Cantharidin-Based Small Molecules as Potential Therapeutic Agents
Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and bio...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2013
- Institución:
- Ministerio de Ciencia, Tecnología e Innovación
- Repositorio:
- Repositorio Minciencias
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.minciencias.gov.co:20.500.14143/34156
- Acceso en línea:
- http://repositorio.colciencias.gov.co/handle/11146/34156
- Palabra clave:
- Productos farmacéuticos
Anticancer activity
Blister beetles
Cantharidin analogs
Diels–Alder cycloaddition reactions
Drug design and development
Protein phosphatases inhibitory activity
Bioquímica vegetal
Aceites esenciales
Aceites combustibles
Aceites vegetales
Biotecnología
Química agrícola
- Rights
- License
- http://purl.org/coar/access_right/c_f1cf
| Summary: | Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models. |
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