Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate

1 documento

Autores:: Herrera, Sócrates

Tipo de recurso:: Investigation report

Fecha de publicación:: 2001

Institución:: Ministerio de Ciencia, Tecnología e Innovación

Repositorio:: Repositorio Minciencias

Idioma:: spa

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spelling	Herrera, Sócrates2024-02-15T20:43:39Z2024-02-15T20:43:39Z2001https://repositorio.minciencias.gov.co/handle/20.500.14143/507661 documentoThis project was aimed at conducting a Phase 1 clinical trial to assess the safety, immunogenicity and protective efficacy of synthetic peptides derived from different regions of the P. vívax es protein in human volunteers. The trial was proposed on the bases of previous studies that had allowed us to partially characterize immunologically the protein . We had study the P . vívax CS antigenicity in humans and monkeys and had defined B, Th and eTL epitopes (refs) . Additionally we had conducted studies on the immunogenicity of peptides derived from this protein both in rodents and in non-human primates using bench quality synthetic peptides . Because of the minimal requirement of the vaccine quality for human use , we proposed to produce 3 long synthetic peptides under GLP conditions and to test them in young human naive volunteers . Although this objective was approved , Colciencias recommended that a further pre-clinical trial in monkeys must be performed with the new GLP quality vaccines . This recommendation was accepted by the group and is reported here.79 p.application/pdfspaUniversidad del ValleColcienciasCalihttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)http://purl.org/coar/access_right/c_abf2Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidateInforme de investigaciónhttp://purl.org/coar/resource_type/c_18wshttp://purl.org/coar/resource_type/c_18ghhttp://purl.org/coar/resource_type/c_93fcTextinfo:eu-repo/semantics/reporthttp://purl.org/redcol/resource_type/INFinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Proyectos de investigaciónBiología molecularInmunologíaParásitosExperimentos clínicosPéptidoEstudiantes, Profesores, Comunidad científica colombiana, etc.11060506397Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate399-97Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] ColcienciasPublicationORIGINAL1106-05-063-97 INFORME FINAL.pdf1106-05-063-97 INFORME FINAL.pdfapplication/pdf42189026https://repositorio.minciencias.gov.co/bitstreams/cbbfd2ea-ad56-42eb-82dd-6f399fda1a17/download650d95c61f32ab5f0b92d3097eaae2f2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.minciencias.gov.co/bitstreams/909ab9ed-0dc6-46d1-bdc9-db2e4fb195ba/download73a5432e0b76442b22b026844140d683MD52TEXT1106-05-063-97 INFORME FINAL.pdf.txt1106-05-063-97 INFORME FINAL.pdf.txtExtracted texttext/plain100695https://repositorio.minciencias.gov.co/bitstreams/d0d804f2-82f2-4de3-998b-4de6ff042f36/download1835530bcb36a53bb1a4649a85c1fec0MD53THUMBNAIL1106-05-063-97 INFORME FINAL.pdf.jpg1106-05-063-97 INFORME FINAL.pdf.jpgGenerated Thumbnailimage/jpeg2545https://repositorio.minciencias.gov.co/bitstreams/28cc1916-dad1-45db-94bb-7ea8ec36e5da/downloadf2c975ca95656a74cc44e5bc08e55a99MD5420.500.14143/50766oai:repositorio.minciencias.gov.co:20.500.14143/507662024-09-02 19:23:09.179https://creativecommons.org/licenses/by/4.0/restrictedhttps://repositorio.minciencias.gov.coRepositorio Institucional de Mincienciascendoc@minciencias.gov.co
dc.title.eng.fl_str_mv	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
title	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
spellingShingle	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate Proyectos de investigación Biología molecular Inmunología Parásitos Experimentos clínicos Péptido
title_short	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
title_full	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
title_fullStr	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
title_full_unstemmed	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
title_sort	Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
dc.creator.fl_str_mv	Herrera, Sócrates
dc.contributor.author.none.fl_str_mv	Herrera, Sócrates
dc.subject.lemb.none.fl_str_mv	Proyectos de investigación Biología molecular Inmunología
topic	Proyectos de investigación Biología molecular Inmunología Parásitos Experimentos clínicos Péptido
dc.subject.proposal.spa.fl_str_mv	Parásitos Experimentos clínicos Péptido
description	1 documento
publishDate	2001
dc.date.issued.none.fl_str_mv	2001
dc.date.accessioned.none.fl_str_mv	2024-02-15T20:43:39Z
dc.date.available.none.fl_str_mv	2024-02-15T20:43:39Z
dc.type.none.fl_str_mv	Informe de investigación
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url	https://repositorio.minciencias.gov.co/handle/20.500.14143/50766
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dc.rights.creativecommons.none.fl_str_mv	Atribución 4.0 Internacional (CC BY 4.0)
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eu_rights_str_mv	openAccess
dc.format.extent.none.fl_str_mv	79 p.
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Universidad del Valle Colciencias
dc.publisher.place.none.fl_str_mv	Cali
publisher.none.fl_str_mv	Universidad del Valle Colciencias
institution	Ministerio de Ciencia, Tecnología e Innovación
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Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate

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