Recent advances in gold-NHC complexes with biological properties

This tutorial review covers the recent advances made in the study of gold complexes containing N-heterocyclic carbene ligands with biological properties. The great stability, ease of modulation of the electronic properties and excellent σ-donating capacity displayed by NHCs allow gold-NHC derivative...

Full description

Autores:
Mora, Malka
Gimeno Concepción, María
Visbal, Renso
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/4587
Acceso en línea:
https://hdl.handle.net/11323/4587
https://repositorio.cuc.edu.co/
Palabra clave:
Antioxidant
Carbene
Coordination compound
Gold
Heterocyclic compound
Methane
Antioxidante
Carbeno
Compuesto de coordinación
Oro
Compuesto heterocíclico
Metano
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/4.0/
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oai_identifier_str oai:repositorio.cuc.edu.co:11323/4587
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Recent advances in gold-NHC complexes with biological properties
dc.title.translated.spa.fl_str_mv Avances recientes en complejos de oro-NHC con propiedades biológicas.
title Recent advances in gold-NHC complexes with biological properties
spellingShingle Recent advances in gold-NHC complexes with biological properties
Antioxidant
Carbene
Coordination compound
Gold
Heterocyclic compound
Methane
Antioxidante
Carbeno
Compuesto de coordinación
Oro
Compuesto heterocíclico
Metano
title_short Recent advances in gold-NHC complexes with biological properties
title_full Recent advances in gold-NHC complexes with biological properties
title_fullStr Recent advances in gold-NHC complexes with biological properties
title_full_unstemmed Recent advances in gold-NHC complexes with biological properties
title_sort Recent advances in gold-NHC complexes with biological properties
dc.creator.fl_str_mv Mora, Malka
Gimeno Concepción, María
Visbal, Renso
dc.contributor.author.spa.fl_str_mv Mora, Malka
Gimeno Concepción, María
Visbal, Renso
dc.subject.spa.fl_str_mv Antioxidant
Carbene
Coordination compound
Gold
Heterocyclic compound
Methane
Antioxidante
Carbeno
Compuesto de coordinación
Oro
Compuesto heterocíclico
Metano
topic Antioxidant
Carbene
Coordination compound
Gold
Heterocyclic compound
Methane
Antioxidante
Carbeno
Compuesto de coordinación
Oro
Compuesto heterocíclico
Metano
description This tutorial review covers the recent advances made in the study of gold complexes containing N-heterocyclic carbene ligands with biological properties. The great stability, ease of modulation of the electronic properties and excellent σ-donating capacity displayed by NHCs allow gold-NHC derivatives to reach high stability in biological media and relatively good internalization into cells and for that they have emerged as excellent potential chemotherapeutics. The new gold-NHC derivatives show superior anticancer activity compared to other standards such as Cisplatin or Auranofin. In addition, the application of gold-NHC complexes in the treatment of other human diseases as antibacterial, antioxidant and antiparasitic agents is reviewed for the first time
publishDate 2018
dc.date.issued.none.fl_str_mv 2018-07-12
dc.date.accessioned.none.fl_str_mv 2019-05-21T12:42:39Z
dc.date.available.none.fl_str_mv 2019-05-21T12:42:39Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.issn.spa.fl_str_mv 03060012
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/4587
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
identifier_str_mv 03060012
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
url https://hdl.handle.net/11323/4587
https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
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eu_rights_str_mv openAccess
dc.publisher.spa.fl_str_mv Universidad de la Costa
institution Corporación Universidad de la Costa
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spelling Mora, MalkaGimeno Concepción, MaríaVisbal, Renso2019-05-21T12:42:39Z2019-05-21T12:42:39Z2018-07-1203060012https://hdl.handle.net/11323/4587Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/This tutorial review covers the recent advances made in the study of gold complexes containing N-heterocyclic carbene ligands with biological properties. The great stability, ease of modulation of the electronic properties and excellent σ-donating capacity displayed by NHCs allow gold-NHC derivatives to reach high stability in biological media and relatively good internalization into cells and for that they have emerged as excellent potential chemotherapeutics. The new gold-NHC derivatives show superior anticancer activity compared to other standards such as Cisplatin or Auranofin. In addition, the application of gold-NHC complexes in the treatment of other human diseases as antibacterial, antioxidant and antiparasitic agents is reviewed for the first timeEsta revisión tutorial cubre los avances recientes realizados en el estudio de complejos de oro que contienen ligandos de carbeno N-heterocíclicos con propiedades biológicas. La gran estabilidad, la facilidad de modulación de las propiedades electrónicas y la excelente capacidad de donación σ mostrada por los NHC permiten que los derivados de oro-NHC alcancen una alta estabilidad en medios biológicos y una internalización relativamente buena en las células y, para ello, han resultado ser excelentes agentes quimioterapéuticos potenciales. Los nuevos derivados de oro-NHC muestran una actividad anticancerígena superior en comparación con otros estándares como Cisplatin o Auranofin. Además, se revisa por primera vez la aplicación de complejos de oro-NHC en el tratamiento de otras enfermedades humanas como agentes antibacterianos, antioxidantes y antiparasitarios.Mora, Malka-6a6f03ac-44da-4475-b29f-d25fd4a93266-0Gimeno Concepción, María-eef11866-39a0-4333-84be-a909c56a9efb-0Visbal, Renso-3bc64685-c62d-4286-be88-187fbdb60355-0engUniversidad de la Costahttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2AntioxidantCarbeneCoordination compoundGoldHeterocyclic compoundMethaneAntioxidanteCarbenoCompuesto de coordinaciónOroCompuesto heterocíclicoMetanoRecent advances in gold-NHC complexes with biological propertiesAvances recientes en complejos de oro-NHC con propiedades biológicas.Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALRECENT ADVANCES IN GOLD.pdfRECENT ADVANCES IN GOLD.pdfapplication/pdf99659https://repositorio.cuc.edu.co/bitstreams/959078d9-25ac-4bd8-807b-548d556d7ecf/downloadd7be16df3e6164a504567c087b681d30MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81031https://repositorio.cuc.edu.co/bitstreams/3cbc8933-2353-429e-bc26-88335bf84c6d/download934f4ca17e109e0a05eaeaba504d7ce4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.cuc.edu.co/bitstreams/03446620-4fd5-439c-92ed-33cefd125bc9/download8a4605be74aa9ea9d79846c1fba20a33MD55THUMBNAILRECENT ADVANCES IN GOLD.pdf.jpgRECENT ADVANCES IN GOLD.pdf.jpgimage/jpeg37964https://repositorio.cuc.edu.co/bitstreams/e9d36ce4-4363-4f62-b00e-f49140163cb1/downloadd5b1d8ff3afe2f3f6c353529c3792982MD57TEXTRECENT ADVANCES IN GOLD.pdf.txtRECENT ADVANCES IN GOLD.pdf.txttext/plain1017https://repositorio.cuc.edu.co/bitstreams/7ea5f0af-58c7-4524-9ae4-3ba8fe1da6fd/download578ac8f277b18674017cc59207dbd09aMD5811323/4587oai:repositorio.cuc.edu.co:11323/45872024-09-17 14:20:25.5http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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