Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community

Several studies, in different populations and environments, have shown that severe and light helminthiases diminish and increase allergy symptoms, respectively. However, data on the simultaneous presence of these contrary effects in a single community is lacking. In a rural community from Colombia,...

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Autores:: Zakzuk, Josefina
Casadiego, Stephanie
Mercado, Ana
Alvis-Guzman, Nelson
Caraballo, Luis

Tipo de recurso:: Article of journal

Fecha de publicación:: 2018

Institución:: Corporación Universidad de la Costa

Repositorio:: REDICUC - Repositorio CUC

Idioma:: eng

Description
Summary:	Several studies, in different populations and environments, have shown that severe and light helminthiases diminish and increase allergy symptoms, respectively. However, data on the simultaneous presence of these contrary effects in a single community is lacking. In a rural community from Colombia, effects of helminthiases on allergy were evaluated. In the study population, age and gender-adjusted prevalence of asthma and rhinitis symptoms in the last year was 14.6% and 34.1%, respectively (N = 739). By stool exam, ascariasis and trichuriasis were 62.5% and 35.7%, respectively. Significant odds ratio (OR) for asthma presentation were Ascaris sensitization, by specific-IgE (aOR: 2.69, 95%CI: 1.21–5.98) or skin prick test (OR: 3.59, 95%CI: 1.55–8.29). Moderate/severe ascariasis was protective from asthma (aOR: 0.34, 95%CI: 0.12–0.99) and moderate/severe trichuriasis from rhinitis (aOR: 0.35, 95%CI: 0.15–0.80). In conclusion, in a rural tropical village, ascariasis exerts risk and protective effects on asthma symptoms, an influence associated with the severity of the infection.

Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community

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