Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility
Q2
- Autores:
-
González Cubides, Daniel Mauricio
Ayala Ramírez, Paola
Gelvez, Nancy
Suarez-Obando, Fernando
Beatriz, Ariza
Ruiz Bolivar, Zulema
Arcila Matiz, Julieth Andrea
Cardozo-Romero, Claudia Cecilia
Rojas, Adriana
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/62147
- Acceso en línea:
- https://www.sciencedirect.com/science/article/pii/S156713482200154X?via%3Dihub
http://hdl.handle.net/10554/62147
https://doi.org/10.1016/j.meegid.2022.105357
- Palabra clave:
- COVID-19
SARS-CoV-2
Disease susceptibility
Epigenetics
Angiotensin-converting enzyme 2
Host factors
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| title |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| spellingShingle |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility COVID-19 SARS-CoV-2 Disease susceptibility Epigenetics Angiotensin-converting enzyme 2 Host factors |
| title_short |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| title_full |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| title_fullStr |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| title_full_unstemmed |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| title_sort |
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility |
| dc.creator.fl_str_mv |
González Cubides, Daniel Mauricio Ayala Ramírez, Paola Gelvez, Nancy Suarez-Obando, Fernando Beatriz, Ariza Ruiz Bolivar, Zulema Arcila Matiz, Julieth Andrea Cardozo-Romero, Claudia Cecilia Rojas, Adriana |
| dc.contributor.author.none.fl_str_mv |
González Cubides, Daniel Mauricio Ayala Ramírez, Paola Gelvez, Nancy Suarez-Obando, Fernando Beatriz, Ariza Ruiz Bolivar, Zulema Arcila Matiz, Julieth Andrea Cardozo-Romero, Claudia Cecilia Rojas, Adriana |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.javerianateacher.none.fl_str_mv |
Ayala Ramírez, Paola Gelvez, Nancy Suarez-Obando, Fernando Rojas, Adriana |
| dc.subject.keyword.spa.fl_str_mv |
COVID-19 SARS-CoV-2 Disease susceptibility Epigenetics Angiotensin-converting enzyme 2 Host factors |
| topic |
COVID-19 SARS-CoV-2 Disease susceptibility Epigenetics Angiotensin-converting enzyme 2 Host factors |
| description |
Q2 |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-10-21T19:43:30Z |
| dc.date.available.none.fl_str_mv |
2022-10-21T19:43:30Z |
| dc.date.created.none.fl_str_mv |
2022-08-28 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S156713482200154X?via%3Dihub |
| dc.identifier.issn.spa.fl_str_mv |
1567-1348 / 1567-7257 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/62147 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.meegid.2022.105357 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.sciencedirect.com/science/article/pii/S156713482200154X?via%3Dihub http://hdl.handle.net/10554/62147 https://doi.org/10.1016/j.meegid.2022.105357 |
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1567-1348 / 1567-7257 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
10 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Infection, Genetics and Evolution |
| dc.relation.citationvolume.spa.fl_str_mv |
104 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2González Cubides, Daniel MauricioAyala Ramírez, PaolaGelvez, NancySuarez-Obando, FernandoBeatriz, ArizaRuiz Bolivar, ZulemaArcila Matiz, Julieth AndreaCardozo-Romero, Claudia CeciliaRojas, AdrianaPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaAyala Ramírez, PaolaGelvez, NancySuarez-Obando, FernandoRojas, Adriana2022-10-21T19:43:30Z2022-10-21T19:43:30Z2022-08-28https://www.sciencedirect.com/science/article/pii/S156713482200154X?via%3Dihub1567-1348 / 1567-7257 (Electrónico)http://hdl.handle.net/10554/62147https://doi.org/10.1016/j.meegid.2022.105357instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengEpigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q2Q2Background: The ACE2 protein acts as a gateway for SARS-CoV-2 in the host cell, playing an essential role in susceptibility to infection by this virus. Genetics and epigenetic mechanisms related to the ACE2 gene are associated with changes in its expression and, therefore, linked to increased susceptibility to infection. Although some variables such as sex, age, and obesity have been described as risk factors for COVID-19, the molecular causes involved in the disease susceptibility are still unknown. Aim: To evaluate the ACE2 gene expression profiles and their association with epigenetic mechanisms and de- mographic or clinical variables. Methods: In 500 adult volunteers, the mRNA expression levels of the ACE2 gene in nasopharyngeal swab samples and its methylation status in peripheral blood samples were quantified by RT-qPCR and qMSP, respectively. The existence of significant differences in the ACE2 gene expression and its determinants were evaluated in different study groups according to several demographic or clinical variables such as sex, age, body mass index (BMI), smoking, SARS-CoV-2 infection, and presence of underlying diseases such as type II diabetes mellitus (DM2), asthma and arterial hypertension (AHT). Results: Our results show that ACE2 gene overexpression, directly involved in susceptibility to SARS-CoV-2 infection, depends on multiple host factors such as male sex, age over 30 years, smoking, the presence of obesity, and DM2. Likewise, it was determined that the ACE2 gene expression is regulated by changes in the DNA methylation patterns in its promoter region. Conclusions: The ACE2 gene expression is highly variable, and this variability is related to habits such as smoking and demographic or clinical variables, which details the impact of environmental and host factors on our epi- genome and, therefore, in susceptibility to SARS-CoV-2 infection.https://orcid.org/0000-0002-0141-1149https://orcid.org/0000-0002-3925-1451https://orcid.org/0000-0001-6336-5347https://orcid.org/0000-0002-2554-8967https://orcid.org/0000-0003-4745-5339https://orcid.org/0000-0002-2739-9619https://orcid.org/0000-0001-8528-4433Revista Internacional - IndexadaA1NoCOVID-19SARS-CoV-2Disease susceptibilityEpigeneticsAngiotensin-converting enzyme 2Host factors110Infection, Genetics and Evolution104ORIGINALEpigenetic mechanisms and host factors impact ACE2 gene.pdfEpigenetic mechanisms and host factors impact ACE2 gene.pdfArtículoapplication/pdf841425http://repository.javeriana.edu.co/bitstream/10554/62147/1/Epigenetic%20mechanisms%20and%20host%20factors%20impact%20ACE2%20gene.pdf5011095df3918272c78bf2bda04e436bMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/62147/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILEpigenetic mechanisms and host factors impact ACE2 gene.pdf.jpgEpigenetic mechanisms and host factors impact ACE2 gene.pdf.jpgIM Thumbnailimage/jpeg10394http://repository.javeriana.edu.co/bitstream/10554/62147/4/Epigenetic%20mechanisms%20and%20host%20factors%20impact%20ACE2%20gene.pdf.jpgfc4963fdff6331043d13deb89666003bMD54open access10554/62147oai:repository.javeriana.edu.co:10554/621472022-10-25 09:39:37.42Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |