An efficient two-step synthesis of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5] triazines
A series of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5]triazines were selectively synthesized by a two-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and hetaroyl isothiocyanates with subsequent amination and cyclization promoted by the couple HgCl2/TEA and DMF as solvent. This approach p...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2012
- Institución:
- Ministerio de Ciencia, Tecnología e Innovación
- Repositorio:
- Repositorio Minciencias
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.minciencias.gov.co:20.500.14143/21975
- Acceso en línea:
- https://repositorio.minciencias.gov.co/handle/20.500.14143/21975
- Palabra clave:
- Síntesis (química orgánica)
Radicales (química)
Amino H-pyrazoles
Pyrazolo[1,5-a][1,3,5]triazines
Pyrazolylthioureas
Guanylation
Nucleophilic amination
Mercury(II) chloride
Reacciones químicas
Tecnología química
Compuestos orgánicos
Química orgánica
Residuos orgánicos
- Rights
- License
- http://purl.org/coar/access_right/c_f1cf
| Summary: | A series of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5]triazines were selectively synthesized by a two-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and hetaroyl isothiocyanates with subsequent amination and cyclization promoted by the couple HgCl2/TEA and DMF as solvent. This approach provided the title compounds in good to excellent yields and under mild reaction conditions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques. |
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