KMP-11: proteína 11 de Membrana de Kinetoplástidos

The kinetoplastid membrane protein KMP-11 is a 11kDa glycoprotein, is present on the surface of all stages of parasites life cycle, but is expressed  at higher levels in vector insect stages. The characteristics presented by this protein, such as its remarkably high degree of sequence homology  amon...

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Autores:
Diez Ortega, Hugo; Laboratorio de Parasitologia Molecular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá
López, Manuel Carlos; Laboratorio de Parasitologia Molecular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá
Thomas, Maricarmen; Laboratorio de Parasitologia Molecular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá
Puerta Bula, Concepción; Laboratorio de Parasitologia Molecular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá
Tipo de recurso:
Article of journal
Fecha de publicación:
2004
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/31677
Acceso en línea:
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/5033
http://hdl.handle.net/10554/31677
Palabra clave:
null
KMP-11, Kinetoplastids, Leishmania, Trypanosoma.
null
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
Description
Summary:The kinetoplastid membrane protein KMP-11 is a 11kDa glycoprotein, is present on the surface of all stages of parasites life cycle, but is expressed  at higher levels in vector insect stages. The characteristics presented by this protein, such as its remarkably high degree of sequence homology  among kinetoplastids, its association to the membrane, as well as to the cytoskeleton and the flagellum, and its immunological reactivity make this protein a potential target for developing chemotherapy or immunotherapy strategies against the diseases caused by these parasites. In this context, here we present the results of the KMP-11 genes study from Trypanosoma rangeli.