Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization

Introuction Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. Methodls This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. Results Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). Discussiojn LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design

• Autores: Crivelli, Lucia; Calandri, Ismael Luis; Kimie Suemoto, Claudia; Salinas, Rosa María; Velilla, Lina Marcela; Sanches Yassuda, Mônica; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sevlever, Gustavo Emilio; Sosa, Ana Luisa; Acosta, Daisy; Charamelo Baietti, Ana María; Cusicanqui, María Isabel; Custodio, Nilton; Dansilio De Simone, Sergio; Delgado Derio, Carolina; Duque Peñailillo, Lissette; Duran, Juan Carlos; Jiménez Velázquez, Ivonne Z.; Leon Salas, Jorge Mario; Bergamo, Yanina; Clarens, María Florencia; Damian, Andrés; Demey, Ignacio; Helou, María Belén; Márquez, Carlos; Martin, María Eugenia; Morais Martin, Maria da Graça; Querze, Diego; Surace, Ezequiel Ignacio; Acosta Egea, Sabrina; Aguirre Salvador, Esteban; Cruz de Souza, Leonardo; da Cunha Peixoto Cançado, Gustavo Henrique; Dozzi Brucki, Sonia Maria; Vasconcelos Friedlaender, Clarisse; Braga Gomes, Karina; Gutierrez, Myriam; Laforcada Ríos, Carlos; Martinez Galindo, Joyce Graciela; Montesinos, Rosa; Nuñez Herrera, Alberto; Ospina Henao, Sebastián; Rodríguez, Guillermina; Victoria Ruiz, Masson; Sánchez, Mónica; Schenk, Christian E.; Soto, Ligia; Tonidandel Barbosa, Maira; Gonçalves Tosatt, Jéssica Abdo; Vicuña, Yosselin; Espeland, Mark; Hakansson, Krister; Kivipelto, Miia; Baker, Laura; Snyder, Heather; Carrillo, María; Allegri, Ricardo Francisco
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Corporación Universidad de la Costa
• Repositorio: REDICUC - Repositorio CUC
• Idioma: eng
• OAI Identifier: oai:repositorio.cuc.edu.co:11323/14070
• Acceso en línea: https://hdl.handle.net/11323/14070; https://repositorio.cuc.edu.co/
• Palabra clave: Alzheimer's disease; Cognitive impairment; Dementia lifestyle; Multidomain intervention; Prevention; Randomized controlled trial; World-Wide FINGERS
• Rights: closedAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)