Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado
Los nuevos procedimientos quirúrgicos han beneficiado a los pacientes con Gliomas de Bajo Grado (GBG), quienes tienen una mayor esperanza de vida. Por este motivo existe un creciente interés en proteger la cognición y mejorar su calidad de vida. Los objetivos del estudio fueron: (1) Construir y admi...
- Autores:
-
Keller, Greta
Carello, María Agostina
Banjsak, Vanina
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/9960
- Acceso en línea:
- https://hdl.handle.net/11323/9960
https://repositorio.cuc.edu.co/
- Palabra clave:
- Lesión
Tumor
Glioma
Neuropsicología
Evaluación
Lesion
Neuropsychology
Evaluation
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
| id |
RCUC2_2a5231aee01612cba1e2e22d0e0ab878 |
|---|---|
| oai_identifier_str |
oai:repositorio.cuc.edu.co:11323/9960 |
| network_acronym_str |
RCUC2 |
| network_name_str |
REDICUC - Repositorio CUC |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| dc.title.translated.none.fl_str_mv |
Fleni coglioma: battery for the detection of cognitive compromise in patients with low grade Glioma |
| title |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| spellingShingle |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado Lesión Tumor Glioma Neuropsicología Evaluación Lesion Neuropsychology Evaluation |
| title_short |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| title_full |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| title_fullStr |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| title_full_unstemmed |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| title_sort |
Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado |
| dc.creator.fl_str_mv |
Keller, Greta Carello, María Agostina Banjsak, Vanina |
| dc.contributor.author.none.fl_str_mv |
Keller, Greta Carello, María Agostina Banjsak, Vanina |
| dc.subject.proposal.spa.fl_str_mv |
Lesión Tumor Glioma Neuropsicología Evaluación |
| topic |
Lesión Tumor Glioma Neuropsicología Evaluación Lesion Neuropsychology Evaluation |
| dc.subject.proposal.eng.fl_str_mv |
Lesion Neuropsychology Evaluation |
| description |
Los nuevos procedimientos quirúrgicos han beneficiado a los pacientes con Gliomas de Bajo Grado (GBG), quienes tienen una mayor esperanza de vida. Por este motivo existe un creciente interés en proteger la cognición y mejorar su calidad de vida. Los objetivos del estudio fueron: (1) Construir y administrar una batería neuropsicológica que permita examinar el perfil cognitivo prequirúrgico en pacientes con GBG y determinar los efectos posquirúrgicos. (2) Diseñar una intervención intraquirúrgica para pacientes con lesiones en el hemisferio izquierdo a fin de minimizar posibles déficits posteriores. Se evaluaron 19 pacientes con una batería prequirúrgica que evalúa los distintos dominios cognitivos: memoria, lenguaje, atención, funciones ejecutivas, habilidades visuoespaciales, cognición social, praxias y gnosias. Asimismo, los pacientes completaron cuestionarios neuropsiquiátricos con el fin de valorar funcionalidad, estado anímico y calidad de vida. Los pacientes presentaron déficit en múltiples dominios cognitivos en la evaluación prequirúrgica, al comparar su rendimiento con valores normativos ajustados por edad, sexo y educación. Los resultados del presente estudio demuestran la importancia de la administración de la batería neuropsicológica específicamente diseñada para pacientes con GBG y la evaluación de los dominios cognitivos para lograr la detección y el seguimiento de posibles trastornos cognitivos. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-15T22:08:27Z |
| dc.date.available.none.fl_str_mv |
2023-03-15T22:08:27Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Keller, G., Carello, M., Banjsak, V., Egido, N., Corvalan, N., Calandri, I., Caffaratti, G., Crivelli, L. & Cervio, A. (2022). Fleni Coglioma: Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado. Journal of Applied Cognitive Neuroscience, 3(2), e00314681. https://doi.org/10.17981/JACN.3.2.2022.04 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11323/9960 |
| dc.identifier.doi.none.fl_str_mv |
10.17981/JACN.3.2.2022.04 |
| dc.identifier.eissn.spa.fl_str_mv |
2745-0031 |
| dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
| dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
| identifier_str_mv |
Keller, G., Carello, M., Banjsak, V., Egido, N., Corvalan, N., Calandri, I., Caffaratti, G., Crivelli, L. & Cervio, A. (2022). Fleni Coglioma: Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado. Journal of Applied Cognitive Neuroscience, 3(2), e00314681. https://doi.org/10.17981/JACN.3.2.2022.04 10.17981/JACN.3.2.2022.04 2745-0031 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| url |
https://hdl.handle.net/11323/9960 https://repositorio.cuc.edu.co/ |
| dc.language.iso.spa.fl_str_mv |
other |
| language_invalid_str_mv |
other |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Applied Cognitive Neuroscience |
| dc.relation.references.spa.fl_str_mv |
Acevedo-Vergara, K.; Perez-Florez, M.; Ramirez, A.; Torres-Bayona, S.; Dau, A.; Salva, S.; Maloof, D.; Garcia, C.; Luque, M. & Felipe Guillen-Burgos, H. (2022). Cognitive deficits in adult patients with high-grade glioma: A systematic review. Clinical neurology and neurosurgery, 219, 1–10. https://doi.org/10.1016/j.clineuro.2022.107296 Ahmadi, R.; Dictus, C.; Hartmann, C.; Zürn, O.; Edler, L.; Hartmann, M.; Combs, S.; Herold-Mende, C.; Wirtz, C. R. & Unterberg, A. (2009). Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients. Acta neurochirurgica, 151(11), 1359–1365. https://doi.org/10.1007/s00701-009-0435-x Anderson, S. W.; Bechara, A.; Damasio, H.; Tranel, D. & Damasio, A. R. (1999). Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature neuroscience, 2(11), 1032–1037. https://doi.org/10.1038/14833 Barzilai, O.; Ben Moshe, S.; Sitt, R.; Sela, G.; Shofty, B. & Ram, Z. (2018). Improvement in cognitive function after surgery for low-grade glioma. Journal of neurosurgery, 130(2), 426–434. https://doi.org/10.3171/2017.9.JNS17658 Benton, A.; Hannay, H. J. & Varney, N. R. (1975). Visual perception of line direction in patients with unilateral brain disease. Neurology, 25(10), 907–910. https://doi.org/10.1212/wnl.25.10.907 Berry, D. T. R.; Allen, R. S.; Schmitt & Frederick, A. (1991). Rey-Osterrieth complex figure: Psychometric characteristics in a geriatric sample. Clinical Neuropsychologist, 5(2), 143–153. https://doi.org/10.1080/13854049108403298 Bird, C. M.; Papadopoulou, K.; Ricciardelli, P.; Rossor, M. N. & Cipolotti, L. (2004). Monitoring cognitive changes: psychometric properties of six cognitive tests. British Journal of Clinical Psychology, 43(2), 197–210. https://doi.org/10.1348/014466504323088051 Bu, L.; Lu, J.; Zhang, J. & Wu, J. (2021). Intraoperative Cognitive Mapping Tasks for Direct Electrical Stimulation in Clinical and Neuroscientific Contexts. Frontiers in human neuroscience, 15, 1–10. https://doi.org/10.3389/fnhum.2021.612891 Cabrera, S.; Edelstein, K.; Mason, W. P. & Tartaglia, M. C. (2016). Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe). Neuro-oncology practice, 3(2), 113–119. https://doi.org/10.1093/nop/npv055 Cázares, F.; Quiceno, J. & Montoya, B. (2016). Preparación psicológica para la intervención quirúrgica: Revisión sistemática de la literatura. Psychologia. Avances de la Disciplina, 10(2), 73–85. https://doi.org/10.21500/19002386.2480 Cochereau, J.; Lemaitre, A.-L.; Wager, M.; Moritz-Gasser, S.; Duffau, H. & Herbet, G. (2020). Network-behavior mapping of lasting executive impairments after low-grade glioma surgery. Brain structure & function, 225(8), 2415–2429. https://doi.org/10.1007/s00429-020-02131-5 Collée, E.; Vincent, A.; Dirven, C. & Satoer, D. (2022). Speech and Language Errors during Awake Brain Surgery and Postoperative Language Outcome in Glioma Patients: A Systematic Review. Cancers, 14(21), 1–16. https://doi.org/10.3390/cancers14215466 Cowan, N. (2008). What are the differences between long-term, short-term, and working memory? Progress in brain research, 169, 323–338. https://doi.org/10.1016/S0079-6123(07)00020-9 Cabrera, S.; Edelstein, K.; Mason, W. P. & Tartaglia, M. C. (2016). Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe). Neuro-oncology practice, 3(2), 113–119. https://doi.org/10.1093/nop/npv055 Cázares, F.; Quiceno, J. & Montoya, B. (2016). Preparación psicológica para la intervención quirúrgica: Revisión sistemática de la literatura. Psychologia. Avances de la Disciplina, 10(2), 73–85. https://doi.org/10.21500/19002386.2480 Cochereau, J.; Lemaitre, A.-L.; Wager, M.; Moritz-Gasser, S.; Duffau, H. & Herbet, G. (2020). Network-behavior mapping of lasting executive impairments after low-grade glioma surgery. Brain structure & function, 225(8), 2415–2429. https://doi.org/10.1007/s00429-020-02131-5 Collée, E.; Vincent, A.; Dirven, C. & Satoer, D. (2022). Speech and Language Errors during Awake Brain Surgery and Postoperative Language Outcome in Glioma Patients: A Systematic Review. Cancers, 14(21), 1–16. https://doi.org/10.3390/cancers14215466 Cowan, N. (2008). What are the differences between long-term, short-term, and working memory? Progress in brain research, 169, 323–338. https://doi.org/10.1016/S0079-6123(07)00020-9 Craft, S.; Newcomer, J.; Kanne, S.; Dagogo-Jack, S.; Cryer, P.; Sheline, Y.; Luby, J.; Dagogo-Jack, A. & Alderson, A. (1996). Memory improvement following induced hyperinsulinemia in Alzheimer’s disease. Neurobiology of aging, 17(1), 123–130. https://doi.org/10.1016/0197-4580(95)02002-0 Cummings, J. L.; Mega, M.; Gray, K.; Rosenberg-Thompson, S.; Carusi, D. A. & Gornbein, J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44(12), 2308–2314. https://doi.org/10.1212/wnl.44.12.2308 De Sousa, S.; Malloy-Diniz, L. F. & Hamdan, A. C. (2012). Validity convergent and reliability test-retest of the Rey Auditory Verbal Learning Test. Clinical Neuropsychiatry: Journal of Treatment Evaluation, 9(3), 129–137. Available: https://www.clinicalneuropsychiatry.org/download/validity-convergent-and-reliability-test-retest-of-the-rey-auditory-verbal-learning-test/ Della, S.; Laiacona, M.; Spinnler, H. & Trivelli, C. (1995). Poppelreuter-Ghent’s Overlapping Figures Test: its sensitivity to age, and its clinical use. Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists, 10(6), 511–534. https://doi.org/10.1016/0887-6177(94)00049-v Diamond, A. (2013). Executive functions. Annual review of psychology, 64, 135–168. https://doi.org/10.1146/annurev-psych-113011-143750 Duffau, H. (2021). New Philosophy, Clinical Pearls, and Methods for Intraoperative Cognition Mapping and Monitoring “à la carte” in Brain Tumor Patients. Neurosurgery, 88(5), 919–930. https://doi.org/10.1093/neuros/nyaa363 Duffau, H. (2014). The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery. Cortex, 58, 325–337. https://doi.org/10.1016/j.cortex.2013.08.005 Duffau, H.; Lopes, M.; Arthuis, F.; Bitar, A.; Sichez, J.-P.; Van Effenterre, R. & Capelle, L. (2005). Contribution of intraoperative electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985-96) and with (1996-2003) functional mapping in the same institution. Journal of neurology, neurosurgery, and psychiatry, 76(6), 845–851. https://doi.org/10.1136/jnnp.2004.048520 Figarella-Branger, D.; Appay, R.; Metais, A.; Tauziède-Espariat, A.; Colin, C.; Rousseau, A. & Varlet, P. (2022). La classification de l’OMS 2021 des tumeurs du système nerveux central. The 2021 WHO classification of tumours of the central nervous system. Annales de pathologie, 42(5), 367–382. https://doi.org/10.1016/j.annpat.2021.11.005 Foundas, A. L. (2013). Apraxia: neural mechanisms and functional recovery. Handbook of clinical neurology, 110, 335–345. https://doi.org/10.1016/B978-0-444-52901-5.00028-9 Grant, D. A. & Berg, E. A. (1948). Wisconsin Card Sorting Test [Database]. APT. https://doi.org/10.1037/t31298-000 Grier, J. T. & Batchelor, T. (2006). Low-grade gliomas in adults. The oncologist, 11(6), 681–693. https://doi.org/10.1634/theoncologist.11-6-681 Grossberg, S. (2021). Attention: Multiple types, brain resonances, psychological functions, and conscious states. Journal of integrative neuroscience, 20(1), 197–232. https://doi.org/10.31083/j.jin.2021.01.406 Henry, M. L. & Grasso, S. M. (2018). Assessment of Individuals with Primary Progressive Aphasia. Seminars in speech and language, 39(3), 231–241. https://doi.org/10.1055/s-0038-1660782 Herbet, G. (2021). Should Complex Cognitive Functions Be Mapped With Direct Electrostimulation in Wide-Awake Surgery? A Network Perspective. Frontiers in neurology, 12, 1–5. https://doi.org/10.3389/fneur.2021.635439 Hervey-Jumper, S. L.; Li, J.; Osorio, J. A.; Lau, D.; Molinaro, A. M.; Benet, A. & Berger, M. S. (2016). Surgical assessment of the insula. Part 2: validation of the Berger-Sanai zone classification system for predicting extent of glioma resection. Journal of Neurosurgery JNS, 124(2), 482–488. https://doi.org/10.3171/2015.4.JNS1521 Jehna, M.; Becker, J.; Zaar, K.; von Campe, G.; Mahdy Ali, K.; Reishofer, G.; Payer, F.; Synowitz, M.; Fazekas, F.; Enzinger, C. & Deutschmann, H. (2017). Symmetry of the arcuate fasciculus and its impact on language performance of patients with brain tumors in the language-dominant hemisphere. Journal of neurosurgery, 127(6), 1407–1416. https://doi.org/10.3171/2016.9.JNS161281 Keles, G. E.; Lamborn, K. R. & Berger, M. S. (2001). Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. Journal of neurosurgery, 95(5), 735–745. https://doi.org/10.3171/jns.2001.95.5.0735 Klein, M. (2012). Neurocognitive functioning in adult WHO grade II gliomas: impact of old and new treatment modalities. Neuro-oncology, 14(Suppl 4), iv17–iv24. https://doi.org/10.1093/neuonc/nos161 Kopp, B.; Lange, F. & Steinke A. (2021). The Reliability of the Wisconsin Card Sorting Test in Clinical Practice. Assessment, 28(1), 248–263. https://doi.org/10.1177/1073191119866257 Kumthekar, P.; Raizer, J. & Singh, S. (2015). Low-grade glioma. In J. Raizer & A. Parsa (eds), Cancer treatment and research (pp. 75–87). Springer. https://doi.org/10.1007/978-3-319-12048-5_5 Latini, F.; Axelson, H.; Fahlström, M.; Jemstedt, M.; Alberius Munkhammar, Å.; Zetterling, M. & Ryttlefors, M. (2021). Role of Preoperative Assessment in Predicting Tumor-Induced Plasticity in Patients with Diffuse Gliomas. Journal of clinical medicine, 10(5), 1–25. https://doi.org/10.3390/jcm10051108 Leal, R. T. M.; Barcellos, B. M. & Landeiro, J. A. (2018). Technical Aspects of Awake Craniotomy with Mapping for Brain Tumors in a Limited Resource Setting. World neurosurgery, 113, 67–72. https://doi.org/10.1016/j.wneu.2018.02.013 Leiguarda, R., Clarens, F., Amengual, A., Drucaroff, L. & Hallett, M. (2014). Short apraxia screening test. JCEN, 36(8), 867–874. https://doi.org/10.1080/13803395.2014.951315 Lemaitre, A.-L.; Herbet, G.; Ng, S.; Moritz-Gasser, S. & Duffau, H. (2022). Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study. Neuro-Oncology, 24(5), 781–793. https://doi.org/10.1093/neuonc/noab275 Louis, D. N.; Perry, A.; Reifenberger, G.; Von Deimling, A.; Figarella-Branger, D.; Cavenee, W. K.; Ohgaki, H.; Wiestler, O. D.; Kleihues, P. & Ellison, D. W. (2016). The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta neuropathologica, 131(6), 803–820. https://doi.org/10.1007/s00401-016-1545-1 Luria, A. R. (1962). Atención y memoria. Martínez Roca. Mandonnet, E. (2021). Should Complex Cognitive Functions Be Mapped With Direct Electrostimulation in Wide-Awake Surgery? A Commentary. Frontiers in neurology, 12, 1–4. https://doi.org/10.3389/fneur.2021.721038 Mesulam, M.-M.; Thompson, C. K.; Weintraub, S. & Rogalski, E. J. (2015). The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia. Brain: a journal of neurology, 138(8), 2423–2437. https://doi.org/10.1093/brain/awv154 Niki, C.; Kumada, T.; Maruyama, T.; Tamura, M.; Kawamata, T. & Muragaki, Y. (2020). Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions. Behavioural neurology, 1–9. https://doi.org/10.1155/2020/7941689 Olderbak, S.; Wilhelm, O.; Olaru, G.; Geiger, M.; Brenneman, M. W. & Roberts, R. D. (2015). A psychometric analysis of the reading the mind in the eyes test: toward a brief form for research and applied settings. Frontiers in Psychology, 6, 1–14. https://doi.org/10.3389/fpsyg.2015.01503 Osterrieth, P. A. (1944). Le test du copie d’une figure complexe: Contribution à l'étude de la perception et de la mémoire. Archives of Psychology, 30, 206–356. Paci, M.; Lorenzini, C.; Fioravanti, E.; Poli, C. & Lombardi, B. (2015). Reliability of the 36-item version of the Token Test in patients with poststroke aphasia. Top Stroke Rehabil, 22(5), 374–376. https://doi.org/10.1179/1074935714Z.0000000049 Park, H.-J. & Friston, K. (2013). Structural and functional brain networks: from connections to cognition. Science (New York, N.Y.), 342(6158), 579-1–579-8. https://doi.org/10.1126/science.1238411 Pedraza, O.; Sachs, B. C.; Ferman, T. J.; Rush, B. K. & Lucas, J. A. (2011). Difficulty and discrimination parameters of Boston naming test items in a consecutive clinical series. Archives of Clinical Neuropsychology, 26(5), 434–444. https://doi.org/10.1093/arclin/acr042 Periáñez, J. A.; Lubrini, G.; García-Gutiérrez, A. & Ríos-Lago, M. (2021). Construct Validity of the Stroop Color-Word Test: Influence of Speed of Visual Search, Verbal Fluency, Working Memory, Cognitive Flexibility, and Conflict Monitoring. Archives of Clinical Neuropsychology, 36(1), 99–111. https://doi.org/10.1093/arclin/acaa034 Poulin-Dubois, D. (2020). Theory of mind development: State of the science and future directions. Progress in brain research, 254, 141–166. https://doi.org/10.1016/bs.pbr.2020.05.021 Reitan, R. M. (1958). Validity of the Trail Making Test as an Indicator of Organic Brain Damage. Perceptual and Motor Skills, 8, 271–276. https://doi.org/10.2466/pms.1958.8.3.271 Rey, A. (1964). L’examen clinique en Psychologia. Pressee Universitaires de France. Richardson, J. T. (2007). Measures of short-term memory: a historical review. Cortex, 43(5), 635–650. https://doi.org/10.1016/s0010-9452(08)70493-3 Rofes, A. & Miceli, G. (2014). Language mapping with verbs and sentences in awake surgery: a review. Neuropsychology review, 24(2), 185–199.https://doi.org/10.1007/s11065-014-9258-5 Roman, F. N.; Rojas, G.; Román, N.; Iturry, M.; Blanco, R.; Leis, A.; Bartoloni, L.; Allegri R. F. & Grupo de trabajo Programa Argecog (2014). Baremos Test de la Mirada. Revista, Neuropsicología y Latinoamericana, 4(3), 1–5. Disponible en https://www.neuropsicolatina.org/index.php/Neuropsicologia_Latinoamericana/article/view/108 Sanai, N.; Mirzadeh, Z. & Berger, M. S. (2008). Functional outcome after language mapping for glioma resection. The New England journal of medicine, 358(1), 18–27. https://doi.org/10.1056/NEJMoa067819 Sanai, N.; Chang, S. & Berger, M. S. (2011). Low-grade gliomas in adults. Journal of neurosurgery, 115(5), 948–965. https://doi.org/10.3171/2011.7.JNS101238 Sánchez-Cubillo, I.; Periañez, J. A.; Adrover-Roig, D.; Rodríguez-Sánchez, J. M.; Ríos-Lago, M.; Tirapu, J. & Barceló, F. (2009). Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities. Journal of the International Neuropsychological Society, 15, 438–450. https://doi.org/10.1017/S1355617709090626 Sanz, A.; Olivares, M. E. & Barcia, J. A. (2011). Aspectos Neuropsicológicos en Pacientes Diagnosticados de Tumores Cerebral. Clínica y Salud, 22(2), 139–155. https://doi.org/10.5093/cl2011v22n2a4 Satoer, D.; Vincent, A.; Smits, M.; Dirven, C. & Visch-Brink, E. (2013). Spontaneous speech of patients with gliomas in eloquent areas before and early after surgery. Acta neurochirurgica, 155(4), 685–692. https://doi.org/10.1007/s00701-013-1638-8 Satoer, D.; Visch-Brink, E.; Smits, M.; Kloet, A.; Looman, C.; Dirven, C. & Vincent, A. (2014). Long-term evaluation of cognition after glioma surgery in eloquent areas. Journal of neuro-oncology, 116(1), 153–160. https://doi.org/10.1007/s11060-013-1275-3 Satoer, D.; Vork, J.; Visch-Brink, E.; Smits, M.; Dirven, C. & Vincent, A. (2012). Cognitive functioning early after surgery of gliomas in eloquent areas. Journal of neurosurgery, 117(5), 831–838. https://doi.org/10.3171/2012.7.JNS12263 Seidel, K.; Szelényi, A. & Bello, L. (2022). Intraoperative mapping and monitoring during brain tumor surgeries. Handbook of clinical neurology, 186, 133–149. https://doi.org/10.1016/b978-0-12-819826-1.00013-2 Shen, C.; Bao, W. M.; Yang, B. J.; Xie, R.; Cao, X. Y.; Luan, S. H. & Mao, Y. (2012). Cognitive deficits in patients with brain tumor. Chinese medical journal, 125(14), 2610–2617. https://doi.org/10.3760/cma.j.issn.0366-6999.2012.14.037 Stroop, J. R. (1935). Studies of Interference in Serial Verbal Reactions. Journal of Experimental Psychology, 18, 643–662. https://doi.org/10.1037/h0054651 Sung, E. (2011). The Reliability and Validity of Short-term and Working Memory Pointing Tasks Developed for Clinical Populations with Speech and Language Disorders. Communication Sciences & Disorders, 16(2), 185–201. Available from https://www.e-csd.org/upload/16-2_7.pdf Tate, M. C.; Herbet, G.; Moritz-Gasser, S.; Tate, J. E. & Duffau, H. (2014). Probabilistic map of critical functional regions of the human cerebral cortex: Broca’s area revisited. Brain: a journal of neurology, 137(10), 2773–2782. https://doi.org/10.1093/brain/awu168 Tirapu, J. (2007). La evaluación neuropsicológica. Psychosocial Intervention, 16(2), 189–211. https://dx.doi.org/10.4321/S1132-05592007000200005 Umezaki, S.; Shinoda, Y.; Mukasa, A.; Tanaka, S.; Takayanagi, S.; Oka, H.; Tagawa, H.; Haga, N. & Yoshino, M. (2020). Factors associated with health-related quality of life in patients with glioma: impact of symptoms and implications for rehabilitation. Japanese journal of clinical oncology, 50(9), 990–998. https://doi.org/10.1093/jjco/hyaa068. Villarreal, S.; Linnavuo, M.; Sepponen, R.; Vuori, O.; Jokinen, H. & Hietanen, M. (2020). Dual-Task in Large Perceptual Space Reveals Subclinical Hemispatial Neglect. Journal of the International Neuropsychological Society: JINS, 26(10), 993–1005. https://doi.org/10.1017/S1355617720000508 Weitzner, M. A.; Meyers, C. A.; Gelke, C. K.; Byrne, K. S.; Cella, D. F. & Levin, V. A. (1995). The Functional Assessment of Cancer Therapy (FACT) Scale. Development of a Brain Subscale and Revalidation of the General Version (FACT-G) in Patients with Primary Brain Tumors. Cancer, 75, 1151–1161. https://doi.org/10.1002/1097-0142(19950301)75:5%3C1151::aid-cncr2820750515%3E3.0.co;2-q Wechsler, D. & Stone, C. P. (1987). Wechsler Memory Scale. The Psychological Corporation. Wollesen, B.; Fricke, M.; Jansen, C. P.; Gordt, K.; Schwenk, M.; Muehlbauer, T.; Morawietz, C.; Kruse, A. & Gramann, K. (2020). A three-armed cognitive-motor exercise intervention to increase spatial orientation and life-space mobility in nursing home residents: study protocol of a randomized controlled trial in the PROfit project. BMC geriatrics, 20(1), 1–15. https://doi.org/10.1186/s12877-020-01840-0. Wu, J.; Lu, J.; Zhang, H.; Zhang, J.; Mao, Y. & Zhou, L. (2015). Probabilistic map of language regions: challenge and implication. Brain: a journal of neurology, 138(3), 1–3. https://doi.org/10.1093/brain/awu247 Zigmond, A. S. & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta psychiatrica Scandinavica, 67(6), 361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x |
| dc.relation.citationendpage.spa.fl_str_mv |
23 |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationissue.spa.fl_str_mv |
2 |
| dc.relation.citationvolume.spa.fl_str_mv |
3 |
| dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
23 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Corporación Universidad de la Costa |
| dc.publisher.place.spa.fl_str_mv |
Colombia |
| dc.source.spa.fl_str_mv |
https://revistascientificas.cuc.edu.co/JACN/article/view/4681 |
| institution |
Corporación Universidad de la Costa |
| bitstream.url.fl_str_mv |
https://repositorio.cuc.edu.co/bitstreams/b5145285-b625-4201-80b8-7190f809ee68/download https://repositorio.cuc.edu.co/bitstreams/b5f70c36-14d5-48ef-bea9-d66762b03827/download https://repositorio.cuc.edu.co/bitstreams/bb86ee37-61f1-4485-94bb-069bc35db6e0/download https://repositorio.cuc.edu.co/bitstreams/f51c19df-8a7e-4aed-8e29-58f9e596dff6/download |
| bitstream.checksum.fl_str_mv |
931159686c2f46c376d2ce32cb4c4602 2f9959eaf5b71fae44bbf9ec84150c7a cbe5b37fc8f88723ea7cf1db85a9a452 ab1dde8b01a687793d6df23979c86199 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio de la Universidad de la Costa CUC |
| repository.mail.fl_str_mv |
repdigital@cuc.edu.co |
| _version_ |
1811760698782384128 |
| spelling |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Copyright (c) 2022 Greta Keller, Maria Agostina Carello, Vanina Banjsak, Noelia Egido, Nicolas Corvalan, Ismael Calandri, Guido Caffaratti , Lucia Crivelli, Andres Cerviohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Keller, GretaCarello, María AgostinaBanjsak, Vanina2023-03-15T22:08:27Z2023-03-15T22:08:27Z2022Keller, G., Carello, M., Banjsak, V., Egido, N., Corvalan, N., Calandri, I., Caffaratti, G., Crivelli, L. & Cervio, A. (2022). Fleni Coglioma: Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado. Journal of Applied Cognitive Neuroscience, 3(2), e00314681. https://doi.org/10.17981/JACN.3.2.2022.04https://hdl.handle.net/11323/996010.17981/JACN.3.2.2022.042745-0031Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Los nuevos procedimientos quirúrgicos han beneficiado a los pacientes con Gliomas de Bajo Grado (GBG), quienes tienen una mayor esperanza de vida. Por este motivo existe un creciente interés en proteger la cognición y mejorar su calidad de vida. Los objetivos del estudio fueron: (1) Construir y administrar una batería neuropsicológica que permita examinar el perfil cognitivo prequirúrgico en pacientes con GBG y determinar los efectos posquirúrgicos. (2) Diseñar una intervención intraquirúrgica para pacientes con lesiones en el hemisferio izquierdo a fin de minimizar posibles déficits posteriores. Se evaluaron 19 pacientes con una batería prequirúrgica que evalúa los distintos dominios cognitivos: memoria, lenguaje, atención, funciones ejecutivas, habilidades visuoespaciales, cognición social, praxias y gnosias. Asimismo, los pacientes completaron cuestionarios neuropsiquiátricos con el fin de valorar funcionalidad, estado anímico y calidad de vida. Los pacientes presentaron déficit en múltiples dominios cognitivos en la evaluación prequirúrgica, al comparar su rendimiento con valores normativos ajustados por edad, sexo y educación. Los resultados del presente estudio demuestran la importancia de la administración de la batería neuropsicológica específicamente diseñada para pacientes con GBG y la evaluación de los dominios cognitivos para lograr la detección y el seguimiento de posibles trastornos cognitivos.New surgical procedures have benefited patients with Low-Grade Gliomas (LGG), who have a longer life expectancy. For this reason there is a growing interest in protecting cognition and improving their quality of life. The objectives of the study were: (1) To construct and administer a neuropsychological battery to examine the pre-surgical cognitive profile in patients with LGG and to determine the post-surgical effects. (2) To design an intra-surgical intervention for patients with lesions in the left hemisphere in order to minimize possible later deficits. 19 patients were evaluated with a pre-surgical battery that assesses different cognitive domains: memory, language, attention, executive functions, visuospatial skills, social cognition, praxias and gnosias. Patients also completed neuropsychiatric questionnaires to assess functionality, mood and quality of life. Patients presented deficits in multiple cognitive domains in the pre-surgical evaluation, when comparing their performance with normative values adjusted for age, sex and education. The results of the present study demonstrate the importance of the administration of the neuropsychological battery specifically designed for LGG patients and the assessment of cognitive domains to achieve detection and follow-up of possible cognitive disorders.23 páginasapplication/pdfotherCorporación Universidad de la CostaColombiahttps://revistascientificas.cuc.edu.co/JACN/article/view/4681Fleni Coglioma: batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo gradoFleni coglioma: battery for the detection of cognitive compromise in patients with low grade GliomaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Journal of Applied Cognitive NeuroscienceAcevedo-Vergara, K.; Perez-Florez, M.; Ramirez, A.; Torres-Bayona, S.; Dau, A.; Salva, S.; Maloof, D.; Garcia, C.; Luque, M. & Felipe Guillen-Burgos, H. (2022). Cognitive deficits in adult patients with high-grade glioma: A systematic review. Clinical neurology and neurosurgery, 219, 1–10. https://doi.org/10.1016/j.clineuro.2022.107296Ahmadi, R.; Dictus, C.; Hartmann, C.; Zürn, O.; Edler, L.; Hartmann, M.; Combs, S.; Herold-Mende, C.; Wirtz, C. R. & Unterberg, A. (2009). Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients. Acta neurochirurgica, 151(11), 1359–1365. https://doi.org/10.1007/s00701-009-0435-xAnderson, S. W.; Bechara, A.; Damasio, H.; Tranel, D. & Damasio, A. R. (1999). Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature neuroscience, 2(11), 1032–1037. https://doi.org/10.1038/14833Barzilai, O.; Ben Moshe, S.; Sitt, R.; Sela, G.; Shofty, B. & Ram, Z. (2018). Improvement in cognitive function after surgery for low-grade glioma. Journal of neurosurgery, 130(2), 426–434. https://doi.org/10.3171/2017.9.JNS17658Benton, A.; Hannay, H. J. & Varney, N. R. (1975). Visual perception of line direction in patients with unilateral brain disease. Neurology, 25(10), 907–910. https://doi.org/10.1212/wnl.25.10.907Berry, D. T. R.; Allen, R. S.; Schmitt & Frederick, A. (1991). Rey-Osterrieth complex figure: Psychometric characteristics in a geriatric sample. Clinical Neuropsychologist, 5(2), 143–153. https://doi.org/10.1080/13854049108403298Bird, C. M.; Papadopoulou, K.; Ricciardelli, P.; Rossor, M. N. & Cipolotti, L. (2004). Monitoring cognitive changes: psychometric properties of six cognitive tests. British Journal of Clinical Psychology, 43(2), 197–210. https://doi.org/10.1348/014466504323088051Bu, L.; Lu, J.; Zhang, J. & Wu, J. (2021). Intraoperative Cognitive Mapping Tasks for Direct Electrical Stimulation in Clinical and Neuroscientific Contexts. Frontiers in human neuroscience, 15, 1–10. https://doi.org/10.3389/fnhum.2021.612891Cabrera, S.; Edelstein, K.; Mason, W. P. & Tartaglia, M. C. (2016). Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe). Neuro-oncology practice, 3(2), 113–119. https://doi.org/10.1093/nop/npv055Cázares, F.; Quiceno, J. & Montoya, B. (2016). Preparación psicológica para la intervención quirúrgica: Revisión sistemática de la literatura. Psychologia. Avances de la Disciplina, 10(2), 73–85. https://doi.org/10.21500/19002386.2480Cochereau, J.; Lemaitre, A.-L.; Wager, M.; Moritz-Gasser, S.; Duffau, H. & Herbet, G. (2020). Network-behavior mapping of lasting executive impairments after low-grade glioma surgery. Brain structure & function, 225(8), 2415–2429. https://doi.org/10.1007/s00429-020-02131-5Collée, E.; Vincent, A.; Dirven, C. & Satoer, D. (2022). Speech and Language Errors during Awake Brain Surgery and Postoperative Language Outcome in Glioma Patients: A Systematic Review. Cancers, 14(21), 1–16. https://doi.org/10.3390/cancers14215466Cowan, N. (2008). What are the differences between long-term, short-term, and working memory? Progress in brain research, 169, 323–338. https://doi.org/10.1016/S0079-6123(07)00020-9Cabrera, S.; Edelstein, K.; Mason, W. P. & Tartaglia, M. C. (2016). Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe). Neuro-oncology practice, 3(2), 113–119. https://doi.org/10.1093/nop/npv055Cázares, F.; Quiceno, J. & Montoya, B. (2016). Preparación psicológica para la intervención quirúrgica: Revisión sistemática de la literatura. Psychologia. Avances de la Disciplina, 10(2), 73–85. https://doi.org/10.21500/19002386.2480Cochereau, J.; Lemaitre, A.-L.; Wager, M.; Moritz-Gasser, S.; Duffau, H. & Herbet, G. (2020). Network-behavior mapping of lasting executive impairments after low-grade glioma surgery. Brain structure & function, 225(8), 2415–2429. https://doi.org/10.1007/s00429-020-02131-5Collée, E.; Vincent, A.; Dirven, C. & Satoer, D. (2022). Speech and Language Errors during Awake Brain Surgery and Postoperative Language Outcome in Glioma Patients: A Systematic Review. Cancers, 14(21), 1–16. https://doi.org/10.3390/cancers14215466Cowan, N. (2008). What are the differences between long-term, short-term, and working memory? Progress in brain research, 169, 323–338. https://doi.org/10.1016/S0079-6123(07)00020-9Craft, S.; Newcomer, J.; Kanne, S.; Dagogo-Jack, S.; Cryer, P.; Sheline, Y.; Luby, J.; Dagogo-Jack, A. & Alderson, A. (1996). Memory improvement following induced hyperinsulinemia in Alzheimer’s disease. Neurobiology of aging, 17(1), 123–130. https://doi.org/10.1016/0197-4580(95)02002-0Cummings, J. L.; Mega, M.; Gray, K.; Rosenberg-Thompson, S.; Carusi, D. A. & Gornbein, J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44(12), 2308–2314. https://doi.org/10.1212/wnl.44.12.2308De Sousa, S.; Malloy-Diniz, L. F. & Hamdan, A. C. (2012). Validity convergent and reliability test-retest of the Rey Auditory Verbal Learning Test. Clinical Neuropsychiatry: Journal of Treatment Evaluation, 9(3), 129–137. Available: https://www.clinicalneuropsychiatry.org/download/validity-convergent-and-reliability-test-retest-of-the-rey-auditory-verbal-learning-test/Della, S.; Laiacona, M.; Spinnler, H. & Trivelli, C. (1995). Poppelreuter-Ghent’s Overlapping Figures Test: its sensitivity to age, and its clinical use. Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists, 10(6), 511–534. https://doi.org/10.1016/0887-6177(94)00049-vDiamond, A. (2013). Executive functions. Annual review of psychology, 64, 135–168. https://doi.org/10.1146/annurev-psych-113011-143750Duffau, H. (2021). New Philosophy, Clinical Pearls, and Methods for Intraoperative Cognition Mapping and Monitoring “à la carte” in Brain Tumor Patients. Neurosurgery, 88(5), 919–930. https://doi.org/10.1093/neuros/nyaa363Duffau, H. (2014). The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery. Cortex, 58, 325–337. https://doi.org/10.1016/j.cortex.2013.08.005Duffau, H.; Lopes, M.; Arthuis, F.; Bitar, A.; Sichez, J.-P.; Van Effenterre, R. & Capelle, L. (2005). Contribution of intraoperative electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985-96) and with (1996-2003) functional mapping in the same institution. Journal of neurology, neurosurgery, and psychiatry, 76(6), 845–851. https://doi.org/10.1136/jnnp.2004.048520Figarella-Branger, D.; Appay, R.; Metais, A.; Tauziède-Espariat, A.; Colin, C.; Rousseau, A. & Varlet, P. (2022). La classification de l’OMS 2021 des tumeurs du système nerveux central. The 2021 WHO classification of tumours of the central nervous system. Annales de pathologie, 42(5), 367–382. https://doi.org/10.1016/j.annpat.2021.11.005Foundas, A. L. (2013). Apraxia: neural mechanisms and functional recovery. Handbook of clinical neurology, 110, 335–345. https://doi.org/10.1016/B978-0-444-52901-5.00028-9Grant, D. A. & Berg, E. A. (1948). Wisconsin Card Sorting Test [Database]. APT. https://doi.org/10.1037/t31298-000Grier, J. T. & Batchelor, T. (2006). Low-grade gliomas in adults. The oncologist, 11(6), 681–693. https://doi.org/10.1634/theoncologist.11-6-681Grossberg, S. (2021). Attention: Multiple types, brain resonances, psychological functions, and conscious states. Journal of integrative neuroscience, 20(1), 197–232. https://doi.org/10.31083/j.jin.2021.01.406Henry, M. L. & Grasso, S. M. (2018). Assessment of Individuals with Primary Progressive Aphasia. Seminars in speech and language, 39(3), 231–241. https://doi.org/10.1055/s-0038-1660782Herbet, G. (2021). Should Complex Cognitive Functions Be Mapped With Direct Electrostimulation in Wide-Awake Surgery? A Network Perspective. Frontiers in neurology, 12, 1–5. https://doi.org/10.3389/fneur.2021.635439Hervey-Jumper, S. L.; Li, J.; Osorio, J. A.; Lau, D.; Molinaro, A. M.; Benet, A. & Berger, M. S. (2016). Surgical assessment of the insula. Part 2: validation of the Berger-Sanai zone classification system for predicting extent of glioma resection. Journal of Neurosurgery JNS, 124(2), 482–488. https://doi.org/10.3171/2015.4.JNS1521Jehna, M.; Becker, J.; Zaar, K.; von Campe, G.; Mahdy Ali, K.; Reishofer, G.; Payer, F.; Synowitz, M.; Fazekas, F.; Enzinger, C. & Deutschmann, H. (2017). Symmetry of the arcuate fasciculus and its impact on language performance of patients with brain tumors in the language-dominant hemisphere. Journal of neurosurgery, 127(6), 1407–1416. https://doi.org/10.3171/2016.9.JNS161281Keles, G. E.; Lamborn, K. R. & Berger, M. S. (2001). Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. Journal of neurosurgery, 95(5), 735–745. https://doi.org/10.3171/jns.2001.95.5.0735Klein, M. (2012). Neurocognitive functioning in adult WHO grade II gliomas: impact of old and new treatment modalities. Neuro-oncology, 14(Suppl 4), iv17–iv24. https://doi.org/10.1093/neuonc/nos161Kopp, B.; Lange, F. & Steinke A. (2021). The Reliability of the Wisconsin Card Sorting Test in Clinical Practice. Assessment, 28(1), 248–263. https://doi.org/10.1177/1073191119866257Kumthekar, P.; Raizer, J. & Singh, S. (2015). Low-grade glioma. In J. Raizer & A. Parsa (eds), Cancer treatment and research (pp. 75–87). Springer. https://doi.org/10.1007/978-3-319-12048-5_5Latini, F.; Axelson, H.; Fahlström, M.; Jemstedt, M.; Alberius Munkhammar, Å.; Zetterling, M. & Ryttlefors, M. (2021). Role of Preoperative Assessment in Predicting Tumor-Induced Plasticity in Patients with Diffuse Gliomas. Journal of clinical medicine, 10(5), 1–25. https://doi.org/10.3390/jcm10051108Leal, R. T. M.; Barcellos, B. M. & Landeiro, J. A. (2018). Technical Aspects of Awake Craniotomy with Mapping for Brain Tumors in a Limited Resource Setting. World neurosurgery, 113, 67–72. https://doi.org/10.1016/j.wneu.2018.02.013Leiguarda, R., Clarens, F., Amengual, A., Drucaroff, L. & Hallett, M. (2014). Short apraxia screening test. JCEN, 36(8), 867–874. https://doi.org/10.1080/13803395.2014.951315Lemaitre, A.-L.; Herbet, G.; Ng, S.; Moritz-Gasser, S. & Duffau, H. (2022). Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study. Neuro-Oncology, 24(5), 781–793. https://doi.org/10.1093/neuonc/noab275Louis, D. N.; Perry, A.; Reifenberger, G.; Von Deimling, A.; Figarella-Branger, D.; Cavenee, W. K.; Ohgaki, H.; Wiestler, O. D.; Kleihues, P. & Ellison, D. W. (2016). The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta neuropathologica, 131(6), 803–820. https://doi.org/10.1007/s00401-016-1545-1Luria, A. R. (1962). Atención y memoria. Martínez Roca. Mandonnet, E. (2021). Should Complex Cognitive Functions Be Mapped With Direct Electrostimulation in Wide-Awake Surgery? A Commentary. Frontiers in neurology, 12, 1–4. https://doi.org/10.3389/fneur.2021.721038Mesulam, M.-M.; Thompson, C. K.; Weintraub, S. & Rogalski, E. J. (2015). The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia. Brain: a journal of neurology, 138(8), 2423–2437. https://doi.org/10.1093/brain/awv154Niki, C.; Kumada, T.; Maruyama, T.; Tamura, M.; Kawamata, T. & Muragaki, Y. (2020). Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions. Behavioural neurology, 1–9. https://doi.org/10.1155/2020/7941689Olderbak, S.; Wilhelm, O.; Olaru, G.; Geiger, M.; Brenneman, M. W. & Roberts, R. D. (2015). A psychometric analysis of the reading the mind in the eyes test: toward a brief form for research and applied settings. Frontiers in Psychology, 6, 1–14. https://doi.org/10.3389/fpsyg.2015.01503Osterrieth, P. A. (1944). Le test du copie d’une figure complexe: Contribution à l'étude de la perception et de la mémoire. Archives of Psychology, 30, 206–356.Paci, M.; Lorenzini, C.; Fioravanti, E.; Poli, C. & Lombardi, B. (2015). Reliability of the 36-item version of the Token Test in patients with poststroke aphasia. Top Stroke Rehabil, 22(5), 374–376. https://doi.org/10.1179/1074935714Z.0000000049Park, H.-J. & Friston, K. (2013). Structural and functional brain networks: from connections to cognition. Science (New York, N.Y.), 342(6158), 579-1–579-8. https://doi.org/10.1126/science.1238411Pedraza, O.; Sachs, B. C.; Ferman, T. J.; Rush, B. K. & Lucas, J. A. (2011). Difficulty and discrimination parameters of Boston naming test items in a consecutive clinical series. Archives of Clinical Neuropsychology, 26(5), 434–444. https://doi.org/10.1093/arclin/acr042Periáñez, J. A.; Lubrini, G.; García-Gutiérrez, A. & Ríos-Lago, M. (2021). Construct Validity of the Stroop Color-Word Test: Influence of Speed of Visual Search, Verbal Fluency, Working Memory, Cognitive Flexibility, and Conflict Monitoring. Archives of Clinical Neuropsychology, 36(1), 99–111. https://doi.org/10.1093/arclin/acaa034Poulin-Dubois, D. (2020). Theory of mind development: State of the science and future directions. Progress in brain research, 254, 141–166. https://doi.org/10.1016/bs.pbr.2020.05.021Reitan, R. M. (1958). Validity of the Trail Making Test as an Indicator of Organic Brain Damage. Perceptual and Motor Skills, 8, 271–276. https://doi.org/10.2466/pms.1958.8.3.271Rey, A. (1964). L’examen clinique en Psychologia. Pressee Universitaires de France.Richardson, J. T. (2007). Measures of short-term memory: a historical review. Cortex, 43(5), 635–650. https://doi.org/10.1016/s0010-9452(08)70493-3Rofes, A. & Miceli, G. (2014). Language mapping with verbs and sentences in awake surgery: a review. Neuropsychology review, 24(2), 185–199.https://doi.org/10.1007/s11065-014-9258-5Roman, F. N.; Rojas, G.; Román, N.; Iturry, M.; Blanco, R.; Leis, A.; Bartoloni, L.; Allegri R. F. & Grupo de trabajo Programa Argecog (2014). Baremos Test de la Mirada. Revista, Neuropsicología y Latinoamericana, 4(3), 1–5. Disponible en https://www.neuropsicolatina.org/index.php/Neuropsicologia_Latinoamericana/article/view/108Sanai, N.; Mirzadeh, Z. & Berger, M. S. (2008). Functional outcome after language mapping for glioma resection. The New England journal of medicine, 358(1), 18–27. https://doi.org/10.1056/NEJMoa067819Sanai, N.; Chang, S. & Berger, M. S. (2011). Low-grade gliomas in adults. Journal of neurosurgery, 115(5), 948–965. https://doi.org/10.3171/2011.7.JNS101238Sánchez-Cubillo, I.; Periañez, J. A.; Adrover-Roig, D.; Rodríguez-Sánchez, J. M.; Ríos-Lago, M.; Tirapu, J. & Barceló, F. (2009). Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities. Journal of the International Neuropsychological Society, 15, 438–450. https://doi.org/10.1017/S1355617709090626Sanz, A.; Olivares, M. E. & Barcia, J. A. (2011). Aspectos Neuropsicológicos en Pacientes Diagnosticados de Tumores Cerebral. Clínica y Salud, 22(2), 139–155. https://doi.org/10.5093/cl2011v22n2a4Satoer, D.; Vincent, A.; Smits, M.; Dirven, C. & Visch-Brink, E. (2013). Spontaneous speech of patients with gliomas in eloquent areas before and early after surgery. Acta neurochirurgica, 155(4), 685–692. https://doi.org/10.1007/s00701-013-1638-8Satoer, D.; Visch-Brink, E.; Smits, M.; Kloet, A.; Looman, C.; Dirven, C. & Vincent, A. (2014). Long-term evaluation of cognition after glioma surgery in eloquent areas. Journal of neuro-oncology, 116(1), 153–160. https://doi.org/10.1007/s11060-013-1275-3Satoer, D.; Vork, J.; Visch-Brink, E.; Smits, M.; Dirven, C. & Vincent, A. (2012). Cognitive functioning early after surgery of gliomas in eloquent areas. Journal of neurosurgery, 117(5), 831–838. https://doi.org/10.3171/2012.7.JNS12263Seidel, K.; Szelényi, A. & Bello, L. (2022). Intraoperative mapping and monitoring during brain tumor surgeries. Handbook of clinical neurology, 186, 133–149. https://doi.org/10.1016/b978-0-12-819826-1.00013-2Shen, C.; Bao, W. M.; Yang, B. J.; Xie, R.; Cao, X. Y.; Luan, S. H. & Mao, Y. (2012). Cognitive deficits in patients with brain tumor. Chinese medical journal, 125(14), 2610–2617. https://doi.org/10.3760/cma.j.issn.0366-6999.2012.14.037Stroop, J. R. (1935). Studies of Interference in Serial Verbal Reactions. Journal of Experimental Psychology, 18, 643–662. https://doi.org/10.1037/h0054651Sung, E. (2011). The Reliability and Validity of Short-term and Working Memory Pointing Tasks Developed for Clinical Populations with Speech and Language Disorders. Communication Sciences & Disorders, 16(2), 185–201. Available from https://www.e-csd.org/upload/16-2_7.pdfTate, M. C.; Herbet, G.; Moritz-Gasser, S.; Tate, J. E. & Duffau, H. (2014). Probabilistic map of critical functional regions of the human cerebral cortex: Broca’s area revisited. Brain: a journal of neurology, 137(10), 2773–2782. https://doi.org/10.1093/brain/awu168Tirapu, J. (2007). La evaluación neuropsicológica. Psychosocial Intervention, 16(2), 189–211. https://dx.doi.org/10.4321/S1132-05592007000200005Umezaki, S.; Shinoda, Y.; Mukasa, A.; Tanaka, S.; Takayanagi, S.; Oka, H.; Tagawa, H.; Haga, N. & Yoshino, M. (2020). Factors associated with health-related quality of life in patients with glioma: impact of symptoms and implications for rehabilitation. Japanese journal of clinical oncology, 50(9), 990–998. https://doi.org/10.1093/jjco/hyaa068.Villarreal, S.; Linnavuo, M.; Sepponen, R.; Vuori, O.; Jokinen, H. & Hietanen, M. (2020). Dual-Task in Large Perceptual Space Reveals Subclinical Hemispatial Neglect. Journal of the International Neuropsychological Society: JINS, 26(10), 993–1005. https://doi.org/10.1017/S1355617720000508Weitzner, M. A.; Meyers, C. A.; Gelke, C. K.; Byrne, K. S.; Cella, D. F. & Levin, V. A. (1995). The Functional Assessment of Cancer Therapy (FACT) Scale. Development of a Brain Subscale and Revalidation of the General Version (FACT-G) in Patients with Primary Brain Tumors. Cancer, 75, 1151–1161. https://doi.org/10.1002/1097-0142(19950301)75:5%3C1151::aid-cncr2820750515%3E3.0.co;2-qWechsler, D. & Stone, C. P. (1987). Wechsler Memory Scale. The Psychological Corporation.Wollesen, B.; Fricke, M.; Jansen, C. P.; Gordt, K.; Schwenk, M.; Muehlbauer, T.; Morawietz, C.; Kruse, A. & Gramann, K. (2020). A three-armed cognitive-motor exercise intervention to increase spatial orientation and life-space mobility in nursing home residents: study protocol of a randomized controlled trial in the PROfit project. BMC geriatrics, 20(1), 1–15. https://doi.org/10.1186/s12877-020-01840-0.Wu, J.; Lu, J.; Zhang, H.; Zhang, J.; Mao, Y. & Zhou, L. (2015). Probabilistic map of language regions: challenge and implication. Brain: a journal of neurology, 138(3), 1–3. https://doi.org/10.1093/brain/awu247Zigmond, A. S. & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta psychiatrica Scandinavica, 67(6), 361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x23123LesiónTumorGliomaNeuropsicologíaEvaluaciónLesionNeuropsychologyEvaluationPublicationORIGINALFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdfFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdfArtículoapplication/pdf1372901https://repositorio.cuc.edu.co/bitstreams/b5145285-b625-4201-80b8-7190f809ee68/download931159686c2f46c376d2ce32cb4c4602MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/b5f70c36-14d5-48ef-bea9-d66762b03827/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdf.txtFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdf.txtExtracted texttext/plain63758https://repositorio.cuc.edu.co/bitstreams/bb86ee37-61f1-4485-94bb-069bc35db6e0/downloadcbe5b37fc8f88723ea7cf1db85a9a452MD53THUMBNAILFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdf.jpgFleni CoGlioma. Batería para la detección de compromiso cognitivo en pacientes con Glioma de bajo grado.pdf.jpgGenerated Thumbnailimage/jpeg13314https://repositorio.cuc.edu.co/bitstreams/f51c19df-8a7e-4aed-8e29-58f9e596dff6/downloadab1dde8b01a687793d6df23979c86199MD5411323/9960oai:repositorio.cuc.edu.co:11323/99602024-09-17 10:16:56.109https://creativecommons.org/licenses/by-nc-nd/4.0/Copyright (c) 2022 Greta Keller, Maria Agostina Carello, Vanina Banjsak, Noelia Egido, Nicolas Corvalan, Ismael Calandri, Guido Caffaratti , Lucia Crivelli, Andres Cervioopen.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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 |