Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species
The protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease,...
- Autores:
- Tipo de recurso:
- article
- Fecha de publicación:
- 2013
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/31584
- Acceso en línea:
- http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187
http://hdl.handle.net/10554/31584
- Palabra clave:
- null
Chagas’ disease, Trypanosoma cruzi, Miconia.
null
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia speciesFerreira, Daniele da Silva; Universidade de FrancaEsperandim, Viviane Rodrigues; Universidade de FrancaMarçal, Maria Gabriela; Universidade de FrancaNeres, Naraya Bruna Dos Reis; Universidade de FrancaCunha, Nayanne Larissa; Universidade de FrancaAndrade e Silva, Márcio Luís; Universidade de FrancaCunha, Wilson Roberto; Universidade de FrancanullChagas’ disease, Trypanosoma cruzi, Miconia.nullThe protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease, but its efficacy during the chronic stage is debatable. The search for new medications that can treat Chagas’ disease is therefore mandatory. Natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Miconia is one of the largest genus of the family Melastomataceae and includes approximately 1,000 plant species; Brazil alone is home to approximately 250 of these species, which exist in forests and savannas. Studies on the various biological activities of the Miconia species have reported promising results. Several researchers have screened these plants as well as their extracts in vitro against trypomastigote forms of T. cruzi, which displayed significant trypanocidal activity. It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity.Pontificia Universidad JaverianaCapes, CNPq, Fapesp2018-02-24T16:00:12Z2020-04-15T18:08:00Z2018-02-24T16:00:12Z2020-04-15T18:08:00Z2013-09-10http://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPDFapplication/pdftext/htmlhttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/618710.11144/Javeriana.SC18-3.npcd2027-13520122-7483http://hdl.handle.net/10554/31584enghttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/5484http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/6504Universitas Scientiarum; Vol 18, No 3 (2013); 243-256Universitas Scientiarum; Vol 18, No 3 (2013); 243-256Universitas Scientiarum; Vol 18, No 3 (2013); 243-256nullnullnullAtribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2reponame:Repositorio Universidad Javerianainstname:Pontificia Universidad Javerianainstacron:Pontificia Universidad Javeriana2023-03-28T21:15:48Z |
dc.title.none.fl_str_mv |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
title |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
spellingShingle |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species Ferreira, Daniele da Silva; Universidade de Franca null Chagas’ disease, Trypanosoma cruzi, Miconia. null |
title_short |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
title_full |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
title_fullStr |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
title_full_unstemmed |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
title_sort |
Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species |
dc.creator.none.fl_str_mv |
Ferreira, Daniele da Silva; Universidade de Franca Esperandim, Viviane Rodrigues; Universidade de Franca Marçal, Maria Gabriela; Universidade de Franca Neres, Naraya Bruna Dos Reis; Universidade de Franca Cunha, Nayanne Larissa; Universidade de Franca Andrade e Silva, Márcio Luís; Universidade de Franca Cunha, Wilson Roberto; Universidade de Franca |
author |
Ferreira, Daniele da Silva; Universidade de Franca |
author_facet |
Ferreira, Daniele da Silva; Universidade de Franca Esperandim, Viviane Rodrigues; Universidade de Franca Marçal, Maria Gabriela; Universidade de Franca Neres, Naraya Bruna Dos Reis; Universidade de Franca Cunha, Nayanne Larissa; Universidade de Franca Andrade e Silva, Márcio Luís; Universidade de Franca Cunha, Wilson Roberto; Universidade de Franca |
author_role |
author |
author2 |
Esperandim, Viviane Rodrigues; Universidade de Franca Marçal, Maria Gabriela; Universidade de Franca Neres, Naraya Bruna Dos Reis; Universidade de Franca Cunha, Nayanne Larissa; Universidade de Franca Andrade e Silva, Márcio Luís; Universidade de Franca Cunha, Wilson Roberto; Universidade de Franca |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Capes, CNPq, Fapesp |
dc.subject.none.fl_str_mv |
null Chagas’ disease, Trypanosoma cruzi, Miconia. null |
topic |
null Chagas’ disease, Trypanosoma cruzi, Miconia. null |
description |
The protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease, but its efficacy during the chronic stage is debatable. The search for new medications that can treat Chagas’ disease is therefore mandatory. Natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Miconia is one of the largest genus of the family Melastomataceae and includes approximately 1,000 plant species; Brazil alone is home to approximately 250 of these species, which exist in forests and savannas. Studies on the various biological activities of the Miconia species have reported promising results. Several researchers have screened these plants as well as their extracts in vitro against trypomastigote forms of T. cruzi, which displayed significant trypanocidal activity. It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-10 2018-02-24T16:00:12Z 2018-02-24T16:00:12Z 2020-04-15T18:08:00Z 2020-04-15T18:08:00Z |
dc.type.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 Artículo de revista http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187 10.11144/Javeriana.SC18-3.npcd 2027-1352 0122-7483 http://hdl.handle.net/10554/31584 |
url |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187 http://hdl.handle.net/10554/31584 |
identifier_str_mv |
10.11144/Javeriana.SC18-3.npcd 2027-1352 0122-7483 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/5484 http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/6504 Universitas Scientiarum; Vol 18, No 3 (2013); 243-256 Universitas Scientiarum; Vol 18, No 3 (2013); 243-256 Universitas Scientiarum; Vol 18, No 3 (2013); 243-256 |
dc.rights.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
PDF application/pdf text/html |
dc.coverage.none.fl_str_mv |
null null null |
dc.publisher.none.fl_str_mv |
Pontificia Universidad Javeriana |
publisher.none.fl_str_mv |
Pontificia Universidad Javeriana |
dc.source.none.fl_str_mv |
reponame:Repositorio Universidad Javeriana instname:Pontificia Universidad Javeriana instacron:Pontificia Universidad Javeriana |
instname_str |
Pontificia Universidad Javeriana |
instacron_str |
Pontificia Universidad Javeriana |
institution |
Pontificia Universidad Javeriana |
reponame_str |
Repositorio Universidad Javeriana |
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Repositorio Universidad Javeriana |
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1803712850172051456 |