LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS

The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up t...

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Tipo de recurso:
article
Fecha de publicación:
2003
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/31536
Acceso en línea:
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
Palabra clave:
null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
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openAccess
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Atribución-NoComercial-SinDerivadas 4.0 Internacional
id JAVERIANA_592d3fccd21b9e1b12091d822021eae9
oai_identifier_str oai:repository.javeriana.edu.co:10554/31536
network_acronym_str JAVERIANA
network_name_str Repositorio Universidad Javeriana
repository_id_str
spelling LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICASSáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, BogotáBarrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.nullHunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteinsnullThe aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A,  hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of  metabolism are caused by deficiency in glycosilated proteins (GP).  Yeast glycosilate proteins, but they have different pattern of   glycosylation from mammalianPontificia Universidad Javeriananull2018-02-24T16:00:06Z2020-04-15T18:07:51Z2018-02-24T16:00:06Z2020-04-15T18:07:51Z2003-07-01http://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPDFapplication/pdfhttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/47382027-13520122-7483http://hdl.handle.net/10554/31536enghttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42nullnullnullAtribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2reponame:Repositorio Universidad Javerianainstname:Pontificia Universidad Javerianainstacron:Pontificia Universidad Javeriana2023-03-28T21:15:44Z
dc.title.none.fl_str_mv LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
spellingShingle LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
title_short LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_full LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_fullStr LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_full_unstemmed LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_sort LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
dc.creator.none.fl_str_mv Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
author Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
author_facet Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
author_role author
author2 Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
author2_role author
dc.contributor.none.fl_str_mv null
dc.subject.none.fl_str_mv null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
topic null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
description The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A,  hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of  metabolism are caused by deficiency in glycosilated proteins (GP).  Yeast glycosilate proteins, but they have different pattern of   glycosylation from mammalian
publishDate 2003
dc.date.none.fl_str_mv 2003-07-01
2018-02-24T16:00:06Z
2018-02-24T16:00:06Z
2020-04-15T18:07:51Z
2020-04-15T18:07:51Z
dc.type.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
Artículo de revista
http://purl.org/coar/resource_type/c_6501
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
2027-1352
0122-7483
http://hdl.handle.net/10554/31536
url http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
identifier_str_mv 2027-1352
0122-7483
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
dc.rights.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv PDF
application/pdf
dc.coverage.none.fl_str_mv null
null
null
dc.publisher.none.fl_str_mv Pontificia Universidad Javeriana
publisher.none.fl_str_mv Pontificia Universidad Javeriana
dc.source.none.fl_str_mv reponame:Repositorio Universidad Javeriana
instname:Pontificia Universidad Javeriana
instacron:Pontificia Universidad Javeriana
instname_str Pontificia Universidad Javeriana
instacron_str Pontificia Universidad Javeriana
institution Pontificia Universidad Javeriana
reponame_str Repositorio Universidad Javeriana
collection Repositorio Universidad Javeriana
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