Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma
Q3
- Autores:
-
Montoya, C.
Rey, L.
Rodríguez Sarmiento, Jorge Luis
Fernández Sánchez, Maria José
Troncoso, D.
Canas, Alejandra
Moreno Niño, Olga María
Henríquez, B.
Rojas, Adriana
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/53284
- Acceso en línea:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057940/
http://hdl.handle.net/10554/53284
https://doi.org/10.3892/or.2020.7489
- Palabra clave:
- Ewing's sarcoma
Epigenetics
Histone
FISH
Translocation
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| title |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| spellingShingle |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma Ewing's sarcoma Epigenetics Histone FISH Translocation |
| title_short |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| title_full |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| title_fullStr |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| title_full_unstemmed |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| title_sort |
Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma |
| dc.creator.fl_str_mv |
Montoya, C. Rey, L. Rodríguez Sarmiento, Jorge Luis Fernández Sánchez, Maria José Troncoso, D. Canas, Alejandra Moreno Niño, Olga María Henríquez, B. Rojas, Adriana |
| dc.contributor.author.none.fl_str_mv |
Montoya, C. Rey, L. Rodríguez Sarmiento, Jorge Luis Fernández Sánchez, Maria José Troncoso, D. Canas, Alejandra Moreno Niño, Olga María Henríquez, B. Rojas, Adriana |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas |
| dc.contributor.javerianateacher.none.fl_str_mv |
Rodríguez Sarmiento, Jorge Luis Fernández Sánchez, Maria José Canas, Alejandra Moreno Niño, Olga María Rojas, Adriana |
| dc.subject.keyword.spa.fl_str_mv |
Ewing's sarcoma Epigenetics Histone FISH Translocation |
| topic |
Ewing's sarcoma Epigenetics Histone FISH Translocation |
| description |
Q3 |
| publishDate |
2020 |
| dc.date.created.none.fl_str_mv |
2020-02-05 |
| dc.date.accessioned.none.fl_str_mv |
2021-03-19T15:34:24Z |
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2021-03-19T15:34:24Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057940/ |
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1021-335X / 1791-2431 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/53284 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3892/or.2020.7489 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057940/ http://hdl.handle.net/10554/53284 https://doi.org/10.3892/or.2020.7489 |
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eng |
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eng |
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1199 |
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1207 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Oncology Reports |
| dc.relation.citationvolume.spa.fl_str_mv |
43 |
| dc.relation.citationissue.spa.fl_str_mv |
4 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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application/pdf |
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Colombia |
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Bogotá (Colombia) |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Montoya, C.Rey, L.Rodríguez Sarmiento, Jorge LuisFernández Sánchez, Maria JoséTroncoso, D.Canas, AlejandraMoreno Niño, Olga MaríaHenríquez, B.Rojas, AdrianaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de PatologíaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. NeumologíaPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias FisiológicasRodríguez Sarmiento, Jorge LuisFernández Sánchez, Maria JoséCanas, AlejandraMoreno Niño, Olga MaríaRojas, AdrianaColombiaBogotá (Colombia)2021-03-19T15:34:24Z2021-03-19T15:34:24Z2020-02-05https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057940/1021-335X / 1791-2431 (Electrónico)http://hdl.handle.net/10554/53284https://doi.org/10.3892/or.2020.7489instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengEpigenetic control of the EWS-FLI1 promoter in Ewing's sarcomaArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q3Q2Pacientes con Sarcoma de EwingEwing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra-osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS-FLI1. The epigenetic profile (histone acetylation and methylation enrichment of the promoter region) that may regulate the expression of the aberrant transcription factor EWS-FLI1, remains poorly studied and understood. Knowledge of epigenetic patterns associated with covalent histone modification and expression of enzymes associated with this process, can contribute to the understanding of the molecular basis of the disease, as well as to the identification of possible molecular targets involved in expression of the EWS-FLI1 gene, so that therapeutic strategies may be improved in the future. In the present study, the transcriptional activation and repression of the EWS-FLI1 fusion gene in ES was accompanied by selective deposition of histone markers on its promoter. The EWS-FLI1 fusion gene was evaluated in two patients with ES using conventional cytogenetic, fluorescence in situ hybridization and nested PCR assays, which revealed that the aberrant expression of the EWS-FLI1 gene is accompanied by enrichment of H3K4Me3, H3K9ac and H3K27ac at the promoter region.https://orcid.org/0000-0002-0084-0339https://orcid.org/0000-0001-6461-2725https://orcid.org/0000-0003-3975-2835https://orcid.org/0000-0002-0826-6191https://orcid.org/0000-0001-8528-4433Revista Internacional - IndexadaA1Ewing's sarcomaEpigeneticsHistoneFISHTranslocation11991207Oncology Reports434ORIGINALArtículo.pdfArtículo.pdfapplication/pdf578140http://repository.javeriana.edu.co/bitstream/10554/53284/1/Art%c3%adculo.pdf296c4d94613774d9def1ae0d1bc1dd9fMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/53284/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILArtículo.pdf.jpgArtículo.pdf.jpgIM Thumbnailimage/jpeg9200http://repository.javeriana.edu.co/bitstream/10554/53284/3/Art%c3%adculo.pdf.jpgbc796ee8be4e7d9597faf2a5b97cc7ccMD53open access10554/53284oai:repository.javeriana.edu.co:10554/532842023-03-16 16:57:58.101Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.coTElDRU5DSUEgWSBBVVRPUklaQUNJw5NOIERFIExPUyBBVVRPUkVTIFBBUkEgUFVCTElDQVIgWSBQRVJNSVRJUiBMQSBDT05TVUxUQSBZIFVTTy4KClBhcnRlIDEuIFTDqXJtaW5vcyBkZSBsYSBsaWNlbmNpYSBnZW5lcmFsIHBhcmEgcHVibGljYWNpw7NuIGRlIG9icmFzIGVuIGVsIHJlcG9zaXRvcmlvIGluc3RpdHVjaW9uYWwKQ29tbyB0aXR1bGFyIChlcykgZGVsIGRlcmVjaG8gZGUgYXV0b3IsIGNvbmZpZXJvIChlcmltb3MpIGEgbGEgUG9udGlmaWNpYSBVbml2ZXJzaWRhZCBKYXZlcmlhbmEgdW5hIGxpY2VuY2lhIG5vIGV4Y2x1c2l2YSwgbGltaXRhZGEgeSBncmF0dWl0YSBzb2JyZSBsYSBvYnJhIHF1ZSBzZSBpbnRlZ3JhcsOhIGVuIGVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwsIHF1ZSBzZSBhanVzdGEgYSBsYXMgc2lndWllbnRlcyBjYXJhY3RlcsOtc3RpY2FzOgphKSAgICAgIEVzdGFyw6EgdmlnZW50ZSBhIHBhcnRpciBkZSBsYSBmZWNoYSBkZSBpbmNsdXNpw7NuIGVuIGVsIHJlcG9zaXRvcmlvLCBwb3IgdW4gcGxhem8gZGUgNSBhw7FvcywgcXVlIHNlcsOhbiBwcm9ycm9nYWJsZXMgaW5kZWZpbmlkYW1lbnRlIHBvciBlbCB0aWVtcG8gcXVlIGR1cmUgZWwgZGVyZWNobyBwYXRyaW1vbmlhbCBkZWwgYXV0b3IuIEVsIGF1dG9yIHBvZHLDoSBkYXIgcG9yIHRlcm1pbmFkYSBsYSBsaWNlbmNpYSBzb2xpY2l0w6FuZG9sbyBhIGxhIFVuaXZlcnNpZGFkIHBvciBlc2NyaXRvLgpiKSAgICAgIEF1dG9yaXphIGEgbGEgUG9udGlmaWNpYSBVbml2ZXJzaWRhZCBKYXZlcmlhbmEgYSBwdWJsaWNhciBsYSBvYnJhIGVuIGRpZ2l0YWwsIGNvbm9jaWVuZG8gcXVlLCBkYWRvIHF1ZSBzZSBwdWJsaWNhIGVuIEludGVybmV0LCBwb3IgZXN0ZSBoZWNobyBjaXJjdWxhIGNvbiB1biBhbGNhbmNlIG11bmRpYWwuCmMpICAgICAgTG9zIGF1dG9yZXMgYWNlcHRhbiBxdWUgbGEgYXV0b3JpemFjacOzbiBzZSBoYWNlIGEgdMOtdHVsbyBncmF0dWl0bywgcG9yIGxvIHRhbnRvIHJlbnVuY2lhbiBhIHJlY2liaXIgYmVuZWZpY2lvIGFsZ3VubyBwb3IgbGEgcHVibGljYWNpw7NuLCBkaXN0cmlidWNpw7NuLCBjb211bmljYWNpw7NuIHDDumJsaWNhIHkgY3VhbHF1aWVyIG90cm8gdXNvIHF1ZSBzZSBoYWdhIGVuIGxvcyB0w6lybWlub3MgZGUgbGEgcHJlc2VudGUgbGljZW5jaWEgeSBkZSBsYSBsaWNlbmNpYSBkZSB1c28gY29uIHF1ZSBzZSBwdWJsaWNhLgpkKSAgICAgIExvcyBhdXRvcmVzIG1hbmlmaWVzdGFuIHF1ZSBzZSB0cmF0YSBkZSB1bmEgb2JyYSBvcmlnaW5hbCBzb2JyZSBsYSBxdWUgdGllbmVuIGxvcyBkZXJlY2hvcyBxdWUgYXV0b3JpemFuIHkgcXVlIHNvbiBlbGxvcyBxdWllbmVzIGFzdW1lbiB0b3RhbCByZXNwb25zYWJpbGlkYWQgcG9yIGVsIGNvbnRlbmlkbyBkZSBzdSBvYnJhIGFudGUgbGEgUG9udGlmaWNpYSBVbml2ZXJzaWRhZCBKYXZlcmlhbmEgeSBhbnRlIHRlcmNlcm9zLiBFbiB0b2RvIGNhc28gbGEgUG9udGlmaWNpYSBVbml2ZXJzaWRhZCBKYXZlcmlhbmEgc2UgY29tcHJvbWV0ZSBhIGluZGljYXIgc2llbXByZSBsYSBhdXRvcsOtYSBpbmNsdXllbmRvIGVsIG5vbWJyZSBkZWwgYXV0b3IgeSBsYSBmZWNoYSBkZSBwdWJsaWNhY2nDs24uCmUpICAgICAgQXV0b3Jpem8gKGFtb3MpIGEgbGEgVW5pdmVyc2lkYWQgcGFyYSBpbmNsdWlyIGxhIG9icmEgZW4gbG9zIMOtbmRpY2VzIHkgYnVzY2Fkb3JlcyBxdWUgZXN0aW1lbiBuZWNlc2FyaW9zIHBhcmEgcHJvbW92ZXIgc3UgZGlmdXNpw7NuLgpmKSAgICAgIEFjZXB0byAoYW1vcykgcXVlIGxhIFBvbnRpZmljaWEgVW5pdmVyc2lkYWQgSmF2ZXJpYW5hIHB1ZWRhIGNvbnZlcnRpciBlbCBkb2N1bWVudG8gYSBjdWFscXVpZXIgbWVkaW8gbyBmb3JtYXRvIHBhcmEgcHJvcMOzc2l0b3MgZGUgcHJlc2VydmFjacOzbiBkaWdpdGFsLgpnKSAgICAgIEF1dG9yaXpvIChhbW9zKSBxdWUgbGEgb2JyYSBzZWEgcHVlc3RhIGEgZGlzcG9zaWNpw7NuIGRlbCBww7pibGljbyBlbiBsb3MgdMOpcm1pbm9zIGF1dG9yaXphZG9zIGVuIGxvcyBsaXRlcmFsZXMgYW50ZXJpb3JlcyBiYWpvIGxvcyBsw61taXRlcyBkZWZpbmlkb3MgcG9yIGxhIHVuaXZlcnNpZGFkIGVuIGxhcyDigJxDb25kaWNpb25lcyBkZSB1c28gZGUgZXN0cmljdG8gY3VtcGxpbWllbnRv4oCdIGRlIGxvcyByZWN1cnNvcyBwdWJsaWNhZG9zIGVuIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwgUFVKICwgY3V5byB0ZXh0byBjb21wbGV0byBzZSBwdWVkZSBjb25zdWx0YXIgZW4gaHR0cDovL3JlcG9zaXRvcnkuamF2ZXJpYW5hLmVkdS5jby8KClNJIEVMIERPQ1VNRU5UTyBTRSBCQVNBIEVOIFVOIFRSQUJBSk8gUVVFIEhBIFNJRE8gUEFUUk9DSU5BRE8gTyBBUE9ZQURPIFBPUiBVTkEgQUdFTkNJQSBPIFVOQSBPUkdBTklaQUNJw5NOLCBDT04gRVhDRVBDScOTTiBERSBMQSBQT05USUZJQ0lBIFVOSVZFUlNJREFEIEpBVkVSSUFOQSwgRUwgKExPUykgQVVUT1IoRVMpIEdBUkFOVElaQShNT1MpIFFVRSBTRSBIQSBDVU1QTElETyBDT04gTE9TIERFUkVDSE9TIFkgT0JMSUdBQ0lPTkVTIFJFUVVFUklET1MgUE9SIEVMIFJFU1BFQ1RJVk8gQ09OVFJBVE8gTyBBQ1VFUkRPLgo= |