First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction and tested for antioxidant ac...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2013
- Institución:
- Ministerio de Ciencia, Tecnología e Innovación
- Repositorio:
- Repositorio Minciencias
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.minciencias.gov.co:20.500.14143/34174
- Acceso en línea:
- http://repositorio.colciencias.gov.co/handle/11146/34174
- Palabra clave:
- Biología vegetal
Productos químicos
Aceites vegetales
AChE inhibitory activity
Alkaloids
α-Aminonitriles
Antioxidant capacity
Girgensohnine
Strecker reaction
Aceites esenciales
Bioquímica vegetal
Biotecnología
Catalizadores
- Rights
- License
- http://purl.org/coar/access_right/c_f1cf
| Summary: | An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity |
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