Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring
Fish consumption and ubiquitous methylmercury (MeHg) exposure represent a public health problem globally. Micronutrients presented in fish affects MeHg uptake/distribution. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, ther...
- Autores:
-
Espitia Pérez, Pedro
Albino Marin, Suelen
Espitia Pérez, Lyda
Brango, Hugo
Da Rosa, Helen Tais
Kleber Silveira, Alexandre
Cerveira, Camila
Moraes Pompéu, Diogo
Mingori Rodrigues, Moara
Tiefensee Ribeiro, Camila
Gelain, D. P
Schnorr, Carlos Eduardo
Fonseca Moreira, José Claudio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/933
- Acceso en línea:
- http://hdl.handle.net/11323/933
https://repositorio.cuc.edu.co/
- Palabra clave:
- Behavior
Co-Exposure
Methylmercury
Oxidative stress
Pregnancy
Retinyl palmitate
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
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|
dc.title.eng.fl_str_mv |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
title |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
spellingShingle |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring Behavior Co-Exposure Methylmercury Oxidative stress Pregnancy Retinyl palmitate |
title_short |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
title_full |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
title_fullStr |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
title_full_unstemmed |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
title_sort |
Neurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their Offspring |
dc.creator.fl_str_mv |
Espitia Pérez, Pedro Albino Marin, Suelen Espitia Pérez, Lyda Brango, Hugo Da Rosa, Helen Tais Kleber Silveira, Alexandre Cerveira, Camila Moraes Pompéu, Diogo Mingori Rodrigues, Moara Tiefensee Ribeiro, Camila Gelain, D. P Schnorr, Carlos Eduardo Fonseca Moreira, José Claudio |
dc.contributor.author.spa.fl_str_mv |
Espitia Pérez, Pedro Albino Marin, Suelen Espitia Pérez, Lyda Brango, Hugo Da Rosa, Helen Tais Kleber Silveira, Alexandre Cerveira, Camila Moraes Pompéu, Diogo Mingori Rodrigues, Moara Tiefensee Ribeiro, Camila Gelain, D. P Schnorr, Carlos Eduardo Fonseca Moreira, José Claudio |
dc.subject.eng.fl_str_mv |
Behavior Co-Exposure Methylmercury Oxidative stress Pregnancy Retinyl palmitate |
topic |
Behavior Co-Exposure Methylmercury Oxidative stress Pregnancy Retinyl palmitate |
description |
Fish consumption and ubiquitous methylmercury (MeHg) exposure represent a public health problem globally. Micronutrients presented in fish affects MeHg uptake/distribution. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. The present study aimed to examine the effects of both MeHg and retinyl palmitate administered to pregnant and lactating rats. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/Kg/day) and retinyl palmitate (7500 μg RAE1/Kg/day), either individually or in combination from the gestational day 0 to weaning. In dams, maternal behavior was scored. In neonatal and infant offspring, associative learning and neurodevelopment were evaluated. Further periadolescent male and female pups were assessed for open field, habituation and object recognition using episodic-like memory paradigm. Maternal and offspring redox parameters were evaluated. Our results showed no effects of MeHg-VitA co-administration in the quality of maternal care but showed subtle alterations in the pro-oxidant response of the hippocampus. In offspring, MeHg-VitA co-exposure affected early associative learning in neonatal pups, with no further modifications in neurodevelopment, and no locomotor or exploratory alterations in later developmental stages. Habituation was altered in a sex-dependent manner, but no overall memory disturbances were encountered. |
publishDate |
2018 |
dc.date.accessioned.none.fl_str_mv |
2018-11-14T01:11:14Z |
dc.date.available.none.fl_str_mv |
2018-11-14T01:11:14Z |
dc.date.issued.none.fl_str_mv |
2018-10-05 |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
acceptedVersion |
dc.identifier.issn.spa.fl_str_mv |
0161813X |
dc.identifier.uri.spa.fl_str_mv |
http://hdl.handle.net/11323/933 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
0161813X Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
http://hdl.handle.net/11323/933 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
Atribución – No comercial – Compartir igual |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.publisher.spa.fl_str_mv |
DOI: 10.1016/j.neuro.2018.10.004 |
institution |
Corporación Universidad de la Costa |
bitstream.url.fl_str_mv |
https://repositorio.cuc.edu.co/bitstream/11323/933/1/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf https://repositorio.cuc.edu.co/bitstream/11323/933/2/license.txt https://repositorio.cuc.edu.co/bitstream/11323/933/4/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf.jpg https://repositorio.cuc.edu.co/bitstream/11323/933/5/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf.txt |
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bitstream.checksumAlgorithm.fl_str_mv |
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repository.name.fl_str_mv |
Repositorio Universidad de La Costa |
repository.mail.fl_str_mv |
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spelling |
Espitia Pérez, Pedro7493f862c003a73504e42525a648f4f9Albino Marin, Suelen69084095956beab948675d33fd5f5df5Espitia Pérez, Lyda50db36b3a0cc5aebf6056539b85bb0f8Brango, Hugode1c3e1df5cd8f3d1a7689684e8bfb90Da Rosa, Helen Tais7646787f57738099ed1b4c3fa1791429Kleber Silveira, Alexandre325b33bca50d917efdf1682dde3d8bcbCerveira, Camilac776c40dd44b53201b4272116cc25e51Moraes Pompéu, Diogo01861f14153cd51512623f6cde0a08edMingori Rodrigues, Moaraa1d63c1b45d228d872783e89ae71ff17Tiefensee Ribeiro, Camila016855c6419ebc105d90f7524deef2fdGelain, D. P8ae9542232d7d15a434484a1a9181d84Schnorr, Carlos Eduardo2b8ae605be739d729c766b18710a9e6dFonseca Moreira, José Claudio4f65fe77cca1f4474e18825a9c2130ea2018-11-14T01:11:14Z2018-11-14T01:11:14Z2018-10-050161813Xhttp://hdl.handle.net/11323/933Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Fish consumption and ubiquitous methylmercury (MeHg) exposure represent a public health problem globally. Micronutrients presented in fish affects MeHg uptake/distribution. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. The present study aimed to examine the effects of both MeHg and retinyl palmitate administered to pregnant and lactating rats. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/Kg/day) and retinyl palmitate (7500 μg RAE1/Kg/day), either individually or in combination from the gestational day 0 to weaning. In dams, maternal behavior was scored. In neonatal and infant offspring, associative learning and neurodevelopment were evaluated. Further periadolescent male and female pups were assessed for open field, habituation and object recognition using episodic-like memory paradigm. Maternal and offspring redox parameters were evaluated. Our results showed no effects of MeHg-VitA co-administration in the quality of maternal care but showed subtle alterations in the pro-oxidant response of the hippocampus. In offspring, MeHg-VitA co-exposure affected early associative learning in neonatal pups, with no further modifications in neurodevelopment, and no locomotor or exploratory alterations in later developmental stages. Habituation was altered in a sex-dependent manner, but no overall memory disturbances were encountered.engDOI: 10.1016/j.neuro.2018.10.004Atribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2BehaviorCo-ExposureMethylmercuryOxidative stressPregnancyRetinyl palmitateNeurobehavioral And Oxidative Stress Alterations Following Methylmercury And Retinyl Palmitate Co-Administration In Pregnant And Lactating Rats And Their OffspringArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionORIGINALNeurobehavioral And Oxidative Stress Alterations.pdfNeurobehavioral And Oxidative Stress Alterations.pdfapplication/pdf284240https://repositorio.cuc.edu.co/bitstream/11323/933/1/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf1461ef01c3fff5cd369fa84a66e4d527MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.cuc.edu.co/bitstream/11323/933/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open accessTHUMBNAILNeurobehavioral And Oxidative Stress Alterations.pdf.jpgNeurobehavioral And Oxidative Stress Alterations.pdf.jpgimage/jpeg62625https://repositorio.cuc.edu.co/bitstream/11323/933/4/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf.jpg1a2bfbdd9b2c06be1e62a59593532f75MD54open accessTEXTNeurobehavioral And Oxidative Stress Alterations.pdf.txtNeurobehavioral And Oxidative Stress Alterations.pdf.txttext/plain2837https://repositorio.cuc.edu.co/bitstream/11323/933/5/Neurobehavioral%20And%20Oxidative%20Stress%20Alterations.pdf.txtff86aec070e599d3ae822a06bc4dd8f9MD55open access11323/933oai:repositorio.cuc.edu.co:11323/9332023-12-14 12:16:51.669open accessRepositorio Universidad de La Costabdigital@metabiblioteca.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 |