Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona

En el presente trabajo se realizó un estudio computacional de un rearreglo sigmatrópico [1,3] de hidrógeno intramolecular para la (Z)-3-(4-(dimetilamino)-bencilidén)tiocroman-4-ona, aplicando la Teoría del Funcional de la Densidad con el funcional de intercambio-correlación B3LYP y el conjunto de fu...

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Autores:
Núñez, Jesús
Márquez, Edgar
Rivas, Carlos
Urdaneta, Neudo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
spa
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oai:repositorio.cuc.edu.co:11323/10741
Acceso en línea:
https://hdl.handle.net/11323/10741
https://repositorio.cuc.edu.co/
Palabra clave:
3-bencilidéntiocroman-4-ona
Rearreglo sigmatrópico
TFD
Estado de transición
3-Benzylidenethiochroman-4-one
Sigmatropic rearrangement
DFT
Transition state
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openAccess
License
Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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oai_identifier_str oai:repositorio.cuc.edu.co:11323/10741
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
dc.title.translated.none.fl_str_mv Computational study of [1,3] sigmatropic rearrangement of the (Z)-3-(4-(dimethylamino)benzyliden)thiocroman-4- one
title Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
spellingShingle Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
3-bencilidéntiocroman-4-ona
Rearreglo sigmatrópico
TFD
Estado de transición
3-Benzylidenethiochroman-4-one
Sigmatropic rearrangement
DFT
Transition state
title_short Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
title_full Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
title_fullStr Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
title_full_unstemmed Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
title_sort Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-ona
dc.creator.fl_str_mv Núñez, Jesús
Márquez, Edgar
Rivas, Carlos
Urdaneta, Neudo
dc.contributor.author.none.fl_str_mv Núñez, Jesús
Márquez, Edgar
Rivas, Carlos
Urdaneta, Neudo
dc.subject.proposal.spa.fl_str_mv 3-bencilidéntiocroman-4-ona
Rearreglo sigmatrópico
TFD
Estado de transición
topic 3-bencilidéntiocroman-4-ona
Rearreglo sigmatrópico
TFD
Estado de transición
3-Benzylidenethiochroman-4-one
Sigmatropic rearrangement
DFT
Transition state
dc.subject.proposal.eng.fl_str_mv 3-Benzylidenethiochroman-4-one
Sigmatropic rearrangement
DFT
Transition state
description En el presente trabajo se realizó un estudio computacional de un rearreglo sigmatrópico [1,3] de hidrógeno intramolecular para la (Z)-3-(4-(dimetilamino)-bencilidén)tiocroman-4-ona, aplicando la Teoría del Funcional de la Densidad con el funcional de intercambio-correlación B3LYP y el conjunto de funciones base 6-31G(d,p), a través del paquete computacional Gaussian 09W. Se evaluaron dos posibles migraciones suprafaciales y antarafaciales del átomo de hidrógeno unido al anillo tiopiran-4-ona de la (Z)-3-(4-(dimetilamino)-bencilidén)tiocroman-4-ona, encontrando una energía de activación 4 Kcal/mol más favorable para un estado de transición con características de un desplazamiento suprafacial [1,2], en comparación con la energía de activación de un estado de transición de un desplazamiento antarafacial [1,3].
publishDate 2017
dc.date.issued.none.fl_str_mv 2017-06-02
dc.date.accessioned.none.fl_str_mv 2024-02-20T14:04:42Z
dc.date.available.none.fl_str_mv 2024-02-20T14:04:42Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv Núñez, J., Márquez, E., Rivas, C., & Urdaneta, N. (2018). Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino) benciliden)tiocroman-4-ona. Avances en Química, 12(2 - 3), 23-30. Recuperado de http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/10116
dc.identifier.issn.spa.fl_str_mv 0041994X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/10741
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv Núñez, J., Márquez, E., Rivas, C., & Urdaneta, N. (2018). Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino) benciliden)tiocroman-4-ona. Avances en Química, 12(2 - 3), 23-30. Recuperado de http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/10116
0041994X
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/10741
https://repositorio.cuc.edu.co/
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.ispartofjournal.spa.fl_str_mv Avances en Quimica
dc.relation.references.spa.fl_str_mv 1. P Böhler, Ch Tamm. The homo-isoflavones, a new class of natural product. Isolation and structure of eucomin and eucomol. Tetrahedron Letters, 8, 3479-3483 (1967).
2. RE Finckh, Ch Tamm. The homo-isoflavones III. Isolation and structure of punctatin, 3,9-Dihydro-Punctatin, 4’-O-Methyl-3,9- dihydro-punctatin, 4’-Demethyl-eucomin and 4’-Demethyl-5-Omethyl-3,9-dihydro-eucomin. Experientia, 26, 472-473 (1970).
3. TM Hung, CV Thu, NT Dat, SW Ryoo, JH Lee, JC Kim, M Na, HJ Jung, K Bae, BS Min. Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro antiinflammation activity. Bioorganic & Medicinal Chemistry Letters, 20, 2412-2416 (2010).
4. P Perjési, U Das, ED Clercq, J Balzarini, M Kawase, H Sakagami, JP Stables, T Lorand, Z Rozmer, JR Dimmock. Design, synthesis and antiproliferative activity of some 3- benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eur. J. Medicinal Chemistry, 43, 839-845 (2008).
5. T Al Nakib, V Bezjak, MJ Meegan, R Chandy. Synthesis and antifungal activity of some 3-benzylidenechroman-4-ones, 3- benzylidenethiochroman-4-ones and 2-benzylidene-1-tetralones. Eur. J. Medicinal Chemistry, 25, 455-462 (1990).
6. YF Li, ZQ Liu, XY Luo. Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and DNA against oxidation. Journal of Agricultural and Food Chemistry, 58, 4126-4131 (2010).
7. S Tait, AL Salvati, N Desideri, L Fiore. Antiviral activity of substituted homoisoflavonoids on enteroviruses. Antiviral Research, 72, 252-255 (2006).
8. AT Nguyen, J Fontaine, H Malonne, P Duez. Homoisoflavanones from Disporopsis aspera. Phytochemistry, 67, 2159-2163 (2006).
9. T Ishikawa, Y Oku, T Tanaka, T Kumamoto. An approach to Anti-HIV-1 active Calophyllum Coumarin synthesis: An enantioselective construction of 2,3-Dimethyl-4-chromanone ring by Quinine-assisted intramolecular Michael-type addition. Tetrahedron Letters, 40, 3777-3780 (1999).
10. A Lévai, Z Dinya, JB Schág, G Tóth, Á Szöllösy. Synthesis of 3-Benzyl-4-chromones and 3-Benzyl-1-thio-4-chromones. Pharmazie, 36, 465-466 (1981).
11. J Andrieux, DRH Barton, H Patin. Rhodium-catalysed isomerisation of some unsaturated organic substrates. J. Chem. Soc., Perkin Transactions 1, 4, 359-363 (1977).
12. J McMurry. Química Orgánica. Sexta Edición. Thomson (2004).
13. RB Woodward, R Hoffmann. Selection rules for sigmatro picreactions. J. Amer. Chem. Soc., 87, 2511-2513 (1965).
14. GB Gill. The application of the Woodward-Hoffman Orbital symmetry rules to concerted organic reactions. Quarterly Reviews Chemical Society, 22, 338-389 (1968).
15. WR Rodwell, WJ Bouma, L Radom. Ab inition studies of 1,3- sigmatropic rearrangements: Effect of basis set and electron correlation. Int. J. Quantum Chemistry, 18, 107-116 (1980).
16. Jr B A Hess, LJ Schaad, J Pancir. Theoretical Studies of [1,n]- sigmatropic rearrangements involving hydrogen transfer in simple methyl-substituted conjugated polyenes. J. Amer. Chem. Soc., 107, 149-154 (1985).
17. LR Domingo, M.J. Aurell, P. Pérez. Understanding the Polar Mechanism of the Ene Reaction. A DFT Study. Org. Biomol. Chem., 12, 7581-7590 (2014)
18. LR Domingo. Why Diels-Alder reactions are non-concerted processes. J. Chil. Chem. Soc., 59, 2615-2518 (2014)
19. LR Domingo, MJ Aurell, P Pérez. The mechanism of ionic Diels-Alder reactions. A DFT study of the oxa-Povarov reaction. RSC Adv., 4, 16567-16577 (2014).
20. D Yepes, JS Murray, P Pérez, LR Domingo, P Politzer, P Jaque. Complementarity of reaction force and electron localization function analyses of asynchronicity in bond formation in DielsAlder reactions. Phys. Chem. Chem. Phys., 16, 6726-6734 (2014).
21. LR Domingo. State of the Art of the Bonding Changes along the Diels-Alder Reaction between Butadiene and Ethylene. Refuting the Pericyclic Mechanism. Organic Chemistry: Current Research, 2, 120 (2013).
22. A Valkonen, K Laihia, E Kolehmainen, R Kauppinen, P Perjési. Structural studies of seven homoisoflavonoids, six thiohomoisoflavonoids, and four structurally related compounds. Structural Chemistry, 23, 209-217 (2012).
23. Gaussian 09W, Revision A.02, Gaussian, Inc., Pittsburgh PA, (2009).
24. E Márquez, J Mora, T Cordoba, G Chuchani. Theoretical Study of the Mechanism for the Gas-Phase Pyrolysis Kinetics of 2- Methylbenzyl Chloride. Int. J. Chemical Kinetics, 3, 537-546 (2011).
25. E Marquez, T Cordova, G Chuchani. DFT Study of the GasPhase Thermal Decomposition Kinetics of 2-Ethoxypyridine into 2-Pyridone. Int. J. Quantum Chemistry, 112, 724–730 (2012)
26. K Fukui. Formulation of the reaction coordinate. J. Physical Chemistry, 74, 4161-4163 (1970).
27. JP Foster, F Weinhold. Natural hybrid orbitals. J. Amer. Chem. Soc., 102, 7211-7218 (1980).
28. KB Wiberg. Application of the pople-santry-segal CNDO method to the cyclopropylcarbinyl and cyclobutyl cation and to bicyclobutane. Tetrahedron, 24, 1083-1096 (1968).
29. A Moyano, MA Pericas, E Valenti. A theoretical study on the mechanism of the thermal and the acid-catalyzed descarboxylation of 2-Oxetanones (-Lactones). J. Org. Chem., 54, 573-582 (1989).
30. O Francia. Síntesis y fotoquímica de tiocromonas para su posible uso en terapia fotodinámica antimicrobiana. Tesis de Licenciatura, Universidad Simón Bolívar, Sartenejas, Venezuela(2011).
31. CE Hudson, D J McAdoo. An ab initio study of substituent effects in [1,3]-hydrogen shifts. J. Org. Chem., 68, 2735-2740 (2003).
32. G Tóth, Å Szöllosy, A Lévai, G Oszbach, W Dietrich, H Kühne. Stereochemistry of 3-Arylideneflavanones and their thio analogues by the use of 3 J(CH) Couplings. Magnetic Resonance in Chemistry, 29, 801-804 (1991).
33. F Bernardi, MA Robb, HB Schlegel, G Tonachini. An MC-SCF study of [1,3] and [1,2] sigmatropic shifts in propene. J. Amer. Chem. Soc., 106, 1198-1202 (1984)
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dc.relation.citationstartpage.spa.fl_str_mv 23
dc.relation.citationissue.spa.fl_str_mv 2-3
dc.relation.citationvolume.spa.fl_str_mv 12
dc.rights.none.fl_str_mv © Copyright 2018 Elsevier B.V., All rights reserved.
dc.rights.license.spa.fl_str_mv Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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spelling Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)© Copyright 2018 Elsevier B.V., All rights reserved.https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Núñez, JesúsMárquez, EdgarRivas, CarlosUrdaneta, Neudo2024-02-20T14:04:42Z2024-02-20T14:04:42Z2017-06-02Núñez, J., Márquez, E., Rivas, C., & Urdaneta, N. (2018). Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino) benciliden)tiocroman-4-ona. Avances en Química, 12(2 - 3), 23-30. Recuperado de http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/101160041994Xhttps://hdl.handle.net/11323/10741Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/En el presente trabajo se realizó un estudio computacional de un rearreglo sigmatrópico [1,3] de hidrógeno intramolecular para la (Z)-3-(4-(dimetilamino)-bencilidén)tiocroman-4-ona, aplicando la Teoría del Funcional de la Densidad con el funcional de intercambio-correlación B3LYP y el conjunto de funciones base 6-31G(d,p), a través del paquete computacional Gaussian 09W. Se evaluaron dos posibles migraciones suprafaciales y antarafaciales del átomo de hidrógeno unido al anillo tiopiran-4-ona de la (Z)-3-(4-(dimetilamino)-bencilidén)tiocroman-4-ona, encontrando una energía de activación 4 Kcal/mol más favorable para un estado de transición con características de un desplazamiento suprafacial [1,2], en comparación con la energía de activación de un estado de transición de un desplazamiento antarafacial [1,3].This research is based on a computational study of a [1,3] sigmatropic intramolecular hydrogen rearrangement for (Z)-3-(4-(dimethylamino)benzylidene)thiochroman-4-one, applying the Density Functional Theory with the exchangecorrelation functional B3LYP and 6-31G(d,p) set basis using software package Gaussian 09W. Two possible suprafacials and anatarafacials migrations of the hydrogen atom bonded to ring thiopyran-4-one of the (Z)-3-(4-(Dimethylamino)- benzylidene)thiochroman-4-one were evaluated, results show an activation energy of 4 Kcal/mol which is more favorable for a transition state featuring characteristics related to a [1,2] suprafacial shift, in comparison with the amount of activation energy of a [1,3] antarafacial shift transition state.8 páginasapplication/pdfspaUniverisdad de Los AndesVenezuelahttps://www.scopus.com/record/display.uri?eid=2-s2.0-85050232002&origin=inward&txGid=13e22fa7ea6a7cb64090d68001afaa07Estudio computacional del rearreglo sigmatrópico [1,3] de la (Z)-3-(4-(dimetilamino)bencilidén)tiocroman-4-onaComputational study of [1,3] sigmatropic rearrangement of the (Z)-3-(4-(dimethylamino)benzyliden)thiocroman-4- oneArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Avances en Quimica1. P Böhler, Ch Tamm. The homo-isoflavones, a new class of natural product. Isolation and structure of eucomin and eucomol. Tetrahedron Letters, 8, 3479-3483 (1967).2. RE Finckh, Ch Tamm. The homo-isoflavones III. Isolation and structure of punctatin, 3,9-Dihydro-Punctatin, 4’-O-Methyl-3,9- dihydro-punctatin, 4’-Demethyl-eucomin and 4’-Demethyl-5-Omethyl-3,9-dihydro-eucomin. Experientia, 26, 472-473 (1970).3. TM Hung, CV Thu, NT Dat, SW Ryoo, JH Lee, JC Kim, M Na, HJ Jung, K Bae, BS Min. Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro antiinflammation activity. Bioorganic & Medicinal Chemistry Letters, 20, 2412-2416 (2010).4. P Perjési, U Das, ED Clercq, J Balzarini, M Kawase, H Sakagami, JP Stables, T Lorand, Z Rozmer, JR Dimmock. Design, synthesis and antiproliferative activity of some 3- benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eur. J. Medicinal Chemistry, 43, 839-845 (2008).5. T Al Nakib, V Bezjak, MJ Meegan, R Chandy. Synthesis and antifungal activity of some 3-benzylidenechroman-4-ones, 3- benzylidenethiochroman-4-ones and 2-benzylidene-1-tetralones. Eur. J. Medicinal Chemistry, 25, 455-462 (1990).6. YF Li, ZQ Liu, XY Luo. Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and DNA against oxidation. Journal of Agricultural and Food Chemistry, 58, 4126-4131 (2010).7. S Tait, AL Salvati, N Desideri, L Fiore. Antiviral activity of substituted homoisoflavonoids on enteroviruses. Antiviral Research, 72, 252-255 (2006).8. AT Nguyen, J Fontaine, H Malonne, P Duez. Homoisoflavanones from Disporopsis aspera. Phytochemistry, 67, 2159-2163 (2006).9. T Ishikawa, Y Oku, T Tanaka, T Kumamoto. An approach to Anti-HIV-1 active Calophyllum Coumarin synthesis: An enantioselective construction of 2,3-Dimethyl-4-chromanone ring by Quinine-assisted intramolecular Michael-type addition. Tetrahedron Letters, 40, 3777-3780 (1999).10. A Lévai, Z Dinya, JB Schág, G Tóth, Á Szöllösy. Synthesis of 3-Benzyl-4-chromones and 3-Benzyl-1-thio-4-chromones. Pharmazie, 36, 465-466 (1981).11. J Andrieux, DRH Barton, H Patin. Rhodium-catalysed isomerisation of some unsaturated organic substrates. J. Chem. Soc., Perkin Transactions 1, 4, 359-363 (1977).12. J McMurry. Química Orgánica. Sexta Edición. Thomson (2004).13. RB Woodward, R Hoffmann. Selection rules for sigmatro picreactions. J. Amer. Chem. Soc., 87, 2511-2513 (1965).14. GB Gill. The application of the Woodward-Hoffman Orbital symmetry rules to concerted organic reactions. Quarterly Reviews Chemical Society, 22, 338-389 (1968).15. WR Rodwell, WJ Bouma, L Radom. Ab inition studies of 1,3- sigmatropic rearrangements: Effect of basis set and electron correlation. Int. J. Quantum Chemistry, 18, 107-116 (1980).16. Jr B A Hess, LJ Schaad, J Pancir. Theoretical Studies of [1,n]- sigmatropic rearrangements involving hydrogen transfer in simple methyl-substituted conjugated polyenes. J. Amer. Chem. Soc., 107, 149-154 (1985).17. LR Domingo, M.J. Aurell, P. Pérez. Understanding the Polar Mechanism of the Ene Reaction. A DFT Study. Org. Biomol. Chem., 12, 7581-7590 (2014)18. LR Domingo. Why Diels-Alder reactions are non-concerted processes. J. Chil. Chem. Soc., 59, 2615-2518 (2014)19. LR Domingo, MJ Aurell, P Pérez. The mechanism of ionic Diels-Alder reactions. A DFT study of the oxa-Povarov reaction. RSC Adv., 4, 16567-16577 (2014).20. D Yepes, JS Murray, P Pérez, LR Domingo, P Politzer, P Jaque. Complementarity of reaction force and electron localization function analyses of asynchronicity in bond formation in DielsAlder reactions. Phys. Chem. Chem. Phys., 16, 6726-6734 (2014).21. LR Domingo. State of the Art of the Bonding Changes along the Diels-Alder Reaction between Butadiene and Ethylene. Refuting the Pericyclic Mechanism. Organic Chemistry: Current Research, 2, 120 (2013).22. A Valkonen, K Laihia, E Kolehmainen, R Kauppinen, P Perjési. Structural studies of seven homoisoflavonoids, six thiohomoisoflavonoids, and four structurally related compounds. Structural Chemistry, 23, 209-217 (2012).23. Gaussian 09W, Revision A.02, Gaussian, Inc., Pittsburgh PA, (2009).24. E Márquez, J Mora, T Cordoba, G Chuchani. Theoretical Study of the Mechanism for the Gas-Phase Pyrolysis Kinetics of 2- Methylbenzyl Chloride. Int. J. Chemical Kinetics, 3, 537-546 (2011).25. E Marquez, T Cordova, G Chuchani. DFT Study of the GasPhase Thermal Decomposition Kinetics of 2-Ethoxypyridine into 2-Pyridone. Int. J. Quantum Chemistry, 112, 724–730 (2012)26. K Fukui. Formulation of the reaction coordinate. J. Physical Chemistry, 74, 4161-4163 (1970).27. JP Foster, F Weinhold. Natural hybrid orbitals. J. Amer. Chem. Soc., 102, 7211-7218 (1980).28. KB Wiberg. 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sigmatrópico [1,3] de la.pdf.jpgEstudio computacional del rearreglo sigmatrópico [1,3] de la.pdf.jpgGenerated Thumbnailimage/jpeg16689https://repositorio.cuc.edu.co/bitstreams/6baeff36-6efb-4595-9b53-830e89cae4de/downloadd70512192c504b16858fac0034a030b0MD5411323/10741oai:repositorio.cuc.edu.co:11323/107412024-09-17 12:47:01.869https://creativecommons.org/licenses/by-nc-sa/4.0/© Copyright 2018 Elsevier B.V., All rights reserved.open.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.


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