Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia
We assessed the public health and economic impact of adding males to the existing female-only quadrivalent HPV vaccine (4vHPV) program in Colombia, analyzing different gender-neutral vaccination (GNV) vaccine coverage rates (VCRs). A published HPV-type dynamic transmission model was used to compare...
- Autores:
-
De Los Angeles Carrasquilla, Maria
ALVIS-ZAKZUK, NELSON J.
Zakzuk Sierra, J
Benavides De La Rosa, Fernanda
Castello Beltran, Carlos
Rojas, M
Prieto, Esteban
Yen, G
Parellada, C
Pavelyev, A
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_816b
- Fecha de publicación:
- 2020
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/8336
- Acceso en línea:
- https://hdl.handle.net/11323/8336
https://doi.org/10.1016/j.jval.2020.04.489
https://repositorio.cuc.edu.co/
- Palabra clave:
- Vaccination
Human Papilloma
HPV
Colombia
- Rights
- openAccess
- License
- CC0 1.0 Universal
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|
dc.title.eng.fl_str_mv |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
title |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
spellingShingle |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia Vaccination Human Papilloma HPV Colombia |
title_short |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
title_full |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
title_fullStr |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
title_full_unstemmed |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
title_sort |
Estimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in Colombia |
dc.creator.fl_str_mv |
De Los Angeles Carrasquilla, Maria ALVIS-ZAKZUK, NELSON J. Zakzuk Sierra, J Benavides De La Rosa, Fernanda Castello Beltran, Carlos Rojas, M Prieto, Esteban Yen, G Parellada, C Pavelyev, A |
dc.contributor.author.spa.fl_str_mv |
De Los Angeles Carrasquilla, Maria ALVIS-ZAKZUK, NELSON J. Zakzuk Sierra, J Benavides De La Rosa, Fernanda Castello Beltran, Carlos Rojas, M Prieto, Esteban Yen, G Parellada, C Pavelyev, A |
dc.subject.eng.fl_str_mv |
Vaccination Human Papilloma HPV Colombia |
topic |
Vaccination Human Papilloma HPV Colombia |
description |
We assessed the public health and economic impact of adding males to the existing female-only quadrivalent HPV vaccine (4vHPV) program in Colombia, analyzing different gender-neutral vaccination (GNV) vaccine coverage rates (VCRs). A published HPV-type dynamic transmission model was used to compare female-only vaccination (FOV) versus GNV with two-dose 4vHPV in the 9-10-year-old cohort over a 100-year timeframe in Colombia. The model compared 35% VCR for FOV with GNV at VCRs of 35% (scenario A), 50% (scenario B) and different VCRs between females/males (50%/35%, scenario C). The predicted health outcomes included HPV 6/11/16/18-related disease and deaths averted [cervical intraepithelial neoplasia, cervical, vaginal, vulvar, penile, anal and head and neck cancers, genital warts (GW), and recurrent respiratory papillomatosis], direct healthcare cost prevented by vaccination, and incremental cost-effectiveness ratios (ICERs). All GNV scenarios are estimated to provide faster and greater reductions in HPV 6/11/16/18-related diseases relative to FOV at 35% VCR, mainly scenarios B and C. The highest cumulative reductions in the incidence of HPV 6/11/16/18-related disease and deaths were seen in scenario B relative to FOV at 35% VCR at year 100, averting 28,001 cervical cancer (CC) cases, 11,968 non-CC cases (4,753 in females and 7,215 in males) and 15,141 deaths. The greatest projected reductions in health care costs are due to diseases caused by HPV-6/11 infection, driven by GW. The cost savings varied from 88 (scenario A) to 184 million (scenario B) relative to FOV at 35%. The ICER for all scenarios was <0, indicating that under the model assumptions it is cost-saving to implement a GNV-4vHPV in Colombia. In Colombia, a GNV-4vHPV program is a cost-saving strategy in the three scenarios analyzed relative to the current FOV program and result in greater improvement of the public health and economic impact in both women and men. |
publishDate |
2020 |
dc.date.issued.none.fl_str_mv |
2020 |
dc.date.accessioned.none.fl_str_mv |
2021-06-02T16:47:07Z |
dc.date.available.none.fl_str_mv |
2021-06-02T16:47:07Z |
dc.date.embargoEnd.none.fl_str_mv |
2022 |
dc.type.spa.fl_str_mv |
Pre-Publicación |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_816b |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/preprint |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ARTOTR |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_816b |
status_str |
acceptedVersion |
dc.identifier.issn.spa.fl_str_mv |
1098-3015 |
dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/11323/8336 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.jval.2020.04.489 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
1098-3015 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
https://hdl.handle.net/11323/8336 https://doi.org/10.1016/j.jval.2020.04.489 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
CC0 1.0 Universal |
dc.rights.uri.spa.fl_str_mv |
http://creativecommons.org/publicdomain/zero/1.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
CC0 1.0 Universal http://creativecommons.org/publicdomain/zero/1.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.source.spa.fl_str_mv |
Value in Health |
institution |
Corporación Universidad de la Costa |
dc.source.url.spa.fl_str_mv |
https://www.valueinhealthjournal.com/article/S1098-3015(20)30677-X/fulltext |
bitstream.url.fl_str_mv |
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De Los Angeles Carrasquilla, Mariade6eeb050ab6c75438d79da02e6b7d1dALVIS-ZAKZUK, NELSON J.382e6397ae2b49cf5c0177ca2eded476Zakzuk Sierra, Jac8a6cae88478dab9a954a1eed672fa8Benavides De La Rosa, Fernandada7e3b1152084ed95fb7a1c49b58ce18Castello Beltran, Carlos0d8e1248ba664b3059980da67a51a406Rojas, M9f657649363c762520db5d71e6d81e34Prieto, Estebanac60305eb176fef4a2169ccd4e495208Yen, Gd052c9237aa64277f418a0f9654afb9fParellada, Ca6c5d137b006b3bb7d95549c7f47ed1cPavelyev, Abf9cbfae4ddb39c8b09f3817d32673ae2021-06-02T16:47:07Z2021-06-02T16:47:07Z202020221098-3015https://hdl.handle.net/11323/8336https://doi.org/10.1016/j.jval.2020.04.489Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/We assessed the public health and economic impact of adding males to the existing female-only quadrivalent HPV vaccine (4vHPV) program in Colombia, analyzing different gender-neutral vaccination (GNV) vaccine coverage rates (VCRs). A published HPV-type dynamic transmission model was used to compare female-only vaccination (FOV) versus GNV with two-dose 4vHPV in the 9-10-year-old cohort over a 100-year timeframe in Colombia. The model compared 35% VCR for FOV with GNV at VCRs of 35% (scenario A), 50% (scenario B) and different VCRs between females/males (50%/35%, scenario C). The predicted health outcomes included HPV 6/11/16/18-related disease and deaths averted [cervical intraepithelial neoplasia, cervical, vaginal, vulvar, penile, anal and head and neck cancers, genital warts (GW), and recurrent respiratory papillomatosis], direct healthcare cost prevented by vaccination, and incremental cost-effectiveness ratios (ICERs). All GNV scenarios are estimated to provide faster and greater reductions in HPV 6/11/16/18-related diseases relative to FOV at 35% VCR, mainly scenarios B and C. The highest cumulative reductions in the incidence of HPV 6/11/16/18-related disease and deaths were seen in scenario B relative to FOV at 35% VCR at year 100, averting 28,001 cervical cancer (CC) cases, 11,968 non-CC cases (4,753 in females and 7,215 in males) and 15,141 deaths. The greatest projected reductions in health care costs are due to diseases caused by HPV-6/11 infection, driven by GW. The cost savings varied from 88 (scenario A) to 184 million (scenario B) relative to FOV at 35%. The ICER for all scenarios was <0, indicating that under the model assumptions it is cost-saving to implement a GNV-4vHPV in Colombia. In Colombia, a GNV-4vHPV program is a cost-saving strategy in the three scenarios analyzed relative to the current FOV program and result in greater improvement of the public health and economic impact in both women and men.application/pdfengCorporación Universidad de la CostaCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Value in Healthhttps://www.valueinhealthjournal.com/article/S1098-3015(20)30677-X/fulltextVaccinationHuman PapillomaHPVColombiaEstimating the impact of a gender-neutral quadrivalent human papillomavirus vaccination program in all hpv 6/11/16/18 -related diseases in ColombiaPre-Publicaciónhttp://purl.org/coar/resource_type/c_816bTextinfo:eu-repo/semantics/preprinthttp://purl.org/redcol/resource_type/ARTOTRinfo:eu-repo/semantics/acceptedVersionCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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