LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up t...
- Autores:
- Tipo de recurso:
- article
- Fecha de publicación:
- 2003
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/31536
- Acceso en línea:
- http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
- Palabra clave:
- null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICASSáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, BogotáBarrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.nullHunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteinsnullThe aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A, hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of metabolism are caused by deficiency in glycosilated proteins (GP). Yeast glycosilate proteins, but they have different pattern of glycosylation from mammalianPontificia Universidad Javeriananull2018-02-24T16:00:06Z2020-04-15T18:07:51Z2018-02-24T16:00:06Z2020-04-15T18:07:51Z2003-07-01http://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPDFapplication/pdfhttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/47382027-13520122-7483http://hdl.handle.net/10554/31536enghttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42nullnullnullAtribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2reponame:Repositorio Universidad Javerianainstname:Pontificia Universidad Javerianainstacron:Pontificia Universidad Javeriana2023-03-28T21:15:44Z |
dc.title.none.fl_str_mv |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
spellingShingle |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
title_short |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_full |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_fullStr |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_full_unstemmed |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_sort |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
dc.creator.none.fl_str_mv |
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela. |
author |
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá |
author_facet |
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela. |
author_role |
author |
author2 |
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
null |
dc.subject.none.fl_str_mv |
null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
topic |
null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
description |
The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A, hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of metabolism are caused by deficiency in glycosilated proteins (GP). Yeast glycosilate proteins, but they have different pattern of glycosylation from mammalian |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-07-01 2018-02-24T16:00:06Z 2018-02-24T16:00:06Z 2020-04-15T18:07:51Z 2020-04-15T18:07:51Z |
dc.type.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 Artículo de revista http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738 2027-1352 0122-7483 http://hdl.handle.net/10554/31536 |
url |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738 http://hdl.handle.net/10554/31536 |
identifier_str_mv |
2027-1352 0122-7483 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667 Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 |
dc.rights.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
PDF application/pdf |
dc.coverage.none.fl_str_mv |
null null null |
dc.publisher.none.fl_str_mv |
Pontificia Universidad Javeriana |
publisher.none.fl_str_mv |
Pontificia Universidad Javeriana |
dc.source.none.fl_str_mv |
reponame:Repositorio Universidad Javeriana instname:Pontificia Universidad Javeriana instacron:Pontificia Universidad Javeriana |
instname_str |
Pontificia Universidad Javeriana |
instacron_str |
Pontificia Universidad Javeriana |
institution |
Pontificia Universidad Javeriana |
reponame_str |
Repositorio Universidad Javeriana |
collection |
Repositorio Universidad Javeriana |
_version_ |
1803712843516739584 |