Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry

Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scaring hair loss and preservation of hair follicles. The information available on disease course, and clinical features of AA is scarce worldwide, and almost nonexistent in Colombia. Objective: To determine the clinical...

Full description

Autores:
Pineda, J.C.
Alvis Zakzuk, N.R.
Moyano Támara, L.
Fierro Lozada, J.
Cera Coll, C.
Celorio Murillo, W.
Alvis Zakzuk, N.J.
Zapata Ospina, J.
Ruiz Gómez, J.F.
Zakzuk, J.
Alvis Guzmán, N.
Castillo Molina, D.
Tipo de recurso:
Article of investigation
Fecha de publicación:
2024
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/13437
Acceso en línea:
https://hdl.handle.net/11323/13437
https://repositorio.cuc.edu.co/
Palabra clave:
Alopecia areata
Alopecia
Epidemiology
Autoimmune diseases
Dermatology
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
id RCUC2_3bdecaaa2c1f65c3f376530ae674f3c9
oai_identifier_str oai:repositorio.cuc.edu.co:11323/13437
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.eng.fl_str_mv Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
dc.title.translated.none.fl_str_mv Características clínicas y sociodemográficas de la alopecia areata en cinco ciudades colombianas: un análisis del RENAAC
title Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
spellingShingle Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
Alopecia areata
Alopecia
Epidemiology
Autoimmune diseases
Dermatology
title_short Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
title_full Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
title_fullStr Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
title_full_unstemmed Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
title_sort Clinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC Registry
dc.creator.fl_str_mv Pineda, J.C.
Alvis Zakzuk, N.R.
Moyano Támara, L.
Fierro Lozada, J.
Cera Coll, C.
Celorio Murillo, W.
Alvis Zakzuk, N.J.
Zapata Ospina, J.
Ruiz Gómez, J.F.
Zakzuk, J.
Alvis Guzmán, N.
Castillo Molina, D.
dc.contributor.author.none.fl_str_mv Pineda, J.C.
Alvis Zakzuk, N.R.
Moyano Támara, L.
Fierro Lozada, J.
Cera Coll, C.
Celorio Murillo, W.
Alvis Zakzuk, N.J.
Zapata Ospina, J.
Ruiz Gómez, J.F.
Zakzuk, J.
Alvis Guzmán, N.
Castillo Molina, D.
dc.subject.proposal.eng.fl_str_mv Alopecia areata
Alopecia
Epidemiology
Autoimmune diseases
Dermatology
topic Alopecia areata
Alopecia
Epidemiology
Autoimmune diseases
Dermatology
description Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scaring hair loss and preservation of hair follicles. The information available on disease course, and clinical features of AA is scarce worldwide, and almost nonexistent in Colombia. Objective: To determine the clinical and sociodemographic characteristics of patients diagnosed with AA who presented to a dermatology consultation in five Colombian cities. Material and methods: This was a retrospective and multicenter study on data from an ongoing National Registry of Alopecia Areata in Colombia (RENAAC) collected in Bogota, Cali, Cartagena, Barranquilla, and Medellin, Colombia from March 2022 through April 2023. Data was recorded in a standardized form by trained physicians. The variables were expressed as measures of central tendency and dispersion, and absolute and relative frequencies. Results: A total of 562 patients were included, 59.4% of whom were women, aged between 15 and 49 years (63.9%) with a mean disease course of 1.7 years. The most common finding was multiple plaque (53.2%), the predominant AA subtype was patchy (71.4%), and 29.5% of the patients had a past dermatological history, 18.3% had a past endocrinological history, and 8.9% had a past psychiatric history. The treatments most widely used were steroid injections (76.4%), 5% topical minoxidil (46.4%), followed by high-potency corticosteroids (42.5%). Study limitations and conclusions: AA was slightly predominant in women. As seen in other populations, this disease had an earlier onset in men vs women. Presentation in pediatric age was uncommon. The previous history of other dermatological diseases was checked in almost one third of the patients. Analysis of the co-presentation of AA with other autoimmune diseases is biased due to excluding patients with systemic erythematous lupus from the study.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-10-16T14:15:17Z
dc.date.available.none.fl_str_mv 2024-10-16T14:15:17Z
dc.date.issued.none.fl_str_mv 2024-02-06
dc.type.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.content.none.fl_str_mv Text
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.citation.none.fl_str_mv J.C. Pineda, N.R. Alvis-Zakzuk, L. Moyano-Támara, J. Fierro-Lozada, C. Cera-Coll, W. Celorio-Murillo, N.J. Alvis-Zakzuk, J. Zapata-Ospina, J.F. Ruiz-Gómez, J. Zakzuk, N. Alvis-Guzmán, D. Castillo-Molina, Clinical and Sociodemographic Features of Alopecia Areata in Five Colombian Cities: An Analysis of the RENAAC Registry, Actas Dermo-Sifiliográficas, Volume 115, Issue 9, 2024, Pages 845-851, ISSN 0001-7310, https://doi.org/10.1016/j.ad.2024.02.018.
dc.identifier.issn.none.fl_str_mv 0001-7310
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11323/13437
dc.identifier.doi.none.fl_str_mv 10.1016/j.ad.2024.02.018
dc.identifier.eissn.none.fl_str_mv 1578-2190
dc.identifier.instname.none.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.none.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.none.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv J.C. Pineda, N.R. Alvis-Zakzuk, L. Moyano-Támara, J. Fierro-Lozada, C. Cera-Coll, W. Celorio-Murillo, N.J. Alvis-Zakzuk, J. Zapata-Ospina, J.F. Ruiz-Gómez, J. Zakzuk, N. Alvis-Guzmán, D. Castillo-Molina, Clinical and Sociodemographic Features of Alopecia Areata in Five Colombian Cities: An Analysis of the RENAAC Registry, Actas Dermo-Sifiliográficas, Volume 115, Issue 9, 2024, Pages 845-851, ISSN 0001-7310, https://doi.org/10.1016/j.ad.2024.02.018.
0001-7310
10.1016/j.ad.2024.02.018
1578-2190
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/13437
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofjournal.none.fl_str_mv Actas Dermo-Sifiliográficas
dc.relation.references.none.fl_str_mv Simakou, T., Butcher, J.P., Reid, S., Henriquez, F.L. Alopecia areata: A multifactorial autoimmune condition (2019) Journal of Autoimmunity, 98, pp. 74-85. Cited 168 times. http://www.elsevier.com/inca/publications/store/6/2/2/8/5/6/index.htt doi: 10.1016/j.jaut.2018.12.001
Hordinsky, M.K. Overview of Alopecia Areata (2013) Journal of Investigative Dermatology Symposium Proceedings, 16 (1), pp. S13-S15. Cited 110 times. https://www.journals.elsevier.com/journal-of-investigative-dermatology-symposium-proceedings doi: 10.1038/jidsymp.2013.4
Pratt, C.H., King, L.E., Messenger, A.G., Christiano, A.M., Sundberg, J.P. Alopecia areata (2017) Nature Reviews Disease Primers, 3, art. no. 17011. Cited 455 times. http://www.nature.com/nrdp/ doi: 10.1038/nrdp.2017.11
Mirzoyev, S.A., Schrum, A.G., Davis, M.D.P., Torgerson, R.R. Lifetime incidence risk of alopecia areata estimated at 2.1% by rochester epidemiology project, 1990-2009 (2014) Journal of Investigative Dermatology, 134 (4), pp. 1141-1142. Cited 242 times. http://www.nature.com/jid/index.html doi: 10.1038/jid.2013.464
Velásquez-Lopera, M.M., Hernández, N., Jansen, A.M., García, A.L., Luna, P.C., Rico-Restrepo, M., del Mar Saez-de-Ocariz, M., (...), Rivitti-Machado, M.C. Alopecia Areata in Latin America: Where are We and Where are We Going? (2023) Dermatology and Therapy, 13 (1), pp. 95-114. Cited 3 times. https://www.springer.com/journal/13555 doi: 10.1007/s13555-022-00845-4
Villasante Fricke, A.C., Miteva, M. Epidemiology and burden of alopecia areata: A systematic review (2015) Clinical, Cosmetic and Investigational Dermatology, 8, pp. 397-403. Cited 286 times. http://www.dovepress.com/getfile.php?fileID=26121 doi: 10.2147/CCID.S53985
Abbafati, C., Abbas, K.M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., (...), Murray, C.J.L. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 (2020) The Lancet, 396 (10258), pp. 1204-1222. Cited 9404 times. http://www.journals.elsevier.com/the-lancet/ doi: 10.1016/S0140-6736(20)30925-9
Cifuentes-Tang, L., Uribe-Caputi, J.C. Factores asociados a alopecia no cicatricial en mujeres adultas, estudio transversal entre enero diciembre 2013 (2018) MedUNAB, 21, pp. 59-66.
Castrillon, J.J.C., Urrego, L.Y.M., García, M.C.B., Reyna, F.J.B., Valbuena, S.M.G., Díaz, D.A.P. Estudio sobre la pérdida de cabello y las prácticas de cuidado entre los estudiantes de la Universidad de Manizales, Manizales (Colombia), 2016 (2019) Arch Med Manizales, 19.
Vañó-Galván, S., Saceda-Corralo, D., Blume-Peytavi, U., Cucchía, J., Dlova, N.C., Gavazzoni Dias, M.F.R., Grimalt, R., (...), Miteva, M. Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study (Open Access) (2019) Skin Appendage Disorders, 5 (5), pp. 309-315. Cited 67 times. https://www.karger.com/Journal/Home/261870 doi: 10.1159/000496708
Guerrero, R., Gallego, A.I., Becerril-Montekio, V., Vásquez, J. The health system of Colombia (2011) Salud Publica de Mexico, 53 (SUPPL. 2), pp. S144-S155. Cited 103 times. http://bvs.insp.mx/rsp/_files/File/2011/vol%2053%20suplemento%202/10Colombia.pdf
Guzmán-sánchez, D.A., Villanueva-quintero, G.D., Alfaro Alfaro, N., Mcmichael, A. A clinical study of alopecia areata in Mexico (2007) International Journal of Dermatology, 46 (12), pp. 1308-1310. Cited 25 times. doi: 10.1111/j.1365-4632.2007.03320.x
Lundin, M., Chawa, S., Sachdev, A., Bhanusali, D., Seiffert-Sinha, K., Sinha, A.A. Gender differences in alopecia areata (2014) Journal of Drugs in Dermatology, 13 (4), pp. 409-413. Cited 46 times. http://jddonline.com/getejddpdf/eJDD1304
Kavak, A., Yeşildal, N., Parlak, A.H., Gökdemir, G., Aydoǧan, I., Anul, H., Baykal, C. Alopecia areata in Turkey: Demographic and clinical features (Open Access) (2008) Journal of the European Academy of Dermatology and Venereology, 22 (8), pp. 977-981. Cited 51 times. doi: 10.1111/j.1468-3083.2008.02699.x
Gil-Lacruz, M., Gil-Lacruz, A.I. Health perception and health care access: Sex differences in behaviors and attitudes (2010) American Journal of Economics and Sociology, 69 (2), pp. 783-801. Cited 21 times. doi: 10.1111/j.1536-7150.2010.00723.x
Lyakhovitsky, A., Gilboa, S., Eshkol, A., Barzilai, A., Baum, S. Late-Onset Alopecia Areata: A Retrospective Cohort Study (Open Access) (2018) Dermatology, 233 (4), pp. 289-294. Cited 14 times. www.karger.com/journals/drm/drm_jh.htm doi: 10.1159/000481881
Lee, S., Lee, H., Lee, C.H., Lee, W.-S. Comorbidities in alopecia areata: A systematic review and meta-analysis (Open Access) (2019) Journal of the American Academy of Dermatology, 80 (2), pp. 466-477.e16. Cited 135 times. http://www.elsevier.com/inca/publications/store/6/2/3/3/7/0/index.htt doi: 10.1016/j.jaad.2018.07.013
Tan, E., Tay, Y.-K., Goh, C.-L., Giam, Y.C. The pattern and profile of alopecia areata in Singapore - A study of 219 Asians (Open Access) (2002) International Journal of Dermatology, 41 (11), pp. 748-753. Cited 230 times. doi: 10.1046/j.1365-4362.2002.01357.x
Yang, S., Yang, J., Liu, J.B., Wang, H.Y., Yang, Q., Gao, M., Liang, Y.H., (...), Zhang, X.J. The genetic epidemiology of alopecia areata in China (Open Access) (2004) British Journal of Dermatology, 151 (1), pp. 16-23. Cited 93 times. doi: 10.1111/j.1365-2133.2004.05915.x
Dennis, R.J., Caraballo, L., García, E., Rojas, M.X., Rondon, M.A., Pérez, A., Aristizabal, G., (...), Jimenez, S. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study (2012) BMC Pulmonary Medicine, 12, art. no. 17. Cited 136 times. http://www.biomedcentral.com/1471-2466/12/17 doi: 10.1186/1471-2466-12-17
Holmes, S., Harries, M., Macbeth, A.E., Chiu, W.S., de Lusignan, S., Messenger, A.G., Tziotzios, C. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study (Open Access) (2023) Clinical and Experimental Dermatology, 48 (4), pp. 325-331. Cited 9 times. https://academic.oup.com/ced doi: 10.1093/ced/llac104
Moreno-Arrones, O.M., Serrano-Villar, S., Perez-Brocal, V., Saceda-Corralo, D., Morales-Raya, C., Rodrigues-Barata, R., Moya, A., (...), Vano-Galvan, S. Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers (2020) Journal of the European Academy of Dermatology and Venereology, 34 (2), pp. 400-405. Cited 75 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083 doi: 10.1111/jdv.15885
Alvarado López, D.E., Erazo Hidalgo, E.T., Lucero Tapia, J.L., Álvarez Morquecho, J.M. Alopecia Areata Y Su Relación Con Valores De Tsh (2019) Rev Investig Talent, 6, pp. 111-121.
Dai, Y.-X., Tai, Y.-H., Chang, Y.-T., Chen, T.-J., Chen, M.-H. Bidirectional association between alopecia areata and thyroid diseases: a nationwide population-based cohort study (2021) Archives of Dermatological Research, 313 (5), pp. 339-346. Cited 15 times. link.springer.de/link/service/journals/00403/index.htm doi: 10.1007/s00403-020-02109-7
Kinoshita-Ise, M., Martinez-Cabriales, S.A., Alhusayen, R. Chronological association between alopecia areata and autoimmune thyroid diseases: A systematic review and meta-analysis (2019) Journal of Dermatology, 46 (8), pp. 702-709. Cited 18 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1346-8138 doi: 10.1111/1346-8138.14940
Brajac, I., Tkalčić, M., Dragojević, D.M., Gruber, F. Roles of Stress, Stress Perception and Trait-Anxiety in the Onset and Course of Alopecia Areata (Open Access) (2003) Journal of Dermatology, 30 (12), pp. 871-878. Cited 87 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1346-8138 doi: 10.1111/j.1346-8138.2003.tb00341.x
Toussi, A., Barton, V.R., Le, S.T., Agbai, O.N., Kiuru, M. Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: A systematic review (Open Access) (2021) Journal of the American Academy of Dermatology, 85 (1), pp. 162-175. Cited 84 times. http://www.elsevier.com/inca/publications/store/6/2/3/3/7/0/index.htt doi: 10.1016/j.jaad.2020.06.047
Sterkens, A., Lambert, J., Bervoets, A. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options (Open Access) (2021) Clinical and Experimental Medicine, 21 (2), pp. 215-230. Cited 76 times. link.springer.de/link/service/journals/10238/index.htm doi: 10.1007/s10238-020-00673-w
Phan, K., Sebaratnam, D.F. JAK inhibitors for alopecia areata: a systematic review and meta-analysis (2019) Journal of the European Academy of Dermatology and Venereology, 33 (5), pp. 850-856. Cited 146 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083 doi: 10.1111/jdv.15489
Roest, Y.B.M., Van Middendorp, H., Evers, A.W.M., Van De Kerkhof, P.C.M., Pasch, M.C. Nail involvement in alopecia areata: A questionnaire-based survey on clinical signs, impact on quality of life and review of the literature (Open Access) (2018) Acta Dermato-Venereologica, 98 (2), pp. 212-217. Cited 28 times. https://www.medicaljournals.se/acta/content_files/download.php?doi=10.2340/00015555-2810 doi: 10.2340/00015555-2810
dc.relation.citationendpage.none.fl_str_mv 851
dc.relation.citationstartpage.none.fl_str_mv 845
dc.relation.citationissue.none.fl_str_mv 9
dc.relation.citationvolume.none.fl_str_mv 115
dc.rights.none.fl_str_mv © 2024 AEDV
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
© 2024 AEDV
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.none.fl_str_mv 7 páginas
dc.format.mimetype.none.fl_str_mv application/pdf
dc.coverage.country.none.fl_str_mv Colombia
dc.publisher.none.fl_str_mv Elsevier
dc.publisher.place.none.fl_str_mv Spain
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0001731024001625?via%3Dihub
institution Corporación Universidad de la Costa
bitstream.url.fl_str_mv https://repositorio.cuc.edu.co/bitstreams/1a57f95d-0a3b-40c8-a3f4-2f5c28fdf472/download
https://repositorio.cuc.edu.co/bitstreams/39ff6a87-19e2-48de-924a-c2777076af3e/download
https://repositorio.cuc.edu.co/bitstreams/36b1a026-3ce5-4f11-b0ad-9ed9cc704b76/download
https://repositorio.cuc.edu.co/bitstreams/1db04426-3188-4fd4-afd9-53a93470dcc3/download
bitstream.checksum.fl_str_mv 8a0d954e342a363dc1227412fa33c565
73a5432e0b76442b22b026844140d683
7c5805011c0485f1ccb61419fb3cbd0d
29a7aeef7be37ecd0b045c90555f2dbf
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio de la Universidad de la Costa CUC
repository.mail.fl_str_mv repdigital@cuc.edu.co
_version_ 1828166569361932288
spelling Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2024 AEDVhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Pineda, J.C.Alvis Zakzuk, N.R.Moyano Támara, L.Fierro Lozada, J.Cera Coll, C.Celorio Murillo, W.Alvis Zakzuk, N.J.Zapata Ospina, J.Ruiz Gómez, J.F.Zakzuk, J.Alvis Guzmán, N.Castillo Molina, D.2024-10-16T14:15:17Z2024-10-16T14:15:17Z2024-02-06J.C. Pineda, N.R. Alvis-Zakzuk, L. Moyano-Támara, J. Fierro-Lozada, C. Cera-Coll, W. Celorio-Murillo, N.J. Alvis-Zakzuk, J. Zapata-Ospina, J.F. Ruiz-Gómez, J. Zakzuk, N. Alvis-Guzmán, D. Castillo-Molina, Clinical and Sociodemographic Features of Alopecia Areata in Five Colombian Cities: An Analysis of the RENAAC Registry, Actas Dermo-Sifiliográficas, Volume 115, Issue 9, 2024, Pages 845-851, ISSN 0001-7310, https://doi.org/10.1016/j.ad.2024.02.018.0001-7310https://hdl.handle.net/11323/1343710.1016/j.ad.2024.02.0181578-2190Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scaring hair loss and preservation of hair follicles. The information available on disease course, and clinical features of AA is scarce worldwide, and almost nonexistent in Colombia. Objective: To determine the clinical and sociodemographic characteristics of patients diagnosed with AA who presented to a dermatology consultation in five Colombian cities. Material and methods: This was a retrospective and multicenter study on data from an ongoing National Registry of Alopecia Areata in Colombia (RENAAC) collected in Bogota, Cali, Cartagena, Barranquilla, and Medellin, Colombia from March 2022 through April 2023. Data was recorded in a standardized form by trained physicians. The variables were expressed as measures of central tendency and dispersion, and absolute and relative frequencies. Results: A total of 562 patients were included, 59.4% of whom were women, aged between 15 and 49 years (63.9%) with a mean disease course of 1.7 years. The most common finding was multiple plaque (53.2%), the predominant AA subtype was patchy (71.4%), and 29.5% of the patients had a past dermatological history, 18.3% had a past endocrinological history, and 8.9% had a past psychiatric history. The treatments most widely used were steroid injections (76.4%), 5% topical minoxidil (46.4%), followed by high-potency corticosteroids (42.5%). Study limitations and conclusions: AA was slightly predominant in women. As seen in other populations, this disease had an earlier onset in men vs women. Presentation in pediatric age was uncommon. The previous history of other dermatological diseases was checked in almost one third of the patients. Analysis of the co-presentation of AA with other autoimmune diseases is biased due to excluding patients with systemic erythematous lupus from the study.7 páginasapplication/pdfengElsevierSpainhttps://www.sciencedirect.com/science/article/pii/S0001731024001625?via%3DihubClinical and sociodemographic features of alopecia areata in five colombian cities: an analysis of the RENAAC RegistryCaracterísticas clínicas y sociodemográficas de la alopecia areata en cinco ciudades colombianas: un análisis del RENAACArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85ColombiaActas Dermo-SifiliográficasSimakou, T., Butcher, J.P., Reid, S., Henriquez, F.L. Alopecia areata: A multifactorial autoimmune condition (2019) Journal of Autoimmunity, 98, pp. 74-85. Cited 168 times. http://www.elsevier.com/inca/publications/store/6/2/2/8/5/6/index.htt doi: 10.1016/j.jaut.2018.12.001Hordinsky, M.K. Overview of Alopecia Areata (2013) Journal of Investigative Dermatology Symposium Proceedings, 16 (1), pp. S13-S15. Cited 110 times. https://www.journals.elsevier.com/journal-of-investigative-dermatology-symposium-proceedings doi: 10.1038/jidsymp.2013.4Pratt, C.H., King, L.E., Messenger, A.G., Christiano, A.M., Sundberg, J.P. Alopecia areata (2017) Nature Reviews Disease Primers, 3, art. no. 17011. Cited 455 times. http://www.nature.com/nrdp/ doi: 10.1038/nrdp.2017.11Mirzoyev, S.A., Schrum, A.G., Davis, M.D.P., Torgerson, R.R. Lifetime incidence risk of alopecia areata estimated at 2.1% by rochester epidemiology project, 1990-2009 (2014) Journal of Investigative Dermatology, 134 (4), pp. 1141-1142. Cited 242 times. http://www.nature.com/jid/index.html doi: 10.1038/jid.2013.464Velásquez-Lopera, M.M., Hernández, N., Jansen, A.M., García, A.L., Luna, P.C., Rico-Restrepo, M., del Mar Saez-de-Ocariz, M., (...), Rivitti-Machado, M.C. Alopecia Areata in Latin America: Where are We and Where are We Going? (2023) Dermatology and Therapy, 13 (1), pp. 95-114. Cited 3 times. https://www.springer.com/journal/13555 doi: 10.1007/s13555-022-00845-4Villasante Fricke, A.C., Miteva, M. Epidemiology and burden of alopecia areata: A systematic review (2015) Clinical, Cosmetic and Investigational Dermatology, 8, pp. 397-403. Cited 286 times. http://www.dovepress.com/getfile.php?fileID=26121 doi: 10.2147/CCID.S53985Abbafati, C., Abbas, K.M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., (...), Murray, C.J.L. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 (2020) The Lancet, 396 (10258), pp. 1204-1222. Cited 9404 times. http://www.journals.elsevier.com/the-lancet/ doi: 10.1016/S0140-6736(20)30925-9Cifuentes-Tang, L., Uribe-Caputi, J.C. Factores asociados a alopecia no cicatricial en mujeres adultas, estudio transversal entre enero diciembre 2013 (2018) MedUNAB, 21, pp. 59-66.Castrillon, J.J.C., Urrego, L.Y.M., García, M.C.B., Reyna, F.J.B., Valbuena, S.M.G., Díaz, D.A.P. Estudio sobre la pérdida de cabello y las prácticas de cuidado entre los estudiantes de la Universidad de Manizales, Manizales (Colombia), 2016 (2019) Arch Med Manizales, 19.Vañó-Galván, S., Saceda-Corralo, D., Blume-Peytavi, U., Cucchía, J., Dlova, N.C., Gavazzoni Dias, M.F.R., Grimalt, R., (...), Miteva, M. Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study (Open Access) (2019) Skin Appendage Disorders, 5 (5), pp. 309-315. Cited 67 times. https://www.karger.com/Journal/Home/261870 doi: 10.1159/000496708Guerrero, R., Gallego, A.I., Becerril-Montekio, V., Vásquez, J. The health system of Colombia (2011) Salud Publica de Mexico, 53 (SUPPL. 2), pp. S144-S155. Cited 103 times. http://bvs.insp.mx/rsp/_files/File/2011/vol%2053%20suplemento%202/10Colombia.pdfGuzmán-sánchez, D.A., Villanueva-quintero, G.D., Alfaro Alfaro, N., Mcmichael, A. A clinical study of alopecia areata in Mexico (2007) International Journal of Dermatology, 46 (12), pp. 1308-1310. Cited 25 times. doi: 10.1111/j.1365-4632.2007.03320.xLundin, M., Chawa, S., Sachdev, A., Bhanusali, D., Seiffert-Sinha, K., Sinha, A.A. Gender differences in alopecia areata (2014) Journal of Drugs in Dermatology, 13 (4), pp. 409-413. Cited 46 times. http://jddonline.com/getejddpdf/eJDD1304Kavak, A., Yeşildal, N., Parlak, A.H., Gökdemir, G., Aydoǧan, I., Anul, H., Baykal, C. Alopecia areata in Turkey: Demographic and clinical features (Open Access) (2008) Journal of the European Academy of Dermatology and Venereology, 22 (8), pp. 977-981. Cited 51 times. doi: 10.1111/j.1468-3083.2008.02699.xGil-Lacruz, M., Gil-Lacruz, A.I. Health perception and health care access: Sex differences in behaviors and attitudes (2010) American Journal of Economics and Sociology, 69 (2), pp. 783-801. Cited 21 times. doi: 10.1111/j.1536-7150.2010.00723.xLyakhovitsky, A., Gilboa, S., Eshkol, A., Barzilai, A., Baum, S. Late-Onset Alopecia Areata: A Retrospective Cohort Study (Open Access) (2018) Dermatology, 233 (4), pp. 289-294. Cited 14 times. www.karger.com/journals/drm/drm_jh.htm doi: 10.1159/000481881Lee, S., Lee, H., Lee, C.H., Lee, W.-S. Comorbidities in alopecia areata: A systematic review and meta-analysis (Open Access) (2019) Journal of the American Academy of Dermatology, 80 (2), pp. 466-477.e16. Cited 135 times. http://www.elsevier.com/inca/publications/store/6/2/3/3/7/0/index.htt doi: 10.1016/j.jaad.2018.07.013Tan, E., Tay, Y.-K., Goh, C.-L., Giam, Y.C. The pattern and profile of alopecia areata in Singapore - A study of 219 Asians (Open Access) (2002) International Journal of Dermatology, 41 (11), pp. 748-753. Cited 230 times. doi: 10.1046/j.1365-4362.2002.01357.xYang, S., Yang, J., Liu, J.B., Wang, H.Y., Yang, Q., Gao, M., Liang, Y.H., (...), Zhang, X.J. The genetic epidemiology of alopecia areata in China (Open Access) (2004) British Journal of Dermatology, 151 (1), pp. 16-23. Cited 93 times. doi: 10.1111/j.1365-2133.2004.05915.xDennis, R.J., Caraballo, L., García, E., Rojas, M.X., Rondon, M.A., Pérez, A., Aristizabal, G., (...), Jimenez, S. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study (2012) BMC Pulmonary Medicine, 12, art. no. 17. Cited 136 times. http://www.biomedcentral.com/1471-2466/12/17 doi: 10.1186/1471-2466-12-17Holmes, S., Harries, M., Macbeth, A.E., Chiu, W.S., de Lusignan, S., Messenger, A.G., Tziotzios, C. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study (Open Access) (2023) Clinical and Experimental Dermatology, 48 (4), pp. 325-331. Cited 9 times. https://academic.oup.com/ced doi: 10.1093/ced/llac104Moreno-Arrones, O.M., Serrano-Villar, S., Perez-Brocal, V., Saceda-Corralo, D., Morales-Raya, C., Rodrigues-Barata, R., Moya, A., (...), Vano-Galvan, S. Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers (2020) Journal of the European Academy of Dermatology and Venereology, 34 (2), pp. 400-405. Cited 75 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083 doi: 10.1111/jdv.15885Alvarado López, D.E., Erazo Hidalgo, E.T., Lucero Tapia, J.L., Álvarez Morquecho, J.M. Alopecia Areata Y Su Relación Con Valores De Tsh (2019) Rev Investig Talent, 6, pp. 111-121.Dai, Y.-X., Tai, Y.-H., Chang, Y.-T., Chen, T.-J., Chen, M.-H. Bidirectional association between alopecia areata and thyroid diseases: a nationwide population-based cohort study (2021) Archives of Dermatological Research, 313 (5), pp. 339-346. Cited 15 times. link.springer.de/link/service/journals/00403/index.htm doi: 10.1007/s00403-020-02109-7Kinoshita-Ise, M., Martinez-Cabriales, S.A., Alhusayen, R. Chronological association between alopecia areata and autoimmune thyroid diseases: A systematic review and meta-analysis (2019) Journal of Dermatology, 46 (8), pp. 702-709. Cited 18 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1346-8138 doi: 10.1111/1346-8138.14940Brajac, I., Tkalčić, M., Dragojević, D.M., Gruber, F. Roles of Stress, Stress Perception and Trait-Anxiety in the Onset and Course of Alopecia Areata (Open Access) (2003) Journal of Dermatology, 30 (12), pp. 871-878. Cited 87 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1346-8138 doi: 10.1111/j.1346-8138.2003.tb00341.xToussi, A., Barton, V.R., Le, S.T., Agbai, O.N., Kiuru, M. Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: A systematic review (Open Access) (2021) Journal of the American Academy of Dermatology, 85 (1), pp. 162-175. Cited 84 times. http://www.elsevier.com/inca/publications/store/6/2/3/3/7/0/index.htt doi: 10.1016/j.jaad.2020.06.047Sterkens, A., Lambert, J., Bervoets, A. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options (Open Access) (2021) Clinical and Experimental Medicine, 21 (2), pp. 215-230. Cited 76 times. link.springer.de/link/service/journals/10238/index.htm doi: 10.1007/s10238-020-00673-wPhan, K., Sebaratnam, D.F. JAK inhibitors for alopecia areata: a systematic review and meta-analysis (2019) Journal of the European Academy of Dermatology and Venereology, 33 (5), pp. 850-856. Cited 146 times. http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083 doi: 10.1111/jdv.15489Roest, Y.B.M., Van Middendorp, H., Evers, A.W.M., Van De Kerkhof, P.C.M., Pasch, M.C. Nail involvement in alopecia areata: A questionnaire-based survey on clinical signs, impact on quality of life and review of the literature (Open Access) (2018) Acta Dermato-Venereologica, 98 (2), pp. 212-217. Cited 28 times. https://www.medicaljournals.se/acta/content_files/download.php?doi=10.2340/00015555-2810 doi: 10.2340/00015555-28108518459115Alopecia areataAlopeciaEpidemiologyAutoimmune diseasesDermatologyPublicationORIGINALClinical and Sociodemographic Features of Alopecia.pdfClinical and Sociodemographic Features of Alopecia.pdfapplication/pdf777531https://repositorio.cuc.edu.co/bitstreams/1a57f95d-0a3b-40c8-a3f4-2f5c28fdf472/download8a0d954e342a363dc1227412fa33c565MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.cuc.edu.co/bitstreams/39ff6a87-19e2-48de-924a-c2777076af3e/download73a5432e0b76442b22b026844140d683MD52TEXTClinical and Sociodemographic Features of Alopecia.pdf.txtClinical and Sociodemographic Features of Alopecia.pdf.txtExtracted texttext/plain94237https://repositorio.cuc.edu.co/bitstreams/36b1a026-3ce5-4f11-b0ad-9ed9cc704b76/download7c5805011c0485f1ccb61419fb3cbd0dMD53THUMBNAILClinical and Sociodemographic Features of Alopecia.pdf.jpgClinical and Sociodemographic Features of Alopecia.pdf.jpgGenerated Thumbnailimage/jpeg15583https://repositorio.cuc.edu.co/bitstreams/1db04426-3188-4fd4-afd9-53a93470dcc3/download29a7aeef7be37ecd0b045c90555f2dbfMD5411323/13437oai:repositorio.cuc.edu.co:11323/134372024-10-17 03:00:28.863https://creativecommons.org/licenses/by-nc-nd/4.0/© 2024 AEDVopen.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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