pdfArtículoapplication/pdf185654https://repositorio.cuc.edu.co/bitstreams/4b4f2748-4b18-42be-b3fc-96a5692be8df/downloada6a7b9308995acf02ed4a9525e0c3a56MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/bfbd906e-2938-4624-adff-8806ae924977/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTAdsorption of aflatoxin B1 by different antimycotoxin additives.pdf.txtAdsorption of aflatoxin B1 by different antimycotoxin additives.pdf.txtExtracted texttext/plain11559https://repositorio.cuc.edu.co/bitstreams/513db20b-22f3-4bc1-868f-21efe3837998/downloadb1aff8991ae2ea9a0294fb9291d862e5MD53THUMBNAILAdsorption of aflatoxin B1 by different antimycotoxin additives.pdf.jpgAdsorption of aflatoxin B1 by different antimycotoxin additives.pdf.jpgGenerated Thumbnailimage/jpeg15522https://repositorio.cuc.edu.co/bitstreams/639ad7f3-194a-4ab2-a904-06e08806a8b3/downloadec7b4b153200791422750526cd6d3a42MD5411323/13293oai:repositorio.cuc.edu.co:11323/132932024-09-17 12:45:00.817https://creativecommons.org/licenses/by/4.0/© 2024 Springer Natureopen.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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