EVALUACIÓN DEL TIEMPO Y TEMPERATURA DE INCUBACIÓN EN EL PROCESO DETOXIFICACIÓN DE UNA TOXINA TETÁNICA
In order to reduce the incubation time and temperature in the Tetanic Toxin detoxification process, different times and temperature were evaluated; taking crops in process that were grown in tetanus Lab production of the National Institute of Health. To determine the exact da y of detoxification a l...
- Autores:
- Tipo de recurso:
- article
- Fecha de publicación:
- 2013
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/31251
- Acceso en línea:
- http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4878
http://hdl.handle.net/10554/31251
- Palabra clave:
- null
Clostridium tétani, Detoxification, Flocculation, Tetanus, Toxin.
null
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
| Summary: | In order to reduce the incubation time and temperature in the Tetanic Toxin detoxification process, different times and temperature were evaluated; taking crops in process that were grown in tetanus Lab production of the National Institute of Health. To determine the exact da y of detoxification a logis tic model was established. The toxin was incubate at 4,22 and 37°C to estimate the optim temperature. Then the physical-chemical characteristics like (pH), and the biologycal characteristics (Lf/mL, unspecific, specific toxicity and antigenicy) of the toxoid were verified. The best conditions for the process are: 25 days of incubation at 37°C. With the characteristics above, yearly there is a possibility to get a profit of 1.513.350 doses that represen! $37.833.750 for the production of the Tetanic Toxin |
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