Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea
Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation...
- Autores:
-
Franco, Claudiomar R.
Miranda Andrades, Jarol R.
Toloza, Carlos A.T.
G. Larrudé, Dunieskys
Maqueira Espinosa, Luis
Aucelio, Ricardo Q.
De Falco, Anna
Pedrozo Peñafiel, Marlin
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/10368
- Acceso en línea:
- https://hdl.handle.net/11323/10368
https://repositorio.cuc.edu.co/
- Palabra clave:
- Mercury
Thiomersal
Vaccines
Flow injection analysis
Photo-degradation
Carbon quantum dots
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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| dc.title.eng.fl_str_mv |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| spellingShingle |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| title_short |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_full |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_fullStr |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_full_unstemmed |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_sort |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| dc.creator.fl_str_mv |
Franco, Claudiomar R. Miranda Andrades, Jarol R. Toloza, Carlos A.T. G. Larrudé, Dunieskys Maqueira Espinosa, Luis Aucelio, Ricardo Q. De Falco, Anna Pedrozo Peñafiel, Marlin |
| dc.contributor.author.none.fl_str_mv |
Franco, Claudiomar R. Miranda Andrades, Jarol R. Toloza, Carlos A.T. G. Larrudé, Dunieskys Maqueira Espinosa, Luis Aucelio, Ricardo Q. De Falco, Anna Pedrozo Peñafiel, Marlin |
| dc.subject.proposal.eng.fl_str_mv |
Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| topic |
Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| description |
Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation (using UV and H2O2) to produce Hg2+ that was determined by flow injection analysis using luminescence probing with carbon quantum dots (prepared from citric acid and thiourea). Linear analytical response was observed in the concentration range of 25 to 900 µg L−1 and the method was efficiently applied to the determination of thiomersal in vaccines against hepatitis B and diphtheria-tetanus with recoveries ranging from 93 to 94%. |
| publishDate |
2023 |
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2023-08-08T19:02:52Z |
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2023-08-08T19:02:52Z |
| dc.date.issued.none.fl_str_mv |
2023 |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/redcol/resource_type/ART |
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Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.100184 |
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2666-8319 |
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https://hdl.handle.net/11323/10368 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.talo.2023.100184 |
| dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
| dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
| identifier_str_mv |
Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.100184 2666-8319 10.1016/j.talo.2023.100184 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| url |
https://hdl.handle.net/11323/10368 https://repositorio.cuc.edu.co/ |
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eng |
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eng |
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Talanta Open |
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[1] WHO, World health organization, https://www.who.int/teams/health-product-pol icy-and-standards/standards-and-specifications/vaccines-quality/thiomersal/, 2022 (Accessed 13 January 2023). [2] M.P. Da Silva, J. Rodriguez, L. Hernandez, ´ Electrochemical oxidative determination of thimerosal in soft contact lens care solutions by cyclic voltammetry, Analyst 119 (1994) 1971–1974, https://doi.org/10.1039/ AN9941901971. [3] V. Branco, S. Caito, M. Farina, J.B.T. Da Rocha, M. Aschner, C. Carvalho, Biomarkers of mercury toxicity: past, present and future trends, J. Toxicol. Environ. Health B Crit. Rev. 20 (2017) 119–154, https://doi.org/10.1080/ 10937404.2017.1289834. [4] A. Tall, K.R. Da Costa, M.J. De Oliveira, I. Tapsoba, U. Rocha, T.O. Sales, M.O. F. Goulart, J.C.C. Santos, Photoluminescent nanoprobes based on thiols capped CdTe quantum dots for direct determination of thimerosal in vaccines, Talanta 221 (2018), 121545, https://doi.org/10.1016/j.talanta.2020.121545. [5] J. Penagos-Llanos, J.A. Calderon, ´ E. Nagles, J.J. Hurtado, Voltammetric determination of thiomersal with a new modified electrode based on a carbon paste electrode decorated with La2O3, J. Electroanal. Chem. 833 (2019) 536–542, https://doi.org/10.1016/j.jelechem.2018.12.040. [6] M.J. De Oliveira, F.A.S. Cunha, J.C.C Santos, Determination of mercury (thimerosal) in vaccines using different oxidants and cold vapor atomic fluorescence spectrometry in dilute acids, J. Anal. At. Spectrom. 32 (2021) 740–746, https://doi.org/10.1039/d1ja00041a. [7] B. Campanella, M. Onor, M.C. Mascherpa, A. D’Ulivo, C. Ferrari, E. Bramanti, Determination of thiomersal by flow injection coupled with microwave-assisted photochemical online oxidative decomposition of organic mercury and cold vapor atomic fluorescence spectroscopy, Anal. Chim. Acta 804 (2013) 66–69, https://doi. org/10.1016/j.aca.2013.10.018. [8] C. Sandoval, S. Ranganathan, E. Ramírez, H.D. Mansilla, R. Dinamarca, G. Pecchi, J. Y´ anez, ˜ Visible light assisted photodegradation of thimerosal by high performance ZnFe2O4/poly(o-phenylenediamine) composite, Mater. Res. Bull. 116 (2019) 8–15, https://doi.org/10.1016/j.materresbull.2019.04.008. [9] M. Martín-Alonso, F. Pena-Pereira, I. Lavilla, C. Bendicho, Gold nanorods for indrop colorimetric determination of thiomersal after photochemical decomposition, Microchim. Acta 185 (2018) 221, https://doi.org/10.1007/s00604-018-2760-3. [10] J.R. Miranda-Andrades, S. Khan, C.A.T. Toloza, E.C. Romani, F.L. Freire Júnior, R. Q. Aucelio, Thiomersal photo-degradation with visible light mediated by graphene quantum dots: indirect quantification using optical multipath mercury cold-vapor absorption spectrophotometry, Spectrochim. Acta Part B. 138 (2017) 81–89, https://doi.org/10.1016/j.sab.2017.10.011. [11] F. Yan, Y. Zou, M. Wang, X. Mu, N. Yang, L. Chen, Highly photoluminescent carbon dots-based fluorescent chemosensors for sensitive and selective detection of mercury ions and application of imaging in living cells, Sens. Actuators B Chem. 192 (2014) 488–495, https://doi.org/10.1016/j.snb.2013.11.041. [12] A. De Falco, E. Santa-Helena, C.A.T. Toloza, J.M.S. Almeida, D.G. Larrude, F.V. P. Meirelles, C.R. Gioda, R.Q. Aucelio, A. Gioda, Luminescence imaging and toxicity assessment of graphene quantum dots using in vitro models, Fuller. Nanotub. 30 (2022) 657–666, https://doi.org/10.1080/1536383X.2021.1995367. [13] J.J. Liu, X.L. Zhang, Z.X. Cong, Z.T. Chen, H.H. Yang, G.N. Chen, Glutathionefunctionalized graphene quantum dots as selective fluorescent probes for phosphate-containing metabolites, Nanoscale 5 (2013) 1810–1815, https://doi. org/10.1039/C3NR33794D. [14] C.A. Toloza, S. Khan, R.L.D. Silva, E.C. Romani, D.G. Larrude, S.R.W. Louro, F. L. Freire Jr., R.Q. Auc´elio, Photoluminescence suppression effect caused by histamine on amino-functionalized graphene quantum dots with the mediation of Fe3+, Cu2+, Eu3+: application in the analysis of spoiled tuna fish, Microchem. J. 133 (2017) 448–459, https://doi.org/10.1016/j.microc.2017.04.013. [15] B. Euvax, Full prescribing information, dosage & side effects | MIMS Indonesia. https://www.mims.com/malaysia/drug/info/euvax-b?type=full, (Accessed 13 January 2023). [16] Diphtheria and tetanus (diphtheria and tetanus toxoids): uses, dosage, side effects, interactions, warning. https://www.rxlist.com/diptheria-and-tetanus-drug. htm#description/, (Accessed 13 January 2023). [17] J.R. Miranda-Andrades, M.J. Pedrozo-Penafiel, J.A. Mendes, R.Q. Aucelio, Thiomersal determination in vaccines using graphene quantum dots-TiO2 nanocomposite to promote temporally selective photo-production of Hg cold vapor, Spectrochim. Acta Part B 194 (2022), 106477, https://doi.org/10.1016/j. sab.2022.106477. [18] O.P. Ajsuvakova, A.A. Tinkov, M. Aschner, J.B.T. Rocha, B. Michalke, M. G. Skalnaya, A.V. Skalny, M. Butnariu, M. Dadar, I. Sarac, J. Aaseth, G. Bjørklund, Sulfhydryl groups as targets of mercury toxicity, Coord. Chem. Ver. 417 (2020), 213343, https://doi.org/10.1016/j.ccr.2020.213343. [19] M. Gochfeld, J. Burger, Mercury interactions with selenium and sulfur and the relevance of the Se:Hg molar ratio to fish consumption advice, Environ. Sci. Pollut. Res. Int. 28 (2021) 18407–18420, https://doi.org/10.1007/s11356-021-12361-7. [20] X. Wang, S.O. Pehkonen, A.K. Ray, Photocatalytic reduction of Hg(II) on two commercial TiO2 catalysts, Electrochim. Acta 49 (2004) 1435–1444, https://doi. org/10.1016/j.electacta.2003.10.030. [21] F. Pena-Pereira, W. Wojnowski, M. Tobiszewski, AGREE-analytical GREEnness metric approach and software, Anal. Chem. 92 (2020) 10076–10082, https://doi. org/10.1021/acs.analchem.0c01887. |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2023 The Authors. Published by Elsevier B.V.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Franco, Claudiomar R.eff09b25a7970052bd0b04e10ea9d8ddMiranda Andrades, Jarol R.ce0998e4c3ab1de4a20d8a9e25fc1160600Toloza, Carlos A.T.260d4698a7e3487bed8256ff21247144G. Larrudé, Dunieskysc5bfbe96038289dc6daf5e607718b6feMaqueira Espinosa, Luis69551d1793cb0fd70c391cec48fbfcb8600Aucelio, Ricardo Q.260b2b49bfd3c3a4cb986947398b84b4De Falco, Annad03e49ca51c3234134e70fcf4a0692c3600Pedrozo Peñafiel, Marlin8f1fc693c115fbc33437e83b213fa4b26002023-08-08T19:02:52Z2023-08-08T19:02:52Z2023Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.1001842666-8319https://hdl.handle.net/11323/1036810.1016/j.talo.2023.100184Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation (using UV and H2O2) to produce Hg2+ that was determined by flow injection analysis using luminescence probing with carbon quantum dots (prepared from citric acid and thiourea). Linear analytical response was observed in the concentration range of 25 to 900 µg L−1 and the method was efficiently applied to the determination of thiomersal in vaccines against hepatitis B and diphtheria-tetanus with recoveries ranging from 93 to 94%.7 páginasapplication/pdfengElsevier BVNetherlandshttps://www.sciencedirect.com/science/article/pii/S266683192300005XDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thioureaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Talanta Open[1] WHO, World health organization, https://www.who.int/teams/health-product-pol icy-and-standards/standards-and-specifications/vaccines-quality/thiomersal/, 2022 (Accessed 13 January 2023).[2] M.P. Da Silva, J. Rodriguez, L. Hernandez, ´ Electrochemical oxidative determination of thimerosal in soft contact lens care solutions by cyclic voltammetry, Analyst 119 (1994) 1971–1974, https://doi.org/10.1039/ AN9941901971.[3] V. Branco, S. Caito, M. Farina, J.B.T. Da Rocha, M. Aschner, C. Carvalho, Biomarkers of mercury toxicity: past, present and future trends, J. Toxicol. Environ. Health B Crit. Rev. 20 (2017) 119–154, https://doi.org/10.1080/ 10937404.2017.1289834.[4] A. Tall, K.R. Da Costa, M.J. De Oliveira, I. Tapsoba, U. Rocha, T.O. Sales, M.O. F. Goulart, J.C.C. Santos, Photoluminescent nanoprobes based on thiols capped CdTe quantum dots for direct determination of thimerosal in vaccines, Talanta 221 (2018), 121545, https://doi.org/10.1016/j.talanta.2020.121545.[5] J. Penagos-Llanos, J.A. Calderon, ´ E. Nagles, J.J. Hurtado, Voltammetric determination of thiomersal with a new modified electrode based on a carbon paste electrode decorated with La2O3, J. Electroanal. Chem. 833 (2019) 536–542, https://doi.org/10.1016/j.jelechem.2018.12.040.[6] M.J. De Oliveira, F.A.S. Cunha, J.C.C Santos, Determination of mercury (thimerosal) in vaccines using different oxidants and cold vapor atomic fluorescence spectrometry in dilute acids, J. Anal. At. Spectrom. 32 (2021) 740–746, https://doi.org/10.1039/d1ja00041a.[7] B. Campanella, M. Onor, M.C. Mascherpa, A. D’Ulivo, C. Ferrari, E. Bramanti, Determination of thiomersal by flow injection coupled with microwave-assisted photochemical online oxidative decomposition of organic mercury and cold vapor atomic fluorescence spectroscopy, Anal. Chim. Acta 804 (2013) 66–69, https://doi. org/10.1016/j.aca.2013.10.018.[8] C. Sandoval, S. Ranganathan, E. Ramírez, H.D. Mansilla, R. Dinamarca, G. Pecchi, J. Y´ anez, ˜ Visible light assisted photodegradation of thimerosal by high performance ZnFe2O4/poly(o-phenylenediamine) composite, Mater. Res. Bull. 116 (2019) 8–15, https://doi.org/10.1016/j.materresbull.2019.04.008.[9] M. Martín-Alonso, F. Pena-Pereira, I. Lavilla, C. Bendicho, Gold nanorods for indrop colorimetric determination of thiomersal after photochemical decomposition, Microchim. Acta 185 (2018) 221, https://doi.org/10.1007/s00604-018-2760-3.[10] J.R. Miranda-Andrades, S. Khan, C.A.T. Toloza, E.C. Romani, F.L. Freire Júnior, R. Q. Aucelio, Thiomersal photo-degradation with visible light mediated by graphene quantum dots: indirect quantification using optical multipath mercury cold-vapor absorption spectrophotometry, Spectrochim. Acta Part B. 138 (2017) 81–89, https://doi.org/10.1016/j.sab.2017.10.011.[11] F. Yan, Y. Zou, M. Wang, X. Mu, N. Yang, L. Chen, Highly photoluminescent carbon dots-based fluorescent chemosensors for sensitive and selective detection of mercury ions and application of imaging in living cells, Sens. Actuators B Chem. 192 (2014) 488–495, https://doi.org/10.1016/j.snb.2013.11.041.[12] A. De Falco, E. Santa-Helena, C.A.T. Toloza, J.M.S. Almeida, D.G. Larrude, F.V. P. Meirelles, C.R. Gioda, R.Q. Aucelio, A. Gioda, Luminescence imaging and toxicity assessment of graphene quantum dots using in vitro models, Fuller. Nanotub. 30 (2022) 657–666, https://doi.org/10.1080/1536383X.2021.1995367.[13] J.J. Liu, X.L. Zhang, Z.X. Cong, Z.T. Chen, H.H. Yang, G.N. Chen, Glutathionefunctionalized graphene quantum dots as selective fluorescent probes for phosphate-containing metabolites, Nanoscale 5 (2013) 1810–1815, https://doi. org/10.1039/C3NR33794D.[14] C.A. Toloza, S. Khan, R.L.D. Silva, E.C. Romani, D.G. Larrude, S.R.W. Louro, F. L. Freire Jr., R.Q. Auc´elio, Photoluminescence suppression effect caused by histamine on amino-functionalized graphene quantum dots with the mediation of Fe3+, Cu2+, Eu3+: application in the analysis of spoiled tuna fish, Microchem. J. 133 (2017) 448–459, https://doi.org/10.1016/j.microc.2017.04.013.[15] B. Euvax, Full prescribing information, dosage & side effects | MIMS Indonesia. https://www.mims.com/malaysia/drug/info/euvax-b?type=full, (Accessed 13 January 2023).[16] Diphtheria and tetanus (diphtheria and tetanus toxoids): uses, dosage, side effects, interactions, warning. https://www.rxlist.com/diptheria-and-tetanus-drug. htm#description/, (Accessed 13 January 2023).[17] J.R. Miranda-Andrades, M.J. Pedrozo-Penafiel, J.A. Mendes, R.Q. Aucelio, Thiomersal determination in vaccines using graphene quantum dots-TiO2 nanocomposite to promote temporally selective photo-production of Hg cold vapor, Spectrochim. Acta Part B 194 (2022), 106477, https://doi.org/10.1016/j. sab.2022.106477.[18] O.P. Ajsuvakova, A.A. Tinkov, M. Aschner, J.B.T. Rocha, B. Michalke, M. G. Skalnaya, A.V. Skalny, M. Butnariu, M. Dadar, I. Sarac, J. Aaseth, G. Bjørklund, Sulfhydryl groups as targets of mercury toxicity, Coord. Chem. Ver. 417 (2020), 213343, https://doi.org/10.1016/j.ccr.2020.213343.[19] M. 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Chem. 92 (2020) 10076–10082, https://doi. org/10.1021/acs.analchem.0c01887.717MercuryThiomersalVaccinesFlow injection analysisPhoto-degradationCarbon quantum dotsORIGINALDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdfDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdfapplication/pdf1109420https://repositorio.cuc.edu.co/bitstream/11323/10368/1/Determination%20of%20thiomersal%20and%20mercurial%20residues%20by%20photo-degradation%20and%20flow%20injection%20analysis%20with%20luminescence%20probing%20using%20carbon%20quantum%20dots%20prepared%20from%20thiourea.pdf958e230c4d79e8403570b5c629714bdaMD51open accessLICENSElicense.txtlicense.txttext/plain; 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carbon quantum dots prepared from thiourea.pdf.jpgDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdf.jpgGenerated Thumbnailimage/jpeg15214https://repositorio.cuc.edu.co/bitstream/11323/10368/4/Determination%20of%20thiomersal%20and%20mercurial%20residues%20by%20photo-degradation%20and%20flow%20injection%20analysis%20with%20luminescence%20probing%20using%20carbon%20quantum%20dots%20prepared%20from%20thiourea.pdf.jpg7efcac4d3b81dc94dc8d128f33b9237eMD54open access11323/10368oai:repositorio.cuc.edu.co:11323/103682023-08-09 03:02:51.475An error occurred on the license name.|||https://creativecommons.org/licenses/by-nc-nd/4.0/open accessRepositorio Universidad de La 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corporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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