BIOLOGÍA DE LAS CÉLULAS DENDRÍTICAS HUMANAS

Antigen presenting cells are capable of capturing and processing antigenic peptides to be presented to T lymphocytes in the context of the Major Histocompatibility Complex. These peptides derived from self or no self proteins could be recognized  by the T Cell Receptor expressed on the surface of T lymphocytes. However, this presentation is not enough to activate peptide specific T lymphocytes. Dendritic cells are potent antigen presenting cells and  also have the capability to generate a second signal to stimulate T cell response. Currently, dendritic cells seem to play a central role in the  development of autoimmune diseases and also in the immune response  to microbial and tumoral antigens. The active study of their function and the possibility to purify dendritic cells form peripheral blood and even differentiate them in vitro from blood precursors will allow future and new  immune therapies for several diseases.

• Autores: Cuéllar Ávila, Adriana; Grupo de Inmunobiología y Biología Celular Departamento de Microbiología Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; Cifuentes Rojas, Catherine; Grupo de Inmunobiología y Biología Celular Departamento de Microbiología Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; Gómez Gutiérrez, Alberto; Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá Departamento de Microbiología Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; González Escobar, John Mario; Grupo de Inmunobiología y Biología Celular Departamento de Microbiología Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá Department of Neurology, Keck Medical School, University of Southern California, Los Angeles, CA, USA.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2004
• Institución: Pontificia Universidad Javeriana
• Repositorio: Repositorio Universidad Javeriana
• Idioma: eng
• OAI Identifier: oai:repository.javeriana.edu.co:10554/31791
• Acceso en línea: http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4917; http://hdl.handle.net/10554/31791
• Palabra clave: null; Cytokines, dendritic cells, monocytes, GM-CSF, IL-4.; null
• Rights: openAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional