Chronic acrolein exposure in wistar rats: the effects of guarana extracts

Previous studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts...

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Autores:
da Silva Bittencourt, Leonardo
Schnorr, Carlos Eduardo
Copetti Santos, Daniela
Rostirolla, Diana Carolina
Moresco, Karla
Ozório, Pedro
Rodrigues Mingori, Moara
Heinfarth, Luana
Gelain, Daniel
Moreira, José Cláudio Fonseca
Tipo de recurso:
Article of journal
Fecha de publicación:
2019
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
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oai:repositorio.cuc.edu.co:11323/7200
Acceso en línea:
https://hdl.handle.net/11323/7200
https://doi.org/10.1016/j.jff.2019.103733
https://repositorio.cuc.edu.co/
Palabra clave:
2-Propenal
Oxidative stress
Guarana
Polyphenols
Cognitive impairment
Neurogenerative diseases
Estrés oxidativo
Guaraná
Polifenoles
Deterioro cognitivo
Enfermedades neurogenerativas
Rights
openAccess
License
CC0 1.0 Universal
id RCUC2_349bf54295188b68c0da19b5222f5256
oai_identifier_str oai:repositorio.cuc.edu.co:11323/7200
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Chronic acrolein exposure in wistar rats: the effects of guarana extracts
dc.title.translated.spa.fl_str_mv Exposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaraná
title Chronic acrolein exposure in wistar rats: the effects of guarana extracts
spellingShingle Chronic acrolein exposure in wistar rats: the effects of guarana extracts
2-Propenal
Oxidative stress
Guarana
Polyphenols
Cognitive impairment
Neurogenerative diseases
Estrés oxidativo
Guaraná
Polifenoles
Deterioro cognitivo
Enfermedades neurogenerativas
title_short Chronic acrolein exposure in wistar rats: the effects of guarana extracts
title_full Chronic acrolein exposure in wistar rats: the effects of guarana extracts
title_fullStr Chronic acrolein exposure in wistar rats: the effects of guarana extracts
title_full_unstemmed Chronic acrolein exposure in wistar rats: the effects of guarana extracts
title_sort Chronic acrolein exposure in wistar rats: the effects of guarana extracts
dc.creator.fl_str_mv da Silva Bittencourt, Leonardo
Schnorr, Carlos Eduardo
Copetti Santos, Daniela
Rostirolla, Diana Carolina
Moresco, Karla
Ozório, Pedro
Rodrigues Mingori, Moara
Heinfarth, Luana
Gelain, Daniel
Moreira, José Cláudio Fonseca
dc.contributor.author.spa.fl_str_mv da Silva Bittencourt, Leonardo
Schnorr, Carlos Eduardo
Copetti Santos, Daniela
Rostirolla, Diana Carolina
Moresco, Karla
Ozório, Pedro
Rodrigues Mingori, Moara
Heinfarth, Luana
Gelain, Daniel
Moreira, José Cláudio Fonseca
dc.subject.spa.fl_str_mv 2-Propenal
Oxidative stress
Guarana
Polyphenols
Cognitive impairment
Neurogenerative diseases
Estrés oxidativo
Guaraná
Polifenoles
Deterioro cognitivo
Enfermedades neurogenerativas
topic 2-Propenal
Oxidative stress
Guarana
Polyphenols
Cognitive impairment
Neurogenerative diseases
Estrés oxidativo
Guaraná
Polifenoles
Deterioro cognitivo
Enfermedades neurogenerativas
description Previous studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this field.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019-12-04
dc.date.accessioned.none.fl_str_mv 2020-11-04T14:47:23Z
dc.date.available.none.fl_str_mv 2020-11-04T14:47:23Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
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dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.spa.fl_str_mv 17564646
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/7200
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.jff.2019.103733
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv 17564646
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/7200
https://doi.org/10.1016/j.jff.2019.103733
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
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spelling da Silva Bittencourt, LeonardoSchnorr, Carlos EduardoCopetti Santos, DanielaRostirolla, Diana CarolinaMoresco, KarlaOzório, PedroRodrigues Mingori, MoaraHeinfarth, LuanaGelain, DanielMoreira, José Cláudio Fonseca2020-11-04T14:47:23Z2020-11-04T14:47:23Z2019-12-0417564646https://hdl.handle.net/11323/7200https://doi.org/10.1016/j.jff.2019.103733Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Previous studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this field.Estudios anteriores han informado que la acroleína puede ejercer efectos nocivos en el cerebro. Sin embargo, no se dispone de información sobre las propiedades neuroprotectoras del guaraná contra la acroleína. Debido a la falta de investigación, iniciamos el estudio actual para investigar los efectos de los extractos de guaraná sobre la toxicidad inducida por acroleína en el hígado y el sistema nervioso central de las ratas Wistar. Doce grupos de ratas Wistar de 60 días de edad tratadas con extractos de guaraná (150, 250 y 350 mg / kg / día) durante 8 semanas, fueron desafiados con acroleína (2.5 mg / kg / día). Se evaluaron varios parámetros asociados con el daño oxidativo del cerebro y la función hepática, así como el comportamiento. Todas las concentraciones probadas de extractos de guaraná ejercieron efectos protectores contra el daño inducido por acroleína. No se observaron daños hepáticos y oxidativos o cambios de comportamiento en los grupos de control de guaraná. Hasta donde sabemos, este es el primer estudio de este tipo y, por lo tanto, un hito en este campo.da Silva Bittencourt, LeonardoSchnorr, Carlos Eduardo-will be generated-orcid-0000-0002-2047-2107-600Copetti Santos, Daniela-will be generated-orcid-0000-0001-6032-5729-600Rostirolla, Diana CarolinaMoresco, Karla-will be generated-orcid-0000-0002-0892-2830-600Ozório, PedroRodrigues Mingori, MoaraHeinfarth, LuanaGelain, Daniel-will be generated-orcid-0000-0001-5254-0509-600Moreira, José Cláudio Fonseca-will be generated-orcid-0000-0002-0619-4913-600application/pdfengCorporación Universidad de la CostaCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Journal of Functional Foodshttps://www.sciencedirect.com/science/article/pii/S1756464619306577?via%3Dihub2-PropenalOxidative stressGuaranaPolyphenolsCognitive impairmentNeurogenerative diseasesEstrés oxidativoGuaranáPolifenolesDeterioro cognitivoEnfermedades neurogenerativasChronic acrolein exposure in wistar rats: the effects of guarana extractsExposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaranáArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionAkbar, M., Essa, M. 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Urology, 38, 413–416. https://doi.org/10. 1016/j.carbpol.2018.05.006.PublicationORIGINALChronic acrolein exposure in Wistar rats The effects of guarana extracts.pdfChronic acrolein exposure in Wistar rats The effects of guarana extracts.pdfapplication/pdf2092303https://repositorio.cuc.edu.co/bitstreams/c4cf12f8-db20-470f-ad84-e4ba7d2db6fa/download306385e718a080181b1db646553352a0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8701https://repositorio.cuc.edu.co/bitstreams/c0409cce-0e6e-4c7a-b1ba-8fe9bd83a55c/download42fd4ad1e89814f5e4a476b409eb708cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83196https://repositorio.cuc.edu.co/bitstreams/77f5f40c-d06e-4434-8a23-f172571eb1d2/downloade30e9215131d99561d40d6b0abbe9badMD53THUMBNAILChronic acrolein exposure in Wistar rats The effects of guarana extracts.pdf.jpgChronic acrolein exposure in Wistar rats The effects of guarana 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