Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization
The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiological mechanisms underlying the synergistic effec...
- Autores:
-
Clemente-Suárez, Vicente Javier
Martín Rodríguez, Alexandra
Curiel Regueros, Agustín
Rubio Zarapuz, Alejandro
Tornero Aguilera, José Francisco
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2025
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/14141
- Acceso en línea:
- https://hdl.handle.net/11323/14141
https://repositorio.cuc.edu.co/
- Palabra clave:
- Neuro-nutrition
Exercise-induced
Neuroplasticity
Bioengineered interventions
Cognitive enhancement
Mental health optimization
Wearable bioelectronics
- Rights
- openAccess
- License
- Atribución 4.0 Internacional (CC BY 4.0)
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Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| title |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| spellingShingle |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization Neuro-nutrition Exercise-induced Neuroplasticity Bioengineered interventions Cognitive enhancement Mental health optimization Wearable bioelectronics |
| title_short |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| title_full |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| title_fullStr |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| title_full_unstemmed |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| title_sort |
Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization |
| dc.creator.fl_str_mv |
Clemente-Suárez, Vicente Javier Martín Rodríguez, Alexandra Curiel Regueros, Agustín Rubio Zarapuz, Alejandro Tornero Aguilera, José Francisco |
| dc.contributor.author.none.fl_str_mv |
Clemente-Suárez, Vicente Javier Martín Rodríguez, Alexandra Curiel Regueros, Agustín Rubio Zarapuz, Alejandro Tornero Aguilera, José Francisco |
| dc.subject.proposal.eng.fl_str_mv |
Neuro-nutrition Exercise-induced Neuroplasticity Bioengineered interventions Cognitive enhancement Mental health optimization Wearable bioelectronics |
| topic |
Neuro-nutrition Exercise-induced Neuroplasticity Bioengineered interventions Cognitive enhancement Mental health optimization Wearable bioelectronics |
| description |
The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiological mechanisms underlying the synergistic effects of tailored nutritional strategies and exercise interventions on brain health and mental well-being. Key topics include the role of micronutrients and macronutrients in modulating neurogenesis and synaptic plasticity, the impact of exercise-induced myokines and neurotrophins on cognitive enhancement, and the integration of wearable bioelectronics for personalized monitoring and optimization. By bridging the disciplines of nutrition, psychology, and sports science with cutting-edge bioengineering, this review highlights translational opportunities for developing targeted interventions that advance mental health outcomes. These insights are particularly relevant for addressing global challenges such as stress, anxiety, and neurodegenerative diseases. The article concludes with a roadmap for future research, emphasizing the potential of bioengineered solutions to revolutionize preventive and therapeutic strategies in mental health care |
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2025 |
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2025-04-25T15:16:25Z |
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2025-04-25T15:16:25Z |
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2025-02-19 |
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Artículo de revista |
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Clemente-Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025). Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization. Bioengineering, 12(2), 208. https://doi.org/10.3390/bioengineering12020208 |
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https://hdl.handle.net/11323/14141 |
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10.3390/bioengineering12020208 |
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2306-5354 |
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Corporación Universidad de la Costa |
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REDICUC - Repositorio CUC |
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https://repositorio.cuc.edu.co/ |
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Clemente-Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025). Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization. Bioengineering, 12(2), 208. https://doi.org/10.3390/bioengineering12020208 10.3390/bioengineering12020208 2306-5354 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
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eng |
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eng |
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Bioengineering |
| dc.relation.references.none.fl_str_mv |
Jia, R.X.; Liang, J.H.; Xu, Y.; Wang, Y.Q. Effects of Physical Activity and Exercise on the Cognitive Function of Patients with Alzheimer Disease: A Meta-Analysis. BMC Geriatr. 2019, 19, 181 Mahalakshmi, B.; Maurya, N.; Lee, S.D.; Kumar, V.B. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegener ation. Int. J. Mol. Sci. 2020, 21, 5895 Hillman, C.H.; Erickson, K.I.; Kramer, A.F. Be Smart, Exercise Your Heart: Exercise Effects on Brain and Cognition. Nat. Rev. Neurosci. 2008, 9, 58–65 Phillips, C. Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging. Neural Plast. 2017, 2017, 3589271 Schuch, F.B.; Vancampfort, D.; Firth, J.; Rosenbaum, S.; Ward, P.B.; Silva, E.S.; Hallgren, M.; De Leon, A.P.; Dunn, A.L.; Deslandes, A.C.; et al. Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies. Am. J. Psychiatry 2018, 175, 631–648 Gómez-Pinilla, F. Brain Foods: The Effects of Nutrients on Brain Function. Nat. Rev. Neurosci. 2008, 9, 568–578 Hötting, K.; Röder, B. Beneficial Effects of Physical Exercise on Neuroplasticity and Cognition. Neurosci. Biobehav. Rev. 2013, 37 Pt B, 2243–2257 Gomez-Pinilla, F.; Hillman, C. The Influence of Exercise on Cognitive Abilities. Compr. Physiol. 2013, 3, 403–428 Kim, J.; Campbell, A.S.; de Ávila, B.E.F.; Wang, J. Wearable Biosensors for Healthcare Monitoring. Nat. Biotechnol. 2019, 37, 389–406 Bandodkar, A.J.; Wang, J. Non-Invasive Wearable Electrochemical Sensors: A Review. Trends Biotechnol. 2014, 32, 363–371 Heikenfeld, J.; Jajack, A.; Rogers, J.; Gutruf, P.; Tian, L.; Pan, T.; Li, R.; Khine, M.; Kim, J.; Wang, J.; et al. Wearable Sensors: Modalities, Challenges, and Prospects. Lab Chip 2018, 18, 217–248 Natarajan, A.; Su, H.W.; Heneghan, C. Assessment of Physiological Signs Associated with COVID-19 Measured Using Wearable Devices. NPJ Digit. Med. 2020, 3, 156 Clemente-Suárez, V.J.; Beltrán-Velasco, A.I.; Redondo-Flórez, L.; Martín-Rodríguez, A.; Tornero-Aguilera, J.F. Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review. Nutrients 2023, 15, 2749 Clemente-Suárez, V.J.; Beltrán-Velasco, A.I.; Redondo-Flórez, L.; Martín-Rodríguez, A.; Yáñez-Sepúlveda, R.; Tornero-Aguilera, J.F. Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review. Nutrients 2023, 15, 3106 Martín-Rodríguez, A.; Bustamante-Sánchez, Á.; Martínez-Guardado, I.; Navarro-Jiménez, E.; Plata-SanJuan, E.; Tornero-Aguilera, J.F.; Clemente-Suárez, V.J. Infancy Dietary Patterns, Development, and Health: An Extensive Narrative Review. Children 2022, 9, 1072 Clemente-Suárez, V.J.; Bustamante-Sanchez, Á.; Tornero-Aguilera, J.F.; Ruisoto, P.; Mielgo-Ayuso, J. Inflammation in COVID-19 and the Effects of Non-Pharmacological Interventions during the Pandemic: A Review. Int. J. Mol. Sci. 2022, 23, 15584 Clemente-Suárez, V.J.; Martínez-González, M.B.; Benitez-Agudelo, J.C.; Navarro-Jiménez, E.; Beltran-Velasco, A.I.; Ruisoto, P.; Diaz Arroyo, E.; Laborde-Cárdenas, C.C.; Tornero-Aguilera, J.F. The Impact of the COVID-19 Pandemic on Mental Disorders. A Critical Review. Int. J. Environ. Res. Public Health 2021, 18, 10041 Bayliak, M.M.; Gospodaryov, D.V.; Lushchak, V.I. Homeostasis of Carbohydrates and Reactive Oxygen Species Is Critically Changed in the Brain of Middle-Aged Mice: Molecular Mechanisms and Functional Reasons. BBA Adv. 2023, 3, 100077 Puente-González, A.S.; Sánchez-González, F.; Hernández-Xumet, J.E.; Sánchez-Sánchez, M.C.; Barbero-Iglesias, F.J.; Méndez Sánchez, R. Short and Medium-Term Effects of a Multicomponent Physical Exercise Program with a Mediterranean Diet on Bone Mineral Density, Gait, Balance, and Fall Risk for Patients with Alzheimer Disease: Randomized Controlled Clinical Trial Study Protocol. Medicine 2020, 99, e22385 Morris, M.C.; Tangney, C.C.; Wang, Y.; Sacks, F.M.; Bennett, D.A.; Aggarwal, N.T. MIND Diet Associated with Reduced Incidence of Alzheimer’s Disease. Alzheimer’s Dement. 2015, 11, 1007–1014 |
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© 2025 The authors |
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Atribución 4.0 Internacional (CC BY 4.0) |
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Atribución 4.0 Internacional (CC BY 4.0)© 2025 The authorshttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Clemente-Suárez, Vicente Javiervirtual::1117-1Martín Rodríguez, AlexandraCuriel Regueros, AgustínRubio Zarapuz, AlejandroTornero Aguilera, José Francisco2025-04-25T15:16:25Z2025-04-25T15:16:25Z2025-02-19Clemente-Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025). Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization. Bioengineering, 12(2), 208. https://doi.org/10.3390/bioengineering12020208https://hdl.handle.net/11323/1414110.3390/bioengineering120202082306-5354Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiological mechanisms underlying the synergistic effects of tailored nutritional strategies and exercise interventions on brain health and mental well-being. Key topics include the role of micronutrients and macronutrients in modulating neurogenesis and synaptic plasticity, the impact of exercise-induced myokines and neurotrophins on cognitive enhancement, and the integration of wearable bioelectronics for personalized monitoring and optimization. By bridging the disciplines of nutrition, psychology, and sports science with cutting-edge bioengineering, this review highlights translational opportunities for developing targeted interventions that advance mental health outcomes. These insights are particularly relevant for addressing global challenges such as stress, anxiety, and neurodegenerative diseases. The article concludes with a roadmap for future research, emphasizing the potential of bioengineered solutions to revolutionize preventive and therapeutic strategies in mental health care59 páginasapplication/pdfengMultidisciplinary Digital Publishing Institute (MDPI)Switzerlandhttps://www.mdpi.com/2306-5354/12/2/208Neuro-Nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimizationArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85BioengineeringJia, R.X.; Liang, J.H.; Xu, Y.; Wang, Y.Q. Effects of Physical Activity and Exercise on the Cognitive Function of Patients with Alzheimer Disease: A Meta-Analysis. BMC Geriatr. 2019, 19, 181Mahalakshmi, B.; Maurya, N.; Lee, S.D.; Kumar, V.B. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegener ation. Int. J. Mol. Sci. 2020, 21, 5895Hillman, C.H.; Erickson, K.I.; Kramer, A.F. Be Smart, Exercise Your Heart: Exercise Effects on Brain and Cognition. Nat. Rev. Neurosci. 2008, 9, 58–65Phillips, C. Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging. Neural Plast. 2017, 2017, 3589271Schuch, F.B.; Vancampfort, D.; Firth, J.; Rosenbaum, S.; Ward, P.B.; Silva, E.S.; Hallgren, M.; De Leon, A.P.; Dunn, A.L.; Deslandes, A.C.; et al. Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies. Am. J. Psychiatry 2018, 175, 631–648Gómez-Pinilla, F. Brain Foods: The Effects of Nutrients on Brain Function. Nat. Rev. Neurosci. 2008, 9, 568–578Hötting, K.; Röder, B. Beneficial Effects of Physical Exercise on Neuroplasticity and Cognition. Neurosci. Biobehav. Rev. 2013, 37 Pt B, 2243–2257Gomez-Pinilla, F.; Hillman, C. The Influence of Exercise on Cognitive Abilities. Compr. Physiol. 2013, 3, 403–428Kim, J.; Campbell, A.S.; de Ávila, B.E.F.; Wang, J. Wearable Biosensors for Healthcare Monitoring. Nat. Biotechnol. 2019, 37, 389–406Bandodkar, A.J.; Wang, J. Non-Invasive Wearable Electrochemical Sensors: A Review. Trends Biotechnol. 2014, 32, 363–371Heikenfeld, J.; Jajack, A.; Rogers, J.; Gutruf, P.; Tian, L.; Pan, T.; Li, R.; Khine, M.; Kim, J.; Wang, J.; et al. Wearable Sensors: Modalities, Challenges, and Prospects. Lab Chip 2018, 18, 217–248Natarajan, A.; Su, H.W.; Heneghan, C. Assessment of Physiological Signs Associated with COVID-19 Measured Using Wearable Devices. NPJ Digit. Med. 2020, 3, 156Clemente-Suárez, V.J.; Beltrán-Velasco, A.I.; Redondo-Flórez, L.; Martín-Rodríguez, A.; Tornero-Aguilera, J.F. Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review. Nutrients 2023, 15, 2749Clemente-Suárez, V.J.; Beltrán-Velasco, A.I.; Redondo-Flórez, L.; Martín-Rodríguez, A.; Yáñez-Sepúlveda, R.; Tornero-Aguilera, J.F. Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review. Nutrients 2023, 15, 3106Martín-Rodríguez, A.; Bustamante-Sánchez, Á.; Martínez-Guardado, I.; Navarro-Jiménez, E.; Plata-SanJuan, E.; Tornero-Aguilera, J.F.; Clemente-Suárez, V.J. Infancy Dietary Patterns, Development, and Health: An Extensive Narrative Review. Children 2022, 9, 1072Clemente-Suárez, V.J.; Bustamante-Sanchez, Á.; Tornero-Aguilera, J.F.; Ruisoto, P.; Mielgo-Ayuso, J. Inflammation in COVID-19 and the Effects of Non-Pharmacological Interventions during the Pandemic: A Review. Int. J. Mol. Sci. 2022, 23, 15584Clemente-Suárez, V.J.; Martínez-González, M.B.; Benitez-Agudelo, J.C.; Navarro-Jiménez, E.; Beltran-Velasco, A.I.; Ruisoto, P.; Diaz Arroyo, E.; Laborde-Cárdenas, C.C.; Tornero-Aguilera, J.F. The Impact of the COVID-19 Pandemic on Mental Disorders. A Critical Review. Int. J. Environ. Res. Public Health 2021, 18, 10041Bayliak, M.M.; Gospodaryov, D.V.; Lushchak, V.I. Homeostasis of Carbohydrates and Reactive Oxygen Species Is Critically Changed in the Brain of Middle-Aged Mice: Molecular Mechanisms and Functional Reasons. BBA Adv. 2023, 3, 100077Puente-González, A.S.; Sánchez-González, F.; Hernández-Xumet, J.E.; Sánchez-Sánchez, M.C.; Barbero-Iglesias, F.J.; Méndez Sánchez, R. Short and Medium-Term Effects of a Multicomponent Physical Exercise Program with a Mediterranean Diet on Bone Mineral Density, Gait, Balance, and Fall Risk for Patients with Alzheimer Disease: Randomized Controlled Clinical Trial Study Protocol. Medicine 2020, 99, e22385Morris, M.C.; Tangney, C.C.; Wang, Y.; Sacks, F.M.; Bennett, D.A.; Aggarwal, N.T. MIND Diet Associated with Reduced Incidence of Alzheimer’s Disease. 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 públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.</li>
      <li>
        Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
        <ol type="i">
          <li>Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.</li>
          <li>Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
        </ol>
      </li>
      <li>Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
    </ol>
  </li>
  <br/>
  <li>
    Representaciones, Garantías y Limitaciones de Responsabilidad.
    <p>A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Limitación de responsabilidad.
    <p>A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Término.
    <ol type="a">
      <li>Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.</li>
      <li>Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.</li>
    </ol>
  </li>
  <br/>
  <li>
    Varios.
    <ol type="a">
      <li>Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.</li>
      <li>Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.</li>
      <li>Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.</li>
      <li>Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.</li>
    </ol>
  </li>
  <br/>
</ol>
 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