First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection

An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction and tested for antioxidant ac...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Ministerio de Ciencia, Tecnología e Innovación
Repositorio:
Repositorio Minciencias
Idioma:
eng
OAI Identifier:
oai:repositorio.minciencias.gov.co:20.500.14143/34174
Acceso en línea:
http://repositorio.colciencias.gov.co/handle/11146/34174
Palabra clave:
Biología vegetal
Productos químicos
Aceites vegetales
AChE inhibitory activity
Alkaloids
α-Aminonitriles
Antioxidant capacity
Girgensohnine
Strecker reaction
Aceites esenciales
Bioquímica vegetal
Biotecnología
Catalizadores
Rights
License
http://purl.org/coar/access_right/c_f1cf
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spelling Colombia2019-04-01T02:42:46Z2019-04-01T02:42:46Z2013info:eu-repo/date/embargoEnd/2024-01-311875-6271http://repositorio.colciencias.gov.co/handle/11146/34174Contiene 26 referencias bibliográficas. Véase documento adjuntoAn efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacityDepartamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias5507-543-31904Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiananopdf5 páginasengPrograma: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co/handle/11146/34163" target="blank">http://repositorio.colciencias.gov.co/handle/11146/34163</a>Current Organic Synthesis, 2013, 10, 969-973First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their BioprospectionArtículo científicoinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Administradores de ciencia y tecnologíaInvestigadoresBiología vegetalProductos químicosAceites vegetalesAChE inhibitory activityAlkaloidsα-AminonitrilesAntioxidant capacityGirgensohnineStrecker reactionAceites esencialesBioquímica vegetalBiotecnologíaCatalizadoreshttp://purl.org/coar/access_right/c_f1cfVargas Méndez, Leonor YamileKouznetsov, Vladimir V.Bio-Red-CO-CENIVAMUniversidad Industrial de Santander, UISUniversidad Santo Tomás, USTA - Seccional Bucaramangakouznet@uis.edu.co2018-01Programas de CT+I Ejecutados por Redes de ConocimientoComunidad científica colombiana0572-2012Artículos de investigaciónPublicationORIGINALArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdfArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdfArtículo Current Organic Synthesisapplication/pdf174862https://repositorio.minciencias.gov.co/bitstreams/c0899e6d-75cb-4fd6-9639-234757cfec13/download1f6b34da4e344718a129236f67d961a6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.minciencias.gov.co/bitstreams/d15a5e1a-d599-4261-b157-09130031e06b/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdf.txtArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdf.txtExtracted texttext/plain24401https://repositorio.minciencias.gov.co/bitstreams/d7fe0aa7-b223-4006-9156-b9379ca427d5/downloada55420d003fd68878f6c434c911cff2aMD55THUMBNAILArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdf.jpgArt_First Girgensohnine Analogs Prepared Through InCl3_catalyzed Strecker Reaction and their Bioprospection.pdf.jpgGenerated Thumbnailimage/jpeg17219https://repositorio.minciencias.gov.co/bitstreams/e2304e99-dba6-4b22-b742-170ae4b658e1/downloadae61c3475eacc3fb6e0cccfcd1f18cbeMD5620.500.14143/34174oai:repositorio.minciencias.gov.co:20.500.14143/341742023-11-29 17:46:38.421restrictedhttps://repositorio.minciencias.gov.coRepositorio Institucional de Mincienciascendoc@minciencias.gov.co
dc.title.es_CO.fl_str_mv First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
title First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
spellingShingle First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
Biología vegetal
Productos químicos
Aceites vegetales
AChE inhibitory activity
Alkaloids
α-Aminonitriles
Antioxidant capacity
Girgensohnine
Strecker reaction
Aceites esenciales
Bioquímica vegetal
Biotecnología
Catalizadores
title_short First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
title_full First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
title_fullStr First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
title_full_unstemmed First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
title_sort First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
dc.subject.lemb.es_CO.fl_str_mv Biología vegetal
Productos químicos
Aceites vegetales
topic Biología vegetal
Productos químicos
Aceites vegetales
AChE inhibitory activity
Alkaloids
α-Aminonitriles
Antioxidant capacity
Girgensohnine
Strecker reaction
Aceites esenciales
Bioquímica vegetal
Biotecnología
Catalizadores
dc.subject.keyword.none.fl_str_mv AChE inhibitory activity
Alkaloids
α-Aminonitriles
Antioxidant capacity
Girgensohnine
Strecker reaction
dc.subject.spines.es_CO.fl_str_mv Aceites esenciales
Bioquímica vegetal
Biotecnología
Catalizadores
description An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity
publishDate 2013
dc.date.issued.none.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2019-04-01T02:42:46Z
dc.date.available.none.fl_str_mv 2019-04-01T02:42:46Z
dc.date.embargoEnd.es_CO.fl_str_mv info:eu-repo/date/embargoEnd/2024-01-31
dc.type.es_CO.fl_str_mv Artículo científico
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dc.type.driver.es_CO.fl_str_mv info:eu-repo/semantics/article
dc.identifier.issn.none.fl_str_mv 1875-6271
dc.identifier.uri.none.fl_str_mv http://repositorio.colciencias.gov.co/handle/11146/34174
dc.identifier.bibliographicCitation.es_CO.fl_str_mv Contiene 26 referencias bibliográficas. Véase documento adjunto
identifier_str_mv 1875-6271
Contiene 26 referencias bibliográficas. Véase documento adjunto
url http://repositorio.colciencias.gov.co/handle/11146/34174
dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.relation.ispartof.es_CO.fl_str_mv Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co/handle/11146/34163" target="blank">http://repositorio.colciencias.gov.co/handle/11146/34163</a>
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_f1cf
rights_invalid_str_mv http://purl.org/coar/access_right/c_f1cf
dc.format.es_CO.fl_str_mv pdf
dc.format.extent.es_CO.fl_str_mv 5 páginas
dc.coverage.spatial.es_CO.fl_str_mv Colombia
dc.source.es_CO.fl_str_mv Current Organic Synthesis, 2013, 10, 969-973
institution Ministerio de Ciencia, Tecnología e Innovación
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