Pharmacovigilance in neuroscience

Adverse Drug Reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance. The primary objective of this article is to describe and compare the adverse reactions produced by drugs of nervous system action (CNS-D) and neurological ADRs produced by drugs of systemic action (Sys-D). To further develop the need of reporting adverse reactions. This is an observational, cross-sectional, retrospective study performed on a database of neurological consultations which took place at the Neurology department. Patients meeting the inclusion criteria were selected and divided into two groups: Sys-D and CNS-D. Demographic and neurological variables were analyzed. Parametric and non-parametric statistics were used according to distribution. The Naranjo Algorithm (NA) was used to define causality. 71 ADRs were described, from which 63.38% (n = 45) were produced by CNS-D, especially antiepileptics by 47% (n = 21) and psycholeptics by 44%. Of the total, 36.62% (n = 26) were caused by Sys-D, such as antineoplastics (n = 9) and antibiotics (n = 9), being Cefepime the most frequent. The diagnosis of ADRs caused by a Sys-D was delayed prolonging hospitalization (p 0.05) due to a lower NA score (p 0.003) compared to the CNS-D group. Multiple frequently used drugs of systemic action, such as antineoplastics and antibiotics, generate neurological adverse effects. From our analysis, it was presumed that the suspicion of a neurological ADR caused by these drugs was scarce, thus causing a higher morbidity for the patient.

• Autores: Sánchez-de-Paz4, María-Pilar; Da-Prat-de-Magalhaes, Gustavo; Isa, Santiago; Aldinio, Victoria; Norberto-Latella, Andres; Mabel-Gatto, Emilia; J. Rojas, Galeno
• Tipo de recurso: Article of journal
• Fecha de publicación: 2021
• Institución: Corporación Universidad de la Costa
• Repositorio: REDICUC - Repositorio CUC
• Idioma: eng
• OAI Identifier: oai:repositorio.cuc.edu.co:11323/10134
• Acceso en línea: https://hdl.handle.net/11323/10134; https://repositorio.cuc.edu.co/
• Palabra clave: Pharmacovigilance; Epidemiology; Adverse reactions; Drugs; Neurology; Pharmacology; Farmacovigilancia; Epidemiología; Reacciones adversas; Fármacos; Neurología; Farmacología
• Rights: openAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)