Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals
Q4
- Autores:
-
Bautista, Diana
Romero-Sanchez, Consuelo
Franco Cortes, Manuel Antonio
Angel, Juana
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65323
- Acceso en línea:
- https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselc&AN=edselc.2-52.0-85150865978&lang=es&site=eds-live&scope=site&custid=s6670599
http://hdl.handle.net/10554/65323
https://doi.org/10.1080/08820139.2023.2187303
- Palabra clave:
- Appendectomy
Homing receptors
Marginal zone B cells
Spectral flow cytometry
Tonsillectomy
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| title |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| spellingShingle |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals Appendectomy Homing receptors Marginal zone B cells Spectral flow cytometry Tonsillectomy |
| title_short |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| title_full |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| title_fullStr |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| title_full_unstemmed |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| title_sort |
Expression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized Individuals |
| dc.creator.fl_str_mv |
Bautista, Diana Romero-Sanchez, Consuelo Franco Cortes, Manuel Antonio Angel, Juana |
| dc.contributor.author.none.fl_str_mv |
Bautista, Diana Romero-Sanchez, Consuelo Franco Cortes, Manuel Antonio Angel, Juana |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.javerianateacher.none.fl_str_mv |
Franco Cortes, Manuel Antonio Angel, Juana |
| dc.subject.keyword.spa.fl_str_mv |
Appendectomy Homing receptors Marginal zone B cells Spectral flow cytometry Tonsillectomy |
| topic |
Appendectomy Homing receptors Marginal zone B cells Spectral flow cytometry Tonsillectomy |
| description |
Q4 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-28T15:42:52Z |
| dc.date.available.none.fl_str_mv |
2023-08-28T15:42:52Z |
| dc.date.created.none.fl_str_mv |
2023-03-21 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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| dc.identifier.issn.spa.fl_str_mv |
0882-0139 / 1532-4311 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65323 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1080/08820139.2023.2187303 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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0882-0139 / 1532-4311 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
439 |
| dc.relation.citationendpage.spa.fl_str_mv |
453 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Immunological Investigations |
| dc.relation.citationvolume.spa.fl_str_mv |
52 |
| dc.relation.citationissue.spa.fl_str_mv |
4 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Bautista, DianaRomero-Sanchez, ConsueloFranco Cortes, Manuel AntonioAngel, JuanaPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaFranco Cortes, Manuel AntonioAngel, Juana2023-08-28T15:42:52Z2023-08-28T15:42:52Z2023-03-21https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselc&AN=edselc.2-52.0-85150865978&lang=es&site=eds-live&scope=site&custid=s66705990882-0139 / 1532-4311 (Electrónico)http://hdl.handle.net/10554/65323https://doi.org/10.1080/08820139.2023.2187303instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengExpression of Homing Receptors in IgM+IgD+CD27+ B Cells and Their Frequencies in Appendectomized and/or Tonsillectomized IndividualsArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q4Q3Pacientes apendicectomizados y/o amigdalectomizadosBackground: In humans, blood circulating IgM+IgD+CD27+ B cells are considered analogous to those described in the marginal zone of the spleen and are involved in important immunological processes. The homing receptors they express, and the organs involved in their development (for example, intestinal organs in rabbits) are only partially known. We recently reported that this population is heterogeneous and composed of at least two subsets: one expressing high levels of IgM – IgMhi B cells – and another low levels – IgMlo B cells. Objectives: To evaluate the expression of homing receptors on IgD+CD27+ IgMhi and IgMlo B cells and quantify their frequencies in blood of control and appendectomized and/or tonsillectomized volunteers. Materials and Methods: Using spectral flow cytometry, the simultaneous expression of 12 previously reported markers that differentiate IgMhi B cells and IgMlo B cells and of α4β7, CCR9, CD22 and CCR10 were evaluated in blood circulating B cells of control and appendectomized and/or tonsillectomized volunteers. Results The existence of phenotypically defined IgMlo and IgMhi B cell subsets was confirmed. They differentially expressed intestinal homing receptors, and the expression of α4β7 and CCR9 seems to determine new IgM subpopulations. IgMlo and IgMhi B cells were detected at lower frequencies in the appendectomized and/or tonsillectomized volunteers relative to controls. Conclusions: Human blood circulating IgD+CD27+ IgMlo and IgMhi B cell subsets differentially express homing receptors, and it is necessary to investigate if mucosal organs are important in their development.https://orcid.org/0000-0002-0817-2718https://orcid.org/0000-0002-6973-7639https://orcid.org/0000-0002-0265-0563https://orcid.org/0000-0001-6623-5337Revista Internacional - IndexadaA2NoAppendectomyHoming receptorsMarginal zone B cellsSpectral flow cytometryTonsillectomy439453Immunological Investigations524LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65323/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALExpression of Homing Receptors in IgM IgD CD27 B Cells and Their Frequencies in Appendectomized and or Tonsillectomized Individuals.pdfExpression of Homing Receptors in IgM IgD CD27 B Cells and Their Frequencies in Appendectomized and or Tonsillectomized Individuals.pdfArtículoapplication/pdf5430999http://repository.javeriana.edu.co/bitstream/10554/65323/1/Expression%20of%20Homing%20Receptors%20in%20IgM%20IgD%20CD27%20B%20Cells%20and%20Their%20Frequencies%20in%20Appendectomized%20and%20or%20Tonsillectomized%20Individuals.pdf2138aa29d723793c9961d2c84bd1972fMD51open accessTHUMBNAILExpression of Homing Receptors in IgM IgD CD27 B Cells and Their Frequencies in Appendectomized and or Tonsillectomized Individuals.pdf.jpgExpression of Homing Receptors in IgM IgD CD27 B Cells and Their Frequencies in Appendectomized and or Tonsillectomized Individuals.pdf.jpgIM Thumbnailimage/jpeg8299http://repository.javeriana.edu.co/bitstream/10554/65323/3/Expression%20of%20Homing%20Receptors%20in%20IgM%20IgD%20CD27%20B%20Cells%20and%20Their%20Frequencies%20in%20Appendectomized%20and%20or%20Tonsillectomized%20Individuals.pdf.jpg3e5c0d878565c306891bab8f7ec6179fMD53open access10554/65323oai:repository.javeriana.edu.co:10554/653232023-08-29 03:05:04.202Repositorio Institucional - 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