Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.

La transmisión doméstica y la urbanización de la Leishmaniasis se han convertido en un fenómeno frecuente en Colombia y otros países de Latinoamérica. El desplazamiento de grupos humanos y la deforestación son factores que contribuyen. La adaptación de los vectores a hábitats alterados se evidencia...

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Autores:: Rubiano, Luisa Consuelo

Tipo de recurso:: Investigation report

Fecha de publicación:: 2010

Institución:: Ministerio de Ciencia, Tecnología e Innovación

Repositorio:: Repositorio Minciencias

Idioma:: spa

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dc.title.spa.fl_str_mv	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
title	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
spellingShingle	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea. Leishmaniasis Enfermedades transmisibles Insectos vectores Leishmaniasis mucocutánea Cutaneous Leishmaniasis Domestic Transmission Human reservoir of infection Microsatellite Genotyping Parasite Burden
title_short	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
title_full	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
title_fullStr	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
title_full_unstemmed	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
title_sort	Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.
dc.creator.fl_str_mv	Rubiano, Luisa Consuelo
dc.contributor.author.none.fl_str_mv	Rubiano, Luisa Consuelo
dc.contributor.corporatename.spa.fl_str_mv	Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM) (Cali, Colombia)
dc.contributor.researchgroup.none.fl_str_mv	COL0001413 - CIDEIM
dc.subject.armarc.none.fl_str_mv	Leishmaniasis Enfermedades transmisibles Insectos vectores Leishmaniasis mucocutánea
topic	Leishmaniasis Enfermedades transmisibles Insectos vectores Leishmaniasis mucocutánea Cutaneous Leishmaniasis Domestic Transmission Human reservoir of infection Microsatellite Genotyping Parasite Burden
dc.subject.proposal.en.fl_str_mv	Cutaneous Leishmaniasis Domestic Transmission Human reservoir of infection Microsatellite Genotyping Parasite Burden
description	La transmisión doméstica y la urbanización de la Leishmaniasis se han convertido en un fenómeno frecuente en Colombia y otros países de Latinoamérica. El desplazamiento de grupos humanos y la deforestación son factores que contribuyen. La adaptación de los vectores a hábitats alterados se evidencia por la frecuencia y presencia diseminada geográficamente de Lutzomyia dentro de las viviendas. (Apartes del texto).
publishDate	2010
dc.date.issued.none.fl_str_mv	2010
dc.date.accessioned.none.fl_str_mv	2019-10-29T23:56:04Z 2020-12-18T00:35:58Z
dc.date.available.none.fl_str_mv	2019-10-29T23:56:04Z 2020-12-18T00:35:58Z
dc.type.spa.fl_str_mv	Informe de investigación
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dc.identifier.uri.none.fl_str_mv	https://colciencias.metadirectorio.org/handle/11146/39571
dc.identifier.instname.spa.fl_str_mv	Colciencias
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dc.format.extent.spa.fl_str_mv	45 páginas.
dc.coverage.spatial.none.fl_str_mv	Colombia
institution	Ministerio de Ciencia, Tecnología e Innovación
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spelling	Rubiano, Luisa Consuelo363c5e6a1e07e4c57853b093120537fa-1Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM) (Cali, Colombia)COL0001413 - CIDEIMColombia2019-10-29T23:56:04Z2020-12-18T00:35:58Z2019-10-29T23:56:04Z2020-12-18T00:35:58Z2010https://colciencias.metadirectorio.org/handle/11146/39571ColcienciasRepositorio Colcienciashttp://colciencias.metabiblioteca.com.coLa transmisión doméstica y la urbanización de la Leishmaniasis se han convertido en un fenómeno frecuente en Colombia y otros países de Latinoamérica. El desplazamiento de grupos humanos y la deforestación son factores que contribuyen. La adaptación de los vectores a hábitats alterados se evidencia por la frecuencia y presencia diseminada geográficamente de Lutzomyia dentro de las viviendas. (Apartes del texto).45 páginas.spaInforme;Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.Informe de investigaciónhttp://purl.org/coar/resource_type/c_18wshttp://purl.org/coar/resource_type/c_93fcTextinfo:eu-repo/semantics/reporthttps://purl.org/redcol/resource_type/PIDinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/submittedVersioninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/LeishmaniasisEnfermedades transmisiblesInsectos vectoresLeishmaniasis mucocutáneaCutaneous LeishmaniasisDomestic TransmissionHuman reservoir of infectionMicrosatellite GenotypingParasite BurdenEstudiantes, Profesores, Comunidad científica colombiana, etc.222951928948252-2010Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] ColcienciasPrograma Nacional de CTeI en SaludProject Goal: To obtain the evidence base to prevent domestic transmission of dermal leishmaniasis and preserve the useful life of first line drugs by defining the burden of Leishmania infection (symptomatic and asymptomatic) in domestically exposed populations and the role of this reservoir of human infection in transmission, and the development and dissemination of drug resistance.Specific Aims : Aim 1. To determine the age-specific prevalence of parasites in blood, mucosa and dermal aspirates of the inhabitants of foci of domestic transmission of leishmaniasis. Research Questions ' What is the prevalence and relative burden of Leishmania in extralesional tissues of symptomatic and asymptomatic populations experiencing domestic transmission of dermal leishmaniasis? ' Is there an age, gender or clinical status bias in the prevalence and burden of parasites indicating that some individuals may be contributing more to transmission? Indicators ' Age specific prevalence of parasites in tissues of clinically apparent and subclinical infection established ' Individuals with high parasite burden identified Implementable outcomes 1. Magnitude of human reservoir of Leishmania infection in setting of domestic transmission estimated. 2. Quantitative reference point for assessment of subsequent interventions to reduce the burden of human infection determined. 3. Target populations for host directed interventions identified.Specific Aims : Aim 2. To discern the relationship between immunological evidence of infection (DTH response to intradermal application of Leishmania antigen-leishmanin) and the presence of parasites in host tissues (blood, mucosa and healthy skin). Research Questions ' Is skin test response correlated with the detectable presence of parasites in tissues? ' Can subclinical infection in the community be parasitologically established using molecular methods? Indicators ' Relationship between skin test response and persistence of parasites established. ' Capacity of molecular amplification of Leishmania DNA to parasitologically detect subclinical infection determined. Implementable outcome 1. A gene-based tool to parasitologically detect asymptomatic infection.Specific Aims : Aim 3. To determine the diversity and interrelationship of Leishmania populations circulating among the inhabitants of a focus of domestic transmission. Research Questions ' Are multiple populations of Leishmania distinguishable in domestic settings of transmission? ' Can the epidemiologic relationship of human infection with domestic transmission be discerned using phenotypic and genotypic markers? Indicators ' Diversity/similarity of Leishmania populations in representative settings of domestic transmission determined. ' Potential of phenotypic and genetic markers to discern epidemiologic relationships in the domestic setting defined. Implementable outcomes 1. Novel epidemiologic tools based on genotypic and functional markers 2. Genetic and phenotypic evidence of common or diverse sources of infection in the human population.Specific Aims : Aim 4. To define the drug susceptibility and persistence of parasites isolated from lesions and extralesional tissues before and after treatment. Research Questions ' Are parasites in blood, mucosa or healthy skin sites of treated patients less susceptible to the drug used to treat patients in the community? ' Is the parasite burden or drug susceptibility of recovered parasites correlated with the clinical response to treatment? Indicators ' In vitro drug susceptibility of parasites that disseminate to extralesional tissues and persist following treatment determined. ' Prevalence and relative burden of Leishmania in extralesional tissues following treatment established. Implementable outcomes 1. Recognition of treatment as a potential control measure for transmission 2. Evidence base to compel the use of combined therapies (co-adjuvant immunotherapy and/or antileishmanial drug combinations) to minimize burden of infection in human p.PublicationORIGINAL222951928948 20142430034272.pdf222951928948 20142430034272.pdfInforme Técnico Finalapplication/pdf11094401https://repositorio.minciencias.gov.co/bitstreams/38b8f756-d40f-4afc-9cd1-823d4a951d8f/downloaddf57f40180745e04361c137b054ce1d0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814798https://repositorio.minciencias.gov.co/bitstreams/712fbe73-4b01-4050-be94-1941096802e2/download88794144ff048353b359a3174871b0d5MD52license.txtlicense.txttext/plain; charset=utf-80https://repositorio.minciencias.gov.co/bitstreams/5ac29843-c356-4e90-a62f-ba2f220fe3c6/downloadd41d8cd98f00b204e9800998ecf8427eMD55TEXT222951928948 20142430034272.pdf.txt222951928948 20142430034272.pdf.txtExtracted texttext/plain45https://repositorio.minciencias.gov.co/bitstreams/499189be-58de-479d-a332-454592ec57e4/downloadf1a122fa4a70ca0c5cc80f76c2bdc217MD53THUMBNAIL222951928948 20142430034272.pdf.jpg222951928948 20142430034272.pdf.jpgGenerated Thumbnailimage/jpeg7169https://repositorio.minciencias.gov.co/bitstreams/1b8d5b9d-f088-4299-b107-0a3de7c78852/download66fde58c7aa521508773de211a65b867MD5420.500.14143/39571oai:repositorio.minciencias.gov.co:20.500.14143/395712023-11-29 17:33:07.454restrictedhttps://repositorio.minciencias.gov.coRepositorio Institucional de Mincienciascendoc@minciencias.gov.co

Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.

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