Clinical features and real-world pharmacological treatment of severe atopic dermatitis in Colombia: data from an ongoing national registry of patients (RENDAC)

Introduction: The development of an atopic dermatitis (AD) national registry offers a representative view of disease status and its medical management. We sought to characterize clinical features, severity rates and real-world pharmacological treatment in Colombia. Methods: An ongoing National Registry of Patients with AD in Colombia was created in July-2021. Data from 906 medical records were extracted based on a structured form. Cases were diagnosed by a dermatologist in the outpatient service. Descriptive statistics are reported. Results: Mean age was 22.3 SD±15.6 years-old, half of patients were children (55.3%). Most patients were phototype III (64.5%) and IV (25.7%). SCORAD was reported in 37.4% of records; 39.5% (CI95%:34.2-44.9), 44.3% (38.8-49.7) and 16.2% (12.2–20.3) of cases were classified as mild, moderate, and severe, respectively. SCORAD correlated with age (rho=0.24, p<0.0001) and was similar between sexes. The severe group was in average older (28.1 years SD±23.28) than other groups (mild: 15.2 SD ±15.3, moderate: 18.52 SD ±15.1)) and had significantly higher total IgE levels and eosinophil counts. Most patients received emollients (89%) and topical corticosteroids (57%) for treatment. In the severe group, 40% received systemic immunosuppressants (24%), being methotrexate the most common (22%), 22% received calcineurin-inhibitors and 33% high potency topical corticosteroids. Dupilumab was the only prescribed biologic (15% among severe cases). Conclusions: Frequency and stronger type-2 responses observed in severe AD coincides with expected rates and patterns reported in the literature. Prescription of recommended pharmacological measures for severe DA was lower than expected. Barrier access to medication must be investigated.

• Autores: Castillo Molina, David; Zakzuk Sierra, Josefina; Moyano Tamara, Lina; Alvis Zakzuk, Nelson Rafael; Fierro Lozada, Jesus Daniel; Alvis Guzman, Nelson; Alvis Zakzuk, Nelson Rafael; Alvis Zakzuk, Nelson J.
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Corporación Universidad de la Costa
• Repositorio: REDICUC - Repositorio CUC
• Idioma: eng
• OAI Identifier: oai:repositorio.cuc.edu.co:11323/13707
• Acceso en línea: https://hdl.handle.net/11323/13707; https://repositorio.cuc.edu.co/
• Palabra clave: Atopic dermatitis; Disease; Pharmacological treatment
• Rights: openAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)