Cantharidin-Based Small Molecules as Potential Therapeutic Agents

Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and bio...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Ministerio de Ciencia, Tecnología e Innovación
Repositorio:
Repositorio Minciencias
Idioma:
eng
OAI Identifier:
oai:repositorio.minciencias.gov.co:20.500.14143/34156
Acceso en línea:
http://repositorio.colciencias.gov.co/handle/11146/34156
Palabra clave:
Productos farmacéuticos
Anticancer activity
Blister beetles
Cantharidin analogs
Diels–Alder cycloaddition reactions
Drug design and development
Protein phosphatases inhibitory activity
Bioquímica vegetal
Aceites esenciales
Aceites combustibles
Aceites vegetales
Biotecnología
Química agrícola
Rights
License
http://purl.org/coar/access_right/c_f1cf
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spelling Colombia2019-03-31T22:49:58Z2019-03-31T22:49:58Z2013info:eu-repo/date/embargoEnd/2024-01-31http://repositorio.colciencias.gov.co/handle/11146/34156Contiene 108 referencias bibliográficas. Véase documento adjunto10.1111/cbdd.12180Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias5507-543-31904Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiananopdf23 páginasengPrograma: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co/handle/11146/34163" target="blank">http://repositorio.colciencias.gov.co/handle/11146/34163</a>Chem Biol Drug Des 2013; 82: 477–499Cantharidin-Based Small Molecules as Potential Therapeutic AgentsArtículo científicoinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Administradores de ciencia y tecnologíaProfesoresInvestigadoresProductos farmacéuticosAnticancer activityBlister beetlesCantharidin analogsDiels–Alder cycloaddition reactionsDrug design and developmentProtein phosphatases inhibitory activityBioquímica vegetalAceites esencialesAceites combustiblesAceites vegetalesBiotecnologíaQuímica agrícolahttp://purl.org/coar/access_right/c_f1cfPuerto Galvis, Carlos EduardoVargas Méndez, Leonor YamileKouznetsov, Vladimir V.Bio-Red-CO-CENIVAMUniversidad Industrial de Santander, UISUniversidad Santo Tomás, USTA - Seccional Bucaramangavkuznechnik@gmail.com2018-01Programas de CT+I Ejecutados por Redes de ConocimientoComunidad científica colombiana0572-2012Artículos de investigaciónPublicationORIGINALArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdfArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdfArtículo Chem Biol Drug Desapplication/pdf2905785https://repositorio.minciencias.gov.co/bitstreams/64b3ebaf-3304-4a85-9d33-de80d1ecfd14/downloadfacf40cab1346d78e43777d29dc9dc92MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.minciencias.gov.co/bitstreams/b9773e85-7477-46a0-b7f9-00f60fd2386f/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdf.txtArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdf.txtExtracted texttext/plain89060https://repositorio.minciencias.gov.co/bitstreams/54906953-8df3-4ceb-870a-7bafa1e44af6/download03d3ae352b7805214757e036b1d464d8MD55THUMBNAILArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdf.jpgArt_Cantharidin-Based Small Molecules as Potential Therapeutic Agents.pdf.jpgGenerated Thumbnailimage/jpeg16137https://repositorio.minciencias.gov.co/bitstreams/9b21bbcc-6496-4879-92f3-2b5ffceb2b1c/downloadd14aabfb3a2709a49b5c63e7a2f4dbddMD5620.500.14143/34156oai:repositorio.minciencias.gov.co:20.500.14143/341562023-11-29 17:35:41.835restrictedhttps://repositorio.minciencias.gov.coRepositorio Institucional de Mincienciascendoc@minciencias.gov.co
dc.title.es_CO.fl_str_mv Cantharidin-Based Small Molecules as Potential Therapeutic Agents
title Cantharidin-Based Small Molecules as Potential Therapeutic Agents
spellingShingle Cantharidin-Based Small Molecules as Potential Therapeutic Agents
Productos farmacéuticos
Anticancer activity
Blister beetles
Cantharidin analogs
Diels–Alder cycloaddition reactions
Drug design and development
Protein phosphatases inhibitory activity
Bioquímica vegetal
Aceites esenciales
Aceites combustibles
Aceites vegetales
Biotecnología
Química agrícola
title_short Cantharidin-Based Small Molecules as Potential Therapeutic Agents
title_full Cantharidin-Based Small Molecules as Potential Therapeutic Agents
title_fullStr Cantharidin-Based Small Molecules as Potential Therapeutic Agents
title_full_unstemmed Cantharidin-Based Small Molecules as Potential Therapeutic Agents
title_sort Cantharidin-Based Small Molecules as Potential Therapeutic Agents
dc.subject.lemb.es_CO.fl_str_mv Productos farmacéuticos
topic Productos farmacéuticos
Anticancer activity
Blister beetles
Cantharidin analogs
Diels–Alder cycloaddition reactions
Drug design and development
Protein phosphatases inhibitory activity
Bioquímica vegetal
Aceites esenciales
Aceites combustibles
Aceites vegetales
Biotecnología
Química agrícola
dc.subject.keyword.none.fl_str_mv Anticancer activity
Blister beetles
Cantharidin analogs
Diels–Alder cycloaddition reactions
Drug design and development
Protein phosphatases inhibitory activity
dc.subject.spines.es_CO.fl_str_mv Bioquímica vegetal
Aceites esenciales
Aceites combustibles
Aceites vegetales
Biotecnología
Química agrícola
description Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
publishDate 2013
dc.date.issued.none.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2019-03-31T22:49:58Z
dc.date.available.none.fl_str_mv 2019-03-31T22:49:58Z
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dc.type.es_CO.fl_str_mv Artículo científico
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dc.identifier.uri.none.fl_str_mv http://repositorio.colciencias.gov.co/handle/11146/34156
dc.identifier.bibliographicCitation.es_CO.fl_str_mv Contiene 108 referencias bibliográficas. Véase documento adjunto
dc.identifier.doi.none.fl_str_mv 10.1111/cbdd.12180
url http://repositorio.colciencias.gov.co/handle/11146/34156
identifier_str_mv Contiene 108 referencias bibliográficas. Véase documento adjunto
10.1111/cbdd.12180
dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.relation.ispartof.es_CO.fl_str_mv Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co/handle/11146/34163" target="blank">http://repositorio.colciencias.gov.co/handle/11146/34163</a>
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dc.format.es_CO.fl_str_mv pdf
dc.format.extent.es_CO.fl_str_mv 23 páginas
dc.coverage.spatial.es_CO.fl_str_mv Colombia
dc.source.es_CO.fl_str_mv Chem Biol Drug Des 2013; 82: 477–499
institution Ministerio de Ciencia, Tecnología e Innovación
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