Iron status in late pregnancy is inversely associated with birth weight in Colombia

Objective: Gestational anaemia (GA) is common in developing countries. This study assessed the relationship of late GA and negative perinatal outcomes in participants recruited in a reference maternity unit of the Caribbean region of Colombia. Design: Prospective analytical birth cohort study. Mater...

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Autores:
puerto lopez, alejandra
Trojan, Annabelle
ALVIS ZAKZUK, NELSON RAFAEL
López-Saleme, Rossana
edna estrada, francisco
Alvarez, Alvaro
Alvis-Guzmán, Nelson
Zakzuk, Josefina
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
spa
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/9082
Acceso en línea:
https://hdl.handle.net/11323/9082
https://doi.org/10.1017/S136898002100166X
https://repositorio.cuc.edu.co/
Palabra clave:
Anaemia
Birth outcomes
Iron deficiency
Iron status
Low birth weight
Pregnancy
Colombia
Rights
openAccess
License
Atribución 4.0 Internacional (CC BY 4.0)
id RCUC2_5a67f19304c6c566a69c90a7bdb46530
oai_identifier_str oai:repositorio.cuc.edu.co:11323/9082
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.eng.fl_str_mv Iron status in late pregnancy is inversely associated with birth weight in Colombia
title Iron status in late pregnancy is inversely associated with birth weight in Colombia
spellingShingle Iron status in late pregnancy is inversely associated with birth weight in Colombia
Anaemia
Birth outcomes
Iron deficiency
Iron status
Low birth weight
Pregnancy
Colombia
title_short Iron status in late pregnancy is inversely associated with birth weight in Colombia
title_full Iron status in late pregnancy is inversely associated with birth weight in Colombia
title_fullStr Iron status in late pregnancy is inversely associated with birth weight in Colombia
title_full_unstemmed Iron status in late pregnancy is inversely associated with birth weight in Colombia
title_sort Iron status in late pregnancy is inversely associated with birth weight in Colombia
dc.creator.fl_str_mv puerto lopez, alejandra
Trojan, Annabelle
ALVIS ZAKZUK, NELSON RAFAEL
López-Saleme, Rossana
edna estrada, francisco
Alvarez, Alvaro
Alvis-Guzmán, Nelson
Zakzuk, Josefina
dc.contributor.author.spa.fl_str_mv puerto lopez, alejandra
Trojan, Annabelle
ALVIS ZAKZUK, NELSON RAFAEL
López-Saleme, Rossana
edna estrada, francisco
Alvarez, Alvaro
Alvis-Guzmán, Nelson
Zakzuk, Josefina
dc.subject.proposal.eng.fl_str_mv Anaemia
Birth outcomes
Iron deficiency
Iron status
Low birth weight
Pregnancy
topic Anaemia
Birth outcomes
Iron deficiency
Iron status
Low birth weight
Pregnancy
Colombia
dc.subject.proposal.spa.fl_str_mv Colombia
description Objective: Gestational anaemia (GA) is common in developing countries. This study assessed the relationship of late GA and negative perinatal outcomes in participants recruited in a reference maternity unit of the Caribbean region of Colombia. Design: Prospective analytical birth cohort study. Maternal Hb and serum ferritin (SF) levels were measured. GA was defined as Hb levels <6·82 mmol/l (<11 g/dl), SF depletion as SF levels <12 µg/l. Birth outcomes such as low birth weight (LBW), preterm birth (PB) and small for gestational age (SGA) were examined. Setting: Mothers in the first stage of labour, living in urban or rural areas of Bolívar, were enrolled in an obstetrical centre located in Cartagena, Colombia. Blood and stool samples were taken prior delivery. Maternal blood count, SF levels and infant anthropometric data were recorded for analysis. Participants: 1218 pregnant women aged 18-42 years and their newborns. Results: Prevalence of GA and SF depletion was 41·6 % and 41·1 %, respectively. GA was positively associated with poverty-related sociodemographic conditions. Prenatal care attendance lowered the risk of PB, LBW and SGA. Birth weight was inversely associated with Hb levels, observing a -36·8 g decrease in newborn weight per 0·62 mmol/l (or 1 g/dl) of maternal Hb. SF depletion, but not anaemia, was associated with PB. SGA outcome showed a significant association with anaemia, but not a significant relationship with SF depletion. Conclusions: Birth weight and other-related perinatal outcomes are negatively associated with Hb and SF depletion. Prenatal care attendance reduced the risk of negative birth outcomes.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-04-16
dc.date.accessioned.none.fl_str_mv 2022-03-16T21:01:31Z
dc.date.available.none.fl_str_mv 2022-03-16T21:01:31Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.content.spa.fl_str_mv Text
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dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/9082
dc.identifier.url.spa.fl_str_mv https://doi.org/10.1017/S136898002100166X
dc.identifier.doi.spa.fl_str_mv 10.1017/S136898002100166X
dc.identifier.eissn.spa.fl_str_mv 1475-2727
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv 1368-9800
10.1017/S136898002100166X
1475-2727
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/9082
https://doi.org/10.1017/S136898002100166X
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.ispartofjournal.spa.fl_str_mv Public Health Nutrition
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4. Yi SW, Han YJ & Ohrr H (2013) Anemia before pregnancy and risk of preterm birth, low birth weight and small-forgestational-age birth in Korean women. Eur J Clin Nutr 67, 337–342.
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6. Col Madendag I, Eraslan Sahin M, Madendag Y et al. (2019) The effect of iron deficiency anemia early in the third trimester on small for gestational age and birth weight: a retrospective cohort study on iron deficiency anemia and fetal weight. Biomed Res Int 2019, 7613868.
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51. Ziaei S, Norrozi M, Faghihzadeh S et al. (2007) A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥ 13.2 g/dl. BJOG 114, 684–688.
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65. Ikeanyi EM & Ibrahim AI (2015) Does antenatal care attendance prevent anemia in pregnancy at term? Niger J Clin Pract 18, 323–327.
66. Zhou H, Wang A, Huang X et al. (2019) Quality antenatal care protects against low birth weight in 42 poor counties of Western China. PLoS One 14, 1–14.
67. Pinz ´on-Rond ´on ÁM, Gutiérrez-Pinzon V, Madrinan-Navia H ˜ et al. (2015) Low birth weight and prenatal care in Colombia: a cross-sectional study. BMC Pregnancy Childbirth 15, 118.
68. Gyorkos TW & Gilbert NL (2014) Blood drain: soiltransmitted helminths and anemia in pregnant women. PLoS Negl Trop Dis 8, 7–8.
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70. Brooker S, Hotez PJ & Bundy DAP (2008) Hookworm-related anaemia among pregnant women: a systematic review. PLoS Negl Trop Dis 2, e291.
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© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society
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spelling puerto lopez, alejandraTrojan, AnnabelleALVIS ZAKZUK, NELSON RAFAELLópez-Saleme, Rossanaedna estrada, franciscoAlvarez, AlvaroAlvis-Guzmán, NelsonZakzuk, Josefina2022-03-16T21:01:31Z2022-03-16T21:01:31Z2021-04-161368-9800https://hdl.handle.net/11323/9082https://doi.org/10.1017/S136898002100166X10.1017/S136898002100166X1475-2727Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Objective: Gestational anaemia (GA) is common in developing countries. This study assessed the relationship of late GA and negative perinatal outcomes in participants recruited in a reference maternity unit of the Caribbean region of Colombia. Design: Prospective analytical birth cohort study. Maternal Hb and serum ferritin (SF) levels were measured. GA was defined as Hb levels <6·82 mmol/l (<11 g/dl), SF depletion as SF levels <12 µg/l. Birth outcomes such as low birth weight (LBW), preterm birth (PB) and small for gestational age (SGA) were examined. Setting: Mothers in the first stage of labour, living in urban or rural areas of Bolívar, were enrolled in an obstetrical centre located in Cartagena, Colombia. Blood and stool samples were taken prior delivery. Maternal blood count, SF levels and infant anthropometric data were recorded for analysis. Participants: 1218 pregnant women aged 18-42 years and their newborns. Results: Prevalence of GA and SF depletion was 41·6 % and 41·1 %, respectively. GA was positively associated with poverty-related sociodemographic conditions. Prenatal care attendance lowered the risk of PB, LBW and SGA. Birth weight was inversely associated with Hb levels, observing a -36·8 g decrease in newborn weight per 0·62 mmol/l (or 1 g/dl) of maternal Hb. SF depletion, but not anaemia, was associated with PB. SGA outcome showed a significant association with anaemia, but not a significant relationship with SF depletion. Conclusions: Birth weight and other-related perinatal outcomes are negatively associated with Hb and SF depletion. Prenatal care attendance reduced the risk of negative birth outcomes.11 Páginasapplication/pdfspaCambridge University PressUnited KingdomAtribución 4.0 Internacional (CC BY 4.0)© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Societyhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Iron status in late pregnancy is inversely associated with birth weight in ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionhttps://www.cambridge.org/core/journals/public-health-nutrition/article/iron-status-in-late-pregnancy-is-inversely-associated-with-birth-weight-in-colombia/6B9A19D15B530A8C0B1DAE0A92DD39ACColombiaPublic Health Nutrition1. World Health Organization (2011) Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Geneva, Switzerland: World Health Organization.2. World Health Organization (2020) WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations. Geneva: World Health Organization.3. Figueiredo ACMG, Gomes-Filho IS, Batista JET et al. (2019) Maternal anemia and birth weight: a prospective cohort study. PLoS One 14, e0212817.4. Yi SW, Han YJ & Ohrr H (2013) Anemia before pregnancy and risk of preterm birth, low birth weight and small-forgestational-age birth in Korean women. Eur J Clin Nutr 67, 337–342.5. Malhotra M, Sharma JB, Batra S et al. (2002) Maternal and perinatal outcome in varying degrees of anemia. Int J Gynecol Obstet 79, 93–100.6. Col Madendag I, Eraslan Sahin M, Madendag Y et al. (2019) The effect of iron deficiency anemia early in the third trimester on small for gestational age and birth weight: a retrospective cohort study on iron deficiency anemia and fetal weight. Biomed Res Int 2019, 7613868.7. 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Ministry of Health and Social Protection (2013) Deworming Guideline “WHO Preventive Anthelmintic Chemotherapy”. https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ET/LINEAMIENTO DESPARASIT ANTIHELMÍNTICA 080122014.pdf (accessed January 2021).510050901524AnaemiaBirth outcomesIron deficiencyIron statusLow birth weightPregnancyColombiaPublicationORIGINALiron-status-in-late-pregnancy-is-inversely-associated-with-birth-weight-in-colombia.pdfiron-status-in-late-pregnancy-is-inversely-associated-with-birth-weight-in-colombia.pdfapplication/pdf767044https://repositorio.cuc.edu.co/bitstreams/c3a605bc-1a96-410a-b478-43b93b037f72/download79ffe9677e36f94c57372131e18d1b79MD51LICENSElicense.txtlicense.txttext/plain; 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