Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology

The COVID-19 pandemic has affected the continuity of cognitive rehabilitation worldwide. However, the use of teleneuropsychology to provide cognitive rehabilitation has contributed significantly to the continuity of the treatment. Objectives: To measure the effects of cognitive telerehabilitation on...

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Autores:
Carlos Martínez Canyazo
Martinez Canyazo, Carlos Alberto
Keller, Greta
Helou, Maria Belen
Arruabarrena, Micaela
Corvalán, Nicolás
Carello, María Agostina
Harris, Paula
Feldman, Mónica Laura
Fernández, Rodrigo S
Calandri, Ismael Luis
Martín, María Eugenia
Allegri, Ricardo Francisco
Crivelli, Lucía
Tipo de recurso:
Article of investigation
Fecha de publicación:
2023
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/13618
Acceso en línea:
https://hdl.handle.net/11323/13618
https://repositorio.cuc.edu.co/
Palabra clave:
Neuropsychology
COVID-19
Cognitive dysfunction
Memory
Neuropsicologia
Disfunção cognitiva
Memória
Rights
openAccess
License
Atribución 4.0 Internacional (CC BY 4.0)
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oai_identifier_str oai:repositorio.cuc.edu.co:11323/13618
network_acronym_str RCUC2
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repository_id_str
dc.title.none.fl_str_mv Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
dc.title.translated.none.fl_str_mv A eficácia da reabilitação cognitiva no comprometimento cognitivo leve usando tele neuropsicologia
title Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
spellingShingle Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
Neuropsychology
COVID-19
Cognitive dysfunction
Memory
Neuropsicologia
Disfunção cognitiva
Memória
title_short Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
title_full Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
title_fullStr Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
title_full_unstemmed Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
title_sort Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology
dc.creator.fl_str_mv Carlos Martínez Canyazo
Martinez Canyazo, Carlos Alberto
Keller, Greta
Helou, Maria Belen
Arruabarrena, Micaela
Corvalán, Nicolás
Carello, María Agostina
Harris, Paula
Feldman, Mónica Laura
Fernández, Rodrigo S
Calandri, Ismael Luis
Martín, María Eugenia
Allegri, Ricardo Francisco
Crivelli, Lucía
dc.contributor.author.none.fl_str_mv Carlos Martínez Canyazo
Martinez Canyazo, Carlos Alberto
Keller, Greta
Helou, Maria Belen
Arruabarrena, Micaela
Corvalán, Nicolás
Carello, María Agostina
Harris, Paula
Feldman, Mónica Laura
Fernández, Rodrigo S
Calandri, Ismael Luis
Martín, María Eugenia
Allegri, Ricardo Francisco
Crivelli, Lucía
dc.subject.proposal.eng.fl_str_mv Neuropsychology
COVID-19
Cognitive dysfunction
Memory
topic Neuropsychology
COVID-19
Cognitive dysfunction
Memory
Neuropsicologia
Disfunção cognitiva
Memória
dc.subject.proposal.jpn.fl_str_mv Neuropsicologia
dc.subject.proposal.por.fl_str_mv Disfunção cognitiva
Memória
description The COVID-19 pandemic has affected the continuity of cognitive rehabilitation worldwide. However, the use of teleneuropsychology to provide cognitive rehabilitation has contributed significantly to the continuity of the treatment. Objectives: To measure the effects of cognitive telerehabilitation on cognition, neuropsychiatric symptoms, and memory strategies in a cohort of patients with mild cognitive impairment. Methods: A sample of 60 patients with mild cognitive impairment according to Petersen’s criteria was randomly divided into two groups: 30 treatment cases and 30 controls (waiting list group). Subjects were matched by age, sex, and Montreal Cognitive Assessment. The treatment group received ten cognitive telerehabilitation sessions of 45 minutes duration once a week. Pre-treatment (week 0) and post-treatment (week 10) measures were assessed for both groups. Different linear mixed models were estimated to test treatment effect (cognitive telerehabilitation vs. controls) on each outcome of interest over time (pre/post-intervention). Results: A significant group (control/treatment) x time (pre/post) interaction revealed that the treatment group at week 10 had better scores in cognitive variables: memory (RAVLT learning trials p=0.030; RAVLT delayed recall p=0.029), phonological fluency (p=0.001), activities of daily living (FAQ p=0.001), satisfaction with memory performance (MMQ satisfaction p=0.004) and use of memory strategies (MMQ strategy p=0.000), as well as, and a significant reduction of affective symptomatology: depression (GDS p=0.000), neuropsychiatric symptoms (NPI-Q p=0.045), forgetfulness (EDO-10 p=0.000), and stress (DAS stress p=0.000). Conclusions: Our study suggests that CTR is an effective intervention.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023
dc.date.accessioned.none.fl_str_mv 2024-10-31T16:23:22Z
dc.date.available.none.fl_str_mv 2024-10-31T16:23:22Z
dc.type.none.fl_str_mv Artículo de revista
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dc.type.content.none.fl_str_mv Text
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.none.fl_str_mv Canyazo, C. M., Keller, G., Helou, B., Arruabarrena, M., Corvalán, N., Carello, A., Harris, P., Feldman, M., Fernández, R., Calandri, I. L., Martin, M. E., Allegri, R. F., & Crivelli, L.. (2023). Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology. Dementia & Neuropsychologia, 17, e20220079. https://doi.org/10.1590/1980-5764-DN-2022-0079
dc.identifier.issn.none.fl_str_mv 1980-5764
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/13618
dc.identifier.doi.none.fl_str_mv 10.1590/1980-5764-DN-2022-0079
dc.identifier.instname.none.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.none.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.none.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv Canyazo, C. M., Keller, G., Helou, B., Arruabarrena, M., Corvalán, N., Carello, A., Harris, P., Feldman, M., Fernández, R., Calandri, I. L., Martin, M. E., Allegri, R. F., & Crivelli, L.. (2023). Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology. Dementia & Neuropsychologia, 17, e20220079. https://doi.org/10.1590/1980-5764-DN-2022-0079
1980-5764
10.1590/1980-5764-DN-2022-0079
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/13618
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofjournal.none.fl_str_mv Dementia e Neuropsychologia
dc.relation.references.none.fl_str_mv 1. Gorbalenya AE, Baker SC, Baric RS, Groot RJ, Drosten C, Gulyaeva AA, et al. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-44. https://doi.org/10.1038/s41564-020-0695-z
2. Arruabarrena MM, Martin ME, Calandri IL, Corvalán N, Helou MB, Martínez C, et al. Teleneuropsychological assessment in South America: a perspective from patients and neuropsychologists. J Appl Cogn Neurosci. 2022;3(2):e00324683. https://doi.org/10.17981/JACN.3.2.2022.05
3. Peng Z, Jiang H, Wang X, Huang K, Zuo Y, Wu X, et al. The efficacy of cognitive training for elderly chinese individuals with mild cognitive impairment. Biomed Res Int. 2019;2019:4347281. https://doi. org/10.1155/2019/4347281
4. Sherman DS, Mauser J, Nuno M, Sherzai D. The efficacy of cognitive intervention in Mild Cognitive Impairment (MCI): a meta-analysis of outcomes on neuropsychological measures. Neuropsychol Rev. 2017;27(4):440–84. https://doi.org/10.1007/s11065-017-9363-3
5. Reijnders J, van Heugten C, van Boxtel M. Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev. 2013;12(1):263-75. https://doi.org/10.1016/j. arr.2012.07.003
6. Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti T, Kneipp S, et al. Evidence based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005;86(8):1681- 92. https://doi.org/10.1016/j.apmr.2005.03.024
7. Teixeira CVL, Gobbi LTB, Corazza DI, Stella F, Costa JLR, Gobbi S. Non- -pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI). Arch Gerontol Geriatr. 2012;54(1):175-80. https://doi.org/10.1016/j.archger.2011.02.014
8. Han JW, Lee H, Hong JW, Kim K, Kim T, Byun HJ, et al. Multimodal cognitive enhancement therapy for patients with mild cognitive impairment and mild dementia: a multi- center, randomized, controlled, double-blind, crossover trial. J Alzheimers Dis. 2017;55(2):787-96. https://doi.org/10.3233/ JAD-160619
9. Crivelli L, Quiroz YT, Calandri IL, Martin ME, Velilla LM, Cusicanqui MI, et al. Working Group Recommendations for the practice of teleneuropsychology in Latin America. Arch Clin Neuropsychol. 2022;37(3):553-567. https:// doi.org/10.1093/arclin/acab080
10. Peretti A, Amenta F, Tayebati SK, Nittari G, Mahdi SS. Telerehabilitation: review of the state-of-the-art and areas of application. JMIR Rehabil Assist Technol. 2017;4(2):e7. https://doi.org/10.2196/rehab.751
11. Marin A, DeCaro R, Schiloski K, Elshaar A, Dwyer B, Vives-Rodriguez A, et al. Home-based electronic cognitive therapy in patients with Alzheimer disease: feasibility randomized controlled trial. JMIR Form Res. 2022;6(9):e34450. https://doi.org/10.2196/34450
12. Isernia S, Pagliari C, Jonsdottir J, Castiglioni C, Gindri P, Gramigna C, et al. Efficiency and patient-reported outcome measures from clinic to home: the human empowerment aging and disability program for digital-health rehabilitation. Front Neurol. 2019;10:1206. https://doi.org/10.3389/ fneur.2019.01206
13. Dodakian L, McKenzie AL, Le V, See J, Pearson-Fuhrhop K, Quinlan EB, et al. A home-based telerehabilitation program for patients with stroke. Neurorehabil Neural Repair. 2017;31(10-11):923-33. https://doi. org/10.1177/1545968317733818
14. Cotelli M, Manenti R, Brambilla M, Gobbi E, Ferrari C, Binetti G, et al. Cognitive telerehabilitation in mild cognitive impairment, Alzheimer’s disease and frontotemporal dementia: a systematic review. J Telemed Telecare. 2019;25(2):67-79. https://doi.org/10.1177/1357633X17740390
15. Pais R, Ruano L, Carvalho OP, Barros H. Global cognitive impairment prevalence and incidence in community-dwelling older adults-a systematic review. Geriatrics (Basel). 2020;5(4):84. https://doi.org/10.3390/ geriatrics5040084
16. Allegri RF, Arizaga RL, Bavec CV, Colli LP, Demey I, Fernández MC, et al. Enfermedad de Alzheimer. Guía de práctica clínica. Neurologia Argentina. 2011;3(2):120-37. https://doi.org/10.1016/S1853-0028(11)70026-X
17. Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66(12):1447-55. https://doi.org/10.1001/archneurol.2009.266
18. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997;9 Suppl 1:65-9. https://doi.org/10.1017/s1041610297004717
19. O’Connor MK, Kraft ML, Daley R, Sugarman MA, Clark EL, Scoglio AAJ, et al. The aging well through interaction and scientific education (AgeWISE) program. Clin Gerontol. 2018;41(5):412-23. https://doi.org/10.1080/073 17115.2017.1387212
20. Serrano C, Sorbara M, Minond A, Finlay J, Arizaga RL, Iturry M, et al. Validation of the Argentine version of the Montreal Cognitive Assessment Test (MOCA): a screening tool for mild cognitive impairment and mild dementia in elderly. Dement Neuropsychol. 2020;14(2):145-52. https:// doi.org/10.1590/1980-57642020dn14-020007
21. Lezak MD. Neuropsychological assessment. 3rd ed. New York: Oxford University Press; 1995.
22. Butters N, Granholm E, Salmon DP, Grant I, Wolfe J. Episodic and semantic memory: a comparison of amnesic and demented patients. J Clin Exp Neuropsychol. 1987;9(5):479-97. https://doi. org/10.1080/01688638708410764
23. Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1-2):165-73. https://doi.org/10.1300/J018v05n01_09
24. Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000;12(2):233-9. https://doi. org/10.1176/jnp.12.2.233
25. Pfeffer RI, Kurosaki TT, Harrah Jr CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323-9. https://doi.org/10.1093/geronj/37.3.323
26. Galvin JE, Roe CM, Xiong C, Morris JC. Validity and reliability of the AD8 informant interview in dementia. Neurology. 2006;67(11):1942-8. https:// doi.org/10.1212/01.wnl.0000247042.15547.eb
27. Riffo N, Reyes F, Véliz de Vos M. Propriedades psicométricas del cuestionario multidimensional de memoria en población chilena adulta. Ter Psicol. 2013;31(2):227-37. http://dx.doi.org/10.4067/S0718- 48082013000200009
28. Jiang LC, Yan YJ, Jin ZS, Hu ML, Wang L, Song Y, et al. The depression anxiety stress scale-21 in Chinese hospital workers: reliability, latent structure, and measurement invariance across genders. Front Psychol. 2020;11:247. https://doi.org/10.3389/fpsyg.2020.00247
29. Matamala-Gomez M, Bottiroli S, Realdon O, Riva G, Galvagni L, Platz T, et al. Telemedicine and virtual reality at time of COVID-19 pandemic: an overview for future perspectives in neurorehabilitation. Front Neurol. 2021;12:646902. https://doi.org/10.3389/fneur.2021.646902
30. Mantovani E, Zucchella C, Bottiroli S, Federico A, Giugno R, Sandrini G, et al. Telemedicine and virtual reality for cognitive rehabilitation: a roadmap for the COVID-19 pandemic. Front Neurol. 2020;11:926. https://doi. org/10.3389/fneur.2020.00926
31. Costanzo MC, Arcidiacono C, Rodolico A, Panebianco M, Aguglia E, Signorelli MS. Diagnostic and Interventional implications of telemedicine in Alzheimer’s disease and mild cognitive impairment: a literature review. Int J Geriatr Psychiatry. 2019;34(1):12-28. https:// doi.org/10.1002/gps.5219
32. Solana J, Cáceres C, García-Molina A, Opisso E, Roig T, Tormos JM, et al. Improving brain injury cognitive rehabilitation by personalized telerehabilitation services: Guttmann neuropersonal trainer. IEEE J Biomed Health Inform. 2015;19(1):124-31. https://doi.org/10.1109/JBHI.2014.2354537
33. Marra DE, Hamlet KM, Bauer RM, Bowers D. Validity of teleneuropsychology for older adults in response to COVID-19: a systematic and critical review. Clin Neuropsychol. 2020;34(7-8):1411-52. https://doi.org/10.10 80/13854046.2020.1769192
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publisher.none.fl_str_mv Academia Brasileira de Neurologia
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spelling Atribución 4.0 Internacional (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Carlos Martínez CanyazoMartinez Canyazo, Carlos AlbertoKeller, GretaHelou, Maria BelenArruabarrena, MicaelaCorvalán, NicolásCarello, María AgostinaHarris, PaulaFeldman, Mónica LauraFernández, Rodrigo SCalandri, Ismael LuisMartín, María EugeniaAllegri, Ricardo Franciscovirtual::74-1Crivelli, Lucía2024-10-31T16:23:22Z2024-10-31T16:23:22Z2023Canyazo, C. M., Keller, G., Helou, B., Arruabarrena, M., Corvalán, N., Carello, A., Harris, P., Feldman, M., Fernández, R., Calandri, I. L., Martin, M. E., Allegri, R. F., & Crivelli, L.. (2023). Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology. Dementia & Neuropsychologia, 17, e20220079. https://doi.org/10.1590/1980-5764-DN-2022-00791980-5764https://hdl.handle.net/11323/1361810.1590/1980-5764-DN-2022-0079Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/The COVID-19 pandemic has affected the continuity of cognitive rehabilitation worldwide. However, the use of teleneuropsychology to provide cognitive rehabilitation has contributed significantly to the continuity of the treatment. Objectives: To measure the effects of cognitive telerehabilitation on cognition, neuropsychiatric symptoms, and memory strategies in a cohort of patients with mild cognitive impairment. Methods: A sample of 60 patients with mild cognitive impairment according to Petersen’s criteria was randomly divided into two groups: 30 treatment cases and 30 controls (waiting list group). Subjects were matched by age, sex, and Montreal Cognitive Assessment. The treatment group received ten cognitive telerehabilitation sessions of 45 minutes duration once a week. Pre-treatment (week 0) and post-treatment (week 10) measures were assessed for both groups. Different linear mixed models were estimated to test treatment effect (cognitive telerehabilitation vs. controls) on each outcome of interest over time (pre/post-intervention). Results: A significant group (control/treatment) x time (pre/post) interaction revealed that the treatment group at week 10 had better scores in cognitive variables: memory (RAVLT learning trials p=0.030; RAVLT delayed recall p=0.029), phonological fluency (p=0.001), activities of daily living (FAQ p=0.001), satisfaction with memory performance (MMQ satisfaction p=0.004) and use of memory strategies (MMQ strategy p=0.000), as well as, and a significant reduction of affective symptomatology: depression (GDS p=0.000), neuropsychiatric symptoms (NPI-Q p=0.045), forgetfulness (EDO-10 p=0.000), and stress (DAS stress p=0.000). Conclusions: Our study suggests that CTR is an effective intervention.A pandemia do COVID-19 afetou a continuidade da reabilitação cognitiva em todo o mundo. No entanto, o uso de tele neuropsicologia para a reabilitação cognitiva tem contribuído significativamente para a continuidade do tratamento. Objetivos: Medir os efeitos da tele reabilitação cognitiva na cognição, nos sintomas neuropsiquiátricos e nas estratégias de memória em uma coorte de pacientes com comprometimento cognitivo leve. Métodos: Uma amostra de 60 pacientes com comprometimento cognitivo leve de acordo com os critérios de Petersen foi dividida aleatoriamente em dois grupos: 30 casos de tratamento e 30 controles (grupo de lista de espera). Os assuntos foram pareados por idade, sexo e Avaliação Cognitiva de Montreal. O grupo de tratamento recebeu dez sessões de tele reabilitação cognitiva de 45 minutos de duração uma vez por semana. As medidas pré-tratamento (semana 0) e pós-tratamento (semana 10) foram avaliadas para ambos os grupos. Diferentes modelos lineares mistos foram estimados para testar o efeito do tratamento (tele reabilitação cognitiva vs. controles) em cada desfecho de interesse ao longo do tempo (pré-/pós-intervenção). Resultados: Uma interação significativa grupo (controle/tratamento) x tempo (pré/pós) revelou que o grupo de tratamento teve melhores pontuações em variáveis cognitivas na semana 10: memória (ensaios de aprendizagem RAVLT p = 0,030; RAVLT recordação tardia p=0,029), fluência fonológica (p=0,001), atividades da vida diária (FAQ p=0,001), satisfação com o desempenho da memória (satisfação MMQ p=0,004) e uso de estratégias de memória (estratégia MMQ p=0,000), bem como uma significativa redução da sintomatologia afetiva: depressão (GDS p=0,000), sintomas neuropsiquiátricos (NPI-Q p=0,045), esquecimento (EDO-10 p=0,000) e estresse (DAS estresse p=0,000). Conclusões: Nosso estudo sugere que a CTR é uma intervenção eficaz. Palavras-chave: Neuropsicologia; COVID-19; Disfunção cognitiva; Memória.8 páginasapplication/pdfengAcademia Brasileira de NeurologiaBrazilhttps://www.scielo.br/j/dn/a/HCGdQPxbpDT4bYNkqZhtcqz/#Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychologyA eficácia da reabilitação cognitiva no comprometimento cognitivo leve usando tele neuropsicologiaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Dementia e Neuropsychologia1. Gorbalenya AE, Baker SC, Baric RS, Groot RJ, Drosten C, Gulyaeva AA, et al. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-44. https://doi.org/10.1038/s41564-020-0695-z2. Arruabarrena MM, Martin ME, Calandri IL, Corvalán N, Helou MB, Martínez C, et al. Teleneuropsychological assessment in South America: a perspective from patients and neuropsychologists. J Appl Cogn Neurosci. 2022;3(2):e00324683. https://doi.org/10.17981/JACN.3.2.2022.053. Peng Z, Jiang H, Wang X, Huang K, Zuo Y, Wu X, et al. The efficacy of cognitive training for elderly chinese individuals with mild cognitive impairment. Biomed Res Int. 2019;2019:4347281. https://doi. org/10.1155/2019/43472814. Sherman DS, Mauser J, Nuno M, Sherzai D. The efficacy of cognitive intervention in Mild Cognitive Impairment (MCI): a meta-analysis of outcomes on neuropsychological measures. Neuropsychol Rev. 2017;27(4):440–84. https://doi.org/10.1007/s11065-017-9363-35. Reijnders J, van Heugten C, van Boxtel M. Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev. 2013;12(1):263-75. https://doi.org/10.1016/j. arr.2012.07.0036. Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti T, Kneipp S, et al. Evidence based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005;86(8):1681- 92. https://doi.org/10.1016/j.apmr.2005.03.0247. Teixeira CVL, Gobbi LTB, Corazza DI, Stella F, Costa JLR, Gobbi S. Non- -pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI). Arch Gerontol Geriatr. 2012;54(1):175-80. https://doi.org/10.1016/j.archger.2011.02.0148. Han JW, Lee H, Hong JW, Kim K, Kim T, Byun HJ, et al. Multimodal cognitive enhancement therapy for patients with mild cognitive impairment and mild dementia: a multi- center, randomized, controlled, double-blind, crossover trial. J Alzheimers Dis. 2017;55(2):787-96. https://doi.org/10.3233/ JAD-1606199. Crivelli L, Quiroz YT, Calandri IL, Martin ME, Velilla LM, Cusicanqui MI, et al. Working Group Recommendations for the practice of teleneuropsychology in Latin America. Arch Clin Neuropsychol. 2022;37(3):553-567. https:// doi.org/10.1093/arclin/acab08010. Peretti A, Amenta F, Tayebati SK, Nittari G, Mahdi SS. Telerehabilitation: review of the state-of-the-art and areas of application. JMIR Rehabil Assist Technol. 2017;4(2):e7. https://doi.org/10.2196/rehab.75111. Marin A, DeCaro R, Schiloski K, Elshaar A, Dwyer B, Vives-Rodriguez A, et al. Home-based electronic cognitive therapy in patients with Alzheimer disease: feasibility randomized controlled trial. JMIR Form Res. 2022;6(9):e34450. https://doi.org/10.2196/3445012. Isernia S, Pagliari C, Jonsdottir J, Castiglioni C, Gindri P, Gramigna C, et al. Efficiency and patient-reported outcome measures from clinic to home: the human empowerment aging and disability program for digital-health rehabilitation. Front Neurol. 2019;10:1206. https://doi.org/10.3389/ fneur.2019.0120613. Dodakian L, McKenzie AL, Le V, See J, Pearson-Fuhrhop K, Quinlan EB, et al. A home-based telerehabilitation program for patients with stroke. Neurorehabil Neural Repair. 2017;31(10-11):923-33. https://doi. org/10.1177/154596831773381814. Cotelli M, Manenti R, Brambilla M, Gobbi E, Ferrari C, Binetti G, et al. Cognitive telerehabilitation in mild cognitive impairment, Alzheimer’s disease and frontotemporal dementia: a systematic review. J Telemed Telecare. 2019;25(2):67-79. https://doi.org/10.1177/1357633X1774039015. Pais R, Ruano L, Carvalho OP, Barros H. Global cognitive impairment prevalence and incidence in community-dwelling older adults-a systematic review. Geriatrics (Basel). 2020;5(4):84. https://doi.org/10.3390/ geriatrics504008416. Allegri RF, Arizaga RL, Bavec CV, Colli LP, Demey I, Fernández MC, et al. Enfermedad de Alzheimer. Guía de práctica clínica. Neurologia Argentina. 2011;3(2):120-37. https://doi.org/10.1016/S1853-0028(11)70026-X17. Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66(12):1447-55. https://doi.org/10.1001/archneurol.2009.26618. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997;9 Suppl 1:65-9. https://doi.org/10.1017/s104161029700471719. O’Connor MK, Kraft ML, Daley R, Sugarman MA, Clark EL, Scoglio AAJ, et al. The aging well through interaction and scientific education (AgeWISE) program. Clin Gerontol. 2018;41(5):412-23. https://doi.org/10.1080/073 17115.2017.138721220. Serrano C, Sorbara M, Minond A, Finlay J, Arizaga RL, Iturry M, et al. Validation of the Argentine version of the Montreal Cognitive Assessment Test (MOCA): a screening tool for mild cognitive impairment and mild dementia in elderly. Dement Neuropsychol. 2020;14(2):145-52. https:// doi.org/10.1590/1980-57642020dn14-02000721. Lezak MD. Neuropsychological assessment. 3rd ed. New York: Oxford University Press; 1995.22. Butters N, Granholm E, Salmon DP, Grant I, Wolfe J. Episodic and semantic memory: a comparison of amnesic and demented patients. J Clin Exp Neuropsychol. 1987;9(5):479-97. https://doi. org/10.1080/0168863870841076423. Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1-2):165-73. https://doi.org/10.1300/J018v05n01_0924. Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000;12(2):233-9. https://doi. org/10.1176/jnp.12.2.23325. Pfeffer RI, Kurosaki TT, Harrah Jr CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323-9. https://doi.org/10.1093/geronj/37.3.32326. Galvin JE, Roe CM, Xiong C, Morris JC. Validity and reliability of the AD8 informant interview in dementia. Neurology. 2006;67(11):1942-8. https:// doi.org/10.1212/01.wnl.0000247042.15547.eb27. Riffo N, Reyes F, Véliz de Vos M. Propriedades psicométricas del cuestionario multidimensional de memoria en población chilena adulta. Ter Psicol. 2013;31(2):227-37. http://dx.doi.org/10.4067/S0718- 4808201300020000928. Jiang LC, Yan YJ, Jin ZS, Hu ML, Wang L, Song Y, et al. The depression anxiety stress scale-21 in Chinese hospital workers: reliability, latent structure, and measurement invariance across genders. Front Psychol. 2020;11:247. https://doi.org/10.3389/fpsyg.2020.0024729. Matamala-Gomez M, Bottiroli S, Realdon O, Riva G, Galvagni L, Platz T, et al. Telemedicine and virtual reality at time of COVID-19 pandemic: an overview for future perspectives in neurorehabilitation. Front Neurol. 2021;12:646902. https://doi.org/10.3389/fneur.2021.64690230. Mantovani E, Zucchella C, Bottiroli S, Federico A, Giugno R, Sandrini G, et al. Telemedicine and virtual reality for cognitive rehabilitation: a roadmap for the COVID-19 pandemic. Front Neurol. 2020;11:926. https://doi. org/10.3389/fneur.2020.0092631. Costanzo MC, Arcidiacono C, Rodolico A, Panebianco M, Aguglia E, Signorelli MS. Diagnostic and Interventional implications of telemedicine in Alzheimer’s disease and mild cognitive impairment: a literature review. Int J Geriatr Psychiatry. 2019;34(1):12-28. https:// doi.org/10.1002/gps.521932. Solana J, Cáceres C, García-Molina A, Opisso E, Roig T, Tormos JM, et al. Improving brain injury cognitive rehabilitation by personalized telerehabilitation services: Guttmann neuropersonal trainer. IEEE J Biomed Health Inform. 2015;19(1):124-31. https://doi.org/10.1109/JBHI.2014.235453733. Marra DE, Hamlet KM, Bauer RM, Bowers D. Validity of teleneuropsychology for older adults in response to COVID-19: a systematic and critical review. Clin Neuropsychol. 2020;34(7-8):1411-52. https://doi.org/10.10 80/13854046.2020.17691928117NeuropsychologyCOVID-19Cognitive dysfunctionMemoryNeuropsicologiaDisfunção 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ara ejercer estos derechos sobre la Obra tal y como se indica a continuación:</p>
    <ol type="a">
      <li>Reproducir la Obra, incorporar la Obra en una o más Obras Colectivas, y reproducir la Obra incorporada en las Obras Colectivas.</li>
      <li>Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.</li>
      <li>Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.</li>
    </ol>
    <p>Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).</p>
  </li>
  <br/>
  <li>
    Restricciones.
    <p>La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:</p>
    <ol type="a">
      <li>Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).</li>
      <li>Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.</li>
      <li>Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.</li>
      <li>
        Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
        <ol type="i">
          <li>Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.</li>
          <li>Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
        </ol>
      </li>
      <li>Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
    </ol>
  </li>
  <br/>
  <li>
    Representaciones, Garantías y Limitaciones de Responsabilidad.
    <p>A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Limitación de responsabilidad.
    <p>A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Término.
    <ol type="a">
      <li>Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.</li>
      <li>Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.</li>
    </ol>
  </li>
  <br/>
  <li>
    Varios.
    <ol type="a">
      <li>Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.</li>
      <li>Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.</li>
      <li>Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.</li>
      <li>Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.</li>
    </ol>
  </li>
  <br/>
</ol>
