Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats
Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the...
- Autores:
-
Gasparotto, Juciano
Chaves Rodrigues, Paloma
Da Boit Martinello, Katia
Da Rosa Siva, Helen Tais
Bortolin, Rafael Calixto
Silva Oliveira, Luis Felipe
Rabelo, Thallita Kelly
Da Silva, Jeferson D
Da Silva, Fernanda Rabaioli
Nordin, Adriane Perachi
Soares, Karina
Borges, Malu Siqueira
Gelain, D. P
Moreira Fonseca, José Cláudio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/919
- Acceso en línea:
- https://hdl.handle.net/11323/919
https://repositorio.cuc.edu.co/
- Palabra clave:
- Coal
Inflammation
Inhalation
Obesity
Oxidative Stress
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
| Summary: | Obesity is an important nutritional disorder worldwide. Its association with environmental pollution may trigger an increase in oxidative stress and inflammatory parameters. Coal is a resource used throughout the world as an important fuel source for generating electricity. The ashes released by the coal combustion cause serious problems for human health due to their high toxicity and their capacity to bioaccumulate. The aim of this work was to investigate the effects of coal dust inhalation in the organs of obese and non-obese Wistar rats. Pro-inflammatory cytokines, oxidative stress, oxidative damage, histological analysis, comet assay, and micronuclei were investigated. Both obesity and coal dust inhalation increased the pro-inflammatory cytokines IL-1β and TNF-α and decreased HSP70 levels in serum, however, in obese animals that inhaled coal dust these changes were more pronounced. Liver histological analysis showed severe microvesicular steatosis in obese animals that inhaled coal dust. Lung histologic investigation showed abnormalities in lung structure of animals exposed to coal dust and showed severe lung distensibility in obese animals exposed to coal dust. |
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