Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review
El propósito de este estudio es establecer el perfil neuropsicológico no lingüístico de las variantes de la Afasia Progresiva Primaria, mediante una revisión sistemática de la literatura de los últimos 5 años. La búsqueda sistemática y manual avanzada se llevó a cabo en las bases de datos Scopus, Pu...
- Autores:
-
lastre meza, karina
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2022
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/9951
- Acceso en línea:
- https://hdl.handle.net/11323/9951
https://repositorio.cuc.edu.co/
- Palabra clave:
- Afasia progresiva primaria
Afasia progresiva no fluente
Afasia progresiva logopénica
Afasia progresiva semántica
Revisión sistemática
Funciones cognitivas
Progressive aphasia
Nonfluent progressive aphasia
Logogenic progressive aphasia
Semantic progressive aphasia
Systematic review
Cognitive functions
Afasia progressiva primária
Afasia progressiva não fluente
Afasia progressiva logopênica
Afasia progressiva semântica
Revisão sistemática
Funções cognitivas
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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dc.title.eng.fl_str_mv |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
dc.title.translated.none.fl_str_mv |
Perfil neuropsicológico no lingüístico de las afasias progresivas primarias: una revisión sistemática |
title |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
spellingShingle |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review Afasia progresiva primaria Afasia progresiva no fluente Afasia progresiva logopénica Afasia progresiva semántica Revisión sistemática Funciones cognitivas Progressive aphasia Nonfluent progressive aphasia Logogenic progressive aphasia Semantic progressive aphasia Systematic review Cognitive functions Afasia progressiva primária Afasia progressiva não fluente Afasia progressiva logopênica Afasia progressiva semântica Revisão sistemática Funções cognitivas |
title_short |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
title_full |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
title_fullStr |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
title_full_unstemmed |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
title_sort |
Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic review |
dc.creator.fl_str_mv |
lastre meza, karina |
dc.contributor.author.none.fl_str_mv |
lastre meza, karina |
dc.subject.proposal.spa.fl_str_mv |
Afasia progresiva primaria Afasia progresiva no fluente Afasia progresiva logopénica Afasia progresiva semántica Revisión sistemática Funciones cognitivas |
topic |
Afasia progresiva primaria Afasia progresiva no fluente Afasia progresiva logopénica Afasia progresiva semántica Revisión sistemática Funciones cognitivas Progressive aphasia Nonfluent progressive aphasia Logogenic progressive aphasia Semantic progressive aphasia Systematic review Cognitive functions Afasia progressiva primária Afasia progressiva não fluente Afasia progressiva logopênica Afasia progressiva semântica Revisão sistemática Funções cognitivas |
dc.subject.proposal.eng.fl_str_mv |
Progressive aphasia Nonfluent progressive aphasia Logogenic progressive aphasia Semantic progressive aphasia Systematic review Cognitive functions |
dc.subject.proposal.por.fl_str_mv |
Afasia progressiva primária Afasia progressiva não fluente Afasia progressiva logopênica Afasia progressiva semântica Revisão sistemática Funções cognitivas |
description |
El propósito de este estudio es establecer el perfil neuropsicológico no lingüístico de las variantes de la Afasia Progresiva Primaria, mediante una revisión sistemática de la literatura de los últimos 5 años. La búsqueda sistemática y manual avanzada se llevó a cabo en las bases de datos Scopus, PubMed, Web of Science y Google Académico para identificar los estudios que describieran el perfil neuropsicológico no lingüístico de las variantes de la Afasia Progresiva Primaria (APP), se establecieron criterios de inclusión y exclusión para la selección de los artículos, se evaluó su calidad y pertinencia. La revisión sistemática arrojó 7084 artículos, de los cuales 131 fueron preseleccionados de acuerdo a lo informado en el resumen y 26 validados para lectura completa. Para la síntesis narrativa se utilizaron 19 artículos. Las variantes de APP cursan con déficits neurocognitivos fuera del dominio del lenguaje, particulares a cada variante. Esto resalta la importancia de una evaluación neuropsicológica integral que aporte información adicional a los criterios de consenso ya establecidos para la evaluación de la APP. |
publishDate |
2022 |
dc.date.issued.none.fl_str_mv |
2022 |
dc.date.accessioned.none.fl_str_mv |
2023-03-15T20:46:00Z |
dc.date.available.none.fl_str_mv |
2023-03-15T20:46:00Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_dcae04bc |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_dcae04bc |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Lastre-Meza, K. (2022). Non-Linguistic Neuropsychological Profile of Primary Progressive Aphasia: A systematic review. Journal of Applied Cognitive Neuroscience, 3(1), e00254547. https://doi.org/10.17981/JACN.3.1.2022.04 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11323/9951 |
dc.identifier.doi.none.fl_str_mv |
10.17981/JACN.3.1.2022.04 |
dc.identifier.eissn.spa.fl_str_mv |
0025-4547 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
Lastre-Meza, K. (2022). Non-Linguistic Neuropsychological Profile of Primary Progressive Aphasia: A systematic review. Journal of Applied Cognitive Neuroscience, 3(1), e00254547. https://doi.org/10.17981/JACN.3.1.2022.04 10.17981/JACN.3.1.2022.04 0025-4547 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
https://hdl.handle.net/11323/9951 https://repositorio.cuc.edu.co/ |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Applied Cognitive Neuroscience |
dc.relation.references.spa.fl_str_mv |
Acosta-Cabronero, J.; Patterson, K.; Fryer, T. D.; Hodges, J. R.; Pengas, G.; Williams, G. B. & Nestor, P. J. (2011). Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain, 134(7), 2025–2035. https://doi.org/10.1093/BRAIN/AWR119 Benhamou, E.; Marshall, C. R.; Russell, L. L.; Hardy, C. J. D.; Bond, R. L.; Sivasathiaseelan, H.; Greaves, C. V.; Friston, K. J.; Rohrer, J. D.; Warren, J. D. & Razi, A. (2020). The neurophysiological architecture of semantic dementia: spectral dynamic causal modelling of a neurodegenerative proteinopathy. Scientific Reports, 10(1), 1–13. https://doi.org/10.1038/s41598-020-72847-1 Bergeron, D.; Gorno-Tempini, M. L.; Rabinovici, G. D.; Santos-Santos, M. A.; Seeley, W.; Miller, B. L.; Pijnenburg, Y.; Keulen, M. A.; Groot, C.; van Berckel, B. N. M.; van der Flier, W. M.; Scheltens, P.; Rohrer, J. D.; Warren, J. D.; Schott, J. M.; Fox, N. C.; Sanchez-Valle, R.; Grau-Rivera, O.; Gelpi, E.; Seelaar, H.; Papma, J. M.; van Swieten, J. C.; Hodges, J. R.; Leyton, C. E.; Piguet, O.; Rogalski, E. J.; Mesulam, M. M.; Koric, L.; Nora, K.; Pariente, J.; Dickerson, B.; Mackenzie, I. R.; Hsiung, G.-Y. R.; Belliard, S.; Irwin, D. J.; Wolk, D. A.; Grossman, M.; Jones, M.; Harris, J.; Mann, D.; Snowden, J. S.; Chrem-Mendez, P.; Calandri, I. L.; Amengual, A. A.; Miguet-Alfonsi, C.; Magnin, E.; Magnani, G.; Santangelo, R.; Deramecourt, V.; Pasquier, F.; Mattsson, N.; Nilsson, C.; Hansson, O.; Keith, J.; Masellis, M.; Black, S. E.; Matías-Guiu, J. A.; María-Nieves Cabrera-Martin.; Paquet, C.; Dumurgier, J.; Teichmann, M.; Sarazin, M.; Bottlaender, M.; Dubois, B.; Rowe, C. C.; Villemagne, V. L.; Vandenberghe, R.; Granadillo, E.; Teng, E.; Mendez, M.; Meyer, P. T.; Frings, L.; Lleó, A.; Blesa, R.; Fortea, J.; Seo, S.-W.; Diehl-Schmid, J.; Grimmer, T.; Frederiksen, K. S.; Sánchez-Juan, P.; Chételat, G.; Jansen, W.; Bouchard, R. W.; Laforce Jr., R.; Visser, P. J. & Ossenkoppele, R. (2018). Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. Annals of Neurology, 84(5), 729–740. https://doi.org/10.1002/ANA.25333 Botha, H.; Duffy, J. R.; Whitwell, J. L.; Strand, E. A.; Machulda, M. M.; Schwarz, C. G.; Reid, R. I.; Spychalla, A. J.; Senjem, M. L.; Jones, D. T.; Lowe, V.; Jack, C. R. & Josephs, K. A. (2015). Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech. Cortex, 69, 220–236. https://doi.org/10.1016/J.CORTEX.2015.05.013 Brambati, S. M.; Amici, S.; Racine, C. A.; Neuhaus, J.; Miller, Z.; Ogar, J.; Dronkers, N.; Miller, B. L.; Rosen, H. & Gorno-Tempini, M. L. (2015). Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study. NeuroImage: Clinical, 8, 345–355. https://doi.org/10.1016/J.NICL.2015.01.011 Butts, A. M.; Machulda, M. M.; Duffy, J. R.; Strand, E. A.; Whitwell, J. L. & Josephs, K. A. (2015). Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia. Journal of the International Neuropsychological Society, 21(6), 429–435. https://doi.org/10.1017/S1355617715000399 Collins, J. A.; Montal, V.; Hochberg, D.; Quimby, M.; Mandelli, M. L.; Makris, N.; Seeley, W. W.; Gorno-Tempini, M. L. & Dickerson, B. C. (2017). Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia. Brain, 140(2), 457–471. https://doi.org/10.1093/BRAIN/AWW313 Coyle-Gilchrist, I. T. S.; Dick, K. M.; Patterson, K.; Rodríquez, P. V.; Wehmann, E.; Wilcox, A.; Lansdall, C. J.; Dawson, K. E.; Wiggins, J.; Mead, S.; Brayne, C. & Rowe, J. B. (2016). Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology, 86(18), 1736–1743. https://doi.org/10.1212/WNL.0000000000002638 Eikelboom, W. S.; Janssen, N.; Jiskoot, L. C.; van den Berg, E.; Roelofs, A. & Kessels, R. P. C. (2018). Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis. Neuroscience & Biobehavioral Reviews, 92, 243–254. https://doi.org/10.1016/J.NEUBIOREV.2018.06.015 Fittipaldi, S.; Ibanez, A.; Baez, S.; Manes, F.; Sedeno, L. & Garcia, A. M. (2019). More than words: Social cognition across variants of primary progressive aphasia. Neuroscience & Biobehavioral Reviews, 100, 263–284. https://doi.org/10.1016/J.NEUBIOREV.2019.02.020 Foxe, D.; Cheung, S. C.; Cordato, N. J.; Burrell, J. R.; Ahmed, R. M.; Taylor-Rubin, C.; Irish, M. & Piguet, O. (2021). Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting. Brain Sciences, 11(8), 1–21. https://doi.org/10.3390/BRAINSCI11081060 Goldberg, Z.-L.; El-Omar, H.; Foxe, D.; Leyton, C. E.; Ahmed, R. M.; Piguet, O. & Irish, M. (2021). Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia. Brain Sciences, 11(12), 1–16. https://doi.org/10.3390/BRAINSCI11121600 Gorbea-Portal, S. & Atrián-Salazar, M. L. (2018). Medición de la obsolescencia de la información en revistas de salud pública de México. Gaceta Médica de México, 154(3), 335–341. https://doi.org/10.24875/GMM.18003293 Gorno-Tempini, M. L.; Hillis, A. E.; Weintraub, S.; Kertesz, A.; Mendez, M.; Cappa, S. F.; Ogar, J. M.; Rohrer, J. D.; Black, S.; Boeve, B. F.; Manes, F.; Dronkers, N. F.; Vandenberghe, R.; Rascovsky, K.; Patterson, K.; Miller, B. L.; Knopman, D. S.; Hodges, J. R.; Mesulam, M. M. & Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006–1014. https://doi.org/10.1212/wnl.0b013e31821103e6 Hailstone, J. C.; Ridgway, G. R.; Bartlett, J. W.; Goll, J. C.; Buckley, A. H.; Crutch, S. J. & Warren, J. D. (2011). Voice processing in dementia: a neuropsychological and neuroanatomical analysis. Brain, 134(9), 2535–2547. https://doi.org/10.1093/BRAIN/AWR205 Harris, J. M.; Saxon, J. A.; Jones, M.; Snowden, J. S. & Thompson, J. C. (2019). Neuropsychological differentiation of progressive aphasic disorders. Journal of Neuropsychology, 13(2), 214–239. https://doi.org/10.1111/JNP.12149 Kamath, V.; Sutherland, E. R. & Chaney, G.-A. (2020). A Meta-Analysis of Neuropsychological Functioning in the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants. Journal of the International Neuropsychological Society, 26(3), 322–330. https://doi.org/10.1017/S1355617719001115 Kamminga, J.; Kumfor, F.; Burrell, J. R.; Piguet, O.; Hodges, J. R. & Irish, M. (2015). Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. Journal of Neurology, Neurosurgery & Psychiatry, 86(10), 1082–1088. https://doi.org/10.1136/JNNP-2014-309120 Karpathiou, N. & Kambanaros, M. (2022). Comparing Individuals With PPA to Individuals With AD: Cognitive and Linguistic Profiles. Frontiers in Communication, 7, 1–15. https://doi.org/10.3389/fcomm.2022.893471 Kumfor, F.; Miller, L.; Lah, S.; Hsieh, S.; Savage, S.; Hodges, J. R. & Piguet, O. (2011). Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Social Neuroscience, 6(5–6), 502–514. https://doi.org/10.1080/17470919.2011.620779 Leyton, C. E.; Ballard, K. J.; Piguet, O. & Hodges, J. R. (2014). Phonologic errors as a clinical marker of the logopenic variant of PPA. Neurology, 82(18), 1620–1627. https://doi.org/10.1212/WNL.0000000000000387 Leyton, C. E.; Piguet, O.; Savage, S.; Burrell, J. & Hodges, J. R. (2012). The Neural Basis of Logopenic Progressive Aphasia. Journal of Alzheimer’s Disease, 32(4), 1051–1059. https://doi.org/10.3233/JAD-2012-121042 Lukic, S.; Mandelli, M. L.; Welch, A.; Jordan, K.; Shwe, W.; Neuhaus, J.; Miller, Z.; Hubbard, H. I.; Henry, M.; Miller, B. L.; Dronkers, N. F. & Gorno-Tempini, M. L. (2019). Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and Language, 194, 35–45. https://doi.org/10.1016/J.BANDL.2019.04.003 Mack, J. E.; Cho-Reyes, S.; Kloet, J. D.; Weintraub, S.; Mesulam, M. M. & Thompson, C. K. (2013). Phonological facilitation of object naming in agrammatic and logopenic Primary Progressive Aphasia (PPA). Cognitive Neuropsychology, 30(3), 172–193. https://doi.org/10.1080/02643294.2013.835717 Macoir, J.; Lavoie, M.; Laforce, R.; Brambati, S. M. & Wilson, M. A. (2017). Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria. Journal of Geriatric Psychiatry Neurology, 30(3), 151–161. https://doi.org/10.1177/0891988717700507 Magnin, E.; Démonet, J. F.; Wallon, D.; Dumurgier, J.; Troussière, A. C.; Jager, A.; Duron, E.; Gabelle, A.; de La Sayette, V.; Volpe-Gillot, L.; Tio, G.; Evain, S.; Boutoleau-Bretonnière, C.; Enderle, A.; Mouton-Liger, F.; Robert, P.; Hannequin, D.; Pasquier, F.; Hugon, J. & Paquet, C. (2016). Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers. Journal of Alzheimer’s Disease, 54(4), 1459–1471. https://doi.org/10.3233/JAD-160536 Marshall, C. R.; Hardy, C. J. D.; Russell, L. L.; Bond, R. L.; Sivasathiaseelan, H.; Greaves, C.; Moore, K. M.; Agustus, J. L.; van Leeuwen, J. E. P.; Wastling, S. J.; Rohrer, J. D.; Kilner, J. M. & Warren, J. D. (2019). The functional neuroanatomy of emotion processing in frontotemporal dementias. Brain, 142(9), 2873–2887. https://doi.org/10.1093/BRAIN/AWZ204 Méndez, M. F.; Monserratt, L. H.; Liang, L. J.; Chavez, D.; Jimenez, E. E.; Maurer, J. J. & Laffey, M. (2019). Neuropsychological Similarities and Differences Between Amnestic Alzheimer’s Disease and its Non-Amnestic Variants. Journal of Alzheimer’s Disease, 69(3), 849–855. https://doi.org/10.3233/JAD-190124 Mesulam, M.-M. (2013). Primary progressive aphasia and the language network. Neurology, 81(5), 456–462. https://doi.org/10.1212/WNL.0B013E31829D87DF Mesulam, M.-M. & Weintraub, S. (2014). Is it time to revisit the classification guidelines for primary progressive aphasia? Neurology, 82(13), 1108–1109. https://doi.org/10.1212/WNL.0000000000000272 Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. & Group, P. (2009a). Standards & Guidelines Linee guida per il reporting di revisioni sistematiche e meta-analisi: il PRISMA Statement. Annals of Internal Medicine, (151), 264–269. https://doi.org/10.7326/0003-4819-151-4-200908180-00135 Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. & The PRISMA Group. (2009b). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med, 6(6), 1–9. https://doi.org/10.1136/bmj.b2535 Montembeault, M.; Chapleau, M.; Jarret, J.; Boukadi, M.; Laforce, R.; Wilson, M. A.; Rouleau, I. & Brambati, S. M. (2019). Differential language network functional connectivity alterations in Alzheimer’s disease and the semantic variant of primary progressive aphasia. Cortex, 117, 284–298. https://doi.org/10.1016/J.CORTEX.2019.03.018 Montreuil, S.; Poulin, E.; Bergeron, D.; Sellami, L.; Verret, L.; Fortin, M. P.; Poulin, S.; MacOir, J.; Hudon, C.; Bouchard, R. W.; Lavoie, M. & Laforce, R. (2020). Cognitive Profile of the Logopenic Variant of Primary Progressive Aphasia Using the Dépistage Cognitif de Québec. Dementia and Geriatric Cognitive Disorders, 49(4), 410–417. https://doi.org/10.1159/000510501 Multani, N.; Galantucci, S.; Wilson, S. M.; Shany-Ur, T.; Poorzand, P.; Growdon, M. E.; Jang, J. Y.; Kramer, J. H.; Miller, B. L.; Rankin, K. P.; Gorno-Tempini, M. L. & Tartaglia, M. C. (2017). Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. NeuroImage: Clinical, 16, 447–454. https://doi.org/10.1016/J.NICL.2017.08.020 Owens, T. E.; Machulda, M. M.; Duffy, J. R.; Strand, E. A.; Clark, H. M.; Boland, S.; Martin, P. R.; Lowe, V. J.; Jack, C. R.; Whitwell, J. L. & Josephs, K. A. (2018). Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia. Journal of Alzheimer’s Disease, 66(3), 1015–1025. https://doi.org/10.3233/JAD-171175 Piguet, O.; Leyton, C. E.; Gleeson, L. D.; Hoon, C. & Hodges, J. R. (2015). Memory and Emotion Processing Performance Contributes to the Diagnosis of Non-Semantic Primary Progressive Aphasia Syndromes. Journal of Alzheimer’s Disease, 44(2), 541–547. https://doi.org/10.3233/JAD-141854 Prabhakar, A. T.; Mathew, V.; Sivadasan, A.; Aaron, S.; George, A. & Alexander, M. (2019). Clinical profile of primary progressive aphasias in a tertiary care centre from India. International Journal of Speech-Language Pathology, 21(6), 547–552. https://doi.org/10.1080/17549507.2018.1545870 Radakovic, R.; Colville, S.; Cranley, D.; Starr, J. M.; Pal, S. & Abrahams, S. (2021). Multidimensional Apathy in Behavioral Variant Frontotemporal Dementia, Primary Progressive Aphasia, and Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology, 34(5), 349–356. https://doi.org/10.1177/0891988720924716 Ramanan, S.; Roquet, D.; Goldberg, Z.-L.; Hodges, J. R.; Piguet, O.; Irish, M. & Ralph, M. A. L. (2020). Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia. Brain Communications, 2(2), 1–50. https://doi.org/10.1093/BRAINCOMMS/FCAA125 Rohrer, J. D.; Volkmer, A.; Rogalski, E.;, Henry, M.; Taylor-Rubin, C.; Ruggero, L.; Khayum, R.; Kindell, J.; Gorno-Tempini, M. L.; Warren, J. & Rohrer, J. (2010). How to understand it Speech and language therapy approaches to managing primary progressive aphasia. Practical Neurology, 20(2), 154–162. https://doi.org/10.1136/practneurol-2018-001921 Santos-Santos, M. A.; Mandelli, M. L.; Binney, R. J.; Ogar, J.; Wilson, S. M.; Henry, M. L.; Hubbard, H. I.; Meese, M.; Attygalle, S.; Rosenberg, L.; Pakvasa, M.; Trojanowski, J. Q.; Grinberg, L. T.; Rosen, H.; Boxer, A. L.; Miller, B. L.; Seeley, W. W. & Gorno-Tempini, M. L. (2016). Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurology, 73(6), 733–742. https://doi.org/10.1001/JAMANEUROL.2016.0412 Santos-Santos, M. A.; Rabinovici, G. D.; Iaccarino, L.; Ayakta, N.; Tammewar, G.; Lobach, I.; Henry, M. L.; Hubbard, I.; Mandelli, M. L.; Spinelli, E.; Miller, Z. A.; Pressman, P. S.; O’Neil, J. P.; Ghosh, P.; Lazaris, A.; Meyer, M.; Watson, C.; Yoon, S. J.; Rosen, H. J.; W. J. Grinberg, L.; Seeley, W. W.; Miller, B. L.; Jagust, W. J. & Gorno-Tempini, M. L. (2018). Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurology, 75(3), 342–352. https://doi.org/10.1001/JAMANEUROL.2017.4309 Singh, T. D.; Duffy, J. R.; Strand, E. A.; Machulda, M. M.; Whitwell, J. L. & Josephs, K. A. (2015). Neuropsychiatric Symptoms in Primary Progressive Aphasia and Apraxia of Speech. Dementia and Geriatric Cognitive Disorders, 39(3–4), 228–238. https://doi.org/10.1159/000369062 Sjoberg, D. I. K. (2010). Confronting the myth of Rapid obsolescence in Computing Research. Communications of the ACM, 53(9), 62–67. https://doi.org/10.1145/1810891.1810911 Tee, B. L. & Gorno-Tempini, M. L. (2019). Primary progressive aphasia: A model for neurodegenerative disease. Current Opinion in Neurology, 32(2), 255–265. https://doi.org/10.1097/WCO.0000000000000673 Tee, B. L.; Watson Pereira, C.; Lukic, S.; Bajorek, L. P.; Allen, I. E.; Miller, Z. A.; Casaletto, K. B.; Miller, B. L. & Gorno-Tempini, M. L. (2022). Neuroanatomical correlations of visuospatial processing in primary progressive aphasia. Brain Communications, 4(2), 1–12. https://doi.org/10.1093/BRAINCOMMS/FCAC060 Teichmann, M.; Migliaccio, R.; Kas, A. & Dubois, B. (2013). Logopenic progressive aphasia beyond Alzheimer’s—an evolution towards dementia with Lewy bodies. Journal of Neurology, Neurosurgery & Psychiatry, 84(1), 113–114. https://doi.org/10.1136/JNNP-2012-302638 Ulugut, H.; Stek, S.; Wagemans, L. E. E.; Jutten, R. J.; Keulen, M. A.; Bouwman, F. H.; Prins, N. D.; Lemstra, A. W.; Krudop, W.; Teunissen, C. E.; van Berckel, B. N. M.; Ossenkoppele, R.; Barkhof, F.; van der Flier, W. M.; Scheltens, P. & Pijnenburg, Y. A. L. (2022). The natural history of primary progressive aphasia: beyond aphasia. Journal of Neurology, 269(3), 1375–1385. https://doi.org/10.1007/S00415-021-10689-1 Urbizagástegui, R. (2016). Estudio sincrónico de obsolescencia de la literatura: el caso de la Ley de Lotka. Investigación Bibliotecológica: Archivonomía, Bibliotecología e Información, 28(63), 85–113. https://doi.org/10.1016/S0187-358X(14)72577-8 Urrútia, G. & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507–511. https://doi.org/10.1016/j.medcli.2010.01.015 Urrútia, G. & Bonfilll, X. (2013). La declaración PRISMA: un paso adelante en la mejora de las publicaciones de la Revista Española de Salud Pública. Revista Española de Salud Pública, 87(2), 99–102. https://doi.org/10.4321/S1135-57272013000200001 Utianski, R. L.; Duffy, J. R.; Clark, H. M.; Strand, E. A.; Botha, H.; Schwarz, C. G.; Machulda, M. M.; Senjem, M. L.; Spychalla, A. J.; Jack, C. R.; Petersen, R. C.; Lowe, V. J.; Whitwell, J. L. & Josephs, K. A. (2018). Prosodic and phonetic subtypes of primary progressive apraxia of speech. Brain and Language, 184, 54–65. https://doi.org/10.1016/J.BANDL.2018.06.004 Watson, C. L.; Possin, K.; Allen, I. E.; Hubbard, H. I.; Meyer, M.; Welch, A. E.; Rabinovici, G. D.; Rosen, H.; Rankin, K. P.; Miller, Z.; Santos-Santos, M. A.; Kramer, J. H.; Miller, B. L. & Gorno-Tempini, M. L. (2018). Visuospatial Functioning in the Primary Progressive Aphasias. Journal of the International Neuropsychological Society, 24(3), 259–268. https://doi.org/10.1017/S1355617717000984 Wilson, S. M.; Galantucci, S.; Tartaglia, M. C. & Gorno-Tempini, M. L. (2012). The neural basis of syntactic deficits in primary progressive aphasia. Brain and Language, 122(3), 190–198. https://doi.org/10.1016/J.BANDL.2012.04.005 Zilli, E. M. & Heilman, K. M. (2015). Spatial neglect in a patient with logopenic progressive aphasia. Neurocase, 22(1), 30–39. https://doi.org/10.1080/13554794.2015.1031254 |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Copyright (c) 2022 karina lastre mezahttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2lastre meza, karina2023-03-15T20:46:00Z2023-03-15T20:46:00Z2022Lastre-Meza, K. (2022). Non-Linguistic Neuropsychological Profile of Primary Progressive Aphasia: A systematic review. Journal of Applied Cognitive Neuroscience, 3(1), e00254547. https://doi.org/10.17981/JACN.3.1.2022.04https://hdl.handle.net/11323/995110.17981/JACN.3.1.2022.040025-4547Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/El propósito de este estudio es establecer el perfil neuropsicológico no lingüístico de las variantes de la Afasia Progresiva Primaria, mediante una revisión sistemática de la literatura de los últimos 5 años. La búsqueda sistemática y manual avanzada se llevó a cabo en las bases de datos Scopus, PubMed, Web of Science y Google Académico para identificar los estudios que describieran el perfil neuropsicológico no lingüístico de las variantes de la Afasia Progresiva Primaria (APP), se establecieron criterios de inclusión y exclusión para la selección de los artículos, se evaluó su calidad y pertinencia. La revisión sistemática arrojó 7084 artículos, de los cuales 131 fueron preseleccionados de acuerdo a lo informado en el resumen y 26 validados para lectura completa. Para la síntesis narrativa se utilizaron 19 artículos. Las variantes de APP cursan con déficits neurocognitivos fuera del dominio del lenguaje, particulares a cada variante. Esto resalta la importancia de una evaluación neuropsicológica integral que aporte información adicional a los criterios de consenso ya establecidos para la evaluación de la APP.The purpose of this study is to establish the non-linguistic neuropsychological profile of variants of Primary Progressive Aphasia, through a systematic review of the literature of the last 5 years. The systematic and advanced manual search was carried out in the databases Scopus, PubMed, Web of Science and Google Scholar to identify the studies that describe the non- linguistic neuropsychological profile of the variants of Primary Progressive Aphasia (PPA), inclusion and exclusion criteria were established for the selection of articles, their quality and relevance were evaluated. The systematic review yielded 7084 articles, of which 131 were pre-selected as reported in the summary and 26 validated for full reading. Nineteen articles were used for the narrative synthesis. PPA variants present with neurocognitive deficits outside the language domain, this underlines the importance of a comprehensive neuropsychological evaluation that provides additional information to the consensus criteria already established for the evaluation of the PPA.O objectivo deste estudo é estabelecer o perfil neuropsicológico não linguístico das variantes da Afasia Progressiva Primária, mediante uma revisão sistemática da literatura dos últimos 5 anos. A busca manual sistemática e avançada foi realizada nas bases de dados Scopus, PubMed, Web of Science e Google Scholar para identificar os estudos que descrevem o perfil neuropsicológico não linguístico das variantes da Afasia Progressiva Primária (APP)Foram estabelecidos critérios de inclusão e exclusão para a seleção dos artigos, avaliados sua qualidade e relevância. A revisão sistemática mostrou 7084 artigos, dos quais 131 foram pré-selecionados de acordo com o resumo e 26 validados para leitura completa. Para a síntese narrativa foram utilizados 19 artigos. As variantes de APP cursam com déficits neurocognitivos fora do domínio da linguagem, particulares a cada variante. Isto sublinha a importância de uma avaliação neuropsicológica integral que forneça informação adicional aos critérios de consenso já estabelecidos para a avaliação da APP.24 páginasapplication/pdfspaCorporación Universidad de la CostaColombiahttps://revistascientificas.cuc.edu.co/JACN/article/view/4547Non-linguistic neuropsychological profile of primary progressive aphasia: a systematic reviewPerfil neuropsicológico no lingüístico de las afasias progresivas primarias: una revisión sistemáticaArtículo de revistahttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Journal of Applied Cognitive NeuroscienceAcosta-Cabronero, J.; Patterson, K.; Fryer, T. D.; Hodges, J. R.; Pengas, G.; Williams, G. B. & Nestor, P. J. (2011). Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain, 134(7), 2025–2035. https://doi.org/10.1093/BRAIN/AWR119Benhamou, E.; Marshall, C. R.; Russell, L. L.; Hardy, C. J. D.; Bond, R. L.; Sivasathiaseelan, H.; Greaves, C. V.; Friston, K. J.; Rohrer, J. D.; Warren, J. D. & Razi, A. (2020). The neurophysiological architecture of semantic dementia: spectral dynamic causal modelling of a neurodegenerative proteinopathy. Scientific Reports, 10(1), 1–13. https://doi.org/10.1038/s41598-020-72847-1Bergeron, D.; Gorno-Tempini, M. L.; Rabinovici, G. D.; Santos-Santos, M. A.; Seeley, W.; Miller, B. L.; Pijnenburg, Y.; Keulen, M. A.; Groot, C.; van Berckel, B. N. M.; van der Flier, W. M.; Scheltens, P.; Rohrer, J. D.; Warren, J. D.; Schott, J. M.; Fox, N. C.; Sanchez-Valle, R.; Grau-Rivera, O.; Gelpi, E.; Seelaar, H.; Papma, J. M.; van Swieten, J. C.; Hodges, J. R.; Leyton, C. E.; Piguet, O.; Rogalski, E. J.; Mesulam, M. M.; Koric, L.; Nora, K.; Pariente, J.; Dickerson, B.; Mackenzie, I. R.; Hsiung, G.-Y. R.; Belliard, S.; Irwin, D. J.; Wolk, D. A.; Grossman, M.; Jones, M.; Harris, J.; Mann, D.; Snowden, J. S.; Chrem-Mendez, P.; Calandri, I. L.; Amengual, A. A.; Miguet-Alfonsi, C.; Magnin, E.; Magnani, G.; Santangelo, R.; Deramecourt, V.; Pasquier, F.; Mattsson, N.; Nilsson, C.; Hansson, O.; Keith, J.; Masellis, M.; Black, S. E.; Matías-Guiu, J. A.; María-Nieves Cabrera-Martin.; Paquet, C.; Dumurgier, J.; Teichmann, M.; Sarazin, M.; Bottlaender, M.; Dubois, B.; Rowe, C. C.; Villemagne, V. L.; Vandenberghe, R.; Granadillo, E.; Teng, E.; Mendez, M.; Meyer, P. T.; Frings, L.; Lleó, A.; Blesa, R.; Fortea, J.; Seo, S.-W.; Diehl-Schmid, J.; Grimmer, T.; Frederiksen, K. S.; Sánchez-Juan, P.; Chételat, G.; Jansen, W.; Bouchard, R. W.; Laforce Jr., R.; Visser, P. J. & Ossenkoppele, R. (2018). Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. Annals of Neurology, 84(5), 729–740. https://doi.org/10.1002/ANA.25333Botha, H.; Duffy, J. R.; Whitwell, J. L.; Strand, E. A.; Machulda, M. M.; Schwarz, C. G.; Reid, R. I.; Spychalla, A. J.; Senjem, M. L.; Jones, D. T.; Lowe, V.; Jack, C. R. & Josephs, K. A. (2015). Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech. Cortex, 69, 220–236. https://doi.org/10.1016/J.CORTEX.2015.05.013Brambati, S. M.; Amici, S.; Racine, C. A.; Neuhaus, J.; Miller, Z.; Ogar, J.; Dronkers, N.; Miller, B. L.; Rosen, H. & Gorno-Tempini, M. L. (2015). Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study. NeuroImage: Clinical, 8, 345–355. https://doi.org/10.1016/J.NICL.2015.01.011Butts, A. M.; Machulda, M. M.; Duffy, J. R.; Strand, E. A.; Whitwell, J. L. & Josephs, K. A. (2015). Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia. Journal of the International Neuropsychological Society, 21(6), 429–435. https://doi.org/10.1017/S1355617715000399Collins, J. A.; Montal, V.; Hochberg, D.; Quimby, M.; Mandelli, M. L.; Makris, N.; Seeley, W. W.; Gorno-Tempini, M. L. & Dickerson, B. C. (2017). Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia. Brain, 140(2), 457–471. https://doi.org/10.1093/BRAIN/AWW313Coyle-Gilchrist, I. T. S.; Dick, K. M.; Patterson, K.; Rodríquez, P. V.; Wehmann, E.; Wilcox, A.; Lansdall, C. J.; Dawson, K. E.; Wiggins, J.; Mead, S.; Brayne, C. & Rowe, J. B. (2016). Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology, 86(18), 1736–1743. https://doi.org/10.1212/WNL.0000000000002638Eikelboom, W. S.; Janssen, N.; Jiskoot, L. C.; van den Berg, E.; Roelofs, A. & Kessels, R. P. C. (2018). Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis. Neuroscience & Biobehavioral Reviews, 92, 243–254. https://doi.org/10.1016/J.NEUBIOREV.2018.06.015Fittipaldi, S.; Ibanez, A.; Baez, S.; Manes, F.; Sedeno, L. & Garcia, A. M. (2019). More than words: Social cognition across variants of primary progressive aphasia. Neuroscience & Biobehavioral Reviews, 100, 263–284. https://doi.org/10.1016/J.NEUBIOREV.2019.02.020Foxe, D.; Cheung, S. C.; Cordato, N. J.; Burrell, J. R.; Ahmed, R. M.; Taylor-Rubin, C.; Irish, M. & Piguet, O. (2021). Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting. Brain Sciences, 11(8), 1–21. https://doi.org/10.3390/BRAINSCI11081060Goldberg, Z.-L.; El-Omar, H.; Foxe, D.; Leyton, C. E.; Ahmed, R. M.; Piguet, O. & Irish, M. (2021). Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia. Brain Sciences, 11(12), 1–16. https://doi.org/10.3390/BRAINSCI11121600Gorbea-Portal, S. & Atrián-Salazar, M. L. (2018). Medición de la obsolescencia de la información en revistas de salud pública de México. Gaceta Médica de México, 154(3), 335–341. https://doi.org/10.24875/GMM.18003293Gorno-Tempini, M. L.; Hillis, A. E.; Weintraub, S.; Kertesz, A.; Mendez, M.; Cappa, S. F.; Ogar, J. M.; Rohrer, J. D.; Black, S.; Boeve, B. F.; Manes, F.; Dronkers, N. F.; Vandenberghe, R.; Rascovsky, K.; Patterson, K.; Miller, B. L.; Knopman, D. S.; Hodges, J. R.; Mesulam, M. M. & Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006–1014. https://doi.org/10.1212/wnl.0b013e31821103e6Hailstone, J. C.; Ridgway, G. R.; Bartlett, J. W.; Goll, J. C.; Buckley, A. H.; Crutch, S. J. & Warren, J. D. (2011). Voice processing in dementia: a neuropsychological and neuroanatomical analysis. Brain, 134(9), 2535–2547. https://doi.org/10.1093/BRAIN/AWR205Harris, J. M.; Saxon, J. A.; Jones, M.; Snowden, J. S. & Thompson, J. C. (2019). Neuropsychological differentiation of progressive aphasic disorders. Journal of Neuropsychology, 13(2), 214–239. https://doi.org/10.1111/JNP.12149Kamath, V.; Sutherland, E. R. & Chaney, G.-A. (2020). A Meta-Analysis of Neuropsychological Functioning in the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants. Journal of the International Neuropsychological Society, 26(3), 322–330. https://doi.org/10.1017/S1355617719001115Kamminga, J.; Kumfor, F.; Burrell, J. R.; Piguet, O.; Hodges, J. R. & Irish, M. (2015). Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. Journal of Neurology, Neurosurgery & Psychiatry, 86(10), 1082–1088. https://doi.org/10.1136/JNNP-2014-309120Karpathiou, N. & Kambanaros, M. (2022). Comparing Individuals With PPA to Individuals With AD: Cognitive and Linguistic Profiles. Frontiers in Communication, 7, 1–15. https://doi.org/10.3389/fcomm.2022.893471Kumfor, F.; Miller, L.; Lah, S.; Hsieh, S.; Savage, S.; Hodges, J. R. & Piguet, O. (2011). Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Social Neuroscience, 6(5–6), 502–514. https://doi.org/10.1080/17470919.2011.620779Leyton, C. E.; Ballard, K. J.; Piguet, O. & Hodges, J. R. (2014). Phonologic errors as a clinical marker of the logopenic variant of PPA. Neurology, 82(18), 1620–1627. https://doi.org/10.1212/WNL.0000000000000387Leyton, C. E.; Piguet, O.; Savage, S.; Burrell, J. & Hodges, J. R. (2012). The Neural Basis of Logopenic Progressive Aphasia. Journal of Alzheimer’s Disease, 32(4), 1051–1059. https://doi.org/10.3233/JAD-2012-121042Lukic, S.; Mandelli, M. L.; Welch, A.; Jordan, K.; Shwe, W.; Neuhaus, J.; Miller, Z.; Hubbard, H. I.; Henry, M.; Miller, B. L.; Dronkers, N. F. & Gorno-Tempini, M. L. (2019). Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and Language, 194, 35–45. https://doi.org/10.1016/J.BANDL.2019.04.003Mack, J. E.; Cho-Reyes, S.; Kloet, J. D.; Weintraub, S.; Mesulam, M. M. & Thompson, C. K. (2013). Phonological facilitation of object naming in agrammatic and logopenic Primary Progressive Aphasia (PPA). Cognitive Neuropsychology, 30(3), 172–193. https://doi.org/10.1080/02643294.2013.835717Macoir, J.; Lavoie, M.; Laforce, R.; Brambati, S. M. & Wilson, M. A. (2017). Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria. Journal of Geriatric Psychiatry Neurology, 30(3), 151–161. https://doi.org/10.1177/0891988717700507Magnin, E.; Démonet, J. F.; Wallon, D.; Dumurgier, J.; Troussière, A. C.; Jager, A.; Duron, E.; Gabelle, A.; de La Sayette, V.; Volpe-Gillot, L.; Tio, G.; Evain, S.; Boutoleau-Bretonnière, C.; Enderle, A.; Mouton-Liger, F.; Robert, P.; Hannequin, D.; Pasquier, F.; Hugon, J. & Paquet, C. (2016). Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers. Journal of Alzheimer’s Disease, 54(4), 1459–1471. https://doi.org/10.3233/JAD-160536Marshall, C. R.; Hardy, C. J. D.; Russell, L. L.; Bond, R. L.; Sivasathiaseelan, H.; Greaves, C.; Moore, K. M.; Agustus, J. L.; van Leeuwen, J. E. P.; Wastling, S. J.; Rohrer, J. D.; Kilner, J. M. & Warren, J. D. (2019). The functional neuroanatomy of emotion processing in frontotemporal dementias. Brain, 142(9), 2873–2887. https://doi.org/10.1093/BRAIN/AWZ204Méndez, M. F.; Monserratt, L. H.; Liang, L. J.; Chavez, D.; Jimenez, E. E.; Maurer, J. J. & Laffey, M. (2019). Neuropsychological Similarities and Differences Between Amnestic Alzheimer’s Disease and its Non-Amnestic Variants. Journal of Alzheimer’s Disease, 69(3), 849–855. https://doi.org/10.3233/JAD-190124Mesulam, M.-M. (2013). Primary progressive aphasia and the language network. Neurology, 81(5), 456–462. https://doi.org/10.1212/WNL.0B013E31829D87DFMesulam, M.-M. & Weintraub, S. (2014). Is it time to revisit the classification guidelines for primary progressive aphasia? Neurology, 82(13), 1108–1109. https://doi.org/10.1212/WNL.0000000000000272Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. & Group, P. (2009a). Standards & Guidelines Linee guida per il reporting di revisioni sistematiche e meta-analisi: il PRISMA Statement. Annals of Internal Medicine, (151), 264–269. https://doi.org/10.7326/0003-4819-151-4-200908180-00135Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. & The PRISMA Group. (2009b). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med, 6(6), 1–9. https://doi.org/10.1136/bmj.b2535Montembeault, M.; Chapleau, M.; Jarret, J.; Boukadi, M.; Laforce, R.; Wilson, M. A.; Rouleau, I. & Brambati, S. M. (2019). Differential language network functional connectivity alterations in Alzheimer’s disease and the semantic variant of primary progressive aphasia. Cortex, 117, 284–298. https://doi.org/10.1016/J.CORTEX.2019.03.018Montreuil, S.; Poulin, E.; Bergeron, D.; Sellami, L.; Verret, L.; Fortin, M. P.; Poulin, S.; MacOir, J.; Hudon, C.; Bouchard, R. W.; Lavoie, M. & Laforce, R. (2020). Cognitive Profile of the Logopenic Variant of Primary Progressive Aphasia Using the Dépistage Cognitif de Québec. Dementia and Geriatric Cognitive Disorders, 49(4), 410–417. https://doi.org/10.1159/000510501Multani, N.; Galantucci, S.; Wilson, S. M.; Shany-Ur, T.; Poorzand, P.; Growdon, M. E.; Jang, J. Y.; Kramer, J. H.; Miller, B. L.; Rankin, K. P.; Gorno-Tempini, M. L. & Tartaglia, M. C. (2017). Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia. NeuroImage: Clinical, 16, 447–454. https://doi.org/10.1016/J.NICL.2017.08.020Owens, T. E.; Machulda, M. M.; Duffy, J. R.; Strand, E. A.; Clark, H. M.; Boland, S.; Martin, P. R.; Lowe, V. J.; Jack, C. R.; Whitwell, J. L. & Josephs, K. A. (2018). Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia. Journal of Alzheimer’s Disease, 66(3), 1015–1025. https://doi.org/10.3233/JAD-171175Piguet, O.; Leyton, C. E.; Gleeson, L. D.; Hoon, C. & Hodges, J. R. (2015). Memory and Emotion Processing Performance Contributes to the Diagnosis of Non-Semantic Primary Progressive Aphasia Syndromes. Journal of Alzheimer’s Disease, 44(2), 541–547. https://doi.org/10.3233/JAD-141854Prabhakar, A. T.; Mathew, V.; Sivadasan, A.; Aaron, S.; George, A. & Alexander, M. (2019). Clinical profile of primary progressive aphasias in a tertiary care centre from India. International Journal of Speech-Language Pathology, 21(6), 547–552. https://doi.org/10.1080/17549507.2018.1545870Radakovic, R.; Colville, S.; Cranley, D.; Starr, J. M.; Pal, S. & Abrahams, S. (2021). Multidimensional Apathy in Behavioral Variant Frontotemporal Dementia, Primary Progressive Aphasia, and Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology, 34(5), 349–356. https://doi.org/10.1177/0891988720924716Ramanan, S.; Roquet, D.; Goldberg, Z.-L.; Hodges, J. R.; Piguet, O.; Irish, M. & Ralph, M. A. L. (2020). Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia. Brain Communications, 2(2), 1–50. https://doi.org/10.1093/BRAINCOMMS/FCAA125Rohrer, J. D.; Volkmer, A.; Rogalski, E.;, Henry, M.; Taylor-Rubin, C.; Ruggero, L.; Khayum, R.; Kindell, J.; Gorno-Tempini, M. L.; Warren, J. & Rohrer, J. (2010). How to understand it Speech and language therapy approaches to managing primary progressive aphasia. Practical Neurology, 20(2), 154–162. https://doi.org/10.1136/practneurol-2018-001921Santos-Santos, M. A.; Mandelli, M. L.; Binney, R. J.; Ogar, J.; Wilson, S. M.; Henry, M. L.; Hubbard, H. I.; Meese, M.; Attygalle, S.; Rosenberg, L.; Pakvasa, M.; Trojanowski, J. Q.; Grinberg, L. T.; Rosen, H.; Boxer, A. L.; Miller, B. L.; Seeley, W. W. & Gorno-Tempini, M. L. (2016). Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurology, 73(6), 733–742. https://doi.org/10.1001/JAMANEUROL.2016.0412Santos-Santos, M. A.; Rabinovici, G. D.; Iaccarino, L.; Ayakta, N.; Tammewar, G.; Lobach, I.; Henry, M. L.; Hubbard, I.; Mandelli, M. L.; Spinelli, E.; Miller, Z. A.; Pressman, P. S.; O’Neil, J. P.; Ghosh, P.; Lazaris, A.; Meyer, M.; Watson, C.; Yoon, S. J.; Rosen, H. J.; W. J. Grinberg, L.; Seeley, W. W.; Miller, B. L.; Jagust, W. J. & Gorno-Tempini, M. L. (2018). Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurology, 75(3), 342–352. https://doi.org/10.1001/JAMANEUROL.2017.4309Singh, T. D.; Duffy, J. R.; Strand, E. A.; Machulda, M. M.; Whitwell, J. L. & Josephs, K. A. (2015). Neuropsychiatric Symptoms in Primary Progressive Aphasia and Apraxia of Speech. Dementia and Geriatric Cognitive Disorders, 39(3–4), 228–238. https://doi.org/10.1159/000369062Sjoberg, D. I. K. (2010). Confronting the myth of Rapid obsolescence in Computing Research. Communications of the ACM, 53(9), 62–67. https://doi.org/10.1145/1810891.1810911Tee, B. L. & Gorno-Tempini, M. L. (2019). Primary progressive aphasia: A model for neurodegenerative disease. Current Opinion in Neurology, 32(2), 255–265. https://doi.org/10.1097/WCO.0000000000000673Tee, B. L.; Watson Pereira, C.; Lukic, S.; Bajorek, L. P.; Allen, I. E.; Miller, Z. A.; Casaletto, K. B.; Miller, B. L. & Gorno-Tempini, M. L. (2022). Neuroanatomical correlations of visuospatial processing in primary progressive aphasia. Brain Communications, 4(2), 1–12. https://doi.org/10.1093/BRAINCOMMS/FCAC060Teichmann, M.; Migliaccio, R.; Kas, A. & Dubois, B. (2013). Logopenic progressive aphasia beyond Alzheimer’s—an evolution towards dementia with Lewy bodies. Journal of Neurology, Neurosurgery & Psychiatry, 84(1), 113–114. https://doi.org/10.1136/JNNP-2012-302638Ulugut, H.; Stek, S.; Wagemans, L. E. E.; Jutten, R. J.; Keulen, M. A.; Bouwman, F. H.; Prins, N. D.; Lemstra, A. W.; Krudop, W.; Teunissen, C. E.; van Berckel, B. N. M.; Ossenkoppele, R.; Barkhof, F.; van der Flier, W. M.; Scheltens, P. & Pijnenburg, Y. A. L. (2022). The natural history of primary progressive aphasia: beyond aphasia. Journal of Neurology, 269(3), 1375–1385. https://doi.org/10.1007/S00415-021-10689-1Urbizagástegui, R. (2016). Estudio sincrónico de obsolescencia de la literatura: el caso de la Ley de Lotka. Investigación Bibliotecológica: Archivonomía, Bibliotecología e Información, 28(63), 85–113. https://doi.org/10.1016/S0187-358X(14)72577-8Urrútia, G. & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507–511. https://doi.org/10.1016/j.medcli.2010.01.015Urrútia, G. & Bonfilll, X. (2013). La declaración PRISMA: un paso adelante en la mejora de las publicaciones de la Revista Española de Salud Pública. Revista Española de Salud Pública, 87(2), 99–102. https://doi.org/10.4321/S1135-57272013000200001Utianski, R. L.; Duffy, J. R.; Clark, H. M.; Strand, E. A.; Botha, H.; Schwarz, C. G.; Machulda, M. M.; Senjem, M. L.; Spychalla, A. J.; Jack, C. R.; Petersen, R. C.; Lowe, V. J.; Whitwell, J. L. & Josephs, K. A. (2018). Prosodic and phonetic subtypes of primary progressive apraxia of speech. Brain and Language, 184, 54–65. https://doi.org/10.1016/J.BANDL.2018.06.004Watson, C. L.; Possin, K.; Allen, I. E.; Hubbard, H. I.; Meyer, M.; Welch, A. E.; Rabinovici, G. D.; Rosen, H.; Rankin, K. P.; Miller, Z.; Santos-Santos, M. A.; Kramer, J. H.; Miller, B. L. & Gorno-Tempini, M. L. (2018). Visuospatial Functioning in the Primary Progressive Aphasias. Journal of the International Neuropsychological Society, 24(3), 259–268. https://doi.org/10.1017/S1355617717000984Wilson, S. M.; Galantucci, S.; Tartaglia, M. C. & Gorno-Tempini, M. L. (2012). The neural basis of syntactic deficits in primary progressive aphasia. Brain and Language, 122(3), 190–198. https://doi.org/10.1016/J.BANDL.2012.04.005Zilli, E. M. & Heilman, K. M. (2015). Spatial neglect in a patient with logopenic progressive aphasia. Neurocase, 22(1), 30–39. https://doi.org/10.1080/13554794.2015.103125424113Afasia progresiva primariaAfasia progresiva no fluenteAfasia progresiva logopénicaAfasia progresiva semánticaRevisión sistemáticaFunciones cognitivasProgressive aphasiaNonfluent progressive aphasiaLogogenic progressive aphasiaSemantic progressive aphasiaSystematic reviewCognitive functionsAfasia progressiva primáriaAfasia progressiva não fluenteAfasia progressiva logopênicaAfasia progressiva semânticaRevisão sistemáticaFunções cognitivasPublicationORIGINALNon-Linguistic Neuropsychological Profile of Primary Progressive Aphasia. A systematic review.pdfNon-Linguistic Neuropsychological Profile of Primary Progressive Aphasia. 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A systematic review.pdf.jpgGenerated Thumbnailimage/jpeg13530https://repositorio.cuc.edu.co/bitstreams/0a57aa44-d34e-4867-97ed-dad92f85fe56/download204ba137d94f1a68fe5d34f8cf851e19MD5411323/9951oai:repositorio.cuc.edu.co:11323/99512024-09-17 11:06:10.323https://creativecommons.org/licenses/by-nc-nd/4.0/Copyright (c) 2022 karina lastre mezaopen.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa 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ada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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