Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea
Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation...
- Autores:
-
Franco, Claudiomar R.
Miranda Andrades, Jarol R.
Toloza, Carlos A.T.
G. Larrudé, Dunieskys
Maqueira Espinosa, Luis
Aucelio, Ricardo Q.
De Falco, Anna
Pedrozo Peñafiel, Marlin
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/10368
- Acceso en línea:
- https://hdl.handle.net/11323/10368
https://repositorio.cuc.edu.co/
- Palabra clave:
- Mercury
Thiomersal
Vaccines
Flow injection analysis
Photo-degradation
Carbon quantum dots
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
| id |
RCUC2_0fbf1ef6f6204d31d375e26e3c612dc0 |
|---|---|
| oai_identifier_str |
oai:repositorio.cuc.edu.co:11323/10368 |
| network_acronym_str |
RCUC2 |
| network_name_str |
REDICUC - Repositorio CUC |
| repository_id_str |
|
| dc.title.eng.fl_str_mv |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| spellingShingle |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| title_short |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_full |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_fullStr |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_full_unstemmed |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| title_sort |
Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea |
| dc.creator.fl_str_mv |
Franco, Claudiomar R. Miranda Andrades, Jarol R. Toloza, Carlos A.T. G. Larrudé, Dunieskys Maqueira Espinosa, Luis Aucelio, Ricardo Q. De Falco, Anna Pedrozo Peñafiel, Marlin |
| dc.contributor.author.none.fl_str_mv |
Franco, Claudiomar R. Miranda Andrades, Jarol R. Toloza, Carlos A.T. G. Larrudé, Dunieskys Maqueira Espinosa, Luis Aucelio, Ricardo Q. De Falco, Anna Pedrozo Peñafiel, Marlin |
| dc.subject.proposal.eng.fl_str_mv |
Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| topic |
Mercury Thiomersal Vaccines Flow injection analysis Photo-degradation Carbon quantum dots |
| description |
Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation (using UV and H2O2) to produce Hg2+ that was determined by flow injection analysis using luminescence probing with carbon quantum dots (prepared from citric acid and thiourea). Linear analytical response was observed in the concentration range of 25 to 900 µg L−1 and the method was efficiently applied to the determination of thiomersal in vaccines against hepatitis B and diphtheria-tetanus with recoveries ranging from 93 to 94%. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-08T19:02:52Z |
| dc.date.available.none.fl_str_mv |
2023-08-08T19:02:52Z |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.100184 |
| dc.identifier.issn.spa.fl_str_mv |
2666-8319 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11323/10368 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.talo.2023.100184 |
| dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
| dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
| identifier_str_mv |
Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.100184 2666-8319 10.1016/j.talo.2023.100184 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
| url |
https://hdl.handle.net/11323/10368 https://repositorio.cuc.edu.co/ |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Talanta Open |
| dc.relation.references.spa.fl_str_mv |
[1] WHO, World health organization, https://www.who.int/teams/health-product-pol icy-and-standards/standards-and-specifications/vaccines-quality/thiomersal/, 2022 (Accessed 13 January 2023). [2] M.P. Da Silva, J. Rodriguez, L. Hernandez, ´ Electrochemical oxidative determination of thimerosal in soft contact lens care solutions by cyclic voltammetry, Analyst 119 (1994) 1971–1974, https://doi.org/10.1039/ AN9941901971. [3] V. Branco, S. Caito, M. Farina, J.B.T. Da Rocha, M. Aschner, C. Carvalho, Biomarkers of mercury toxicity: past, present and future trends, J. Toxicol. Environ. Health B Crit. Rev. 20 (2017) 119–154, https://doi.org/10.1080/ 10937404.2017.1289834. [4] A. Tall, K.R. Da Costa, M.J. De Oliveira, I. Tapsoba, U. Rocha, T.O. Sales, M.O. F. Goulart, J.C.C. Santos, Photoluminescent nanoprobes based on thiols capped CdTe quantum dots for direct determination of thimerosal in vaccines, Talanta 221 (2018), 121545, https://doi.org/10.1016/j.talanta.2020.121545. [5] J. Penagos-Llanos, J.A. Calderon, ´ E. Nagles, J.J. Hurtado, Voltammetric determination of thiomersal with a new modified electrode based on a carbon paste electrode decorated with La2O3, J. Electroanal. Chem. 833 (2019) 536–542, https://doi.org/10.1016/j.jelechem.2018.12.040. [6] M.J. De Oliveira, F.A.S. Cunha, J.C.C Santos, Determination of mercury (thimerosal) in vaccines using different oxidants and cold vapor atomic fluorescence spectrometry in dilute acids, J. Anal. At. Spectrom. 32 (2021) 740–746, https://doi.org/10.1039/d1ja00041a. [7] B. Campanella, M. Onor, M.C. Mascherpa, A. D’Ulivo, C. Ferrari, E. Bramanti, Determination of thiomersal by flow injection coupled with microwave-assisted photochemical online oxidative decomposition of organic mercury and cold vapor atomic fluorescence spectroscopy, Anal. Chim. Acta 804 (2013) 66–69, https://doi. org/10.1016/j.aca.2013.10.018. [8] C. Sandoval, S. Ranganathan, E. Ramírez, H.D. Mansilla, R. Dinamarca, G. Pecchi, J. Y´ anez, ˜ Visible light assisted photodegradation of thimerosal by high performance ZnFe2O4/poly(o-phenylenediamine) composite, Mater. Res. Bull. 116 (2019) 8–15, https://doi.org/10.1016/j.materresbull.2019.04.008. [9] M. Martín-Alonso, F. Pena-Pereira, I. Lavilla, C. Bendicho, Gold nanorods for indrop colorimetric determination of thiomersal after photochemical decomposition, Microchim. Acta 185 (2018) 221, https://doi.org/10.1007/s00604-018-2760-3. [10] J.R. Miranda-Andrades, S. Khan, C.A.T. Toloza, E.C. Romani, F.L. Freire Júnior, R. Q. Aucelio, Thiomersal photo-degradation with visible light mediated by graphene quantum dots: indirect quantification using optical multipath mercury cold-vapor absorption spectrophotometry, Spectrochim. Acta Part B. 138 (2017) 81–89, https://doi.org/10.1016/j.sab.2017.10.011. [11] F. Yan, Y. Zou, M. Wang, X. Mu, N. Yang, L. Chen, Highly photoluminescent carbon dots-based fluorescent chemosensors for sensitive and selective detection of mercury ions and application of imaging in living cells, Sens. Actuators B Chem. 192 (2014) 488–495, https://doi.org/10.1016/j.snb.2013.11.041. [12] A. De Falco, E. Santa-Helena, C.A.T. Toloza, J.M.S. Almeida, D.G. Larrude, F.V. P. Meirelles, C.R. Gioda, R.Q. Aucelio, A. Gioda, Luminescence imaging and toxicity assessment of graphene quantum dots using in vitro models, Fuller. Nanotub. 30 (2022) 657–666, https://doi.org/10.1080/1536383X.2021.1995367. [13] J.J. Liu, X.L. Zhang, Z.X. Cong, Z.T. Chen, H.H. Yang, G.N. Chen, Glutathionefunctionalized graphene quantum dots as selective fluorescent probes for phosphate-containing metabolites, Nanoscale 5 (2013) 1810–1815, https://doi. org/10.1039/C3NR33794D. [14] C.A. Toloza, S. Khan, R.L.D. Silva, E.C. Romani, D.G. Larrude, S.R.W. Louro, F. L. Freire Jr., R.Q. Auc´elio, Photoluminescence suppression effect caused by histamine on amino-functionalized graphene quantum dots with the mediation of Fe3+, Cu2+, Eu3+: application in the analysis of spoiled tuna fish, Microchem. J. 133 (2017) 448–459, https://doi.org/10.1016/j.microc.2017.04.013. [15] B. Euvax, Full prescribing information, dosage & side effects | MIMS Indonesia. https://www.mims.com/malaysia/drug/info/euvax-b?type=full, (Accessed 13 January 2023). [16] Diphtheria and tetanus (diphtheria and tetanus toxoids): uses, dosage, side effects, interactions, warning. https://www.rxlist.com/diptheria-and-tetanus-drug. htm#description/, (Accessed 13 January 2023). [17] J.R. Miranda-Andrades, M.J. Pedrozo-Penafiel, J.A. Mendes, R.Q. Aucelio, Thiomersal determination in vaccines using graphene quantum dots-TiO2 nanocomposite to promote temporally selective photo-production of Hg cold vapor, Spectrochim. Acta Part B 194 (2022), 106477, https://doi.org/10.1016/j. sab.2022.106477. [18] O.P. Ajsuvakova, A.A. Tinkov, M. Aschner, J.B.T. Rocha, B. Michalke, M. G. Skalnaya, A.V. Skalny, M. Butnariu, M. Dadar, I. Sarac, J. Aaseth, G. Bjørklund, Sulfhydryl groups as targets of mercury toxicity, Coord. Chem. Ver. 417 (2020), 213343, https://doi.org/10.1016/j.ccr.2020.213343. [19] M. Gochfeld, J. Burger, Mercury interactions with selenium and sulfur and the relevance of the Se:Hg molar ratio to fish consumption advice, Environ. Sci. Pollut. Res. Int. 28 (2021) 18407–18420, https://doi.org/10.1007/s11356-021-12361-7. [20] X. Wang, S.O. Pehkonen, A.K. Ray, Photocatalytic reduction of Hg(II) on two commercial TiO2 catalysts, Electrochim. Acta 49 (2004) 1435–1444, https://doi. org/10.1016/j.electacta.2003.10.030. [21] F. Pena-Pereira, W. Wojnowski, M. Tobiszewski, AGREE-analytical GREEnness metric approach and software, Anal. Chem. 92 (2020) 10076–10082, https://doi. org/10.1021/acs.analchem.0c01887. |
| dc.relation.citationstartpage.spa.fl_str_mv |
7 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.relation.citationvolume.spa.fl_str_mv |
7 |
| dc.rights.eng.fl_str_mv |
© 2023 The Authors. Published by Elsevier B.V. |
| dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
7 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Elsevier BV |
| dc.publisher.place.spa.fl_str_mv |
Netherlands |
| dc.source.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S266683192300005X |
| institution |
Corporación Universidad de la Costa |
| bitstream.url.fl_str_mv |
https://repositorio.cuc.edu.co/bitstreams/e55f9ae2-e1ec-4e1c-955e-e0adee0a10fb/download https://repositorio.cuc.edu.co/bitstreams/c0d15d7c-cd5c-4c5e-a618-b202012b3c98/download https://repositorio.cuc.edu.co/bitstreams/d6b63c64-997e-451a-9367-20f974d677e9/download https://repositorio.cuc.edu.co/bitstreams/7de9e878-8198-4406-b56e-ee3e9103c4a4/download |
| bitstream.checksum.fl_str_mv |
958e230c4d79e8403570b5c629714bda 2f9959eaf5b71fae44bbf9ec84150c7a f5213df050e37fc9241c7b47e97e288d 7efcac4d3b81dc94dc8d128f33b9237e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio de la Universidad de la Costa CUC |
| repository.mail.fl_str_mv |
repdigital@cuc.edu.co |
| _version_ |
1828166813364518912 |
| spelling |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2023 The Authors. Published by Elsevier B.V.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Franco, Claudiomar R.Miranda Andrades, Jarol R.Toloza, Carlos A.T.G. Larrudé, DunieskysMaqueira Espinosa, LuisAucelio, Ricardo Q.De Falco, AnnaPedrozo Peñafiel, Marlin2023-08-08T19:02:52Z2023-08-08T19:02:52Z2023Claudiomar R. Franco, Jarol R. Miranda-Andrades, Carlos A.T. Toloza, Dunieskys G. Larrudé, Luis Maqueira-Espinosa, Ricardo Q. Aucelio, Anna De Falco, Marlin J. Pedrozo-Peñafiel, Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea, Talanta Open, Volume 7, 2023, 100184, ISSN 2666-8319, https://doi.org/10.1016/j.talo.2023.1001842666-8319https://hdl.handle.net/11323/1036810.1016/j.talo.2023.100184Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation (using UV and H2O2) to produce Hg2+ that was determined by flow injection analysis using luminescence probing with carbon quantum dots (prepared from citric acid and thiourea). Linear analytical response was observed in the concentration range of 25 to 900 µg L−1 and the method was efficiently applied to the determination of thiomersal in vaccines against hepatitis B and diphtheria-tetanus with recoveries ranging from 93 to 94%.7 páginasapplication/pdfengElsevier BVNetherlandshttps://www.sciencedirect.com/science/article/pii/S266683192300005XDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thioureaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Talanta Open[1] WHO, World health organization, https://www.who.int/teams/health-product-pol icy-and-standards/standards-and-specifications/vaccines-quality/thiomersal/, 2022 (Accessed 13 January 2023).[2] M.P. Da Silva, J. Rodriguez, L. Hernandez, ´ Electrochemical oxidative determination of thimerosal in soft contact lens care solutions by cyclic voltammetry, Analyst 119 (1994) 1971–1974, https://doi.org/10.1039/ AN9941901971.[3] V. Branco, S. Caito, M. Farina, J.B.T. Da Rocha, M. Aschner, C. Carvalho, Biomarkers of mercury toxicity: past, present and future trends, J. Toxicol. Environ. Health B Crit. Rev. 20 (2017) 119–154, https://doi.org/10.1080/ 10937404.2017.1289834.[4] A. Tall, K.R. Da Costa, M.J. De Oliveira, I. Tapsoba, U. Rocha, T.O. Sales, M.O. F. Goulart, J.C.C. Santos, Photoluminescent nanoprobes based on thiols capped CdTe quantum dots for direct determination of thimerosal in vaccines, Talanta 221 (2018), 121545, https://doi.org/10.1016/j.talanta.2020.121545.[5] J. Penagos-Llanos, J.A. Calderon, ´ E. Nagles, J.J. Hurtado, Voltammetric determination of thiomersal with a new modified electrode based on a carbon paste electrode decorated with La2O3, J. Electroanal. Chem. 833 (2019) 536–542, https://doi.org/10.1016/j.jelechem.2018.12.040.[6] M.J. De Oliveira, F.A.S. Cunha, J.C.C Santos, Determination of mercury (thimerosal) in vaccines using different oxidants and cold vapor atomic fluorescence spectrometry in dilute acids, J. Anal. At. Spectrom. 32 (2021) 740–746, https://doi.org/10.1039/d1ja00041a.[7] B. Campanella, M. Onor, M.C. Mascherpa, A. D’Ulivo, C. Ferrari, E. Bramanti, Determination of thiomersal by flow injection coupled with microwave-assisted photochemical online oxidative decomposition of organic mercury and cold vapor atomic fluorescence spectroscopy, Anal. Chim. Acta 804 (2013) 66–69, https://doi. org/10.1016/j.aca.2013.10.018.[8] C. Sandoval, S. Ranganathan, E. Ramírez, H.D. Mansilla, R. Dinamarca, G. Pecchi, J. Y´ anez, ˜ Visible light assisted photodegradation of thimerosal by high performance ZnFe2O4/poly(o-phenylenediamine) composite, Mater. Res. Bull. 116 (2019) 8–15, https://doi.org/10.1016/j.materresbull.2019.04.008.[9] M. Martín-Alonso, F. Pena-Pereira, I. Lavilla, C. Bendicho, Gold nanorods for indrop colorimetric determination of thiomersal after photochemical decomposition, Microchim. Acta 185 (2018) 221, https://doi.org/10.1007/s00604-018-2760-3.[10] J.R. Miranda-Andrades, S. Khan, C.A.T. Toloza, E.C. Romani, F.L. Freire Júnior, R. Q. Aucelio, Thiomersal photo-degradation with visible light mediated by graphene quantum dots: indirect quantification using optical multipath mercury cold-vapor absorption spectrophotometry, Spectrochim. Acta Part B. 138 (2017) 81–89, https://doi.org/10.1016/j.sab.2017.10.011.[11] F. Yan, Y. Zou, M. Wang, X. Mu, N. Yang, L. Chen, Highly photoluminescent carbon dots-based fluorescent chemosensors for sensitive and selective detection of mercury ions and application of imaging in living cells, Sens. Actuators B Chem. 192 (2014) 488–495, https://doi.org/10.1016/j.snb.2013.11.041.[12] A. De Falco, E. Santa-Helena, C.A.T. Toloza, J.M.S. Almeida, D.G. Larrude, F.V. P. Meirelles, C.R. Gioda, R.Q. Aucelio, A. Gioda, Luminescence imaging and toxicity assessment of graphene quantum dots using in vitro models, Fuller. Nanotub. 30 (2022) 657–666, https://doi.org/10.1080/1536383X.2021.1995367.[13] J.J. Liu, X.L. Zhang, Z.X. Cong, Z.T. Chen, H.H. Yang, G.N. Chen, Glutathionefunctionalized graphene quantum dots as selective fluorescent probes for phosphate-containing metabolites, Nanoscale 5 (2013) 1810–1815, https://doi. org/10.1039/C3NR33794D.[14] C.A. Toloza, S. Khan, R.L.D. Silva, E.C. Romani, D.G. Larrude, S.R.W. Louro, F. L. Freire Jr., R.Q. Auc´elio, Photoluminescence suppression effect caused by histamine on amino-functionalized graphene quantum dots with the mediation of Fe3+, Cu2+, Eu3+: application in the analysis of spoiled tuna fish, Microchem. J. 133 (2017) 448–459, https://doi.org/10.1016/j.microc.2017.04.013.[15] B. Euvax, Full prescribing information, dosage & side effects | MIMS Indonesia. https://www.mims.com/malaysia/drug/info/euvax-b?type=full, (Accessed 13 January 2023).[16] Diphtheria and tetanus (diphtheria and tetanus toxoids): uses, dosage, side effects, interactions, warning. https://www.rxlist.com/diptheria-and-tetanus-drug. htm#description/, (Accessed 13 January 2023).[17] J.R. Miranda-Andrades, M.J. Pedrozo-Penafiel, J.A. Mendes, R.Q. Aucelio, Thiomersal determination in vaccines using graphene quantum dots-TiO2 nanocomposite to promote temporally selective photo-production of Hg cold vapor, Spectrochim. Acta Part B 194 (2022), 106477, https://doi.org/10.1016/j. sab.2022.106477.[18] O.P. Ajsuvakova, A.A. Tinkov, M. Aschner, J.B.T. Rocha, B. Michalke, M. G. Skalnaya, A.V. Skalny, M. Butnariu, M. Dadar, I. Sarac, J. Aaseth, G. Bjørklund, Sulfhydryl groups as targets of mercury toxicity, Coord. Chem. Ver. 417 (2020), 213343, https://doi.org/10.1016/j.ccr.2020.213343.[19] M. Gochfeld, J. Burger, Mercury interactions with selenium and sulfur and the relevance of the Se:Hg molar ratio to fish consumption advice, Environ. Sci. Pollut. Res. Int. 28 (2021) 18407–18420, https://doi.org/10.1007/s11356-021-12361-7.[20] X. Wang, S.O. Pehkonen, A.K. Ray, Photocatalytic reduction of Hg(II) on two commercial TiO2 catalysts, Electrochim. Acta 49 (2004) 1435–1444, https://doi. org/10.1016/j.electacta.2003.10.030.[21] F. Pena-Pereira, W. Wojnowski, M. Tobiszewski, AGREE-analytical GREEnness metric approach and software, Anal. Chem. 92 (2020) 10076–10082, https://doi. org/10.1021/acs.analchem.0c01887.717MercuryThiomersalVaccinesFlow injection analysisPhoto-degradationCarbon quantum dotsPublicationORIGINALDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdfDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdfapplication/pdf1109420https://repositorio.cuc.edu.co/bitstreams/e55f9ae2-e1ec-4e1c-955e-e0adee0a10fb/download958e230c4d79e8403570b5c629714bdaMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/c0d15d7c-cd5c-4c5e-a618-b202012b3c98/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdf.txtDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdf.txtExtracted texttext/plain45962https://repositorio.cuc.edu.co/bitstreams/d6b63c64-997e-451a-9367-20f974d677e9/downloadf5213df050e37fc9241c7b47e97e288dMD53THUMBNAILDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdf.jpgDetermination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea.pdf.jpgGenerated Thumbnailimage/jpeg15214https://repositorio.cuc.edu.co/bitstreams/7de9e878-8198-4406-b56e-ee3e9103c4a4/download7efcac4d3b81dc94dc8d128f33b9237eMD5411323/10368oai:repositorio.cuc.edu.co:11323/103682024-09-17 14:12:59.888https://creativecommons.org/licenses/by-nc-nd/4.0/© 2023 The Authors. Published by Elsevier B.V.open.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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 |