New insights on enzyme stabilization for industrial biocatalysis

Due to their versatility and ability to provide tunable chemo-, regio-, and enantio-selectivitites, enzyme-mediated transformations offer an effective and eco-friendly alternative to the traditional multistep chemical synthesis methods, which often require organic solvents, hazardous reagents, and t...

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Autores:
Fernández-Lucas, Jesús
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/9062
Acceso en línea:
https://hdl.handle.net/11323/9062
https://doi.org/10.1021/acssuschemeng.1c06785
https://repositorio.cuc.edu.co/
Palabra clave:
Peptides and proteins
Nanoparticles
Immobilization
Post-translational modification
Stability
Rights
embargoedAccess
License
Copyright © Published 2021 by American Chemical Society
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dc.title.eng.fl_str_mv New insights on enzyme stabilization for industrial biocatalysis
title New insights on enzyme stabilization for industrial biocatalysis
spellingShingle New insights on enzyme stabilization for industrial biocatalysis
Peptides and proteins
Nanoparticles
Immobilization
Post-translational modification
Stability
title_short New insights on enzyme stabilization for industrial biocatalysis
title_full New insights on enzyme stabilization for industrial biocatalysis
title_fullStr New insights on enzyme stabilization for industrial biocatalysis
title_full_unstemmed New insights on enzyme stabilization for industrial biocatalysis
title_sort New insights on enzyme stabilization for industrial biocatalysis
dc.creator.fl_str_mv Fernández-Lucas, Jesús
dc.contributor.author.spa.fl_str_mv Fernández-Lucas, Jesús
dc.subject.proposal.eng.fl_str_mv Peptides and proteins
Nanoparticles
Immobilization
Post-translational modification
Stability
topic Peptides and proteins
Nanoparticles
Immobilization
Post-translational modification
Stability
description Due to their versatility and ability to provide tunable chemo-, regio-, and enantio-selectivitites, enzyme-mediated transformations offer an effective and eco-friendly alternative to the traditional multistep chemical synthesis methods, which often require organic solvents, hazardous reagents, and tedious purification processes. While enzymes provide high catalytic and specific activity at mild conditions, several operational drawbacks hamper the application of enzymes as industrial biocatalysts. These include poor performance when confronting non-natural substrates, inhibition by certain components in the reaction media, short lifetime, lack of reusability, and recovery postreaction. Among these, achieving enzyme stabilization is most challenging from a practical standpoint.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-03-10T19:03:49Z
dc.date.available.none.fl_str_mv 2022
2022-03-10T19:03:49Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.citation.spa.fl_str_mv ACS Sustainable Chem. Eng. 2021, 9, 45, 15073–15074 Publication Date:November 15, 2021 https://doi.org/10.1021/acssuschemeng.1c06785
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/9062
dc.identifier.url.spa.fl_str_mv https://doi.org/10.1021/acssuschemeng.1c06785
dc.identifier.doi.spa.fl_str_mv 10.1021/acssuschemeng.1c06785
dc.identifier.eissn.spa.fl_str_mv 2168-0485
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
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identifier_str_mv ACS Sustainable Chem. Eng. 2021, 9, 45, 15073–15074 Publication Date:November 15, 2021 https://doi.org/10.1021/acssuschemeng.1c06785
10.1021/acssuschemeng.1c06785
2168-0485
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/9062
https://doi.org/10.1021/acssuschemeng.1c06785
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofjournal.spa.fl_str_mv ACS Sustainable Chemistry and Engineering
dc.relation.citationvolume.spa.fl_str_mv 9
dc.rights.spa.fl_str_mv Copyright © Published 2021 by American Chemical Society
Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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dc.publisher.spa.fl_str_mv American Chemical Society
dc.publisher.place.spa.fl_str_mv United States
institution Corporación Universidad de la Costa
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spelling Fernández-Lucas, Jesús2022-03-10T19:03:49Z20222022-03-10T19:03:49Z2021ACS Sustainable Chem. Eng. 2021, 9, 45, 15073–15074 Publication Date:November 15, 2021 https://doi.org/10.1021/acssuschemeng.1c06785https://hdl.handle.net/11323/9062https://doi.org/10.1021/acssuschemeng.1c0678510.1021/acssuschemeng.1c067852168-0485Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Due to their versatility and ability to provide tunable chemo-, regio-, and enantio-selectivitites, enzyme-mediated transformations offer an effective and eco-friendly alternative to the traditional multistep chemical synthesis methods, which often require organic solvents, hazardous reagents, and tedious purification processes. While enzymes provide high catalytic and specific activity at mild conditions, several operational drawbacks hamper the application of enzymes as industrial biocatalysts. These include poor performance when confronting non-natural substrates, inhibition by certain components in the reaction media, short lifetime, lack of reusability, and recovery postreaction. 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