Aloe vera: from ancient knowledge to the patent and innovation landscape – a review
Aloe vera is one of the oldest and most traditional medicinal plant in history, with its use dating back over a thousand years. Today, its biological activity is not limited to curative purposes. The expansion in the A. vera industry became evident during the 90′s, when the development of this crop...
- Autores:
-
Martínez Burgos, Walter Jose
Lima Serra, Josilene
Marsiglia F, Ronald M
Montoya, Pedro
Sarmiento Vásquez, Zulma
Marina, Oranys
Gallego Cartagena, Euler
Paternina Arboledaf, Carlos D.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/9271
- Acceso en línea:
- https://hdl.handle.net/11323/9271
https://doi.org/10.1016/j.sajb.2022.02.034
https://repositorio.cuc.edu.co/
- Palabra clave:
- Aloe vera
Processing
GelMarket
Patents
- Rights
- embargoedAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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|
dc.title.eng.fl_str_mv |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
title |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
spellingShingle |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review Aloe vera Processing GelMarket Patents |
title_short |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
title_full |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
title_fullStr |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
title_full_unstemmed |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
title_sort |
Aloe vera: from ancient knowledge to the patent and innovation landscape – a review |
dc.creator.fl_str_mv |
Martínez Burgos, Walter Jose Lima Serra, Josilene Marsiglia F, Ronald M Montoya, Pedro Sarmiento Vásquez, Zulma Marina, Oranys Gallego Cartagena, Euler Paternina Arboledaf, Carlos D. |
dc.contributor.author.spa.fl_str_mv |
Martínez Burgos, Walter Jose Lima Serra, Josilene Marsiglia F, Ronald M Montoya, Pedro Sarmiento Vásquez, Zulma Marina, Oranys Gallego Cartagena, Euler Paternina Arboledaf, Carlos D. |
dc.subject.proposal.eng.fl_str_mv |
Aloe vera Processing GelMarket Patents |
topic |
Aloe vera Processing GelMarket Patents |
description |
Aloe vera is one of the oldest and most traditional medicinal plant in history, with its use dating back over a thousand years. Today, its biological activity is not limited to curative purposes. The expansion in the A. vera industry became evident during the 90′s, when the development of this crop began to emerge due to a global demand from consumers more concerned with a healthy lifestyle. Considering the agro-industrial and economic relevance that this plant has acquired, this work reviewed its chemical, biological, and nutritional characteristics, plant processing methods, innovations, and industrial applications. Aloe vera is a plant that contain more than 75 bioactive compounds, among them the most relevant are polysaccharides, phenolics, and phytosterols. Additionally, the main processing technologies for A. vera leaves are described, including those used to obtain pressed filleted gel, whole leaf gel and manual filleted gel. This article shows its applications in the pharmaceutical, cosmetic and food industries are presented and the world landscape of the million-dollar market generated around this product, which in 2018 was around $1.60 billion. The applications of A. vera in the food industry as a natural functional ingredient or as fortifier in the food products of animal and vegetable origin has been a trend explored in the last years. Finally, through an in-depth analysis of patents and research articles, the current scenario of science and innovation developed for this industry is described. |
publishDate |
2022 |
dc.date.accessioned.none.fl_str_mv |
2022-06-21T15:12:49Z |
dc.date.available.none.fl_str_mv |
2022-06-21T15:12:49Z 2024-03-01 |
dc.date.issued.none.fl_str_mv |
2022-03-01 |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.citation.spa.fl_str_mv |
W .J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al., Aloe vera: From ancient knowledge to the patent and innovation landscape A review, South African Journal of Botany (2022), https://doi.org/10.1016/j.sajb.2022.02.034 |
dc.identifier.issn.spa.fl_str_mv |
0254-6299 |
dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/11323/9271 |
dc.identifier.url.spa.fl_str_mv |
https://doi.org/10.1016/j.sajb.2022.02.034 |
dc.identifier.doi.spa.fl_str_mv |
10.1016/j.sajb.2022.02.034 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
W .J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al., Aloe vera: From ancient knowledge to the patent and innovation landscape A review, South African Journal of Botany (2022), https://doi.org/10.1016/j.sajb.2022.02.034 0254-6299 10.1016/j.sajb.2022.02.034 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
https://hdl.handle.net/11323/9271 https://doi.org/10.1016/j.sajb.2022.02.034 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournal.spa.fl_str_mv |
South African Journal of Botany |
dc.relation.references.spa.fl_str_mv |
Ahlawat, K.S., Khatkar, B.S., 2011. Processing, food applications and safety of Aloe vera products: a review. Chem. Sci. Rev. Lett. 48, 525–533. https://doi.org/10.1007/ s13197-011-0229-z. Alvarado-Morales, G., Minjares-Fuentes, R., Contreras-Esquivel, J.C., Monta~nez, J., Meza-Vel azquez, J.A., Femenia, A., 2019. Application of thermosonication for Aloe vera (Aloe barbadensis Miller) juice processing: impact on the functional properties and the main bioactive polysaccharides. Ultrason. Sonochem. 56, 125–133. https:// doi.org/10.1016/j.ultsonch.2019.03.030. Anibarro-Ortega, M., Pinela, J., Barros, L., Ciric, A., Silva, S.P., Coelho, E., Mocan, A., Calhelha, R.C., Sokovic, M., Coimbra, M.A., Ferreira, I., 2019. Compositional features and bioactive properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower. Antioxidants 8, 1–21. https://doi.org/10.3390/antiox8100444. Antignac, E., Nohynek, G.J., Re, T., Clouzeau, J., Toutain, H., 2011. Safety of botanical ingredients in personal care products/cosmetics. Food Chem. Toxicol. 49, 324–341. https://doi.org/10.1016/j.fct.2010.11.022. Atherton, P., 1998. First Aid Plant. Chemistry in Britain, pp. 33–36. Baruah, A., Bordoloi, M., Deka Baruah, H.P., 2016. Aloe vera: a multipurpose industrial crop. Ind. Crops Prod. 94, 951–963. https://doi.org/10.1016/j.indcrop.2016.08.034. Basannavar, S., Pothuraju, R., Sharma, R.K., 2014. Effect of Aloe vera (Aloe barbadensis Miller) on survivability, extent of proteolysis and ACE inhibition of potential probi- otic cultures in fermented milk. J. Sci. Food Agric. 94, 2712–2717. https://doi.org/ 10.1002/jsfa.6615. Berardi, A., Perinelli, D.R., Merchant, H.A., Bisharat, L., Basheti, I.A., Bonacucina, G., Cespi, M., Palmieri, G.F., 2020. Hand sanitisers amid CoViD-19: a critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int. J. Pharm. 119431. https://doi.org/10.1016/j. ijpharm.2020.119431. Borges-arg aez, R., Chan-balan, R., Cetina-montejo, L., 2019. In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several deriva- tives against strains of in fl uenza virus. Ind. Crops Prod. 132, 468–475. https://doi. org/10.1016/j.indcrop.2019.02.056. Bozzi, A., Perrin, C., Austin, S., Arce Vera, F., 2007. Quality and authenticity of commer- cial Aloe vera gel powders. Food Chem. 103, 22–30. https://doi.org/10.1016/j.food- chem.2006.05.061. Brown D., 2006. Antioxidant compositions for the eye. US patent 20070207116A1 Burger et al., 1994 A. Burger, M. Grubert, O. Schuster Aloe vera- The renascence of a tradicional natural drug as a dermopharmaceutical SOFW J, 120 (1994), pp. 527-529 Canche-Escamilla, G., Colli-Acevedo, P., Borges-Argaez, R., Quintana-Owen, P., May-Crespo, J.F., C aceres-Farfan, M., Yam Puc, J.A., Sansores-Peraza, P., Vera-Ku, B.M., 2019. Extraction of phenolic components from an Aloe vera (Aloe barbadensis Miller) crop and their potential as antimicrobials and textile dyes. Sus- tain. Chem. Pharmacy 14, 100168. https://doi.org/10.1016/j.scp.2019.100168. Castillo, S., Navarro, D., Zapata, P.J., Guill en, F., Valero, D., Serrano, M., Martínez-Romero, D., 2010. Antifungal efficacy of Aloe vera in vitro and its use as a preharvest treatment to maintain postharvest table grape quality. Postharvest Biol. Technol. 57, 183–188. https://doi.org/10.1016/j.postharvbio.2010.04.006. Cavasana, A.L., Santos, C.H.M.dos, Dourado, D.M., Guimar~aes, F.dos S., Barros, F.H.R., de Campos, G.C.O., Leme, G.A.L., Silva, L.D.M.da, Wahl, L.M., Gutterres, N.B.de A., Matias, R., C^amara, S.J.F., Santos, S.E.de O., 2020. Effectiveness of the Aloe vera extract in the treatment of fistula-in-ano. J. Coloproctol. 40, 67–72. https://doi.org/ 10.1016/j.jcol.2019.09.003. CBI, 2020. The European market potential for Aloe vera. https://www.cbi.eu/market- information/natural-ingredients-health-products/aloe-vera/market-potential. Accessed 09 September 2020. Chandegara, V.K., Varshney, A.K., 2013. Aloe vera L. processing and products : a review. Int. J. Med. Aromatic Plants 3, 492–506. Choi, S.W., Son, B.W., Son, Y.S., Park, Y.I., Lee, S.K., Chung, M.H., 2001. The wound-heal- ing effect of a glycoprotein fraction isolated from aloe vera. J. Dermatol. 145, 535– 545. https://doi.org/10.1046/j.1365-2133.2001.04410.x. Coats, B., 1994. Method of processing stabilized aloe vera gel obtained from the whole aloe vera leaf. US patent 5356811 15. Costello, J., 1997. Cream formulation for topical application. US patent 5874094A 5874094. Da Silva Lima, S.C., Oliveira De Arruda, G., Dias Renovato, R., Martins Alvarenga, M.R., 2012. Representations and uses of medicinal plants in elderly men. Rev. Lat. Am. Enfermagem 20, 778–786. Dammak, I., Lasram, S., Hamdi, Z., Ben, O., Mkadmini, K., Trigui, I., Houissa, H., Mliki, A., Hassouna, M., 2018. In vitro antifungal and anti-ochratoxigenic activities of Aloe vera gel against Aspergillus carbonarius isolated from grapes. Ind. Crops Prod. 123, 416–423. https://doi.org/10.1016/j.indcrop.2018.07.023. Danish, P., Ali, Q., Hafeez, M., Malik, A., 2020. Antifungal and antibacterial activity of Aloe vera plant extract. Biol. Clin. Sci. Res. J. 4, 1–8. Denius, H.R., Homann, P.H., 1972. The relation between photosynthesis, respiration, and crassulacean acid metabolism in leaf slices of aloe arborescens mill. Plant Phys- iol. 49, 873–880. https://doi.org/10.1104/pp.49.6.873. Domíguez-Fernandez, R., Arzate-Vazquez, I., Chanona-Perez, J., Welti-Chanes, J., Alvarado-Gonzalez, J., Garibay-Febles, V., Gutierrez-Lopez, G., 2012. El gel de Aloe vera: estructura, composicion quimica,procesameinto,actividad biologica e impor- tancia en la industria farmaceutica y alimentaria. Revista Mexicana de Ingeniería Química 11, 23–43. Eigeles, D., Culcusica, M. 2019. Method and apparatus for producing tailored composi- tions of A. vera with probiotics and minerals products. Us patent 20200260769A1. El-Sayed, S.M., El-Sayed, H.S., 2020. Production of UF-soft cheese using probiotic bacte- ria and Aloe vera pulp as a good source of nutrients. Annals of Agricultural Sciences 65, 13–20. https://doi.org/10.1016/j.aoas.2020.05.002. Eshun, K., He, Q., 2004. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries - a review. Crit. Rev. Food Sci. Nutr. 44, 91–96. https://doi. org/10.1080/10408690490424694. Etusim, P.E., Okafor, E.E., Nwachukwu, N., Melariri, P., Ogbonnaya, C.I., 2013. A Study on Antibacterial activities of Aloe vera Leaves, Stems and Roots on some selected organisms. Indian Journals 6, 570–572. Flores-Lopez, M.L., Romaní, A., Cerqueira, M.A., Rodríguez-García, R., Jasso de Rodríguez, D., Vicente, A.A., 2016. Compositional features and bioactive properties of whole fraction from Aloe vera processing. Ind. Crops Prod. 91, 179– 185. https://doi.org/10.1016/j.indcrop.2016.07.011. Florez, D.H., 2014. Estudio de inteligencia competitiva para la cadena productiva de la sabila, Agrosabia. https://doi.org/10.13140/RG.2.1.3517.6087 Fonseca, V.J.A., Braga, A.L., Filho, J.R., Teixeira, C.S., Hora, G.C.A., Morais-Braga, M.F.B., 2022. A review on the antimicrobial properties of lectins. Int. J. Biol. Macromol. 195, 163–178. https://doi.org/10.1016/j.ijbiomac.2021.11.209. Funemi, T., Uchida, K., 2003. Stabilizer for fermented milk food, fermented milk food and method for producing the food. JP patent 2004305071A 2003. Gao, Y., Kuok, K.I., Jin, Y., Wang, R., 2019. Biomedical applications of Aloe vera. Crit. Rev. Food Sci. Nutr. 59, 244–256. https://doi.org/10.1080/10408398.2018.1496320. Ghani, U., Naeem, M., Rafeeq, H., Imtiaz, U., Amjad, A., Ullah, S., Rehman, A., Qasim, F., 2019. A novel approach towards nutraceuticals and biomedical applications. Schol. Int. J. Biochem. 02, 245–252. https://doi.org/10.36348/sijb.2019.v02i10.001. Grace, O.M., 2011. Current perspectives on the economic botany of the genus Aloe L . (Xanthorrhoeaceae). S. Afr. J. Bot. 77, 980–987. https://doi.org/10.1016/j. sajb.2011.07.002. Guerrero-Beltran, J.A., Barbosa-C anovas, G.V., 2004. Review: advantages and limita- tions on processing foods by UV light. Food Sci. Technol. Int. 10, 137–147. https:// doi.org/10.1177/1082013204044359. Gupta, K., Jaiswal, P., Gupta, H., Anurag, R.K., Nain, L., Prasanna, R., 2020. Exploring the potential of Aloe vera as a carrier for developing a novel cyanobacterial formula- tion. S. Afr. J. Bot. 135, 437–443. https://doi.org/10.1016/j.sajb.2020.09.035. Hamman, J.H., 2008. Composition and applications of Aloe vera Leaf Gel. Molecules 13, 1599–1616. https://doi.org/10.3390/molecules13081599. Hamman, J.H., Viljoen, A., 2009. Use of Aloe vera for increasing the bioavailability of poorly absorbable drugs. World Intellect. Prop. Organ. Int. WO 2009/ 103093 Al. ARTICLE IN PRESSJID: SAJB [m5G;March 1, 2022;5:13] 12 W.J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al. South African Journal of Botany 00 (2022) 114 Hiyanes, S., 1997. Cosmetic e.g. shampoo - consists of sap of Aloe vera, moisturiser, alcohol, surfactant, antiseptic and spice at predefined weight ratio. JP patent 11005724-A 11005724. Huang, C.-T., Hung, C.-Y., Hseih, Y.-C., Chang, C.-S., Velu, A.B., He, Y.-C., Huang, Y.-L., Chen, T.-A., Chen, T.-C., Lin, C.-Y., Lin, Y.-C., Shih, S.-R., Dutta, A., 2019a. Phytomedi- cine Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine 64, 152904. https://doi.org/10.1016/j. phymed.2019.152904. Huang, Y.L., Oppong, M.B., Guo, Y., Wang, L.Z., Fang, S.M., Deng, Y.R., Gao, X.M., 2019b. The Oleaceae family: a source of secoiridoids with multiple biological activities. FitoterapiaFitoterapia 136, 104155. https://doi.org/10.1016/j.fitote.2019.04.010. Huangyi, X., 2013. External medicament for treating scalds and preparation method thereof. CN patent 103690728A 2013. Hussain, S.A., Patil, G.R., Reddi, S., Yadav, V., Pothuraju, R., Singh, R.R.B., Kapila, S., 2017. Aloe vera (Aloe barbadensis Miller) supplemented probiotic lassi prevents shigella infiltration from epithelial barrier into systemic blood flow in mice model. Microb. Pathog. 102, 143–147. https://doi.org/10.1016/j.micpath.2016.11.023. IARC, 2016. Some drugs and herbal products. IARC Monogr. Eval. Carcinog. Risks Hum. 108, 251–262. Iberica, H., 1981. A procedure for stabilizing clear gel from Aloe vera leaves. ES patent 8305214A3 8305214. Javed, S., Atta-Ur, R., 2014. Aloe vera gel in food, health products, and cosmetics indus- try. Studies in Natural Products Chemistry. Elsevier B.V., pp. 261–285. https://doi. org/10.1016/B978-0-444-63294-4.00009-7. Jianping, L., Meihua, W., Jun, L., 2014. Qiqing baidu drink and preparation method thereof. CN patent 103638268A. Jingcai, C., Jinzhi, W., 2003. Application method of aloe vera L. extract in preventing and curing diabetes. CN patent 1575803A 1575803. Jot, H., Kim, J., Lee, K., Ohs, T., Park, I., 2009. Pharmaceutical composition for use as health food for preventing or treating type II diabetes and diabetes related symp- toms or diseases e.g. hyperglycemia, comprises processed aloe vera gel and speci- fied amount of polysaccharide. KR patent 2009081860-A 2009. Khan, I., Ahmad, T., Zia, R., Murid, M., Abrar, M., 2018. The therapeutic properties and applications of Aloe vera: a review. J. Herb. Med. 12, 1–10. https://doi.org/10.1016/ j.hermed.2018.01.002. Khatri, D., Panigrahi, J., Prajapati, A., Bariya, H., 2020. Attributes of Aloe vera gel and chi- tosan treatments on the quality and biochemical traits of post-harvest tomatoes. Sci. Hortic. 259, 108837. https://doi.org/10.1016/j.scienta.2019.108837. Kluge, M., Knapp, I., Kramer, D., Schwerdtner, I., Ritter, H., 1979. Crassulacean acid metabolism (CAM) in leaves of Aloe arborescens mill. plant. 145, 357–363. https:// doi.org/10.1007/bf00388361. Liu, H., Liu, S., Du, B., Dong, K., Wang, Y., Zhang, Y., 2021. Aloe vera gel coating aggra- vates superficial scald incidence in ‘Starking’ apples during low-temperature stor- age. Food Chem. 339, 128151. https://doi.org/10.1016/j.foodchem.2020.128151. Lopez-Cervantes, J., Sanchez-Machado, D.I., Cruz-Flores, P., Mariscal-Domínguez, M.F., Servín de la Mora-Lopez, G., Campas-Baypoli, O.N., 2018. Antioxidant capacity, proximate composition, and lipid constituents of aloe vera flowers. J. Appl. Res. Medicinal Aromatic Plants 10, 93–98. https://doi.org/10.1016/j. jarmap.2018.02.004. Maan, A.A., Nazir, A., Khan, M.K.I., Ahmad, T., Zia, R., Murid, M., Abrar, M., 2018. The therapeutic properties and applications of aloe vera: a review. J. Herbal Medicine12 1–10. https://doi.org/10.1016/j.hermed.2018.01.002. Majumder, R., Das, C.K., Mandal, M., 2019. Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacol. Res. 148, 104416. Manvitha, K., Bidya, B., 2014. Aloe vera: a wonder plant its history, cultivation and medicinal uses. J. Pharmacogn Phytochem. 2, 85–88. Maret, R., 1972. Process for preparing extracts of Aloe vera. US patent 3878197-A 3878197. Martínez-S anchez, A., Lopez-Ca~navate, M.E., Guirao-Martínez, J., Roca, M.J., Aguayo, E., 2020. Aloe vera flowers, a byproduct with great potential and wide application, depending on maturity Stage. Foods 9, 1–21. Martínez, M.J., Betancourt Badell, J., Alonso Gonzalez, N., 1996. Ausencia de actividad antimicrobiana de un extracto acuoso liofilizado de Aloe vera (sabila). Revista Cubana de Plantas Medicinales 1, 18–20. Martínez, W.J., Paternina-Arboleda, C.D., Paroddy, A., Velez Ramírez, M., Tapia, L.P., Espitia, R., 2017. Optimizacion del proceso de eliminacion de aloína del gel file- teado mecanico de Aloe vera concentrado 10X. Revista Cumbres 3, 9–16. Maughan, R., 1982. Controlled temperature process for manufacturing of improved sta- bilized aloe vera. US ptaent 4446131A 4446131. McAnalley, B.H.., Prairie, G., 1988. Process for preparation of Aloe products, produced thereby and components thereo. US Patent 4735935. Medina-Torres, L., Nunez-Ramírez, D.M., Calderas, F., Gonzalez-Laredo, R.F., Minjares-Fuentes, R., Valadez-García, M.A., Bernad-Bernad, M.J., Manero, O., 2019. Microencapsulation of gallic acid by spray drying with Aloe vera mucilage (Aloe barbadensis miller) as wall material. Ind. Crops Prod. 138, 111461. https://doi.org/ 10.1016/j.indcrop.2019.06.024. Meijuan, Y., 2014. Gingko tea. CN patent 103749850-A . Mendy, T.K., Misran, A., Mahmud, T.M.M., Ismail, S.I., 2019. Antifungal properties of aloe vera through in vitro and in vivo screening against postharvest pathogens of papaya fruit. Sci. Hortic. 257, 108767. https://doi.org/10.1016/j.scienta.2019.108767. Minamide, A., 1999. Stone named syotoku stone produced in japan-containing cos- metic composition. JP patent 2001031557A 1999. MINFAR, 1990 MINFAR, I.S. de M.M. "Dr. L.D.S., 1990. Compendio De Investigaciones Sobre El Aloe barbadensis Miller (sábila) Cultivado En Cuba. La Habana, Cuba. http://scielo.sld.cu/scieloOrg/php/reflinks.php?refpid=S0864-0319200600030000400006&lng=pt&pid=S0864-03192006000300004. Accessed 05 September 2021. Mingwei, Y., 2005a. Production process of food level aloe gel 200:1 frozen dry powder. CN patent 1672569A 1672569. Mingwei, Y., 2005b. Production process of spray dried food level Aloe gel 200:1 spray- ing dry powder. CN patent 1672570A 1672570. MSANVS -Ministerio da Saude e Agencia Nacional de Vigilancia Sanitaria, 2007. Regla- mento tecnico sobre aditivos aromatizantes, Diario Oficial da Uniao, de 17 de janeiro de 2007. https://doi.org/10.1017/CBO9781107415324.004 Mpiana, P.T., Ngbolua, K.te N., Tshibangu, D.S.T., Kilembe, J.T., Gbolo, B.Z., Mwanangombo, D.T., Inkoto, C.L., Lengbiye, E.M., Mbadiko, C.M., Matondo, A., Bongo, G.N., Tshilanda, D.D., 2020. Identification of potential inhibitors of SARS- CoV-2 main protease from aloe vera compounds: a molecular docking study. Chem. Phys. Lett. 754, 137751. https://doi.org/10.1016/j.cplett.2020.137751. Mudgil, D., Barak, S., Darji, P., 2016. Development and characterization of functional cultured buttermilk utilizing aloe vera juice. Food Biosci. 15, 105–109. https://doi. org/10.1016/j.fbio.2016.06.001. Mukherjee, P.K., Nema, N.K., Maity, N., Mukherjee, K., Harwansh, R.K., 2014. Phyto- chemical and therapeutic profile of aloe vera. J. Natur. Remed. 14, 1–26. https://doi. org/10.18311/jnr/2014/84. Murugesan, M.P., Venkata Ratnam, M., Mengitsu, Y., Kandasamy, K., 2020. Evaluation of anti-cancer activity of phytosomes formulated from Aloe vera extract. Mater. Today: Proceedings J. 42, 631–636. https://doi.org/10.1016/j.matpr.2020.11.047. Nagaraj, G., Brundha, D., Kowsalya, V., Chandraleka, C., Sangavi, S., Jayalakshmi, R., Arulpriya, M., Sathya, N., Prasath, M., Tamilarasu, S., 2020. Biosynthesis of zinc doped aloe vera for green nanoparticles. Mater. Today: Proc. 43, 3354–3358. https://doi.org/10.1016/j.matpr.2020.05.318. Nicolau-Lapena, I., Aguilo-Aguayo, I., Kramer, B., Abadias, M., Vinas, I., Muranyi, P., 2021. Combination of ferulic acid with aloe vera gel or alginate coatings for shelf- life prolongation of fresh-cut apples. Food packaging and shelf life 27, 100620. https://doi.org/10.1016/j.fpsl.2020.100620 Ortega-Toro, R., Collazo-Bligliardi;, S., Rosello;, J., Santamarina;, P., Amparo, C., 2017. Antifungal starch-based edible films containing aloe vera. Food Hydrocoll. 72, 1–10 . https://doi.org/10.1016/j.foodhyd.2017.05.023. Ortiz, R., Fernandez, V., 2000. Therapeutic after-shave care lotion. US patent 6352691B1 6352691. Ozturk, B., Karakaya, O., Kenan, Y., Saracoglu, O., 2019. Effects of aloe vera gel and MAP on bioactive compounds and quality attributes of cherry laurel fruit during cold storage. Sci. Hortic. 249, 31–37. https://doi.org/10.1016/j.scienta.2019.01.030. Ozturk, G., Young, G.M., 2017. Food evolution: the impact of society and science on the fermentation of cocoa beans. Comprehen. Rev. Food Sci. Food Safety 16, 431–455. https://doi.org/10.1111/1541-4337.12264. Pandey, A., Singh, S., 2016. Aloe vera : a systematic review of its industrial and ethno- medicinal efficacy. Int. J. Pharmaceut. Res. Allied Sci. 5, 21–33. Pasco, D., Pugh, N., Ross, S., Elsohly, M., 2001. High molecular weight polysaccharide fraction from Aloe vera with immunostimulatory activity. International application published under the patent cooperation treaty (PCT) WO2002003999A1 2001. Pothuraju, R., Sharma, R.K., Chagalamarri, J., Kavadi, P.K., Jangra, S., 2015. Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6 J mice. Food Function J. 6, 3576–3584. https://doi.org/10.1039/ c5fo00781j. Pothuraju, R., Sharma, R.K., Kavadi, P.K., Chagalamarri, J., Jangra, S., Bhakri, G., De, S., 2016a. Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6 J mice. Benef Microbes 7, 375–385. https://doi.org/10.3920/BM2015.0083. Pothuraju, R., Sharma, R.K., Onteru, S.K., Singh, S., Hussain, S.A., 2016b. Hypoglycemic and hypolipidemic effects of aloe vera extract preparations: a review. Phytother. Res. 30, 200–207. https://doi.org/10.1002/ptr.5532. Pyo, J., Pjeong, J., Jin, W., Hyon, S., Khan, J. 2015. Antioxidant composition useful as health food, for preventing and improving liver diseases including hepatitis and liver cirrhosis, comprises Aloe vera extract extracted from 4 to 6 months old A. vera. KR patent 2014147949-A Quispe, C., Villalobos, M., Borquez, J., Simirgiotis, M., 2018. Chemical composition and antioxidant activity of aloe vera from the pica oasis (Tarapaca, Chile) by UHPLC-Q/ Orbitrap/MS/MS. J. Chem. 1, 1–12. https://doi.org/10.1155/2018/6123850. Radha, M.H., Laxmipriya, N.P., 2015. Evaluation of biological properties and clinical effectiveness of aloe vera : a systematic review. J. Tradit Complement Med. 5, 21– 26. https://doi.org/10.1016/j.jtcme.2014.10.006. Rahoui, W., Merzouk, H., El Haci, I.A., Bettioui, R., Azzi, R., Benali, M., 2018. Beneficial effects of aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant sta- tus in obese rats. J. Funct. Foods 48, 525–532. https://doi.org/10.1016/j. jff.2018.07.050. Ramachandra, C.T., Srinivasa Rao, P., 2008. Processing of aloe vera leaf gel: a review. Am. J. Agric. Biol. Sci. 3, 502–510. https://doi.org/10.3844/ajabssp.2008.502.510. Reynolds, T., 1985. The compounds in alo€e leaf exudates: a review. Botanical J. Linnean Soc. 90, 157–177. https://doi.org/10.1111/j.1095-8339.1985.tb00377.x. Reynolds, T., 2004. Aloes: the Genus Aloe. Medicinal and aromatic plants-industrial profiles, 1st ed. Reynolds, T., Dweck, A.C., 1999. Aloe vera leaf gel: a review update. J. Ethnopharmacol. 68, 3–37. https://doi.org/10.1016/S0378-8741(99)00085-9. Martínez, R., Rodríguez Leyes, E.A., Menendez Castillo, R., Fernandez Romero, J.A., Del Barrio Alonso, G., Gonzalez Sanabia, T.M.L., 2002. Obtenci on y caracterizacion preliminar de un extracto de Aloe vera con actividad antiviral. Revista Cubana de Plantas Medicinales 7, 32–38. ARTICLE IN PRESSJID: SAJB [m5G;March 1, 2022;5:13] 13 W.J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al. South African Journal of Botany 00 (2022) 114 Rodríguez-Rodríguez, M.Z., Melendez-Pizarro, C.O., Espinoza-Hicks, J.C., Quintero-Ramos, A., Sanchez-Madrigal, M., Meza-Velazquez, J.A., Jimenez-Castro, J.A., 2019. Effects of UV-C irradiation and traditional thermal proc- essing on acemannan contained in Aloe vera gel blends. Carbohydr. Polym. 222, 114998. https://doi.org/10.1016/j.carbpol.2019.114998. Rodriguez, D.J.de, Angulo-Sanchez, J.L., Silva, J.A.T.da, Aguilar-Gonzalez, C.N., 2006. Review of aloe species ’ medicinal properties and bioactive compounds. Floric. Ornam. Plant Biotechnol IV, 460–471. Rodríguez, E.R., Martín, J.D., Romero, C.D., 2010. Aloe vera as a Functional Ingredient in Foods. Crit. Rev. Food Sci. Nutr. 50, 305–326. https://doi.org/10.1080/ 10408390802544454. Rodríguez Leyes, E.A., Rodríguez Chanfrau, J.E., Pardo Ruiz, Z., Pavon, V., 2000. Determi- nacion de polisacaridos totales en gel liquido de Aloe vera L para su empleo como materia prima en formulaciones de suplementos dieteticos. Revista Tecnologia. e Higiene de los Alimentos 313, 79–82. Roig, J.T., 1988. Plantas medicinales, Aromaticas o Venenosas De Cuba. Editorial Cientí- fico, La Habana, Cuba. 1ed. 548p. Saeed, Ahmada, I., Yaqub, U., Shazia, A., Amran, W., Saleem, M., 2004. Aloe vera: A plant of vital significance. Science Vision 9, 1–13. Sahu, P.K., Giri, D.D., Singh, R., Pandey, P., Gupta, S., Shrivastava, A.K., Kumar, A., Pandey, K.D., 2013. Therapeutic and medicinal uses of aloe vera : a review. Pharma- col. Pharmacy 2013, 599–610 http://dx.doi.org/10.4236/pp.2013.48086. Salama, H.E., Abdel Aziz, M.S., 2020. Optimized alginate and aloe vera gel edible coating reinforced with nTiO2 for the shelf-life extension of tomatoes. Int. J. Biol. Macro- mol. 165, 2693–2701. https://doi.org/10.1016/j.ijbiomac.2020.10.108. Sanchez-Machado, D.I., Lopez-cervantes, J., Send on, R., Sanches-, A., 2017. Aloe vera: ancient knowledge with new frontiers. Trends Food Sci. Technol. 64, 94–102. https://doi.org/10.1016/j.tifs.2016.12.005. Sanzana, S., Gras, M.L., Vidal-Brotons, D., 2011. Functional foods enriched in aloe vera. effects of vacuum impregnation and temperature on the respiration rate and the respiratory quotient of some vegetables. Procedia Food Sci. 1, 1528–1533. https:// doi.org/10.1016/j.profoo.2011.09.226. Scala, K.Di, Vega-Galvez, A., Ah-Hen, K., Nunez-Mancilla, Y., Tabilo-Munizaga, G., Perez-Won, M., Giovagnoli, C., 2013. Chemical and physical properties of Aloe vera (Aloe barbadensis Miller) gel stored after high hydrostatic pressure proc- essing. Food Sci. Technol. 33, 52–59. https://doi.org/10.1590/S0101- 20612013005000002. Serafini, M., Stanzione, A., Foddai, S., Anton, R., Delmulle, L., 2012. The european role on traditional herbal medicinal products and traditional plant food supplements. J. Clin. Gastroenterol. 46, S93–S94. https://doi.org/10.1097/mcg.0b013e318266b08f. Serrano, M., Valverde, J.M., Guill en, F., Castillo, S., Martínez-Romero, D., Valero, D., 2006. Use of aloe vera gel coating preserves the functional properties of table grapes. J. Agric. Food Chem. 54, 3882–3886. https://doi.org/10.1021/jf060168p. Shahrezaee, M., Soleimanian-Zad, S., Soltanizadeh, N., Akbari-Alavijeh, S., 2018. Use of Aloe vera gel powder to enhance the shelf life of chicken nugget during refrigera- tion storage. Lwt- Food Sci. Technol. 95, 380–386. https://doi.org/10.1016/j. lwt.2018.04.066. Shakib, Z., Shahraki, N., Razavi, B.M., Hosseinzadeh, H., 2019. Aloe vera as an herbal medicine in the treatment of metabolic syndrome: a review. Phytother. Res. 33, 2649–2660. https://doi.org/10.1002/ptr.6465. Sharma, P., Kharkwal, A., Kharkwal, H., Abdin, M., Varma, A., 2014. A review on phar- macological properties of Solanum tuberosum. Res. J. Pharmacy Technol. 10, 1517. https://doi.org/10.5958/0974-360X.2017.00267.0. Shelton, R.M., 1991. Aloe vera: its chemical and therapeutic properties. Int. J. Dermatol. 30, 679–683 10.1111/j.1365-4362.1991.tb02607.x Simal, S., Rossello, C., Femenia, A., S anchez, E., 1999. Compositional features of polysac- charides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr. Polym. 39, 109–117. https://doi.org/10.1016/S0144-8617(98)00163-5. Singh, S., Kaur, M.C. 2018. Nutraceutical composition for ready-to-drink juice com- prises guava juice and Aloe vera. IN patent 201721000471-A Steenkamp, E.J., 2015. A profile on the Aloe industry for export a focus on South Africa. https://www.nda.agric.za/doaDev/sideMenu/internationalTrade/docs/tradeFacili- tation/Aloe_%2024%20April%202015_high.pdf. Accessed 01 September 2020. Steenkamp, V., Stewart, M.J., 2008. Medicinal Applications and Toxicological Activities of Aloe. Products. Pharmaceut. Biol. 45, 411–420. https://doi.org/10.1080/ 13880200701215307. Technavio, 2015. Estudio del mercado global de bebidas de Aloe vera estimado para el periodo comprendido entre los anos 2016-2020. The Plant List. 2012. A working list of all plant species. http://www.theplantlist.org/1.1/ browse/A/Xanthorrhoeaceae/. Accessed 08 February 2022. Torres-Giner, S., Wilkanowicz, S., Melendez-Rodriguez, B., Lagaron, J.M., 2017. Nanoen- capsulation of Aloe vera in Synthetic and Naturally Occurring Polymers by Electro- hydrodynamic Processing of Interest in Food Technology and Bioactive Packaging. J. Agric. Food Chem. 65, 4439–4448. https://doi.org/10.1021/acs.jafc.7b01393. Vakhania, M., Alexidze, G.I., Aleksidze, N.G., 2014. Allocation of lectins in flowerorgans ofaloe plant (aloearistata) and their biochemical characteristics. Biochem. Biotech- nol. 12, 22–26. Vandenberghe, L.P.de S., Pandey, A., Carvalho, J.C.de, Letti, L.A.J., Woiciechowski, A.L., Karp, S.G., Thomaz-Soccol, V., Martínez-Burgos, W.J., Penha, R.de O., Herrmann, L.W., Rodrigues, A.O., Soccol, C.R., 2020. Solid-state fermentation tech- nology and innovation for the production of agricultural and animal feed bioprod- ucts. Syst. Microbiol. Biomanufact. 1, 142–165. https://doi.org/10.1007/s43393- 020-00015-7. Vega-Galvez, A., Uribe, E., Perez, M., Tabilo-Munizaga, G., Vergara, J., Garcia-Segovia, P., Lara, E., Di Scala, K., 2011. Effect of high hydrostatic pressure pretreatment on dry- ing kinetics, antioxidant activity, firmness and microstructure of Aloe vera (Aloe barbadensis Miller) gel. LWT- Food Science & Technology 44, 384–391. https://doi. org/10.1016/j.lwt.2010.08.004. A.N.L. Vega, G., Ampuero, C., Díaz, N., Lemus, M., 2005. El Aloe vera (Aloe Barbadensis Miller) Como Componente De Alimentos Funcionales. Revista chilena de nutricion 32. https://doi.org/10.4067/s0717-75182005000300005. Vinson, J.A., Al Kharrat, H., Andreoli, L., 2005. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine 12, 760–765. https:// doi.org/10.1016/j.phymed.2003.12.013. Weng, X.C., Gordon, M.H., 1992. Antioxidant Activity of Quinones Extracted from Tanshen (Salvia miltiorrhiza Bunge). J. Agric. Food Chem. 40, 1331–1336. https:// doi.org/10.1021/jf00020a007. WIPO, 2020a. Reasons for patenting your inventions. World Intellect. Prop. Organ.. https://www.wipo.int/sme/en/ip_business/importance/reasons.htm. Accessed 25 May 2020. WIPO, 2020b. The International Patent Classification. World Intellect. Prop. Organ.. https://www.wipo.int/classifications/ipc/en/. Accessed 02 May 2020. Yan, Z., 2014. Aloe beverage. CN patent 105614600A 2014. Yonghua, M., 2012. Xylitol-containing strawberry-aloe beverage and preparation method thereof. CN patent 103876210A. Yuanying, W., 2012. Aloe beverage. CN patent 103859539A 2012. Zapata, P.J., Navarro, D., Guillen, F., Castillo, S., Martínez-Romero, D., Valero, D., Serrano, M., 2013. Characterisation of gels from different Aloe spp. as antifungal treatment: potential crops for industrial applications. Ind. Crops Prod. 42, 223–230 10.1016/j.indcrop.2012.06.002 |
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Martínez Burgos, Walter JoseLima Serra, JosileneMarsiglia F, Ronald MMontoya, PedroSarmiento Vásquez, ZulmaMarina, OranysGallego Cartagena, EulerPaternina Arboledaf, Carlos D.2022-06-21T15:12:49Z2024-03-012022-06-21T15:12:49Z2022-03-01W .J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al., Aloe vera: From ancient knowledge to the patent and innovation landscape A review, South African Journal of Botany (2022), https://doi.org/10.1016/j.sajb.2022.02.0340254-6299https://hdl.handle.net/11323/9271https://doi.org/10.1016/j.sajb.2022.02.03410.1016/j.sajb.2022.02.034Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Aloe vera is one of the oldest and most traditional medicinal plant in history, with its use dating back over a thousand years. Today, its biological activity is not limited to curative purposes. The expansion in the A. vera industry became evident during the 90′s, when the development of this crop began to emerge due to a global demand from consumers more concerned with a healthy lifestyle. Considering the agro-industrial and economic relevance that this plant has acquired, this work reviewed its chemical, biological, and nutritional characteristics, plant processing methods, innovations, and industrial applications. Aloe vera is a plant that contain more than 75 bioactive compounds, among them the most relevant are polysaccharides, phenolics, and phytosterols. Additionally, the main processing technologies for A. vera leaves are described, including those used to obtain pressed filleted gel, whole leaf gel and manual filleted gel. This article shows its applications in the pharmaceutical, cosmetic and food industries are presented and the world landscape of the million-dollar market generated around this product, which in 2018 was around $1.60 billion. The applications of A. vera in the food industry as a natural functional ingredient or as fortifier in the food products of animal and vegetable origin has been a trend explored in the last years. Finally, through an in-depth analysis of patents and research articles, the current scenario of science and innovation developed for this industry is described.14 páginasapplication/pdfengElsevierNetherlandsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2022 SAAB. Published by Elsevier B.V. All rights reserved.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfAloe vera: from ancient knowledge to the patent and innovation landscape – a reviewArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85https://www.sciencedirect.com/science/article/pii/S0254629922000813South African Journal of BotanyAhlawat, K.S., Khatkar, B.S., 2011. Processing, food applications and safety of Aloe vera products: a review. Chem. Sci. Rev. Lett. 48, 525–533. https://doi.org/10.1007/ s13197-011-0229-z.Alvarado-Morales, G., Minjares-Fuentes, R., Contreras-Esquivel, J.C., Monta~nez, J., Meza-Vel azquez, J.A., Femenia, A., 2019. Application of thermosonication for Aloe vera (Aloe barbadensis Miller) juice processing: impact on the functional properties and the main bioactive polysaccharides. Ultrason. Sonochem. 56, 125–133. https:// doi.org/10.1016/j.ultsonch.2019.03.030.Anibarro-Ortega, M., Pinela, J., Barros, L., Ciric, A., Silva, S.P., Coelho, E., Mocan, A., Calhelha, R.C., Sokovic, M., Coimbra, M.A., Ferreira, I., 2019. Compositional features and bioactive properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower. Antioxidants 8, 1–21. https://doi.org/10.3390/antiox8100444.Antignac, E., Nohynek, G.J., Re, T., Clouzeau, J., Toutain, H., 2011. Safety of botanical ingredients in personal care products/cosmetics. Food Chem. Toxicol. 49, 324–341. https://doi.org/10.1016/j.fct.2010.11.022.Atherton, P., 1998. First Aid Plant. Chemistry in Britain, pp. 33–36. Baruah, A., Bordoloi, M., Deka Baruah, H.P., 2016. Aloe vera: a multipurpose industrial crop. Ind. Crops Prod. 94, 951–963. https://doi.org/10.1016/j.indcrop.2016.08.034.Basannavar, S., Pothuraju, R., Sharma, R.K., 2014. Effect of Aloe vera (Aloe barbadensis Miller) on survivability, extent of proteolysis and ACE inhibition of potential probi- otic cultures in fermented milk. J. Sci. Food Agric. 94, 2712–2717. https://doi.org/ 10.1002/jsfa.6615.Berardi, A., Perinelli, D.R., Merchant, H.A., Bisharat, L., Basheti, I.A., Bonacucina, G., Cespi, M., Palmieri, G.F., 2020. Hand sanitisers amid CoViD-19: a critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int. J. Pharm. 119431. https://doi.org/10.1016/j. ijpharm.2020.119431.Borges-arg aez, R., Chan-balan, R., Cetina-montejo, L., 2019. In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several deriva- tives against strains of in fl uenza virus. Ind. Crops Prod. 132, 468–475. https://doi. org/10.1016/j.indcrop.2019.02.056.Bozzi, A., Perrin, C., Austin, S., Arce Vera, F., 2007. Quality and authenticity of commer- cial Aloe vera gel powders. Food Chem. 103, 22–30. https://doi.org/10.1016/j.food- chem.2006.05.061.Brown D., 2006. Antioxidant compositions for the eye. US patent 20070207116A1Burger et al., 1994 A. Burger, M. Grubert, O. Schuster Aloe vera- The renascence of a tradicional natural drug as a dermopharmaceutical SOFW J, 120 (1994), pp. 527-529Canche-Escamilla, G., Colli-Acevedo, P., Borges-Argaez, R., Quintana-Owen, P., May-Crespo, J.F., C aceres-Farfan, M., Yam Puc, J.A., Sansores-Peraza, P., Vera-Ku, B.M., 2019. Extraction of phenolic components from an Aloe vera (Aloe barbadensis Miller) crop and their potential as antimicrobials and textile dyes. Sus- tain. Chem. Pharmacy 14, 100168. https://doi.org/10.1016/j.scp.2019.100168.Castillo, S., Navarro, D., Zapata, P.J., Guill en, F., Valero, D., Serrano, M., Martínez-Romero, D., 2010. Antifungal efficacy of Aloe vera in vitro and its use as a preharvest treatment to maintain postharvest table grape quality. Postharvest Biol. Technol. 57, 183–188. https://doi.org/10.1016/j.postharvbio.2010.04.006.Cavasana, A.L., Santos, C.H.M.dos, Dourado, D.M., Guimar~aes, F.dos S., Barros, F.H.R., de Campos, G.C.O., Leme, G.A.L., Silva, L.D.M.da, Wahl, L.M., Gutterres, N.B.de A., Matias, R., C^amara, S.J.F., Santos, S.E.de O., 2020. Effectiveness of the Aloe vera extract in the treatment of fistula-in-ano. J. Coloproctol. 40, 67–72. https://doi.org/ 10.1016/j.jcol.2019.09.003.CBI, 2020. The European market potential for Aloe vera. https://www.cbi.eu/market- information/natural-ingredients-health-products/aloe-vera/market-potential. Accessed 09 September 2020.Chandegara, V.K., Varshney, A.K., 2013. Aloe vera L. processing and products : a review. Int. J. Med. Aromatic Plants 3, 492–506.Choi, S.W., Son, B.W., Son, Y.S., Park, Y.I., Lee, S.K., Chung, M.H., 2001. The wound-heal- ing effect of a glycoprotein fraction isolated from aloe vera. J. Dermatol. 145, 535– 545. https://doi.org/10.1046/j.1365-2133.2001.04410.x.Coats, B., 1994. Method of processing stabilized aloe vera gel obtained from the whole aloe vera leaf. US patent 5356811 15.Costello, J., 1997. Cream formulation for topical application. US patent 5874094A 5874094.Da Silva Lima, S.C., Oliveira De Arruda, G., Dias Renovato, R., Martins Alvarenga, M.R., 2012. Representations and uses of medicinal plants in elderly men. Rev. Lat. Am. Enfermagem 20, 778–786.Dammak, I., Lasram, S., Hamdi, Z., Ben, O., Mkadmini, K., Trigui, I., Houissa, H., Mliki, A., Hassouna, M., 2018. In vitro antifungal and anti-ochratoxigenic activities of Aloe vera gel against Aspergillus carbonarius isolated from grapes. Ind. Crops Prod. 123, 416–423. https://doi.org/10.1016/j.indcrop.2018.07.023.Danish, P., Ali, Q., Hafeez, M., Malik, A., 2020. Antifungal and antibacterial activity of Aloe vera plant extract. Biol. Clin. Sci. Res. J. 4, 1–8.Denius, H.R., Homann, P.H., 1972. The relation between photosynthesis, respiration, and crassulacean acid metabolism in leaf slices of aloe arborescens mill. Plant Phys- iol. 49, 873–880. https://doi.org/10.1104/pp.49.6.873.Domíguez-Fernandez, R., Arzate-Vazquez, I., Chanona-Perez, J., Welti-Chanes, J., Alvarado-Gonzalez, J., Garibay-Febles, V., Gutierrez-Lopez, G., 2012. El gel de Aloe vera: estructura, composicion quimica,procesameinto,actividad biologica e impor- tancia en la industria farmaceutica y alimentaria. Revista Mexicana de Ingeniería Química 11, 23–43.Eigeles, D., Culcusica, M. 2019. Method and apparatus for producing tailored composi- tions of A. vera with probiotics and minerals products. Us patent 20200260769A1.El-Sayed, S.M., El-Sayed, H.S., 2020. Production of UF-soft cheese using probiotic bacte- ria and Aloe vera pulp as a good source of nutrients. Annals of Agricultural Sciences 65, 13–20. https://doi.org/10.1016/j.aoas.2020.05.002.Eshun, K., He, Q., 2004. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries - a review. Crit. Rev. Food Sci. Nutr. 44, 91–96. https://doi. org/10.1080/10408690490424694.Etusim, P.E., Okafor, E.E., Nwachukwu, N., Melariri, P., Ogbonnaya, C.I., 2013. A Study on Antibacterial activities of Aloe vera Leaves, Stems and Roots on some selected organisms. Indian Journals 6, 570–572.Flores-Lopez, M.L., Romaní, A., Cerqueira, M.A., Rodríguez-García, R., Jasso de Rodríguez, D., Vicente, A.A., 2016. Compositional features and bioactive properties of whole fraction from Aloe vera processing. Ind. Crops Prod. 91, 179– 185. https://doi.org/10.1016/j.indcrop.2016.07.011.Florez, D.H., 2014. Estudio de inteligencia competitiva para la cadena productiva de la sabila, Agrosabia. https://doi.org/10.13140/RG.2.1.3517.6087Fonseca, V.J.A., Braga, A.L., Filho, J.R., Teixeira, C.S., Hora, G.C.A., Morais-Braga, M.F.B., 2022. A review on the antimicrobial properties of lectins. Int. J. Biol. Macromol. 195, 163–178. https://doi.org/10.1016/j.ijbiomac.2021.11.209.Funemi, T., Uchida, K., 2003. Stabilizer for fermented milk food, fermented milk food and method for producing the food. JP patent 2004305071A 2003.Gao, Y., Kuok, K.I., Jin, Y., Wang, R., 2019. Biomedical applications of Aloe vera. Crit. Rev. Food Sci. Nutr. 59, 244–256. https://doi.org/10.1080/10408398.2018.1496320.Ghani, U., Naeem, M., Rafeeq, H., Imtiaz, U., Amjad, A., Ullah, S., Rehman, A., Qasim, F., 2019. A novel approach towards nutraceuticals and biomedical applications. Schol. Int. J. Biochem. 02, 245–252. https://doi.org/10.36348/sijb.2019.v02i10.001.Grace, O.M., 2011. Current perspectives on the economic botany of the genus Aloe L . (Xanthorrhoeaceae). S. Afr. J. Bot. 77, 980–987. https://doi.org/10.1016/j. sajb.2011.07.002.Guerrero-Beltran, J.A., Barbosa-C anovas, G.V., 2004. Review: advantages and limita- tions on processing foods by UV light. Food Sci. Technol. Int. 10, 137–147. https:// doi.org/10.1177/1082013204044359.Gupta, K., Jaiswal, P., Gupta, H., Anurag, R.K., Nain, L., Prasanna, R., 2020. Exploring the potential of Aloe vera as a carrier for developing a novel cyanobacterial formula- tion. S. Afr. J. Bot. 135, 437–443. https://doi.org/10.1016/j.sajb.2020.09.035.Hamman, J.H., 2008. Composition and applications of Aloe vera Leaf Gel. Molecules 13, 1599–1616. https://doi.org/10.3390/molecules13081599.Hamman, J.H., Viljoen, A., 2009. Use of Aloe vera for increasing the bioavailability of poorly absorbable drugs. World Intellect. Prop. Organ. Int. WO 2009/ 103093 Al. ARTICLE IN PRESSJID: SAJB [m5G;March 1, 2022;5:13] 12W.J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al. South African Journal of Botany 00 (2022) 114Hiyanes, S., 1997. Cosmetic e.g. shampoo - consists of sap of Aloe vera, moisturiser, alcohol, surfactant, antiseptic and spice at predefined weight ratio. JP patent 11005724-A 11005724.Huang, C.-T., Hung, C.-Y., Hseih, Y.-C., Chang, C.-S., Velu, A.B., He, Y.-C., Huang, Y.-L., Chen, T.-A., Chen, T.-C., Lin, C.-Y., Lin, Y.-C., Shih, S.-R., Dutta, A., 2019a. Phytomedi- cine Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine 64, 152904. https://doi.org/10.1016/j. phymed.2019.152904.Huang, Y.L., Oppong, M.B., Guo, Y., Wang, L.Z., Fang, S.M., Deng, Y.R., Gao, X.M., 2019b. The Oleaceae family: a source of secoiridoids with multiple biological activities. FitoterapiaFitoterapia 136, 104155. https://doi.org/10.1016/j.fitote.2019.04.010. Huangyi, X., 2013. External medicament for treating scalds and preparation method thereof. CN patent 103690728A 2013.Hussain, S.A., Patil, G.R., Reddi, S., Yadav, V., Pothuraju, R., Singh, R.R.B., Kapila, S., 2017. Aloe vera (Aloe barbadensis Miller) supplemented probiotic lassi prevents shigella infiltration from epithelial barrier into systemic blood flow in mice model. Microb. Pathog. 102, 143–147. https://doi.org/10.1016/j.micpath.2016.11.023.IARC, 2016. Some drugs and herbal products. IARC Monogr. Eval. Carcinog. Risks Hum. 108, 251–262.Iberica, H., 1981. A procedure for stabilizing clear gel from Aloe vera leaves. ES patent 8305214A3 8305214.Javed, S., Atta-Ur, R., 2014. Aloe vera gel in food, health products, and cosmetics indus- try. Studies in Natural Products Chemistry. Elsevier B.V., pp. 261–285. https://doi. org/10.1016/B978-0-444-63294-4.00009-7.Jianping, L., Meihua, W., Jun, L., 2014. Qiqing baidu drink and preparation method thereof. CN patent 103638268A.Jingcai, C., Jinzhi, W., 2003. Application method of aloe vera L. extract in preventing and curing diabetes. CN patent 1575803A 1575803.Jot, H., Kim, J., Lee, K., Ohs, T., Park, I., 2009. Pharmaceutical composition for use as health food for preventing or treating type II diabetes and diabetes related symp- toms or diseases e.g. hyperglycemia, comprises processed aloe vera gel and speci- fied amount of polysaccharide. KR patent 2009081860-A 2009.Khan, I., Ahmad, T., Zia, R., Murid, M., Abrar, M., 2018. The therapeutic properties and applications of Aloe vera: a review. J. Herb. Med. 12, 1–10. https://doi.org/10.1016/ j.hermed.2018.01.002.Khatri, D., Panigrahi, J., Prajapati, A., Bariya, H., 2020. Attributes of Aloe vera gel and chi- tosan treatments on the quality and biochemical traits of post-harvest tomatoes. Sci. Hortic. 259, 108837. https://doi.org/10.1016/j.scienta.2019.108837.Kluge, M., Knapp, I., Kramer, D., Schwerdtner, I., Ritter, H., 1979. Crassulacean acid metabolism (CAM) in leaves of Aloe arborescens mill. plant. 145, 357–363. https:// doi.org/10.1007/bf00388361.Liu, H., Liu, S., Du, B., Dong, K., Wang, Y., Zhang, Y., 2021. Aloe vera gel coating aggra- vates superficial scald incidence in ‘Starking’ apples during low-temperature stor- age. Food Chem. 339, 128151. https://doi.org/10.1016/j.foodchem.2020.128151.Lopez-Cervantes, J., Sanchez-Machado, D.I., Cruz-Flores, P., Mariscal-Domínguez, M.F., Servín de la Mora-Lopez, G., Campas-Baypoli, O.N., 2018. Antioxidant capacity, proximate composition, and lipid constituents of aloe vera flowers. J. Appl. Res. Medicinal Aromatic Plants 10, 93–98. https://doi.org/10.1016/j. jarmap.2018.02.004.Maan, A.A., Nazir, A., Khan, M.K.I., Ahmad, T., Zia, R., Murid, M., Abrar, M., 2018. The therapeutic properties and applications of aloe vera: a review. J. Herbal Medicine12 1–10. https://doi.org/10.1016/j.hermed.2018.01.002.Majumder, R., Das, C.K., Mandal, M., 2019. Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacol. Res. 148, 104416.Manvitha, K., Bidya, B., 2014. Aloe vera: a wonder plant its history, cultivation and medicinal uses. J. Pharmacogn Phytochem. 2, 85–88.Maret, R., 1972. Process for preparing extracts of Aloe vera. US patent 3878197-A 3878197.Martínez-S anchez, A., Lopez-Ca~navate, M.E., Guirao-Martínez, J., Roca, M.J., Aguayo, E., 2020. Aloe vera flowers, a byproduct with great potential and wide application, depending on maturity Stage. Foods 9, 1–21.Martínez, M.J., Betancourt Badell, J., Alonso Gonzalez, N., 1996. Ausencia de actividad antimicrobiana de un extracto acuoso liofilizado de Aloe vera (sabila). Revista Cubana de Plantas Medicinales 1, 18–20.Martínez, W.J., Paternina-Arboleda, C.D., Paroddy, A., Velez Ramírez, M., Tapia, L.P., Espitia, R., 2017. Optimizacion del proceso de eliminacion de aloína del gel file- teado mecanico de Aloe vera concentrado 10X. Revista Cumbres 3, 9–16.Maughan, R., 1982. Controlled temperature process for manufacturing of improved sta- bilized aloe vera. US ptaent 4446131A 4446131.McAnalley, B.H.., Prairie, G., 1988. Process for preparation of Aloe products, produced thereby and components thereo. US Patent 4735935.Medina-Torres, L., Nunez-Ramírez, D.M., Calderas, F., Gonzalez-Laredo, R.F., Minjares-Fuentes, R., Valadez-García, M.A., Bernad-Bernad, M.J., Manero, O., 2019.Microencapsulation of gallic acid by spray drying with Aloe vera mucilage (Aloe barbadensis miller) as wall material. Ind. Crops Prod. 138, 111461. https://doi.org/ 10.1016/j.indcrop.2019.06.024.Meijuan, Y., 2014. Gingko tea. CN patent 103749850-A .Mendy, T.K., Misran, A., Mahmud, T.M.M., Ismail, S.I., 2019. Antifungal properties of aloe vera through in vitro and in vivo screening against postharvest pathogens of papaya fruit. Sci. Hortic. 257, 108767. https://doi.org/10.1016/j.scienta.2019.108767.Minamide, A., 1999. Stone named syotoku stone produced in japan-containing cos- metic composition. JP patent 2001031557A 1999.MINFAR, 1990 MINFAR, I.S. de M.M. "Dr. L.D.S., 1990. Compendio De Investigaciones Sobre El Aloe barbadensis Miller (sábila) Cultivado En Cuba. La Habana, Cuba. http://scielo.sld.cu/scieloOrg/php/reflinks.php?refpid=S0864-0319200600030000400006&lng=pt&pid=S0864-03192006000300004. Accessed 05 September 2021.Mingwei, Y., 2005a. Production process of food level aloe gel 200:1 frozen dry powder. CN patent 1672569A 1672569.Mingwei, Y., 2005b. Production process of spray dried food level Aloe gel 200:1 spray- ing dry powder. CN patent 1672570A 1672570.MSANVS -Ministerio da Saude e Agencia Nacional de Vigilancia Sanitaria, 2007. Regla- mento tecnico sobre aditivos aromatizantes, Diario Oficial da Uniao, de 17 de janeiro de 2007. https://doi.org/10.1017/CBO9781107415324.004Mpiana, P.T., Ngbolua, K.te N., Tshibangu, D.S.T., Kilembe, J.T., Gbolo, B.Z., Mwanangombo, D.T., Inkoto, C.L., Lengbiye, E.M., Mbadiko, C.M., Matondo, A., Bongo, G.N., Tshilanda, D.D., 2020. Identification of potential inhibitors of SARS- CoV-2 main protease from aloe vera compounds: a molecular docking study. Chem. Phys. Lett. 754, 137751. https://doi.org/10.1016/j.cplett.2020.137751.Mudgil, D., Barak, S., Darji, P., 2016. Development and characterization of functional cultured buttermilk utilizing aloe vera juice. Food Biosci. 15, 105–109. https://doi. org/10.1016/j.fbio.2016.06.001.Mukherjee, P.K., Nema, N.K., Maity, N., Mukherjee, K., Harwansh, R.K., 2014. Phyto- chemical and therapeutic profile of aloe vera. J. Natur. Remed. 14, 1–26. https://doi. org/10.18311/jnr/2014/84.Murugesan, M.P., Venkata Ratnam, M., Mengitsu, Y., Kandasamy, K., 2020. Evaluation of anti-cancer activity of phytosomes formulated from Aloe vera extract. Mater. Today: Proceedings J. 42, 631–636. https://doi.org/10.1016/j.matpr.2020.11.047.Nagaraj, G., Brundha, D., Kowsalya, V., Chandraleka, C., Sangavi, S., Jayalakshmi, R., Arulpriya, M., Sathya, N., Prasath, M., Tamilarasu, S., 2020. Biosynthesis of zinc doped aloe vera for green nanoparticles. Mater. Today: Proc. 43, 3354–3358. https://doi.org/10.1016/j.matpr.2020.05.318.Nicolau-Lapena, I., Aguilo-Aguayo, I., Kramer, B., Abadias, M., Vinas, I., Muranyi, P., 2021. Combination of ferulic acid with aloe vera gel or alginate coatings for shelf- life prolongation of fresh-cut apples. Food packaging and shelf life 27, 100620. https://doi.org/10.1016/j.fpsl.2020.100620Ortega-Toro, R., Collazo-Bligliardi;, S., Rosello;, J., Santamarina;, P., Amparo, C., 2017. Antifungal starch-based edible films containing aloe vera. Food Hydrocoll. 72, 1–10 . https://doi.org/10.1016/j.foodhyd.2017.05.023.Ortiz, R., Fernandez, V., 2000. Therapeutic after-shave care lotion. US patent 6352691B1 6352691.Ozturk, B., Karakaya, O., Kenan, Y., Saracoglu, O., 2019. Effects of aloe vera gel and MAP on bioactive compounds and quality attributes of cherry laurel fruit during cold storage. Sci. Hortic. 249, 31–37. https://doi.org/10.1016/j.scienta.2019.01.030.Ozturk, G., Young, G.M., 2017. Food evolution: the impact of society and science on the fermentation of cocoa beans. Comprehen. Rev. Food Sci. Food Safety 16, 431–455. https://doi.org/10.1111/1541-4337.12264.Pandey, A., Singh, S., 2016. Aloe vera : a systematic review of its industrial and ethno- medicinal efficacy. Int. J. Pharmaceut. Res. Allied Sci. 5, 21–33.Pasco, D., Pugh, N., Ross, S., Elsohly, M., 2001. High molecular weight polysaccharide fraction from Aloe vera with immunostimulatory activity. International application published under the patent cooperation treaty (PCT) WO2002003999A1 2001.Pothuraju, R., Sharma, R.K., Chagalamarri, J., Kavadi, P.K., Jangra, S., 2015. Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6 J mice. Food Function J. 6, 3576–3584. https://doi.org/10.1039/ c5fo00781j.Pothuraju, R., Sharma, R.K., Kavadi, P.K., Chagalamarri, J., Jangra, S., Bhakri, G., De, S., 2016a. Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6 J mice. Benef Microbes 7, 375–385. https://doi.org/10.3920/BM2015.0083.Pothuraju, R., Sharma, R.K., Onteru, S.K., Singh, S., Hussain, S.A., 2016b. Hypoglycemic and hypolipidemic effects of aloe vera extract preparations: a review. Phytother. Res. 30, 200–207. https://doi.org/10.1002/ptr.5532.Pyo, J., Pjeong, J., Jin, W., Hyon, S., Khan, J. 2015. Antioxidant composition useful as health food, for preventing and improving liver diseases including hepatitis and liver cirrhosis, comprises Aloe vera extract extracted from 4 to 6 months old A. vera. KR patent 2014147949-AQuispe, C., Villalobos, M., Borquez, J., Simirgiotis, M., 2018. Chemical composition and antioxidant activity of aloe vera from the pica oasis (Tarapaca, Chile) by UHPLC-Q/ Orbitrap/MS/MS. J. Chem. 1, 1–12. https://doi.org/10.1155/2018/6123850.Radha, M.H., Laxmipriya, N.P., 2015. Evaluation of biological properties and clinical effectiveness of aloe vera : a systematic review. J. Tradit Complement Med. 5, 21– 26. https://doi.org/10.1016/j.jtcme.2014.10.006.Rahoui, W., Merzouk, H., El Haci, I.A., Bettioui, R., Azzi, R., Benali, M., 2018. Beneficial effects of aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant sta- tus in obese rats. J. Funct. Foods 48, 525–532. https://doi.org/10.1016/j. jff.2018.07.050.Ramachandra, C.T., Srinivasa Rao, P., 2008. Processing of aloe vera leaf gel: a review. Am. J. Agric. Biol. Sci. 3, 502–510. https://doi.org/10.3844/ajabssp.2008.502.510.Reynolds, T., 1985. The compounds in alo€e leaf exudates: a review. Botanical J. Linnean Soc. 90, 157–177. https://doi.org/10.1111/j.1095-8339.1985.tb00377.x.Reynolds, T., 2004. Aloes: the Genus Aloe. Medicinal and aromatic plants-industrial profiles, 1st ed.Reynolds, T., Dweck, A.C., 1999. Aloe vera leaf gel: a review update. J. Ethnopharmacol. 68, 3–37. https://doi.org/10.1016/S0378-8741(99)00085-9.Martínez, R., Rodríguez Leyes, E.A., Menendez Castillo, R., Fernandez Romero, J.A., Del Barrio Alonso, G., Gonzalez Sanabia, T.M.L., 2002. Obtenci on y caracterizacion preliminar de un extracto de Aloe vera con actividad antiviral. Revista Cubana de Plantas Medicinales 7, 32–38. ARTICLE IN PRESSJID: SAJB [m5G;March 1, 2022;5:13] 13 W.J. Martínez-Burgos, J.L. Serra, R.M. MarsigliaF et al. South African Journal of Botany 00 (2022) 114Rodríguez-Rodríguez, M.Z., Melendez-Pizarro, C.O., Espinoza-Hicks, J.C., Quintero-Ramos, A., Sanchez-Madrigal, M., Meza-Velazquez, J.A., Jimenez-Castro, J.A., 2019. Effects of UV-C irradiation and traditional thermal proc- essing on acemannan contained in Aloe vera gel blends. Carbohydr. Polym. 222, 114998. https://doi.org/10.1016/j.carbpol.2019.114998.Rodriguez, D.J.de, Angulo-Sanchez, J.L., Silva, J.A.T.da, Aguilar-Gonzalez, C.N., 2006. Review of aloe species ’ medicinal properties and bioactive compounds. Floric. Ornam. Plant Biotechnol IV, 460–471.Rodríguez, E.R., Martín, J.D., Romero, C.D., 2010. Aloe vera as a Functional Ingredient in Foods. Crit. Rev. Food Sci. Nutr. 50, 305–326. https://doi.org/10.1080/ 10408390802544454.Rodríguez Leyes, E.A., Rodríguez Chanfrau, J.E., Pardo Ruiz, Z., Pavon, V., 2000. Determi- nacion de polisacaridos totales en gel liquido de Aloe vera L para su empleo como materia prima en formulaciones de suplementos dieteticos. Revista Tecnologia. e Higiene de los Alimentos 313, 79–82.Roig, J.T., 1988. Plantas medicinales, Aromaticas o Venenosas De Cuba. Editorial Cientí- fico, La Habana, Cuba. 1ed. 548p.Saeed, Ahmada, I., Yaqub, U., Shazia, A., Amran, W., Saleem, M., 2004. Aloe vera: A plant of vital significance. Science Vision 9, 1–13.Sahu, P.K., Giri, D.D., Singh, R., Pandey, P., Gupta, S., Shrivastava, A.K., Kumar, A., Pandey, K.D., 2013. Therapeutic and medicinal uses of aloe vera : a review. Pharma- col. Pharmacy 2013, 599–610 http://dx.doi.org/10.4236/pp.2013.48086.Salama, H.E., Abdel Aziz, M.S., 2020. Optimized alginate and aloe vera gel edible coating reinforced with nTiO2 for the shelf-life extension of tomatoes. Int. J. Biol. Macro- mol. 165, 2693–2701. https://doi.org/10.1016/j.ijbiomac.2020.10.108.Sanchez-Machado, D.I., Lopez-cervantes, J., Send on, R., Sanches-, A., 2017. Aloe vera: ancient knowledge with new frontiers. Trends Food Sci. Technol. 64, 94–102. https://doi.org/10.1016/j.tifs.2016.12.005.Sanzana, S., Gras, M.L., Vidal-Brotons, D., 2011. Functional foods enriched in aloe vera. effects of vacuum impregnation and temperature on the respiration rate and the respiratory quotient of some vegetables. Procedia Food Sci. 1, 1528–1533. https:// doi.org/10.1016/j.profoo.2011.09.226.Scala, K.Di, Vega-Galvez, A., Ah-Hen, K., Nunez-Mancilla, Y., Tabilo-Munizaga, G., Perez-Won, M., Giovagnoli, C., 2013. Chemical and physical properties of Aloe vera (Aloe barbadensis Miller) gel stored after high hydrostatic pressure proc- essing. Food Sci. Technol. 33, 52–59. https://doi.org/10.1590/S0101- 20612013005000002.Serafini, M., Stanzione, A., Foddai, S., Anton, R., Delmulle, L., 2012. The european role on traditional herbal medicinal products and traditional plant food supplements. J. Clin. Gastroenterol. 46, S93–S94. https://doi.org/10.1097/mcg.0b013e318266b08f.Serrano, M., Valverde, J.M., Guill en, F., Castillo, S., Martínez-Romero, D., Valero, D., 2006. Use of aloe vera gel coating preserves the functional properties of table grapes. J. Agric. Food Chem. 54, 3882–3886. https://doi.org/10.1021/jf060168p.Shahrezaee, M., Soleimanian-Zad, S., Soltanizadeh, N., Akbari-Alavijeh, S., 2018. Use of Aloe vera gel powder to enhance the shelf life of chicken nugget during refrigera- tion storage. Lwt- Food Sci. Technol. 95, 380–386. https://doi.org/10.1016/j. lwt.2018.04.066.Shakib, Z., Shahraki, N., Razavi, B.M., Hosseinzadeh, H., 2019. Aloe vera as an herbal medicine in the treatment of metabolic syndrome: a review. Phytother. Res. 33, 2649–2660. https://doi.org/10.1002/ptr.6465.Sharma, P., Kharkwal, A., Kharkwal, H., Abdin, M., Varma, A., 2014. A review on phar- macological properties of Solanum tuberosum. Res. J. Pharmacy Technol. 10, 1517. https://doi.org/10.5958/0974-360X.2017.00267.0.Shelton, R.M., 1991. Aloe vera: its chemical and therapeutic properties. Int. J. Dermatol. 30, 679–683 10.1111/j.1365-4362.1991.tb02607.xSimal, S., Rossello, C., Femenia, A., S anchez, E., 1999. Compositional features of polysac- charides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr. Polym. 39, 109–117. https://doi.org/10.1016/S0144-8617(98)00163-5.Singh, S., Kaur, M.C. 2018. Nutraceutical composition for ready-to-drink juice com- prises guava juice and Aloe vera. IN patent 201721000471-ASteenkamp, E.J., 2015. A profile on the Aloe industry for export a focus on South Africa. https://www.nda.agric.za/doaDev/sideMenu/internationalTrade/docs/tradeFacili- tation/Aloe_%2024%20April%202015_high.pdf. Accessed 01 September 2020. Steenkamp, V., Stewart, M.J., 2008. Medicinal Applications and Toxicological Activities of Aloe. Products. Pharmaceut. Biol. 45, 411–420. https://doi.org/10.1080/ 13880200701215307.Technavio, 2015. Estudio del mercado global de bebidas de Aloe vera estimado para el periodo comprendido entre los anos 2016-2020.The Plant List. 2012. A working list of all plant species. http://www.theplantlist.org/1.1/ browse/A/Xanthorrhoeaceae/. Accessed 08 February 2022.Torres-Giner, S., Wilkanowicz, S., Melendez-Rodriguez, B., Lagaron, J.M., 2017. Nanoen- capsulation of Aloe vera in Synthetic and Naturally Occurring Polymers by Electro- hydrodynamic Processing of Interest in Food Technology and Bioactive Packaging. J. Agric. Food Chem. 65, 4439–4448. https://doi.org/10.1021/acs.jafc.7b01393.Vakhania, M., Alexidze, G.I., Aleksidze, N.G., 2014. Allocation of lectins in flowerorgans ofaloe plant (aloearistata) and their biochemical characteristics. Biochem. Biotech- nol. 12, 22–26.Vandenberghe, L.P.de S., Pandey, A., Carvalho, J.C.de, Letti, L.A.J., Woiciechowski, A.L., Karp, S.G., Thomaz-Soccol, V., Martínez-Burgos, W.J., Penha, R.de O., Herrmann, L.W., Rodrigues, A.O., Soccol, C.R., 2020. Solid-state fermentation tech- nology and innovation for the production of agricultural and animal feed bioprod- ucts. Syst. Microbiol. Biomanufact. 1, 142–165. https://doi.org/10.1007/s43393- 020-00015-7.Vega-Galvez, A., Uribe, E., Perez, M., Tabilo-Munizaga, G., Vergara, J., Garcia-Segovia, P., Lara, E., Di Scala, K., 2011. Effect of high hydrostatic pressure pretreatment on dry- ing kinetics, antioxidant activity, firmness and microstructure of Aloe vera (Aloe barbadensis Miller) gel. LWT- Food Science & Technology 44, 384–391. https://doi. org/10.1016/j.lwt.2010.08.004.A.N.L. Vega, G., Ampuero, C., Díaz, N., Lemus, M., 2005. El Aloe vera (Aloe Barbadensis Miller) Como Componente De Alimentos Funcionales. Revista chilena de nutricion 32. https://doi.org/10.4067/s0717-75182005000300005.Vinson, J.A., Al Kharrat, H., Andreoli, L., 2005. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine 12, 760–765. https:// doi.org/10.1016/j.phymed.2003.12.013.Weng, X.C., Gordon, M.H., 1992. Antioxidant Activity of Quinones Extracted from Tanshen (Salvia miltiorrhiza Bunge). J. Agric. Food Chem. 40, 1331–1336. https:// doi.org/10.1021/jf00020a007.WIPO, 2020a. Reasons for patenting your inventions. World Intellect. Prop. Organ.. https://www.wipo.int/sme/en/ip_business/importance/reasons.htm. Accessed 25 May 2020.WIPO, 2020b. The International Patent Classification. World Intellect. Prop. Organ.. https://www.wipo.int/classifications/ipc/en/. Accessed 02 May 2020.Yan, Z., 2014. Aloe beverage. CN patent 105614600A 2014.Yonghua, M., 2012. Xylitol-containing strawberry-aloe beverage and preparation method thereof. CN patent 103876210A.Yuanying, W., 2012. Aloe beverage. CN patent 103859539A 2012.Zapata, P.J., Navarro, D., Guillen, F., Castillo, S., Martínez-Romero, D., Valero, D., Serrano, M., 2013. Characterisation of gels from different Aloe spp. as antifungal treatment: potential crops for industrial applications. Ind. 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