Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats
Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the...
- Autores:
-
Gasparotto, Juciano
Chaves Rodrigues, Paloma
Da Boit Martinello, Katia
Da Rosa Siva, Helen Tais
Bortolin, Rafael Calixto
Silva Oliveira, Luis Felipe
Rabelo, Thallita Kelly
Da Silva, Jeferson D
Da Silva, Fernanda Rabaioli
Nordin, Adriane Perachi
Soares, Karina
Borges, Malu Siqueira
Gelain, D. P
Moreira Fonseca, José Cláudio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/919
- Acceso en línea:
- https://hdl.handle.net/11323/919
https://repositorio.cuc.edu.co/
- Palabra clave:
- Coal
Inflammation
Inhalation
Obesity
Oxidative Stress
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
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| dc.title.eng.fl_str_mv |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| title |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| spellingShingle |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats Coal Inflammation Inhalation Obesity Oxidative Stress |
| title_short |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| title_full |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| title_fullStr |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| title_full_unstemmed |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| title_sort |
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats |
| dc.creator.fl_str_mv |
Gasparotto, Juciano Chaves Rodrigues, Paloma Da Boit Martinello, Katia Da Rosa Siva, Helen Tais Bortolin, Rafael Calixto Silva Oliveira, Luis Felipe Rabelo, Thallita Kelly Da Silva, Jeferson D Da Silva, Fernanda Rabaioli Nordin, Adriane Perachi Soares, Karina Borges, Malu Siqueira Gelain, D. P Moreira Fonseca, José Cláudio |
| dc.contributor.author.spa.fl_str_mv |
Gasparotto, Juciano Chaves Rodrigues, Paloma Da Boit Martinello, Katia Da Rosa Siva, Helen Tais Bortolin, Rafael Calixto Silva Oliveira, Luis Felipe Rabelo, Thallita Kelly Da Silva, Jeferson D Da Silva, Fernanda Rabaioli Nordin, Adriane Perachi Soares, Karina Borges, Malu Siqueira Gelain, D. P Moreira Fonseca, José Cláudio |
| dc.subject.eng.fl_str_mv |
Coal Inflammation Inhalation Obesity Oxidative Stress |
| topic |
Coal Inflammation Inhalation Obesity Oxidative Stress |
| description |
Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the coal combustion cause serious problems for human health due to their high toxicity and their capacity to bioaccumulate. The aim of this work was to investigate the effects of coal dust inhalation in the organs of obese and non-obese Wistar rats. Pro-inflammatory cytokines, oxidative stress, oxidative damage, histological analysis, comet assay, and micronuclei were investigated. Both obesity and coal dust inhalation increased the pro-inflammatory cytokines IL-1β and TNF-α and decreased HSP70 levels in serum, however, in obese animals that inhaled coal dust these changes were more pronounced. Liver histological analysis showed severe microvesicular steatosis in obese animals that inhaled coal dust. Lung histologic investigation showed abnormalities in lung structure of animals exposed to coal dust and showed severe lung distensibility in obese animals exposed to coal dust. |
| publishDate |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2018-11-13T22:16:30Z |
| dc.date.available.none.fl_str_mv |
2018-11-13T22:16:30Z |
| dc.date.issued.none.fl_str_mv |
2018-08-26 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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info:eu-repo/semantics/article |
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http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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acceptedVersion |
| dc.identifier.issn.spa.fl_str_mv |
01476513 |
| dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/11323/919 |
| dc.identifier.doi.spa.fl_str_mv |
DOI: 10.1016/j.ecoenv.2018.08.097 |
| dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
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REDICUC - Repositorio CUC |
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https://repositorio.cuc.edu.co/ |
| identifier_str_mv |
01476513 DOI: 10.1016/j.ecoenv.2018.08.097 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| url |
https://hdl.handle.net/11323/919 https://repositorio.cuc.edu.co/ |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.spa.fl_str_mv |
Atribución – No comercial – Compartir igual |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.publisher.spa.fl_str_mv |
Ecotoxicology And Environmental Safety |
| institution |
Corporación Universidad de la Costa |
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Gasparotto, JucianoChaves Rodrigues, PalomaDa Boit Martinello, KatiaDa Rosa Siva, Helen TaisBortolin, Rafael CalixtoSilva Oliveira, Luis FelipeRabelo, Thallita KellyDa Silva, Jeferson DDa Silva, Fernanda RabaioliNordin, Adriane PerachiSoares, KarinaBorges, Malu SiqueiraGelain, D. PMoreira Fonseca, José Cláudio2018-11-13T22:16:30Z2018-11-13T22:16:30Z2018-08-2601476513https://hdl.handle.net/11323/919DOI: 10.1016/j.ecoenv.2018.08.097Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the coal combustion cause serious problems for human health due to their high toxicity and their capacity to bioaccumulate. The aim of this work was to investigate the effects of coal dust inhalation in the organs of obese and non-obese Wistar rats. Pro-inflammatory cytokines, oxidative stress, oxidative damage, histological analysis, comet assay, and micronuclei were investigated. Both obesity and coal dust inhalation increased the pro-inflammatory cytokines IL-1β and TNF-α and decreased HSP70 levels in serum, however, in obese animals that inhaled coal dust these changes were more pronounced. Liver histological analysis showed severe microvesicular steatosis in obese animals that inhaled coal dust. Lung histologic investigation showed abnormalities in lung structure of animals exposed to coal dust and showed severe lung distensibility in obese animals exposed to coal dust.Gasparotto, Juciano-a7ba2163-3c88-45e4-b4f0-627833f8b03f-0Chaves Rodrigues, Paloma-f8967be3-2854-4038-aaf9-11f45d652363-0Da Boit Martinello, Katia-332fc0f5-2d21-40f8-b210-63ad92c93b2a-0Da Rosa Siva, Helen Tais-fba50b96-8879-4ba1-ab4c-cb26d9ae97b4-0Bortolin, Rafael Calixto-0000-0003-4780-8499-600Silva Oliveira, Luis Felipe-5c1c9b54-f160-4f3c-bcd5-b9f532c778af-0Rabelo, Thallita Kelly-3cca46bc-d2d5-4941-8fff-bd3b0074486b-0Da Silva, Jeferson D-732dabec-f9f9-4d43-899e-d7b77379b278-0Da Silva, Fernanda Rabaioli-6e788809-1a5d-48bf-a3dc-27c587567ea2-0Nordin, Adriane Perachi-53262304-0646-4cdf-93d3-c4ed6d60d3b8-0Soares, Karina-b7e79b0c-a1fa-42cf-9323-31b73d43e936-0Borges, Malu Siqueira-c2e04bc0-83cc-4130-a181-baee3d2692dc-0Gelain, D. P-410bf449-252e-437c-9afc-71a1866db0eb-0Moreira Fonseca, José Cláudio-4373df94-e345-42b4-861c-55953fd27b36-0engEcotoxicology And Environmental SafetyAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2CoalInflammationInhalationObesityOxidative StressObese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese ratsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALObese Rats Are More Vulnerable To Inflammation.pdfObese Rats Are More Vulnerable To Inflammation.pdfapplication/pdf334838https://repositorio.cuc.edu.co/bitstreams/4ada9b5b-8776-4cf7-89ca-28eaf78a9e23/downloadd9ea4792d4c85e6b94f67ae13223f1b6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.cuc.edu.co/bitstreams/7a1cbef0-6909-47bb-94c7-a602e0c6fa3c/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILObese Rats Are More Vulnerable To Inflammation.pdf.jpgObese Rats Are More Vulnerable To Inflammation.pdf.jpgimage/jpeg56884https://repositorio.cuc.edu.co/bitstreams/43956f5c-8487-480d-b101-68be760f89ac/download622095316cd83ed2f478f1b5b0486637MD54TEXTObese Rats Are More Vulnerable To Inflammation.pdf.txtObese Rats Are More Vulnerable To Inflammation.pdf.txttext/plain2338https://repositorio.cuc.edu.co/bitstreams/b3445b80-ba69-4f0e-b043-2c20a9a31e6b/download640e704ba6c7caca04373f2aad864bd5MD5511323/919oai:repositorio.cuc.edu.co:11323/9192024-09-17 14:11:11.056open.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |