Pharmacovigilance in neuroscience
Adverse Drug Reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance. The primary objective of this article is to describe and compare the adverse reactions produced by drug...
- Autores:
-
Sánchez-de-Paz4, María-Pilar
Da-Prat-de-Magalhaes, Gustavo
Isa, Santiago
Aldinio, Victoria
Norberto-Latella, Andres
Mabel-Gatto, Emilia
J. Rojas, Galeno
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
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- oai:repositorio.cuc.edu.co:11323/10134
- Acceso en línea:
- https://hdl.handle.net/11323/10134
https://repositorio.cuc.edu.co/
- Palabra clave:
- Pharmacovigilance
Epidemiology
Adverse reactions
Drugs
Neurology
Pharmacology
Farmacovigilancia
Epidemiología
Reacciones adversas
Fármacos
Neurología
Farmacología
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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Pharmacovigilance in neuroscience |
| dc.title.translated.none.fl_str_mv |
Farmacovigilancia en neurociencia |
| title |
Pharmacovigilance in neuroscience |
| spellingShingle |
Pharmacovigilance in neuroscience Pharmacovigilance Epidemiology Adverse reactions Drugs Neurology Pharmacology Farmacovigilancia Epidemiología Reacciones adversas Fármacos Neurología Farmacología |
| title_short |
Pharmacovigilance in neuroscience |
| title_full |
Pharmacovigilance in neuroscience |
| title_fullStr |
Pharmacovigilance in neuroscience |
| title_full_unstemmed |
Pharmacovigilance in neuroscience |
| title_sort |
Pharmacovigilance in neuroscience |
| dc.creator.fl_str_mv |
Sánchez-de-Paz4, María-Pilar Da-Prat-de-Magalhaes, Gustavo Isa, Santiago Aldinio, Victoria Norberto-Latella, Andres Mabel-Gatto, Emilia J. Rojas, Galeno |
| dc.contributor.author.none.fl_str_mv |
Sánchez-de-Paz4, María-Pilar Da-Prat-de-Magalhaes, Gustavo Isa, Santiago Aldinio, Victoria Norberto-Latella, Andres Mabel-Gatto, Emilia J. Rojas, Galeno |
| dc.subject.proposal.eng.fl_str_mv |
Pharmacovigilance Epidemiology Adverse reactions Drugs Neurology Pharmacology |
| topic |
Pharmacovigilance Epidemiology Adverse reactions Drugs Neurology Pharmacology Farmacovigilancia Epidemiología Reacciones adversas Fármacos Neurología Farmacología |
| dc.subject.proposal.spa.fl_str_mv |
Farmacovigilancia Epidemiología Reacciones adversas Fármacos Neurología Farmacología |
| description |
Adverse Drug Reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance. The primary objective of this article is to describe and compare the adverse reactions produced by drugs of nervous system action (CNS-D) and neurological ADRs produced by drugs of systemic action (Sys-D). To further develop the need of reporting adverse reactions. This is an observational, cross-sectional, retrospective study performed on a database of neurological consultations which took place at the Neurology department. Patients meeting the inclusion criteria were selected and divided into two groups: Sys-D and CNS-D. Demographic and neurological variables were analyzed. Parametric and non-parametric statistics were used according to distribution. The Naranjo Algorithm (NA) was used to define causality. 71 ADRs were described, from which 63.38% (n = 45) were produced by CNS-D, especially antiepileptics by 47% (n = 21) and psycholeptics by 44%. Of the total, 36.62% (n = 26) were caused by Sys-D, such as antineoplastics (n = 9) and antibiotics (n = 9), being Cefepime the most frequent. The diagnosis of ADRs caused by a Sys-D was delayed prolonging hospitalization (p 0.05) due to a lower NA score (p 0.003) compared to the CNS-D group. Multiple frequently used drugs of systemic action, such as antineoplastics and antibiotics, generate neurological adverse effects. From our analysis, it was presumed that the suspicion of a neurological ADR caused by these drugs was scarce, thus causing a higher morbidity for the patient. |
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2021 |
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2021-08-27 |
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2023-05-15T13:09:14Z |
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2023-05-15T13:09:14Z |
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Sánchez-de-Paz, M.-P., Da-Prat-de-Magalhaes, G., Isa, S., Aldinio, V., Norberto-Latella, A., Mabel-Gatto, E., & Rojas, G. J. (2021). Pharmacovigilance in Neuroscience: Farmacovigilancia en neurociencia. Journal of Applied Cognitive Neuroscience, 2(1), e00163800. https://doi.org/10.17981/JACN.2.1.2021.04 |
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https://hdl.handle.net/11323/10134 |
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10.17981/JACN.2.1.2021.04 |
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2745-0031 |
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Corporación Universidad de la Costa |
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Sánchez-de-Paz, M.-P., Da-Prat-de-Magalhaes, G., Isa, S., Aldinio, V., Norberto-Latella, A., Mabel-Gatto, E., & Rojas, G. J. (2021). Pharmacovigilance in Neuroscience: Farmacovigilancia en neurociencia. Journal of Applied Cognitive Neuroscience, 2(1), e00163800. https://doi.org/10.17981/JACN.2.1.2021.04 10.17981/JACN.2.1.2021.04 2745-0031 Corporación Universidad de la Costa REDICUC – Repositorio CUC |
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eng |
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Journal of Applied Cognitive Neuroscience |
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Bignone, I. y Schiaffino, S. (2016). Manual de Buenas Prácticas de Farmacovigilancia. [1a ed.]. Buenos Aires: Ediciones Farmacológicas. Bolaños, R. (Coord.). (2016). Psicotrópicos y estupefacientes. Buenos Aires: Administración Nacional de Medicamentos, Alimentos y Tecnología Médica. Buenos Aires: ANMAT. Recuperado de http://www.anmat.gov.ar/ssce/Libro-psicotropicos-estupefacientes.pdf Chaio, S.; Toibaro, J.; Valicenti, P. & Saidón, P. (2013). Reacciones adversas medicamentosas y errores de prescripción: Morbi-Mortalidad. Medicina, 73(2), 111–118. Recuperadode http://www.scielo.org.ar/pdf/medba/v73n2/v73n2a03.pdf Edwards, R. & Aronson, J. (2000). Adverse drug reactions: definitions, diagnosis, and management. Lancet, 356(9237), 1255–1259. https://doi.org/10.1016/S0140-6736(00)02799-9 Grill, M. F. & Maganti, R. K. (2011). Neurotoxic effects associated with antibiotic use: management considerations. British Journal of Clinical Pharmacology, 72(3), 381–393. https://doi.org/10.1111/j.1365-2125.2011.03991.x Lazarou, J.; Pomeranz, B. & Corey P. (1998). Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies. JAMA, 279(15), 1200–1205. https://doi.org/10.1001/jama.279.15.1200 Martino, G.; Rojas, G.; Sánchez, M. P.; Isaa, S.; Bres, M.; Camino, M. V..; Merchán, X.; Aldinio, V.; Parisi, V.; Persi, G.; Pereira, N. & Gatto, E. (2019). Seguridad de fármacos antineoplásicos e inmunomoduladores aplicados a la neurología. Neurolargía Argentina, 11(3), 136–144. https://doi.org/10.1016/j.neuarg.2019.03.001 Naranjo, C. A.; Busto, U.; Sellers, E. M.; Sandor, P.; Ruiz, I.; Roberts E.A.; Janecek, E.; Domecq C. & Greenblatt, D. J. (1981). A method for estimating the probability of adverse drug reactions. Clinical Pharmacology and Therapeutics, 30(2), 239–245. https://doi.org/10.1038/clpt.1981.154 Orta, I. A.; Garcia, O.; Triolet, A. T.; Gómez, C. & Ruiz, K. (2008). Reacciones adversas a medicamentos en una unidad de terapia intensiva. Revista Electrónica de Biomedicina, 2, 10–18. Disponible en http://biomed.uninet.edu/2008/n2/alfonso.html Ponte, M. L.; Ragusa, M.; Armenteros, C. & Wachs, A. (2013). Relevancia de la farmacovigilancia hospitalaria en la práctica médica actual. Medicina (Buenos Aires), 73(1), 35–38. Recuperado de http://www.scielo.org.ar/pdf/medba/v73n1/v73n1a07.pdf Rattagan, M. L.; Lisei, D.; Rojas, J. G.; Persi, G.; Parisi, V.; López , M.; Da Prat, G.; Bres M. & Gatto, E. (2016). Uso de psicotrópicos y carga sedativa en pacientes adultos con y sin demencia. Vertex, XXVII(129), 332–338. Disponible en http://www.editorialpolemos.com.ar/vertex129.php República de Argentina. Ministerio de Salud. (10 de septiembre de 2012). Buenas practicas de farmacovigilancia. [Disposición n° 5358]. Boletín Nacional: 23-Ene-2013. Disponible en https://www.argentina.gob.ar/normativa/nacional/disposici%C3%B 3n-5358-2012-207727 Rojas, G.; Demey, I. & Arizaga, R. L. (2013). Medicamentos utilizados para trastornos cognitivos. Análisis de un millón y medio de prescripciones en la Argentina. Medicina (Buenos Aires), 73(3), 213–223. Recuperado de http://www.scielo.org.ar/pdf/medba/v73n3/v73n3a03.pdf Sauro, K. M.; Quan, H.; Sikdar, K.; Faris, P. & Jette, N. (2017). Hospital safety among neurologic patients: A population-based cohort study of adverse events. Neurology, 89(3), 284–290. https://doi.org/10.1212/wnl.0000000000004111 VNM. (s.f.). Vademecum Nacional de Medicamentos. Buenos Aires: ANMAT. Disponible en http://anmatvademecum.servicios.pami.org.ar/index.html WHO. (2010). International Statistical Classification of Diseases and Related Health Problems 10th Revision. Sweden: CDC. Available: http://apps.who.int/classifications/icd10/browse/2010/en WHO. (1999). Perspectivas políticas de la OMS sobre medicamentos: La farmacovigilancia: garantía de seguridad en el uso de los medicamentos. [WHO/EDM/QSM/99.1]. Ginebra: OMS. Disponible en https://apps.who.int/iris/handle/10665/65892 WHO/Centre for Drug Statistics Methodology. (2021). The Anatomical Therapeutic Chemical (ATC) classification system. [Online]. Available: https://www.whocc.no/atc_ddd_index/ WHO. The Uppsala Monitoring Centre. (2001). Vigilancia de la seguridad de los medicamentos. Guía para la instalación y puesta en funcionamiento de un Centro de Farmacovigilancia. Sweden: UMC. Available: http://www.essalud.gob.pe/ietsi/pdfs/informacion_tecnica/OMS_guia_farmacovigilancia.pdf |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Copyright (c) 2021 Journal of Applied Cognitive Neurosciencehttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Sánchez-de-Paz4, María-PilarDa-Prat-de-Magalhaes, GustavoIsa, SantiagoAldinio, VictoriaNorberto-Latella, AndresMabel-Gatto, EmiliaJ. Rojas, Galeno2023-05-15T13:09:14Z2023-05-15T13:09:14Z2021-08-27Sánchez-de-Paz, M.-P., Da-Prat-de-Magalhaes, G., Isa, S., Aldinio, V., Norberto-Latella, A., Mabel-Gatto, E., & Rojas, G. J. (2021). Pharmacovigilance in Neuroscience: Farmacovigilancia en neurociencia. Journal of Applied Cognitive Neuroscience, 2(1), e00163800. https://doi.org/10.17981/JACN.2.1.2021.04https://hdl.handle.net/11323/1013410.17981/JACN.2.1.2021.042745-0031Corporación Universidad de la CostaREDICUC – Repositorio CUChttps://repositorio.cuc.edu.co/Adverse Drug Reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance. The primary objective of this article is to describe and compare the adverse reactions produced by drugs of nervous system action (CNS-D) and neurological ADRs produced by drugs of systemic action (Sys-D). To further develop the need of reporting adverse reactions. This is an observational, cross-sectional, retrospective study performed on a database of neurological consultations which took place at the Neurology department. Patients meeting the inclusion criteria were selected and divided into two groups: Sys-D and CNS-D. Demographic and neurological variables were analyzed. Parametric and non-parametric statistics were used according to distribution. The Naranjo Algorithm (NA) was used to define causality. 71 ADRs were described, from which 63.38% (n = 45) were produced by CNS-D, especially antiepileptics by 47% (n = 21) and psycholeptics by 44%. Of the total, 36.62% (n = 26) were caused by Sys-D, such as antineoplastics (n = 9) and antibiotics (n = 9), being Cefepime the most frequent. The diagnosis of ADRs caused by a Sys-D was delayed prolonging hospitalization (p 0.05) due to a lower NA score (p 0.003) compared to the CNS-D group. Multiple frequently used drugs of systemic action, such as antineoplastics and antibiotics, generate neurological adverse effects. From our analysis, it was presumed that the suspicion of a neurological ADR caused by these drugs was scarce, thus causing a higher morbidity for the patient.Las Reacciones Adversas a Medicamentos (RAM) tienen un alto impacto en la morbilidad y mortalidad de la población, convirtiéndose en un problema de salud pública. El estudio y la publicación de las mismas se denomina farmacovigilancia. El objetivo principal de este artículo es describir y comparar las reacciones adversas producidas por medicamentos de acción sobre el sistema nervioso (SNC-D) y las RAM neurológicas producidas por medicamentos de acción sistémica (Sys-D). Profundizar en la necesidad de notificar las reacciones adversas. Es un estudio observacional, transversal y retrospectivo realizado sobre una base de datos de consultas neurológicas que tuvieron lugar en el servicio de Neurología. Se seleccionaron los pacientes que cumplían los criterios de inclusión y se dividieron en dos grupos: Sys-D y CNS-D. Se analizaron variables demográficas y neurológicas. Se utilizó estadística paramétrica y no paramétrica según la distribución. Se utilizó el Algoritmo de Naranjo (NA) para definir la causalidad. Se describieron 71 RAM, de las cuales el 63,38% (n = 45) fueron producidas por SNC-D, especialmente antiepilépticos en un 47% (n = 21) y psicolépticos en un 44%. Del total, el 36,62% (n = 26) fueron causadas por Sys-D, como antineoplásicos (n = 9) y antibióticos (n = 9), siendo la Cefepime la más frecuente. El diagnóstico de las RAM causadas por un Sys-D se retrasó prolongando la hospitalización (p 0,05) debido a una menor puntuación de NA (p 0.003) en comparación con el grupo de SNC-D. Múltiples fármacos de acción sistémica frecuentemente utilizados, como los antineoplásicos y los antibióticos, generan efectos adversos neurológicos. A partir de nuestro análisis, se presume que la sospecha de una RAM neurológica causada por estos fármacos es escasa, provocando así una mayor morbilidad para el paciente.12 páginasapplication/pdfengCorporación Universidad de la CostaColombiahttps://revistascientificas.cuc.edu.co/JACN/article/view/3800Pharmacovigilance in neuroscienceFarmacovigilancia en neurocienciaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Journal of Applied Cognitive NeuroscienceBignone, I. y Schiaffino, S. (2016). Manual de Buenas Prácticas de Farmacovigilancia. [1a ed.]. Buenos Aires: Ediciones Farmacológicas.Bolaños, R. (Coord.). (2016). Psicotrópicos y estupefacientes. Buenos Aires: Administración Nacional de Medicamentos, Alimentos y Tecnología Médica. Buenos Aires: ANMAT. Recuperado de http://www.anmat.gov.ar/ssce/Libro-psicotropicos-estupefacientes.pdfChaio, S.; Toibaro, J.; Valicenti, P. & Saidón, P. (2013). Reacciones adversas medicamentosas y errores de prescripción: Morbi-Mortalidad. Medicina, 73(2), 111–118. Recuperadode http://www.scielo.org.ar/pdf/medba/v73n2/v73n2a03.pdfEdwards, R. & Aronson, J. (2000). Adverse drug reactions: definitions, diagnosis, and management. Lancet, 356(9237), 1255–1259. https://doi.org/10.1016/S0140-6736(00)02799-9Grill, M. F. & Maganti, R. K. (2011). Neurotoxic effects associated with antibiotic use: management considerations. British Journal of Clinical Pharmacology, 72(3), 381–393. https://doi.org/10.1111/j.1365-2125.2011.03991.xLazarou, J.; Pomeranz, B. & Corey P. (1998). Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies. JAMA, 279(15), 1200–1205. https://doi.org/10.1001/jama.279.15.1200Martino, G.; Rojas, G.; Sánchez, M. P.; Isaa, S.; Bres, M.; Camino, M. V..; Merchán, X.; Aldinio, V.; Parisi, V.; Persi, G.; Pereira, N. & Gatto, E. (2019). Seguridad de fármacos antineoplásicos e inmunomoduladores aplicados a la neurología. Neurolargía Argentina, 11(3), 136–144. https://doi.org/10.1016/j.neuarg.2019.03.001Naranjo, C. A.; Busto, U.; Sellers, E. M.; Sandor, P.; Ruiz, I.; Roberts E.A.; Janecek, E.; Domecq C. & Greenblatt, D. J. (1981). A method for estimating the probability of adverse drug reactions. Clinical Pharmacology and Therapeutics, 30(2), 239–245. https://doi.org/10.1038/clpt.1981.154Orta, I. A.; Garcia, O.; Triolet, A. T.; Gómez, C. & Ruiz, K. (2008). Reacciones adversas a medicamentos en una unidad de terapia intensiva. Revista Electrónica de Biomedicina, 2, 10–18. Disponible en http://biomed.uninet.edu/2008/n2/alfonso.htmlPonte, M. L.; Ragusa, M.; Armenteros, C. & Wachs, A. (2013). Relevancia de la farmacovigilancia hospitalaria en la práctica médica actual. Medicina (Buenos Aires), 73(1), 35–38. Recuperado de http://www.scielo.org.ar/pdf/medba/v73n1/v73n1a07.pdfRattagan, M. L.; Lisei, D.; Rojas, J. G.; Persi, G.; Parisi, V.; López , M.; Da Prat, G.; Bres M. & Gatto, E. (2016). Uso de psicotrópicos y carga sedativa en pacientes adultos con y sin demencia. Vertex, XXVII(129), 332–338. Disponible en http://www.editorialpolemos.com.ar/vertex129.phpRepública de Argentina. Ministerio de Salud. (10 de septiembre de 2012). Buenas practicas de farmacovigilancia. [Disposición n° 5358]. Boletín Nacional: 23-Ene-2013. Disponible en https://www.argentina.gob.ar/normativa/nacional/disposici%C3%B 3n-5358-2012-207727Rojas, G.; Demey, I. & Arizaga, R. L. (2013). Medicamentos utilizados para trastornos cognitivos. Análisis de un millón y medio de prescripciones en la Argentina. Medicina (Buenos Aires), 73(3), 213–223. Recuperado de http://www.scielo.org.ar/pdf/medba/v73n3/v73n3a03.pdfSauro, K. M.; Quan, H.; Sikdar, K.; Faris, P. & Jette, N. (2017). Hospital safety among neurologic patients: A population-based cohort study of adverse events. Neurology, 89(3), 284–290. https://doi.org/10.1212/wnl.0000000000004111VNM. (s.f.). Vademecum Nacional de Medicamentos. Buenos Aires: ANMAT. Disponible en http://anmatvademecum.servicios.pami.org.ar/index.htmlWHO. (2010). International Statistical Classification of Diseases and Related Health Problems 10th Revision. Sweden: CDC. Available: http://apps.who.int/classifications/icd10/browse/2010/enWHO. (1999). Perspectivas políticas de la OMS sobre medicamentos: La farmacovigilancia: garantía de seguridad en el uso de los medicamentos. [WHO/EDM/QSM/99.1]. Ginebra: OMS. Disponible en https://apps.who.int/iris/handle/10665/65892WHO/Centre for Drug Statistics Methodology. (2021). The Anatomical Therapeutic Chemical (ATC) classification system. [Online]. Available: https://www.whocc.no/atc_ddd_index/WHO. The Uppsala Monitoring Centre. (2001). Vigilancia de la seguridad de los medicamentos. Guía para la instalación y puesta en funcionamiento de un Centro de Farmacovigilancia. Sweden: UMC. Available: http://www.essalud.gob.pe/ietsi/pdfs/informacion_tecnica/OMS_guia_farmacovigilancia.pdf12112PharmacovigilanceEpidemiologyAdverse reactionsDrugsNeurologyPharmacologyFarmacovigilanciaEpidemiologíaReacciones adversasFármacosNeurologíaFarmacologíaPublicationORIGINALPharmacovigilance in Neuroscience.pdfPharmacovigilance in Neuroscience.pdfArtículoapplication/pdf595319https://repositorio.cuc.edu.co/bitstreams/8129845e-b43d-41ff-bd0a-62ac2bdb4e32/downloadd0069d0007d8731e8c236dd16cdceac4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.cuc.edu.co/bitstreams/ee01bb6a-4400-4ef4-8822-236b500b5153/download2f9959eaf5b71fae44bbf9ec84150c7aMD52TEXTPharmacovigilance in Neuroscience.pdf.txtPharmacovigilance in Neuroscience.pdf.txtExtracted texttext/plain35411https://repositorio.cuc.edu.co/bitstreams/290245ca-d1ec-4a1e-8f84-189b7574fb9d/downloadb85223907fdb48c0630de6f336835559MD53THUMBNAILPharmacovigilance in Neuroscience.pdf.jpgPharmacovigilance in 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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