What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?

Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily characterized by changes in behavior, personality, and language, with disinhibition being one of its core symptoms. However, because there is no single definition that captures the totality of behavioral symptom...

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Autores:
Magrath Guimet, Nahuel
Miller, Bruce L
Allegri, Ricardo F
Rankin, Katherine P
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
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oai:repositorio.cuc.edu.co:11323/8553
Acceso en línea:
https://hdl.handle.net/11323/8553
https://repositorio.cuc.edu.co/
Palabra clave:
disinhibition
semantic variant primary progressive aphasia
brain networks
semantic cognition
frontotemporal dementia
behavioral variant frontotemporal dementia
behavioral disinhibition
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openAccess
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CC0 1.0 Universal
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repository_id_str
dc.title.spa.fl_str_mv What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
title What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
spellingShingle What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
disinhibition
semantic variant primary progressive aphasia
brain networks
semantic cognition
frontotemporal dementia
behavioral variant frontotemporal dementia
behavioral disinhibition
title_short What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
title_full What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
title_fullStr What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
title_full_unstemmed What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
title_sort What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
dc.creator.fl_str_mv Magrath Guimet, Nahuel
Miller, Bruce L
Allegri, Ricardo F
Rankin, Katherine P
dc.contributor.author.spa.fl_str_mv Magrath Guimet, Nahuel
Miller, Bruce L
Allegri, Ricardo F
Rankin, Katherine P
dc.subject.spa.fl_str_mv disinhibition
semantic variant primary progressive aphasia
brain networks
semantic cognition
frontotemporal dementia
behavioral variant frontotemporal dementia
behavioral disinhibition
topic disinhibition
semantic variant primary progressive aphasia
brain networks
semantic cognition
frontotemporal dementia
behavioral variant frontotemporal dementia
behavioral disinhibition
description Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily characterized by changes in behavior, personality, and language, with disinhibition being one of its core symptoms. However, because there is no single definition that captures the totality of behavioral symptoms observed in these patients, disinhibition is an umbrella term used to encompass socially disruptive or morally unacceptable behaviors that may arise from distinct neural etiologies. This paper aims to review the current knowledge about behavioral disinhibition in this syndrome, considering the cultural factors related to our perception of behavior, the importance of phenomenological interpretation, neuroanatomy, the brain networks involved and, finally, a new neuroscientific theory that offers a conceptual framework for understanding the diverse components of behavioral disinhibition in this neurodegenerative disorder.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-08-19T15:09:31Z
dc.date.available.none.fl_str_mv 2021-08-19T15:09:31Z
dc.date.issued.none.fl_str_mv 2021-07-07
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
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dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.spa.fl_str_mv 1664-2295
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/8553
dc.identifier.doi.spa.fl_str_mv 10.3389/fneur.2021.707799
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv 1664-2295
10.3389/fneur.2021.707799
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
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dc.language.iso.none.fl_str_mv eng
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dc.relation.references.spa.fl_str_mv 1. Zamboni G, Huey ED, Krueger F, Nichelli PF, Grafman J. Apathyand disinhibition in frontotemporal dementia: insights into their neuralcorrelates.Neurology. (2008) 71:736–42. doi: 10.1212/01.wnl.0000324920.96835.95
2. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH,Neuhaus J, et al. Sensitivity of revised diagnostic criteria forthebehavioural variant of frontotemporal dementia.Brain. (2011)134:2456–77. doi: 10.1093/brain/awr179
3. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, SeeleyWW, et al. Distinct subtypes of behavioral variant frontotemporaldementia based on patterns of network degeneration.JAMA Neurol. (2016)73:1078. doi: 10.1001/jamaneurol.2016.2016
4. Ber IL, Guedj E, Gabelle A, Verpillat P, Volteau M, Thomas-Anterion C,et al. Demographic, neurological and behavioural characteristics and brainperfusion SPECT in frontal variant of frontotemporal dementia.Brain. (2006)129:3051–65. doi: 10.1093/brain/awl288
5. Duara R, Barker W, Luis CA. Frontotemporal dementia and Alzheimer’sdisease: differential diagnosis.Dement Geriatr Cogn Disord. (1999) 10:37–42. doi: 10.1159/000051210
6. Pose M, Cetkovich M, Gleichgerrcht E, Ibáñez A, Torralva T, Manes F. Theoverlap of symptomatic dimensions between frontotemporal dementia andseveral psychiatric disorders that appear in late adulthood.Int Rev Psychiatry.(2013) 25:159–67. doi: 10.3109/09540261.2013.769939
7. Mariano LI, O’Callaghan C, Guimarães HC, Gambogi LB, da SilvaTBL, Yassuda MS, et al. Disinhibition in frontotemporal dementia andAlzheimer’s disease: a neuropsychological and behavioural investigation.J IntNeuropsychol Soc. (2020) 26:163–71. doi: 10.1017/S1355617719000973
8. Galimberti D, Dell’Osso B, Altamura AC, Scarpini E. Psychiatricsymptoms in frontotemporal dementia: epidemiology, phenotypes,and differential diagnosis.Biol Psychiatry. (2015) 78:684–92. doi: 10.1016/j.biopsych.2015.03.028
9. Reus LM, Vijverberg EGB, Tijms BM, ten Kate M, Gossink F, KrudopWA, et al. Disease trajectories in behavioural variant frontotemporaldementia, primary psychiatric and other neurodegenerative disorderspresenting with behavioural change.J Psychiatr Res. (2018) 104:183–91. doi: 10.1016/j.jpsychires.2018.07.014
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27. Lansdall CJ, Coyle-Gilchrist ITS, Jones PS, Vázquez RodríguezP, Wilcox A, Wehmann E, et al. Apathy and impulsivity infrontotemporal lobar degeneration syndromes.Brain. (2017)140:1792–807. doi: 10.1093/brain/awx101
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54. Ralph MAL, Jefferies E, Patterson K, Rogers TT. The neural andcomputational bases of semantic cognition.Nat Rev Neurosci. (2017) 18:42–55. doi: 10.1038/nrn.2016.150
55. Binney RJ, Ramsey R. Social semantics: the role of conceptual knowledgeand cognitive control in a neurobiological model of the social brain. NeurosciBiobehav Rev. (2020) 112:28–38. doi: 10.1016/j.neubiorev.2020.01.030
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57. Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, et al.Behavioral features in semantic dementia vs. other forms of progressiveaphasias.Neurology. (2006) 67:1752–6. doi: 10.1212/01.wnl.0000247630.29222.34
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spelling Magrath Guimet, NahuelMiller, Bruce LAllegri, Ricardo FRankin, Katherine P2021-08-19T15:09:31Z2021-08-19T15:09:31Z2021-07-071664-2295https://hdl.handle.net/11323/855310.3389/fneur.2021.707799Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily characterized by changes in behavior, personality, and language, with disinhibition being one of its core symptoms. However, because there is no single definition that captures the totality of behavioral symptoms observed in these patients, disinhibition is an umbrella term used to encompass socially disruptive or morally unacceptable behaviors that may arise from distinct neural etiologies. This paper aims to review the current knowledge about behavioral disinhibition in this syndrome, considering the cultural factors related to our perception of behavior, the importance of phenomenological interpretation, neuroanatomy, the brain networks involved and, finally, a new neuroscientific theory that offers a conceptual framework for understanding the diverse components of behavioral disinhibition in this neurodegenerative disorder.Magrath Guimet, NahuelMiller, Bruce LAllegri, Ricardo FRankin, Katherine Papplication/pdfengFRONTIERS IN NEUROLOGYCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2disinhibitionsemantic variant primary progressive aphasiabrain networkssemantic cognitionfrontotemporal dementiabehavioral variant frontotemporal dementiabehavioral disinhibitionWhat Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionhttps://ezproxy.cuc.edu.co:2080/wos/woscc/full-record/WOS:000674727600001https://www.frontiersin.org/articles/10.3389/fneur.2021.707799/full1. Zamboni G, Huey ED, Krueger F, Nichelli PF, Grafman J. Apathyand disinhibition in frontotemporal dementia: insights into their neuralcorrelates.Neurology. (2008) 71:736–42. doi: 10.1212/01.wnl.0000324920.96835.952. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH,Neuhaus J, et al. Sensitivity of revised diagnostic criteria forthebehavioural variant of frontotemporal dementia.Brain. (2011)134:2456–77. doi: 10.1093/brain/awr1793. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, SeeleyWW, et al. Distinct subtypes of behavioral variant frontotemporaldementia based on patterns of network degeneration.JAMA Neurol. (2016)73:1078. doi: 10.1001/jamaneurol.2016.20164. Ber IL, Guedj E, Gabelle A, Verpillat P, Volteau M, Thomas-Anterion C,et al. Demographic, neurological and behavioural characteristics and brainperfusion SPECT in frontal variant of frontotemporal dementia.Brain. (2006)129:3051–65. doi: 10.1093/brain/awl2885. Duara R, Barker W, Luis CA. Frontotemporal dementia and Alzheimer’sdisease: differential diagnosis.Dement Geriatr Cogn Disord. (1999) 10:37–42. doi: 10.1159/0000512106. Pose M, Cetkovich M, Gleichgerrcht E, Ibáñez A, Torralva T, Manes F. Theoverlap of symptomatic dimensions between frontotemporal dementia andseveral psychiatric disorders that appear in late adulthood.Int Rev Psychiatry.(2013) 25:159–67. doi: 10.3109/09540261.2013.7699397. Mariano LI, O’Callaghan C, Guimarães HC, Gambogi LB, da SilvaTBL, Yassuda MS, et al. Disinhibition in frontotemporal dementia andAlzheimer’s disease: a neuropsychological and behavioural investigation.J IntNeuropsychol Soc. (2020) 26:163–71. doi: 10.1017/S13556177190009738. Galimberti D, Dell’Osso B, Altamura AC, Scarpini E. Psychiatricsymptoms in frontotemporal dementia: epidemiology, phenotypes,and differential diagnosis.Biol Psychiatry. (2015) 78:684–92. doi: 10.1016/j.biopsych.2015.03.0289. Reus LM, Vijverberg EGB, Tijms BM, ten Kate M, Gossink F, KrudopWA, et al. 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(2010) 293:35–8. doi: 10.1016/j.jns.2010.03.012PublicationORIGINALWhat do we mean by behavioral disinhibition in frontotemporal.pdfWhat do we mean by behavioral disinhibition in frontotemporal.pdfapplication/pdf4844899https://repositorio.cuc.edu.co/bitstreams/49823705-a6eb-40e0-87e6-3f7e384f548c/download23c2b15ea31d79401f8527fab1c89a6cMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8701https://repositorio.cuc.edu.co/bitstreams/d7f5a87e-d764-4dc4-8325-f055fe02051b/download42fd4ad1e89814f5e4a476b409eb708cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83196https://repositorio.cuc.edu.co/bitstreams/adcce951-4b4a-4189-be1d-edcb64033915/downloade30e9215131d99561d40d6b0abbe9badMD53THUMBNAILWhat do we mean by behavioral disinhibition in frontotemporal.pdf.jpgWhat do we mean by behavioral disinhibition in 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